| scholarly article | Q13442814 |
| P356 | DOI | 10.1021/BI00266A045 |
| P698 | PubMed publication ID | 6758842 |
| P50 | author | F. Peter Guengerich | Q5424002 |
| P2093 | author name string | L S Kaminsky | |
| M V Martin | |||
| G A Dannan | |||
| S T Wright | |||
| P433 | issue | 23 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 6019-6030 | |
| P577 | publication date | 1982-11-01 | |
| P1433 | published in | Biochemistry | Q764876 |
| P1476 | title | Purification and characterization of liver microsomal cytochromes p-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or beta-naphthoflavone | |
| P478 | volume | 21 |
| Q33298342 | 21 Identification of human cytochrome P450s as autoantigens |
| Q67842846 | 40 Induction of cytochromes P450IA1 and P450IA2 and measurement of catalytic activities |
| Q67842876 | 5 Azidowarfarin as photoaffinity probe of cytochromes P450 |
| Q73994228 | A comparison of hepatic cytochrome P450 protein expression between infancy and postinfancy |
| Q47818939 | A cytochrome P4501B gene from a fish, Pleuronectes platessa |
| Q34418056 | A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking |
| Q67967413 | Activation of cyclophosphamide in mouse limb bud cultures using a reconstituted cytochrome P-450 system |
| Q51851619 | Acute toxicity of fluorinated ether anesthetics: Role of 2,2,2-trifluoroethanol and other metabolites |
| Q72827580 | Age dependent different influence of carbon tetrachloride on biotransformation of xenobiotics, glutathione content, lipid peroxidation and histopathology of rat liver |
| Q67746230 | Alteration in surface structure of Clara cells and pulmonary cytochrome P-450b level in rats exposed to ozone |
| Q28297944 | Aminopyrine metabolism by multiple forms of cytochrome P-450 from rat liver microsomes: Simultaneous quantitation of four aminopyrine metabolites by high-performance liquid chromatography |
| Q67714233 | Aminopyrine-N-demethylase. II. Characterization of a unique monooxygenase isoform P-450ap |
| Q42738195 | Androgen hydroxylation catalysed by a cell line (SD1) that stably expresses rat hepatic cytochrome P-450 PB-4 (IIB1) |
| Q34253837 | Anti-liver endoplasmic reticulum autoantibodies are directed against human cytochrome P-450IA2. A specific marker of dihydralazine-induced hepatitis. |
| Q37360013 | Antigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera. |
| Q60787070 | Antipyrine as a probe for human oxidative drug metabolism: Identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation* |
| Q42749924 | Assessment of subclinical, toxicant-induced hepatic gene expression profiles after low-dose, short-term exposures in mice. |
| Q37521850 | At least six forms of extremely homologous cytochromes P-450 in rat liver are encoded at two closely linked genetic loci |
| Q46373604 | Brain microsomal oxidation of delta 8- and delta 9-tetrahydrocannabinol |
| Q71926093 | Caffeine increases its own metabolism through cytochrome P4501A induction in rats |
| Q43729032 | Catalytic and immunochemical properties of hepatic cytochrome P450 1A in three avian species treated with beta-naphthoflavone or isosafrole |
| Q50196114 | Changes in the quantity and activity of cytochrome P-450 isozymes in primary cultured rat hepatocytes |
| Q34416806 | Characterisation of theophylline metabolism in human liver microsomes |
| Q30917115 | Characterization of Pulmonary CYP4B2, Specific Catalyst of Methyl Oxidation of 3-Methylindole |
| Q70702408 | Characterization of a common genetic defect of cytochrome P-450 function (debrisoquine-sparteine type polymorphism)--increased Michaelis is Constant (Km) and loss of stereoselectivity of bufuralol 1'-hydroxylation in poor metabolizers |
| Q37578460 | Characterization of a human liver cytochrome P-450 involved in the oxidation of debrisoquine and other drugs by using antibodies raised to the analogous rat enzyme |
| Q72038626 | Characterization of benzo[a]pyrene metabolism and related cytochrome P‐450 isozymes in Syrian hamster livers |
