| review article | Q7318358 |
| scholarly article | Q13442814 |
| P2093 | author name string | Lindros KO | |
| Oinonen T | |||
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| Female-predominant rat hepatic P-450 forms j (IIE1) and 3 (IIA1) are under hormonal regulatory controls distinct from those of the sex-specific P-450 forms | Q42199309 | ||
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| Heterogeneity of the rat hepatic Ah receptor and evidence for transformation in vitro and in vivo | Q42206398 | ||
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| Heterogeneous distribution of drug metabolism in elutriated rat hepatocytes | Q42227789 | ||
| Phenobarbital-induced rat liver cytochrome P-450. Purification and characterization of two closely related isozymic forms | Q42258217 | ||
| Transcriptional regulation of rat P-450 2C gene subfamily members by the sexually dimorphic pattern of growth hormone secretion | Q42460244 | ||
| Regulation of cytochrome P-450b/e and P-450p gene expression by growth hormone in adult rat hepatocytes cultured on a reconstituted basement membrane | Q42465145 | ||
| Sex-dependent expression and clofibrate inducibility of cytochrome P450 4A fatty acid omega-hydroxylases. Male specificity of liver and kidney CYP4A2 mRNA and tissue-specific regulation by growth hormone and testosterone | Q42468297 | ||
| Modulation by oxygen of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in rat hepatocyte cultures | Q42476734 | ||
| Divergent effects of cycloheximide on the induction of class II and class III cytochrome P450 mRNAs in cultures of adult rat hepatocytes | Q42485690 | ||
| Different hepatocytes express the cholesterol 7 alpha-hydroxylase gene during its circadian modulation in vivo | Q42486288 | ||
| Long-lasting effects of tobacco smoking on pulmonary drug-metabolizing enzymes: a case-control study on lung cancer patients | Q42512900 | ||
| Zone-specific inducibility of cytochrome P450 2B1/2 is retained in isolated perivenous hepatocytes | Q42793024 | ||
| Heterogeneity of rat liver parenchyma in cholesterol 7 alpha-hydroxylase and bile acid synthesis | Q42797114 | ||
| Hormonal regulation of the zonated expression of cytochrome P-450 3A in rat liver | Q42821615 | ||
| Immunocytochemical localization of cytochrome P-450 in hepatic and extra-hepatic tissues of the rat with a monoclonal antibody against cytochrome P-450 c. | Q43538163 | ||
| Pretranslational control by thyroid hormone of rat liver steroid 5 alpha-reductase and comparison to the thyroid dependence of two growth hormone-regulated CYP2C mRNAs. | Q43730840 | ||
| Genetic susceptibility to squamous cell carcinoma of the lung in relation to cigarette smoking dose | Q44012878 | ||
| Growth hormone regulation of the cytochrome P-450IIC subfamily in the rat: inductive, repressive, and transcriptional effects on P-450f (IIC7) and P-450PB1 (IIC6) gene expression | Q45016235 | ||
| Transcriptional regulation of cholesterol 7 alpha-hydroxylase mRNA by conjugated bile acids in primary cultures of rat hepatocytes | Q45091680 | ||
| Hepatic expression of rat P450 mRNA assessed by in situ hybridization to oligomer probes | Q45113280 | ||
| Neonatal imprinting of liver microsomal hydroxylation and reduction of steroids. | Q47987494 | ||
| Transactivation of the rat CYP2C13 gene promoter involves HNF-1, HNF-3, and members of the orphan receptor subfamily | Q48079864 | ||
| Gene structure of a major form of phenobarbital-inducible cytochrome P-450 in rat liver | Q48377239 | ||
| Pituitary regulation of sex-specific forms of cytochrome P-450 in liver microsomes of rats | Q48461915 | ||
| Ethanol-, fasting-, and acetone-inducible cytochromes P-450 in rat liver: regulation and characteristics of enzymes belonging to the IIB and IIE gene subfamilies. | Q34176813 | ||
| Evidence for an Endogenous Ultradian Rhythm Governing Growth Hormone Secretion in the Rat | Q34180923 | ||
