Safety of acid-suppressing drugs

scientific article published on February 1995

Safety of acid-suppressing drugs is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1007/BF02214872
P698PubMed publication ID7859585

P2093author name stringLam SK
Berlin RG
Hawkey CJ
Langman MJ
Smallwood RA
Festen HP
Parkinson A
Lundborg P
Castagnoli N
P2860cites workHuman cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylaminesQ24339615
Endocrine adverse effects of omeprazoleQ28316627
Pharmacokinetic and clinical studies in patients with cimetidine-associated mental confusionQ28318405
Cimetidine and bradycardiaQ28318448
Cimetidine hepatitisQ28326883
Acute interstitial nephritis due to omeprazoleQ28327283
Bone-Marrow Suppression Associated with CimetidineQ28327982
Cimetidine: Does Neurotoxicity Occur? Report of Three CasesQ28329647
Cimetidine cholestatic jaundice in childrenQ28332330
First-degree atrioventricular block in a young duodenal ulcer patient treated with a standard oral dose of ranitidineQ33169152
Mechanism of ranitidine associated anemiaQ33433475
Clinically important adverse effects and drug interactions with H2-receptor antagonists: an updateQ33444086
Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man.Q34037250
A study of the interaction between omeprazole and cyclosporine in renal transplant patientsQ34403554
Effect of cimetidine on gonadal function in manQ34449895
Postmarketing surveillance of the safety of cimetidine: mortality during second, third, and fourth years of follow upQ34487626
Ranitidine does not affect gonadal function in manQ34513180
Influence of cimetidine on verapamil kinetics and dynamicsQ70615871
Cimetidine in pregnancy: apparent transient liver impairment in the newbornQ70645299
[The effect of cimetidine on the metabolism and effects of alcohol]Q70798111
Effects of cimetidine on pituitary function: Alterations in hormone secretion profilesQ70999288
Inhibitory effect of cimetidine on liver regeneration after two-thirds hepatectomy in ratsQ71020910
Cimetidine as an immunomodulator: chronic mucocutaneous candidiasis as a modelQ71131291
Prophylaxis of upper gastrointestinal bleeding with cimetidine in patients undergoing partial hepatectomyQ71382424
Central nervous system-mediated stimulation of prolactin secretion by cimetidine, a histamine H2-receptor antagonist: impaired responsiveness in patients with prolactin-secreting tumors and idiopathic hyperprolactinemiaQ71401949
Interactions of nitrogen heterocycles with cytochrome P-450 and monooxygenase activityQ71423394
Purification and characterization of liver microsomal cytochromes p-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or beta-naphthoflavoneQ71468820
Bridging hepatic necrosis associated with cimetidineQ71499725
Cimetidine and polymyositisQ71773920
Histamine-2 receptor antagonists do not alter serum ethanol levels in fed, nonalcoholic menQ72212035
Inotropic effects of histamine in human myocardium: differentiation between positive and negative componentsQ72381812
Omeprazole, a gastric 'proton pump inhibitor': lack of effect on renal handling of electrolytes and urinary acidificationQ72389382
Effects of cimetidine, ranitidine, and antacid on renal functionQ72392835
Effect of the new H2-receptor antagonist ranitidine on plasma prolactin levels in duodenal ulcer patientsQ72505007
Ranitidine also reduces liver blood flowQ72517426
The acute and long term effect of the H2-receptor antagonists cimetidine and ranitidine on the pituitary-gonadal axis in menQ72555196
[Chronic toxicity study of ranitidine hydrochloride orally administered in rats]Q72555785
Rapid healing of duodenal ulcers with omeprazole: double-blind dose-comparative trialQ72556156
Effects of cimetidine and ranitidine on delayed-type hypersensitivityQ72557795
Side effects of histamine2-receptor antagonistsQ72561677
Negative inotropic effect of some H2-receptor antagonists on the isolated human atriaQ72566710
Ranitidine and confusionQ72578218
Omeprazole: no evidence for frequent hepatic reactionsQ72580565
In Vivo Interactions Between H2-Receptor Antagonists and Ethanol Metabolism in Man and in RatsQ72592683
Drug interactions involving cimetidine--mechanisms, documentation, implicationsQ72601853
Renal function and cimetidine. Urinary albumin and beta 2-microglobulin excretion and creatine clearance during cimetidine treatmentQ72635027