| Q43437354 | Characterization of hepatic and pulmonary cytochromes P-450 in 3-methylcholanthrene-treated hamsters |
| Q67917679 | Characterization of pig liver purified cytochrome P-450 isoenzymes for ochratoxin a metabolism studies |
| Q70448228 | Chemical modification of microsomal cytochrome P450: role of lysyl residues in hydroxylation activity |
| Q35048546 | Cloning of a cDNA coding for P-450 LM3c from rabbit liver microsomes and regulation of its expression |
| Q73041458 | Combined effects of ethanol and cigarette smoke on hepatic and pulmonary xenobiotic metabolizing enzymes in rats |
| Q84695565 | Comparative cytotoxicity of non-steroidal anti-inflammatory drugs in primary cultures of rat hepatocytes |
| Q23917240 | Comparative metabolism of Bis(2-methoxyethyl) ether by rat and human hepatic microsomes: formation of 2-methoxyethanol |
| Q52607538 | Comparison of Drosophila cytochrome P450 metabolism of natural and model substrates. |
| Q67802319 | Comparison of in vitro and in vivo biotransformation in patients with liver disease of differing severity |
| Q81640796 | Comparison of metabolite profiles generated in Aroclor-induced rat liver and human liver subcellular fractions: considerations for in vitro genotoxicity hazard assessment |
| Q41670058 | Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different species |
| Q70162396 | Comparisons of warfarin metabolism by liver microsomes of rats treated with a series of polybrominated biphenyl congeners and by the component-purified cytochrome P-450 isozymes |
| Q68341323 | Complexation of cytochrome P-450 isozymes in hepatic microsomes from SKF 525-A-induced rats |
| Q73555489 | Conformational change of cytochrome P450 1A2 induced by phospholipids and detergents |
| Q71825636 | Conformational change of cytochrome P450 1A2 induced by sodium chloride |
| Q72713834 | Coordinate induction of multiple mRNAs specific for rat liver phenobarbital-lnducible cytochromes P-450 |
| Q34659529 | Cytochrome P-450 isozymes and monooxygenase activity in aquatic animals |
| Q68681983 | Cytochrome P-450 localization in normal human adult and foetal liver by immunocytochemistry using a monoclonal antibody against human cytochrome P-450 |
| Q86711322 | Cytochrome P-450 mediated O-dealkylation of 7-alkoxycoumarins in liver microsomes from rainbow trout (Salmo gairdneri) |
| Q43546458 | Cytochrome P450 (P450) isoforms expression, P450 concentration, monooxygenase activities, reactive oxygen species formation, lipid peroxidation, and glutathione content in wild catch carp and tench liver--influence of a two weeks exposure to phenoba |
| Q34575691 | Cytochrome P450 7A1 cholesterol 7alpha-hydroxylation: individual reaction steps in the catalytic cycle and rate-limiting ferric iron reduction |
| Q46730724 | Cytochrome P450-mediated warfarin metabolic ability is not a critical determinant of warfarin sensitivity in avian species: In vitro assays in several birds and in vivo assays in chicken. |
| Q33693676 | Cytochrome b5 potentiation of cytochrome P-450 catalytic activity demonstrated by a vaccinia virus-mediated in situ reconstitution system |
| Q72584054 | Debrisoquine-type polymorphism of drug oxidation: purification from human liver of a cytochrome P450 isozyme with high activity for bufuralol hydroxylation |
| Q45060321 | Determination of "active" cytochrome P-450 from relaxation kinetics of product formation |
| Q45261831 | Determination of compound-specific acceptable daily intakes for 11 mutagenic carcinogens used in pharmaceutical synthesis |
| Q28570568 | Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotide-dependent protective systems |
| Q42793907 | Differences in the cytochrome P-450 isoenzymes involved in the 2-hydroxylation of oestradiol and 17 alpha-ethinyloestradiol. Relative activities of rat and human liver enzymes |
| Q46856924 | Differential effect of interleukin-1 alpha on rat hepatic cytochrome P450 monooxygenases |