| Demonstration by in situ hybridization of the zonal modulation of rat liver cytochrome P-450b and P-450e gene expression after phenobarbital | Q34560400 | ||
| Metabolic zonation of the liver: regulation and implications for liver function | Q35417325 | ||
| Phenobarbital induction of cytochrome P-450 gene expression | Q35887158 | ||
| Hepatic steroid hydroxylating enzymes are controlled by the sexually dimorphic pattern of growth hormone secretion in normal and dwarf rats | Q35890648 | ||
| The Ah receptor and the mechanism of dioxin toxicity | Q36390569 | ||
| Regulation of mouse cytochrome P3-450 by the Ah receptor. Studies with a P3-450 cDNA clone | Q36602943 | ||
| Transcriptional control of the rat hepatic CYP2E1 gene | Q36723111 | ||
| Role of the liver-enriched transcription factor DBP in expression of the cytochrome P450 CYP2C6 gene | Q36817778 | ||
| Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes | Q36884204 | ||
| The 1990 Pharmaceutical Manufacturers Association of Canada Keynote Lecture. The role of the cytochromes P450 in the detoxication and activation of drugs and other chemicals | Q37220959 | ||
| Interpulse interval in circulating growth hormone patterns regulates sexually dimorphic expression of hepatic cytochrome P450. | Q37568745 | ||
| Hepatic sequestration and biliary secretion of epidermal growth factor: evidence for a high-capacity uptake system | Q37615497 | ||
| Molecular genetics of the P-450 superfamily | Q38140202 | ||
| A novel cis-acting element in a liver cytochrome P450 3A gene confers synergistic induction by glucocorticoids plus antiglucocorticoids | Q38288736 | ||
| Intermittent plasma growth hormone triggers tyrosine phosphorylation and nuclear translocation of a liver-expressed, Stat 5-related DNA binding protein. Proposed role as an intracellular regulator of male-specific liver gene transcription | Q38294444 | ||
| Interaction of the peroxisome proliferator-activated receptor alpha with the retinoid X receptor alpha unmasks a cryptic peroxisome proliferator response element that overlaps an ARP-1-binding site in the CYP4A6 promoter | Q38306361 | ||
| Hepatocyte nuclear factor 3 is a major determinant of CYP2C6 promoter activity in hepatoma cells. | Q38306506 | ||
| Characterization of the interaction of transformed rat hepatic cytosolic Ah receptor with a dioxin responsive transcriptional enhancer | Q38337434 | ||
| In vivo phenobarbital treatment increases protein binding to a putative AP-1 site in the CYP2B2 promoter | Q38351890 | ||
| Growth hormone activation of Stat 1, Stat 3, and Stat 5 in rat liver. Differential kinetics of hormone desensitization and growth hormone stimulation of both tyrosine phosphorylation and serine/threonine phosphorylation | Q38360551 | ||
| Localization of cytochrome P-450 gene expression in normal and diseased human liver by in situ hybridization of wax-embedded archival material. | Q38487230 | ||
| Functional specialization of different hepatocyte populations | Q38663205 | ||
| Interactions of hepatic cytochromes P-450 with steroid hormones. Regioselectivity and stereospecificity of steroid metabolism and hormonal regulation of rat P-450 enzyme expression | Q39626603 | ||
| The regulation of gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin. | Q39663871 | ||
| Cytochrome P-450 distribution in rat liver and the effect of sodium phenobarbitone administration | Q40150907 | ||
| A tentative review of recent in vitro observations of the enzymatic deiodination of iodothyronines and its possible physiological implications | Q40237004 | ||
| Xenobiotic-inducible transcription of cytochrome P450 genes. | Q40456814 | ||
| Zonation of metabolism and gene expression in liver. | Q40459673 | ||
| The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature | Q40484461 | ||
| The 1992 Bernard B. Brodie Award Lecture. Bioactivation and detoxication of toxic and carcinogenic chemicals. | Q40708498 | ||