Effects of two histamine H2-receptor blocking drugs on basal levels of gonadotrophins, prolactin, testosterone and oestradiol-17β during treatment of duodenal ulcer in male patientsQ72885182
Possible ranitidine hepatitisQ72918738
Comparison between dose-responses of prolactin, thyroid stimulating hormone and growth hormone to two different histamine H-2 receptor antagonists in normal menQ72920059
Oral ranitidine in labourQ93610782
Possible Ranitidine HepatotoxicityQ70221450
Effects of cimetidine on the elimination and actions of ethanolQ70232988
Cimetidine and renal allograft rejectionQ70251099
Cimetidine and thrombocytopeniaQ70263797
Dose-response study of omeprazole on meal-stimulated gastric acid secretion and gastrin releaseQ70290554
Evidence for induction of hepatic microsomal cytochrome P-450 by cimetidine: binding and kinetic studiesQ70291786
Enprostil, in contrast to cimetidine, does not inhibit propranolol metabolismQ70292706
Cimetidine-induced maniaQ70491579
Ranitidine has no effect on postbreakfast ethanol absorptionQ70539273
Cimetidine induced arrhythmiasQ70543078
Cancer occurrence in a cohort of patients treated with cimetidineQ34532561
Active proton secretion and potassium absorption in the rabbit outer medullary collecting duct. Functional evidence for proton-potassium-activated adenosine triphosphataseQ34577970
No detectable concentrations of oxmetidine but measurable concentrations of cimetidine in cerebrospinal fluid (CSF) during multiple dose treatmentQ34621218
Dose and concentration dependent effect of ranitidine on procainamide disposition and renal clearance in manQ34621491
High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolismQ34637307
Focus on misoprostol: review of worldwide safety data.Q34685591
Cimetidine, a Histamine H2Receptor Antagonist, Occupies Androgen Receptors*Q34697969
Effect of cimetidine on portal hypertension in cirrhotic patients.Q34750960
Cimetidine and gastric cancer: preliminary report from post-marketing surveillance study.Q34764885
Influence of cimetidine on pharmacokinetics of propranololQ34780424
Postmarketing surveillance of the safety of cimetidine: 12 month mortality reportQ34993287
Chronic active hepatitis associated with cimetidineQ35707957
Ouabain-insensitive K-adenosine triphosphatase in distal nephron segments of the rabbitQ35811612
Review: post-marketing surveillance of the safety of cimetidine--the problems of data interpretationQ36422602
The drug interaction potential of ranitidine: an updateQ36881820
Omeprazole drug interaction studiesQ36890310
Effects of antacids on the clinical pharmacokinetics of drugs. An updateQ37583868
Cimetidine: an immunomodulatorQ37850684
Side effects of anti-ulcer prostaglandins: an overview of the worldwide clinical experience.Q38237842
Effect of cimetidine and ranitidine on cardiovascular drugsQ38655898
Ranitidine. An updated review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in peptic ulcer disease and other allied diseasesQ38672468
Safety profile of omeprazole. Adverse events with short-term treatmentQ38749255
Omeprazole: pharmacology, pharmacokinetics and interactionsQ38749269
Cimetidine, an H2-antihistamine, stimulates prolactin secretion in manQ39155812
Characterization and development of cimetidine as a histamine H2-receptor antagonistQ39179168
The use of gastrointestinal drugs during pregnancy and lactationQ39397204
Adverse reactions and interactions with H2-receptor antagonistsQ39460908
Drugs other than H2-receptor antagonists as clinically important inhibitors of drug metabolism in vivoQ39463874
Hepatic effects of drugs used in the treatment of peptic ulcer diseaseQ39464423
A pharmacokinetic profile of nizatidine in man.Q39465653
Hepatotoxic and hepatoprotective potential of histamine (H2)-receptor antagonistsQ39465764
Newer H2-receptor antagonists. Clinical pharmacokinetics and drug interaction potentialQ39471071
Haematological adverse effects of histamine H2-receptor antagonistsQ39471834
Ranitidine versus cimetidine. A comparison of their potential to cause clinically important drug interactionsQ39513613
Disposition kinetics and metabolism of omeprazole in extensive and poor metabolizers of S-mephenytoin 4'-hydroxylation recruited from an Oriental population.Q44306866
Stimulation of prolactin release by intravenous cimetidine: a dose-response studyQ44485860