| Q74523507 | Differential effects of B- and T-lymphocyte mitogens on cytochrome P450 in mice |
| Q73575152 | Differential effects of flavonoids on testosterone-metabolizing cytochrome P450s |
| Q28362524 | Differential haemin-mediated restoration of cytochrome P-450 N-demethylases after inactivation by allylisopropylacetamide |
| Q72013050 | Differential responses of hepatic monooxygenases and glutathione S-transferases of mice to a combination of cadmium and nickel |
| Q42284671 | Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes |
| Q72038623 | Dimethylnitrosamine‐induced DNA damage and toxic cell death in cultured mouse hepatocytes |
| Q42859924 | Distinct forms of cytochrome P-450 are responsible for 6 beta-hydroxylation of bile acids and of neutral steroids |
| Q71958821 | Downregulation of male-specific cytochrome P450s 2C11 and 3A2 in bile duct–ligated male rats: Importance to reduced hepatic content of cytochrome P450 in cholestasis |
| Q34570298 | Downregulation of the male-specific hepatic microsomal steroid 16 alpha-hydroxylase, cytochrome P-450UT-A, in rats with portal bypass. Relevance to estradiol accumulation and impaired drug metabolism in hepatic cirrhosis |
| Q59164801 | Effect of carrageenan-induced granuloma on hepatic cytochrome P-450 isozymes in rats |
| Q73515836 | Effect of gestational and lactational 2,3,7, 8-tetrachlorodibenzo-p-dioxin exposure on the level and catalytic activities of hepatic microsomal CYP1A in prepubertal and adult rats |
| Q23921511 | Effect of in vivo nicotine exposure on chlorpyrifos pharmacokinetics and pharmacodynamics in rats |
| Q44864579 | Effect of protein-calorie malnutrition on cytochromes P450 and glutathione S-transferase |
| Q53445164 | Effects of cytochrome P450 inducers on tamoxifen genotoxicity in female mice in vivo. |
| Q68501086 | Effects of growth hormone on cytochrome P-450j |
| Q69638252 | Effects of inducers on the regio- and stereoselective metabolism of benzo[a]pyrene by mouse tissue microsomes |
| Q68307962 | Effects of long-term choline deficiency on hepatic microsomal cytochrome P-450-mediated steroid and xenobiotic hydroxylases in the female rat |
| Q23913389 | Effects of paving asphalt fume exposure on genotoxic and mutagenic activities in the rat lung |
| Q43678625 | Effects of simvastatin, a lipoprotein-lowering drug, on the hepatic enzymes involved in drug metabolism in the Wistar rat |
| Q28362434 | Effects of the induction of hepatic microsomal metabolism on the toxicity of cyclophosphamide |
| Q73018734 | Effects of tris(4-chlorophenyl)methanol on the rat following short-term oral exposure |
| Q73335852 | Effects of various pretreatments on the hepatotoxicity of inhaled styrene in the B6C3F1 mouse |
| Q37656515 | Elimination of inhaled 3,3'-dichlorobiphenyl and the formation of the 4-hydroxylated metabolite |
| Q47261654 | Evaluation of rat hepatic 2E1 activity in function of age, sex and inducers: choice of an experimental model capable of testing the hepatotoxicity of low molecular weight compounds |
| Q24299140 | Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver |
| Q44002063 | Evidence for the presence of active cytochrome P450 systems in Schistosoma mansoni and Schistosoma haematobium adult worms |
| Q93658405 | Evidence that covalent binding of metabolically activated phenol to microsomal proteins is caused by oxidised products of hydroquinone and catechol |
| Q42558066 | Exposure to various benzene derivatives differently induces cytochromes P450 2B1 and P450 2E1 in rat liver |
| Q70229905 | Expression of cytochromes P-450 in rat hepatoma cells. Analysis by monoclonal antibodies specific for cytochromes P-450 from rat liver induced by 3-methylcholanthrene or phenobarbital |
| Q40743025 | Extrahepatic metabolism of drugs in humans |
| Q68434198 | Felbamate Increases Phenytoin but Decreases Carbamazepine Concentrations |
| Q69196880 | Fingerprinting rat liver microsomal cytochromes P-450 as a means of delineating sexually distinctive forms |