| The AH-receptor: genetics, structure and function | Q40803701 | ||
| Regulation of cytochrome P450 genes: molecular mechanisms | Q40853525 | ||
| Role of cytochrome P4501A2 in chemical carcinogenesis: implications for human variability in expression and enzyme activity. | Q40946792 | ||
| Heterogeneous expression of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase genes in the rat liver lobulus | Q41010263 | ||
| Heterogeneous (positional) expression of hepatic glutamine synthetase: features, regulation and implications for hepatocarcinogenesis | Q41053206 | ||
| Modulation of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene by oxygen in rat hepatocyte cultures. Evidence for a heme protein as oxygen sensor | Q41096160 | ||
| P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. | Q41142872 | ||
| Differential effects of human anaphylatoxin C3a on glucose output and flow in rat liver during orthograde and retrograde perfusion: the periportal scavenger cell hypothesis | Q41186358 | ||
| Thyroid hormone-binding proteins in plasma facilitate uniform distribution of thyroxine within tissues: a perfused rat liver study | Q41383282 | ||
| Hepatocyte heterogeneity in response to icosanoids. The perivenous scavenger cell hypothesis | Q41395438 | ||
| Tissue differences in the concentration of triiodothyronine nuclear binding sites in the rat: liver, kidney, pituitary, heart, brain, spleen, and testis | Q48528666 | ||
| Difference in the susceptibility of two phenobarbital-inducible forms, P450IIB1 and P450IIB2, to thyroid hormone- and growth hormone-induced suppression in rat liver: phenobarbital-inducible P450IIB2 suppression by thyroid hormone acting directly, b | Q48709809 | ||
| Pituitary regulation of the male-specific steroid 6 beta-hydroxylase P-450 2a (gene product IIIA2) in adult rat liver. Suppressive influence of growth hormone and thyroxine acting at a pretranslational leve;. | Q49065927 | ||
| Hepatic zonation of drug metabolizing enzymes. Studies on hepatocytes isolated from the periportal or perivenous region of the liver acinus. | Q50886328 | ||
| A specific loss of growth hormone abolished sex-dependent expression of hepatic cytochrome P450 in dwarf rats: reversal of the profiles by growth hormone-treatment. | Q50981238 | ||
| Interaction of a novel sex-dependent, growth hormone-regulated liver nuclear factor with CYP2C12 promoter. | Q50988786 | ||
| Feminization of hepatic cytochrome P450s by nominal levels of growth hormone in the feminine plasma profile. | Q50993233 | ||
| Cytochrome P450 CYP1A1 MspI polymorphism and lung cancer susceptibility. | Q50998730 | ||
| Strain- and sex-specific variations in hepatic glutamine synthetase activity and distribution in rats and mice. | Q50999466 | ||
| Heterogeneous expression of sulphotransferases in periportal and perivenous hepatocytes prepared from male and female rat liver. | Q51040366 | ||
| Transcriptional control of CYP2E1 in the perivenous liver region and during starvation. | Q51613493 | ||
| Developmental expression and in situ localization of the phenobarbital-inducible rat hepatic mRNAs for cytochromes CYP2B1, CYP2B2, CYP2C6, and CYP3A1. | Q52239994 | ||
| Role of growth hormone in modulating the constitutive and phenobarbital-induced levels of two P-450(6)beta (testosterone 6 beta-hydroxylase) mRNAs in rat livers. | Q52243987 | ||
| Thyroid hormone suppression of hepatic levels of phenobarbital-inducible P-450b and P-450e and other neonatal P-450s in hypophysectomized rats. | Q52246667 | ||
| Adult male-specific and neonatally programmed rat hepatic P-450 forms RLM2 and 2a are not dependent on pulsatile plasma growth hormone for expression. | Q52250583 | ||
| Circadian clock genes are ticking. | Q52442074 | ||
| Polychlorinated biphenyls, classified as either phenobarbital- or 3-methylcholanthrene-type inducers of cytochrome P-450, are both hepatic tumor promoters in diethylnitrosamine-initiated rats. | Q53534840 | ||