The effects of omeprazole on endocrine function in man.Q44538249
Haemodynamic effects of famotidine and cimetidine in critically ill patientsQ44625105
Steric factors in the inhibitory interaction of imidazoles with microsomal enzymesQ45082457
Coinduction of multiple hepatic cytochrome P-450 proteins and their mRNAs in rats treated with imidazole antimycotic agentsQ45142520
Influence of histamine receptors on basal left ventricular contractile tone in humans: assessment using the H2 receptor antagonist famotidine and the beta-adrenoceptor antagonist esmolol as pharmacologic probesQ45347707
Cholestatic hepatosis under CimetidineQ46791421
An evaluation of the anti-androgen effects associated with H2 antagonist therapyQ48256546
Cimetidine-induced prolactin release: possible involvement of the GABA-ergic systemQ48517645
Effects of histamine, H1- and H2-receptor antagonists on the activity of serotonergic neurons in the dorsal raphe nucleus.Q48722769
The Effect of Histamine Stimulation and H2-Receptor Inhibition on the Pituitary Prolactin and ACTH Release and on Cortisol Secretion in Human MalesQ48857759
Prenatal and neonatal exposure to cimetidine results in gonadal and sexual dysfunction in adult malesQ49075478
Lack of effect of omeprazole, cimetidine, and ranitidine on the pharmacokinetics of ethanol in fasting male volunteers.Q51607387
[4 weeks' administration of omeprazole: effect on acid behavior and basal hormone levels]Q51642539
Effect of single dose of omeprazole on the gastrointestinal peptide response to foodQ51643615
Reduction of liver blood flow and propranolol metabolism by cimetidine.Q51655375
Effect of omeprazole and cimetidine on plasma diazepam levels.Q51742548
Effect of omeprazole treatment on diazepam plasma levels in slow versus normal rapid metabolizers of omeprazole.Q51743867
The interaction of omeprazole with rat liver cytochrome P450-mediated monooxygenase reactions in vitro and in vivo.Q51773767
Omeprazole inhibits oxidative drug metabolism. Studies with diazepam and phenytoin in vivo and 7-ethoxycoumarin in vitro.Q51818926
Cimetidine, antacids, and pulmonary aspiration.Q51852294
Influence of cimetidine on the pharmacokinetics of desmethyldiazepam and oxazepam.Q51873196
Low clearance of cimetidine across the human placenta.Q52595280
Increase of cytochrome P450IA2 activity by omeprazole: evidence by the 13C-[N-3-methyl]-caffeine breath test in poor and extensive metabolizers of S-mephenytoinQ53025508
Cimetidine-induced liver injury. Report of three cases.Q54266034
Haemodynamic effects of the i.v. administration of cimetidine or ranitidine in the critically ill patient. A double-blind prospective study.Q54397288
Slow omeprazole metabolizers are also poor S-mephenytoin hydroxylators.Q54402781
Cimetidine blocks testosterone synthesis.Q54647642
Cimetidine and serum prolactin.Q55691235
Propranolol steady-state pharmacokinetics are unaltered by omeprazoleQ57386578
Histamine and noradrenaline decrease calcium-activated potassium conductance in hippocampal pyramidal cellsQ59066396
Urticaria from ranitidineQ62660090
Hyperosmolar non-ketotic diabetes and cimetidineQ66698957
Cimetidine-associated thrombocytopeniaQ66703665
Life-threatening arrhythmias and intravenous cimetidineQ66979372
Modulation of suppressor-cell activity by cimetidine in patients with common variable hypogammaglobulinemiaQ67274440
Ranitidine, cimetidine, famotidine have no effect on post-prandial absorption of ethanol 0.8 g/kg taken after an evening mealQ67525684
Induction of cytochrome P450IA genes (CYP1A) by omeprazole in the human alimentary tractQ67576505
Effects of ranitidine on blood alcohol levels after ethanol ingestion. Comparison with other H2-receptor antagonistsQ67716663
Quinidine single dose pharmacokinetics and pharmacodynamics are unaltered by omeprazoleQ67863426
The effect of ranitidine, cimetidine or famotidine on low-dose post-prandial alcohol absorptionQ67968758
Omeprazole treatment does not affect the metabolism of caffeineQ67970019
Theophylline pharmacokinetics: effect of continuous versus intermittent cimetidine i.v. infusionQ67976839
Effect of omeprazole on gastric first-pass metabolism of ethanolQ68127011
Characterisation of theophylline metabolism by human liver microsomes. Inhibition and immunochemical studiesQ68142727