| Q67589278 | Fluorenone and 2-benzoylfluorenone: different short-term effects on drug-metabolizing liver enzymes and on cell proliferation |
| Q48775974 | Forging the links between metabolism and carcinogenesis |
| Q28362226 | Fractionation and purification of hepatic microsomal cytochrome P-450 isoenzymes from phenobarbital-pretreated rats by h.p.l.c. A convenient tool for screening of isoenzymes inactivated by allylisopropylacetamide |
| Q84586294 | Gender dependent effects of cigarette smoke on hepatic and pulmonary xenobiotic metabolizing enzymes in rats |
| Q70158595 | Genetic polymorphisms for a phenobarbital-inducible cytochrome P-450 map to the Coh locus in mice |
| Q44947499 | Genetically determined polymorphisms in drug oxidation |
| Q57747321 | High-performance liquid chromatographic separation of 11-hydroxylauric acid enantiomers |
| Q68659804 | High-performance liquid chromatography of the metabolites of nitrendipine and investigation into the metabolic pathways of this dihydropyridine |
| Q67842161 | High-performance metal chelate affinity chromatography of cytochromes P-450 using Chelating Superose |
| Q36812371 | Human cytochrome P450 2E1 mutations that alter mitochondrial targeting efficiency and susceptibility to ethanol-induced toxicity in cellular models |
| Q42929087 | Human cytochrome P450 4F11: heterologous expression in bacteria, purification, and characterization of catalytic function |
| Q45711505 | Hydroxylation of fatty acids by microsomal and reconstituted cytochrome P450 2B1. |
| Q72585757 | Identification of P450 enzymes involved in metabolism of verapamil in humans |
| Q37543129 | Identification of an inducible form of cytochrome P-450 in human liver |
| Q42867249 | Identification of human cytochromes P-450 analogous to forms induced by phenobarbital and 3-methylcholanthrene in the rat. |
| Q93921323 | Identification of in vitro cytochrome P450 modulators to detect induction by prototype inducers in the mallard duckling (Anas platyrhynchos) |
| Q41889182 | Immunochemical evidence for multiple steroid-inducible hepatic cytochromes P-450 in the rat. |
| Q70288777 | Immunochemical evidences that hexachlorobenzene induces two forms of cytochrome P-450 in the rat liver microsomes |
| Q42736635 | Immunochemical quantification of cytochrome P450IA and IIB subfamilies in the livers of metyrapone-treated rats. Relevance to the ability of metyrapone to prevent the loss of cytochrome P-450 in rat hepatocyte culture |
| Q32061576 | Immunohistochemical demonstration of beta-naphthoflavone-inducible cytochrome P450 1A1/1A2 in rat intrahepatic biliary epithelial cells |
| Q45119026 | Immunoquantitation of some cytochrome P-450 isozymes in liver microsomes from streptozotocin-diabetic rats |
| Q67917657 | In vivo intestinal metabolism of 7-ethoxycoumarin in the rat: Production and distribution of phase I and II metabolites in the isolated, perfused intestinal loop |
| Q71844012 | Inducibility of cytochromes P-450 by dioxin in liver and extrahepatic tissues of the marmoset monkey (Callithrix jacchus) |
| Q39938979 | Induction and substrate specificity of the lanosterol 14 alpha-demethylase from Saccharomyces cerevisiae Y222 |
| Q72571235 | Induction of cytochrome P-450 by glucocorticoids in rat liver. I. Evidence that glucocorticoids and pregnenolone 16 alpha-carbonitrile regulate de novo synthesis of a common form of cytochrome P-450 in cultures of adult rat hepatocytes and in the li |
| Q72571239 | Induction of cytochrome P-450 by glucocorticoids in rat liver. II. Evidence that glucocorticoids regulate induction of cytochrome P-450 by a nonclassical receptor mechanism |
| Q41889858 | Induction of cytochrome P-450 in cultured rat hepatocytes. The heterogeneous localization of specific isoenzymes using immunocytochemistry |
| Q45150495 | Induction of cytochrome P-450c in hematopoietic cells of fetal liver |