| Characterization, localization and regulation of a novel phenobarbital-inducible form of cytochrome P450, compared with three further P450-isoenzymes, NADPH P450-reductase, glutathione transferases and microsomal epoxide hydrolase. | Q53551308 | ||
| Immunofluorescence of phenobarbital inducible cytochrome P-450 in the hepatic lobule of normal and phenobarbital-treated rats. | Q53563771 | ||
| Hormonal regulation of male-specific rat hepatic cytochrome P-450g (P-450IIC13) by androgens and the pituitary. | Q53963847 | ||
| Localization of a phenobarbital-responsive element (PBRE) in the 5′-flanking region of the rat CYP2B2 gene | Q54008148 | ||
| Regulation of hydroxylation of 5 alpha-androstane-3 beta, 17 beta-diol in liver microsomes from male and female rats. | Q54154319 | ||
| Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma. | Q54216734 | ||
| Growth hormone regulation of male-specific rat liver P450s 2A2 and 3A2: induction by intermittent growth hormone pulses in male but not female rats rendered growth hormone deficient by neonatal monosodium glutamate | Q58483726 | ||
| Phenobarbital induction of cytochrome P-450 in normal and preneoplastic rat liver: comparison of enzyme and mRNA expression as detected by immunohistochemistry and in situ hybridization | Q58483852 | ||
| Plasma Growth Hormone Pattern Regulates Epidermal Growth Factor (EGF) Receptor Messenger Ribonucleic Acid Levels and EGF Binding in the Rat Liver* | Q59487835 | ||
| Alpha-naphthoflavone acts as an antagonist of 2,3,7, 8-tetrachlorodibenzo-p-dioxin by forming an inactive complex with the Ah receptor. | Q64982828 | ||
| Regulatory gene product of the Ah locus. Characterization of the cytosolic inducer-receptor complex and evidence for its nuclear translocation | Q66961535 | ||
| Positive correlation between high aryl hydrocarbon hydroxylase activity and primary lung cancer as analyzed in cryopreserved lymphocytes | Q67232854 | ||
| Immunohistochemical localizations of cytochromes P-450 in rat liver | Q67437911 | ||
| Heterogeneity of rat hepatic Ah receptor: identification of two receptor forms which differ in their biochemical properties | Q67510012 | ||
| Zonation of cytochrome P450 isozyme expression and induction in rat liver | Q67754009 | ||
| Point-mutational MspI and Ile-Val polymorphisms closely linked in the CYP1A1 gene: lack of association with susceptibility to lung cancer in a Finnish study population | Q67809023 | ||
| The dynamics of the expression of C/EBP mRNA in the adult rat liver lobulus qualifies it as a pericentral mRNA | Q67956834 | ||
| Acinar heterogeneity of the epidermal growth factor receptor in the liver of male rats | Q68006850 | ||
| Constitutive expression and hormonal regulation of male sexually differentiated cytochromes P450 in primary cultured rat hepatocytes | Q68043913 | ||
| Responses to insulin by two forms of rat hepatic microsomal cytochrome P-450 that undergo major (RLM6) and minor (RLM5b) elevations in diabetes | Q68189168 | ||
| Increased catalytic activity of cytochrome P-450IIE1 in pericentral hepatocytes compared to periportal hepatocytes isolated from pyrazole-treated rats | Q68294998 | ||
| Effects of growth hormone on cytochrome P-450j | Q68501086 | ||
| Modulation of hepatic level of microsomal testosterone 7 alpha-hydroxylase, P-450a (P450IIA), by thyroid hormone and growth hormone in rat liver | Q68687457 | ||
| Effect of growth hormone on rat hepatic cytochrome P-450f mRNA: a new mode of regulation | Q68708106 | ||
| Quantitative analysis of smooth and rough endoplasmic reticulum proliferation in differentiating hepatocytes of midpostnatal mice treated with phenobarbital | Q68712946 | ||
| Effect of different doses of 3-methylcholanthrene on the localization of the 3-methylcholanthrene-inducible isoenzymes of cytochrome P450 within the centrilobular and periportal zones of the rat liver | Q68795510 | ||