Post-cimetidine surveillance for up to ten years: incidence of carcinoma of the stomach and oesophagusQ68287732
Effects of various concomitant medications on gastric alcohol dehydrogenase and the first-pass metabolism of ethanolQ68326088
Cimetidine-induced mania in depressed patientsQ39558874
The use of ranitidine in bone marrow transplantation. A review of 223 casesQ39653030
Pharmacokinetic interactions of cimetidine 1987.Q39662361
Ranitidine drug interactions--a literature reviewQ39671379
The treatment of gastrointestinal disease in pregnancy.Q39738810
Histamine H2-antagonist drug interactions in perspective: mechanistic concepts and clinical implicationsQ40095987
Inhibitors of Cytochrome P-450s and their mechanism of actionQ40317968
Cimetidine-induced acute interstitial nephritisQ40340966
Cimetidine-induced neutropenia: a possible dose-related phenomenonQ40711103
Immunomodulatory properties of cimetidine in ARC patientsQ40785381
Hyperpyrexia associated with intravenous cimetidine therapy. Report of a caseQ40805306
Fever after cimetidine and ranitidineQ40807340
Effects of cimetidine on prolactin, LH, and sex steroid secretion in male and female volunteersQ40917796
Cimetidine in the treatment of acute alcoholic pancreatitis. A randomized, double-blind studyQ41079458
Gynaecomastia associated with cimetidineQ41494862
Hypothalamic-Pituitary-Gonadal Dysfunction in Men Using CimetidineQ41514497
Prolactin responses to cimetidineQ41815108
Antisecretory drugs and gastric cancerQ41820551
Omeprazole and ranitidine in duodenal ulcer healing and subsequent relapse: a randomized double-blind study with weekly endoscopic assessment.Q41923222
Mechanism for histamine H2-receptor induced cell-cycle changes in the bone marrow stem cellQ41930027
The effect of ranitidine on the plasma clearance and hepatic extraction of indocyanine green in patients with chronic liver diseaseQ41953904
Oral phenytoin pharmacokinetics during omeprazole therapyQ42014803
Omeprazole: effects on oxidative drug metabolismQ42106854
Effects of H2-receptor antagonists on ethanol metabolism in Japanese volunteersQ42122933
Cimetidine and adverse reactions: a meta-analysis of randomized clinical trials of short-term therapyQ42199048
Inhibition by omeprazole of adrenocortical response to ACTH: clinical studies and experiments on bovine adrenal cortex in vitroQ42205460
Recurrent myalgias associated with cimetidineQ42221454
Cimetidine hepatitisQ42223538
Ranitidine-associated hallucinationsQ42229886
Immunologic studies in cimetidine-induced nephropathy and polymyositisQ42244051
Cimetidine-induced impotence and breast changes in patients with gastric hypersecretory statesQ42259171
Cimetidine-induced interstitial nephritis with response to prednisone therapyQ42259223
Dose and serum concentration relationships in cimetidine-associated mental confusionQ42261654
Hepatitis following cimetidine administrationQ42263817
Cimetidine-induced hepatitis. Electron microscopic observations and clinical pattern of liver injuryQ42268344
A case report of cimetidine-induce depressive syndromeQ42273253
Cimetidine-induced renal failureQ42332658
Use of ranitidine, without mental confusion, in patients with renal failureQ42592454
Neurosensory adverse effects after phenylbutazone and misoprostol combined treatmentQ42702376
Cimetidine interaction with liver microsomes in vitro and in vivo. Involvement of an activated complex with cytochrome P-450.Q43411735
A comparative study of the effects of ranitidine and cimetidine on carbohydrate tolerance, growth hormone secretion and the hypothalamic-pituitary-gonadal axis in man.Q43547373
H2-antagonists and hepatitisQ43740408
Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450.Q43863401
Ranitidine as an inhibitor of liver regenerationQ43981489
Inhibition of testosterone biosynthesis in testicular microsomes by various imidazole drugs. Comparative study with ketoconazoleQ44142106
Influence of gastric acidity on the bioavailability of digoxinQ44299461
H-K-ATPase immunoreactivity in cortical and outer medullary collecting ductQ68491387
Effect of histamine H2-receptor antagonist, ranitidine on renal brush border and basolateral membranesQ68494590
Spectral and kinetic studies of the interaction of imidazole anti-fungal agents with microsomal cytochromes P-450Q68551587
[Acute pancreatitis induced by cimetidine]Q68692237