| Q77449569 | Induction of cytochrome P450 1A1 in rat liver slices by 7-ethoxycoumarin and 4-methyl-7-ethoxycoumarin |
| Q74257761 | Induction of cytochromes P450 2B and 2E1 in rat liver by isomeric picoline N-oxides |
| Q42051834 | Induction of glutathione S-transferase P-form in primary cultured rat liver parenchymal cells by co-planar polychlorinated biphenyl congeners |
| Q53490992 | Induction of hepatic CYP1A activity as a biomarker for environmental exposure to Aroclor 1254 in feral rodents. |
| Q67465696 | Induction of hepatic CYP1A in male F344/NCr rats by dietary exposure to Aroclor 1254: examination of immunochemical, RNA, catalytic, and pharmacokinetic endpoints |
| Q73040897 | Induction of rat hepatic cytochrome P4501A and P4502B by the methoxsalen |
| Q68342419 | Induction of renal cytochrome P-450 in hepatic microsomes of diabetic rats |
| Q68443365 | Induction of the rat hepatic microsomal mixed-function oxidases by 3 imidazole-containing antifungal agents: selectivity for the cytochrome P-450IIB and P-450III families of cytochromes P-450 |
| Q77449555 | Influence of 2-acetylaminofluorene (2-AAF) on biotransformation and lipid peroxidation in salivary glands and liver from male rats |
| Q41765028 | Influence of Inducers of Cytochrome P-450 on Dealkylation of 7-Alkoxycoumarins |
| Q47382643 | Influence of tumor size on the main drug-metabolizing enzyme systems in mouse colon adenocarcinoma Co38. |
| Q68630709 | Influence of xenobiotics on drug metabolism and its sensitive detection |
| Q23914525 | Influenza virus-induced alterations of cytochrome P-450 enzyme activities following exposure of mice to coal and diesel particulates |
| Q28570581 | Inhibition by retinoids of benzo(A)pyrene metabolism catalyzed by 3-methylcholanthrene-induced rat cytochrome P-450 1A1 |
| Q43574315 | Inhibition of liver methionine adenosyltransferase gene expression by 3-methylcolanthrene: protective effect of S-adenosylmethionine. |
| Q42215029 | Inhibition of steroid 5α-reductase and its effects on testosterone hydroxylation by rat liver microsomal cytochrome P-450 |
| Q48809909 | Inhibitory effects of H2-receptor antagonists on cytochrome P450 in male ICR mice |
| Q41032462 | Inhibitory monoclonal antibody to human cytochrome P450 2B6. |
| Q33750356 | Inter-individual differences in the metabolism of environmental toxicants: cytochrome P450 1A2 as a prototype |
| Q42278536 | Inter-relatedness of some isoenzymes of cytochrome P-450 from rat, rabbit and human, determined with monoclonal antibodies |
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| Q70359819 | Ion-exchange fast protein liquid chromatography; optimization of the purification of cytochrome P-450 from marmoset monkeys |
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| Q36458584 | Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase |
| Q24568198 | Isolation and sequence of a human cytochrome P-450 cDNA clone |
| Q71422832 | Luminol-and lucigenin-amplified chemiluminescence with rat liver microsomes. Kinetics and influence of ascorbic acid, glutathione, dimethylsulfoxide, N-t-butyl-a-phenyl-nitrone, copper-ions and a copper complex, catalase, superoxide dismutase, hexob |
| Q50196108 | Metabolic activation of chemical carcinogens by hepatic preparations from streptozotocin-treated rats |
| Q53448681 | Metabolism of carcinogenic N-nitroso-N-methylaniline by purified cytochromes P450 2B1 and P450 2B2. |
| Q41876962 | Metabolism of the aldose reductase inhibitor ALO1567 in man. |
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| Q24796562 | Minipig cytochrome P450 3A, 2A and 2C enzymes have similar properties to human analogs |
| Q28571662 | Mitochondrial targeted cytochrome P450 2E1 (P450 MT5) contains an intact N terminus and requires mitochondrial specific electron transfer proteins for activity |
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| Q41560473 | On the metabolizing systems for short-term genotoxicity assays: a review. |
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