| Identification of intratissue sites for xenobiotic activation and detoxication | Q68906300 | ||
| Suppression of levels of phenobarbital-inducible rat liver cytochrome P-450 by pituitary hormone | Q69025749 | ||
| Acinar distribution of glutathione-dependent detoxifying enzymes. Low glutathione peroxidase activity in perivenous hepatocytes | Q69051508 | ||
| Induction of P-450IIB genes within the rat liver acinus is not dependent on the chemical inducer or on the acinar organization | Q69070707 | ||
| Functional hepatocyte heterogeneity. Vascular 2-oxoglutarate is almost exclusively taken up by perivenous, glutamine-synthetase-containing hepatocytes | Q69370680 | ||
| Hepatocyte heterogeneity in response to extracellular ATP | Q69467959 | ||
| The hepatic sinusoid is not well-stirred: estimation of the degree of axial mixing by analysis of lobular concentration gradients formed during uptake of thyroxine by the perfused rat liver | Q69494409 | ||
| Distribution and induction of cytochrome P-450 and two cytochrome P-450-dependent monooxygenase activities in rat liver parenchymal cell subpopulations separated by centrifugal elutriation | Q69647215 | ||
| Immunohistochemical localization of cytochrome P450b/e in hepatic and extrahepatic tissues of the rat | Q69804111 | ||
| Hormonal and developmental regulation of expression of the hepatic microsomal steroid 16 alpha-hydroxylase cytochrome P-450 apoprotein in the rat | Q69873409 | ||
| Perivenous localisation of Na-dependent glutamate transport in perfused rat liver | Q69904334 | ||
| Centrilobular expression of ethanol-inducible cytochrome P-450 (IIE1) in rat liver | Q69927431 | ||
| Induction of rat hepatic N-nitrosodimethylamine demethylase by acetone is due to protein stabilization | Q69942868 | ||
| An immunohistochemical study on the localization and distributions of phenobarbital- and 3-methylcholanthrene-inducible cytochromes P-450 within the livers of untreated rats | Q70153865 | ||
| Effect of phenobarbital on the distribution of drug metabolizing enzymes between periportal and perivenous rat hepatocytes prepared by digitonin-collagenase liver perfusion | Q70162243 | ||
| Growth hormone (GH) regulation of cytochrome P-450IIC12, insulin-like growth factor-I (IGF-I), and GH receptor messenger RNA expression in primary rat hepatocytes: a hormonal interplay with insulin, IGF-I, and thyroid hormone | Q70256815 | ||
| Effects of 3-methylcholanthrene, beta-naphthoflavone, and phenobarbital on the 3-methylcholanthrene-inducible isozyme of cytochrome P-450 within centrilobular, midzonal, and periportal hepatocytes | Q70266149 | ||
| Immunohistochemical localization of carbamoyl-phosphate synthetase (ammonia) in adult rat liver; evidence for a heterogeneous distribution | Q70355638 | ||
| A high-spin form of cytochrome P-450 highly purified from polychlorinated biphenyl-treated rats. Catalytic characterization and immunochemical quantitation in liver microsomes | Q70438519 | ||
| Phenobarbital induction and tissue-specific expression of the rat CYP2B2 gene in transgenic mice | Q70500768 | ||
| A rapid method to study heterogeneous gene expression in liver by direct assay of messenger RNA from periportal and perivenous cell lysates | Q70588194 | ||
| Portal blood concentrations of conjugated cholic and chenodeoxycholic acids. Relationships to bile salt synthesis in liver cells | Q70668151 | ||
| Effects of phenobarbital and 3-methylcholanthrene pretreatments on monooxygenase activities and proportions of isolated rat hepatocyte subpopulations | Q70989045 | ||
| Distinct effects of phenobarbital and its N-methylated derivative on liver cytochrome P450 induction | Q71097837 | ||
| Differential induction of two 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible forms of cytochrome P-450 in extrahepatic versus hepatic tissues | Q71306390 | ||
| Purification and characterization of liver microsomal cytochromes p-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or beta-naphthoflavone | Q71468820 | ||