Safety aspects of omeprazoleQ68728980
Associations between drugs administered during pregnancy and congenital abnormalities of the fetusQ68751892
The comparative efficacy of cimetidine and ranitidine in controlling gastric pH in critically ill patientsQ68882822
A study of the interaction between omeprazole and phenytoin in epileptic patientsQ68910380
[Disorders of atrioventricular conduction caused by intravenous ranitidine]Q69011448
Comparative effects of ranitidine and cimetidine on the pharmacokinetics and pharmacodynamics of warfarin in manQ69021385
High magnitude hepatic cytochrome P-450 induction by an N-substituted imidazole antimycotic, clotrimazoleQ69267280
Bone marrow hypoplasia during intensive care: bone marrow culture studies implicating ranitidine in the suppression of haemopoiesisQ69470586
Agranulocytosis and ranitidineQ69505245
The clinical safety of omeprazoleQ69561615
Stereoselective interaction of omeprazole with warfarin in healthy menQ69605483
Cimetidine and alcohol absorptionQ69721477
Influence of cimetidine and ranitidine on ethanol pharmacokineticsQ69848120
CSF concentrations of ranitidineQ69856349
Effects of H2-blocking agents on hepatocytes in vitro: correlation with potential for causing hepatic disease in patientsQ69885220
Effects of H2-receptor antagonists on the rat liver after partial hepatectomy or carbon tetrachloride-induced hepatic injuryQ69889511
Effect of famotidine on hepatic hemodynamics and peptic ulcerQ69899164
Negative inotropic effects of famotidineQ69905313
Safety of nizatidine in clinical trials conducted in the USA and EuropeQ69911424
Effects of short- and long-term administrations of famotidine and ranitidine on some pituitary, sexual and thyroid hormonesQ69911905
Prevention of NSAID-induced gastric ulcer with misoprostol: multicentre, double-blind, placebo-controlled trialQ69927046
Plasma prolactin, sex steroids and gastrin in human volunteers treated for 2 weeks with therapeutic doses of cimetidine or the new histamine H2-receptor antagonist ramixotidine (CM 57755A)Q69930872
Effects of cimetidine on gastric alcohol dehydrogenase activity and blood ethanol levelsQ69936476
Long-term treatment with cimetidine does not essentially affect the hypothalamic-pituitary-gonadal axis in manQ69950244
Overview of clinical safety with misoprostolQ69968599
Characterization of K-ATPase activity in distal nephron: stimulation by potassium depletionQ70037265
The effect of ranitidine and cimetidine on single-dose diltiazem pharmacokineticsQ70078049
Effects of cimetidine and ranitidine on splanchnic hemodynamics in patients with chronic liver diseaseQ70081944
Post-marketing surveillance of the safety of cimetidine: twelve-month morbidity reportQ70096815
Omeprazole and the induction of human cytochrome P-450: a response to concerns about potential adverse effectsQ70113905
Endocrine effects of acute and chronic cimetidine administrationQ70159645
Effect of cimetidine and ranitidine on the pharmacokinetics and anti-hypertensive effect of nifedipineQ70174837
Prenatal and neonatal exposure of male rat pups to cimetidine but not ranitidine adversely affects subsequent adult sexual functioningQ70191076
Is ethanol metabolism affected by oral administration of cimetidine and ranitidine at therapeutic doses?Q70191151
Ranitidine and cimetidine in renal transplantation: a clinical trialQ70197197
Lack of effect of omeprazole treatment on steady-state plasma levels of metoprololQ70212923
[Ranitidine and cimetidine in the prevention of stress: ulcer hemorrhage a prospective comparative multicenter study]Q70219827
Hepatitis Associated with RanitidineQ70221448
P433issue2 Suppl
P304page(s)63S-80S
P577publication date1995-02-01
P1433published inDigestive Diseases and SciencesQ15716711
P1476titleSafety of acid-suppressing drugs
P478volume40

Reverse relations

cites work (P2860)
Q33914348A risk-benefit assessment of pharmacological and nonpharmacological treatments for nausea and vomiting of pregnancy
Q35084804Abdominal pain during pregnancy.
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Q33904367The risk of acute pancreatitis associated with acid-suppressing drugs
Q40378564The safety of H(2)-blockers use during pregnancy
Q36851934Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions

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