| Zonation of cytochrome P450 enzyme expression in rat liver. Isozyme-specific regulation by pituitary dependent hormones | Q71487608 | ||
| Effects of phenobarbital, pregnenolone-16 alpha-carbonitrile, and 3-methylcholanthrene pretreatments on the distribution of NADPH-cytochrome c (P-450) reductase within the liver lobule | Q71518939 | ||
| Distributions of monooxygenase components and epoxide hydratase within the livers of untreated male rats | Q71542847 | ||
| Purification and characterization of a second form of hepatic cytochrome P-448 from rats treated with a pure polychlorinated biphenyl isomer | Q71590193 | ||
| Distribution and induction of CYP3A1 and CYP3A2 in rat liver and extrahepatic tissues | Q71634683 | ||
| Glucocorticoid receptor-independent transcriptional induction of cytochrome P450 3A1 by metyrapone and its potentiation by glucocorticoid | Q71668481 | ||
| Expression and distribution of cholesterol 7 alpha-hydroxylase in rat liver | Q71706478 | ||
| Expression of cytochrome P450 CYP1B1 in breast cancer | Q71816201 | ||
| Insulin suppresses the induction of CYP2B1 and CYP2B2 gene expression by phenobarbital in adult rat cultured hepatocytes | Q71857915 | ||
| Selective centrilobular expression of the aryl hydrocarbon receptor in rat liver | Q71975547 | ||
| Induction of the cytochrome P450 3A subfamily in rat liver correlates with the binding of inducers to a microsomal protein | Q71993358 | ||
| Induction of cytochrome p450 and peroxisomal enzymes by clofibric acid in vivo and in VITRO | Q72083900 | ||
| Modulation of the rat hepatic cytochrome P450 composition by long-term streptozotocin-induced insulin-dependent diabetes | Q72153820 | ||
| Different drug metabolizing capacities in cultured periportal and pericentral hepatocytes | Q72174187 | ||
| cAMP-associated inhibition of phenobarbital-inducible cytochrome P450 gene expression in primary rat hepatocyte cultures | Q72259878 | ||
| Pretranslational induction of cytochrome P4501A enzymes by beta-naphthoflavone and 3-methylcholanthrene occurs in different liver zones | Q72384540 | ||
| Modulation of the Glucagon-Dependent Induction of Phosphoenolpyruvate Carboxykinase and Tyrosine Aminotransferase by Arterial and Venous Oxygen Concentrations in Hepatocyte Cultures | Q72509019 | ||
| Insulin suppresses bile acid synthesis in cultured rat hepatocytes by down-regulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase gene transcription | Q72511343 | ||
| Oxygen tension, insulin, and glucagon affect the preservation and induction of cytochrome P450 isoforms in cultured rat hepatocytes | Q72532109 | ||
| Immunohistochemical localization of cytochrome P-450a in liver sections from untreated rats and rats treated with phenobarbital or 3-methylcholanthrene | Q72561755 | ||
| Induction of cytochrome P-450 by glucocorticoids in rat liver. II. Evidence that glucocorticoids regulate induction of cytochrome P-450 by a nonclassical receptor mechanism | Q72571239 | ||
| Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture | Q72584826 | ||
| The phenobarbital-induced transcriptional activation of cytochrome P-450 genes is blocked by the glucocorticoid-progesterone antagonist RU486 | Q72584853 | ||
| Intrasplenic transplantation of isolated periportal and perivenous hepatocytes as a long-term system for study of liver-specific gene expression | Q72672374 | ||
| Association of liver fluke (Opisthorchis viverrini) infestation with increased expression of cytochrome P450 and carcinogen metabolism in male hamster liver | Q72693340 | ||
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 17-35 | |
| P577 | publication date | 1998-01-01 | |
| P1433 | published in | Biochemical Journal | Q864221 |
| P1476 | title | Zonation of hepatic cytochrome P-450 expression and regulation | |
| P478 | volume | 329 ( Pt 1) |
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