Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage

scientific article published on 24 July 2017

Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1090780650
P356DOI10.1038/S41598-017-04574-Z
P932PMC publication ID5524914
P698PubMed publication ID28740200

P50authorLars KuepferQ52350941
Ute HofmannQ56433692
Donato TeutonicoQ83449830
Andreas SchuppertQ42413919
Lars Ole SchwenQ42530594
Ahmed GhallabQ43208341
Jan G HengstlerQ49800573
P2093author name stringArne Schenk
Albert Braeuning
Michael Schwarz
Reham Hassan
P2860cites workBiotransformation of pravastatin sodium in humansQ68317456
Species differences in metabolism of codeine: urinary excretion of codeine glucuronide, morphine-3-glucuronide and morphine-6-glucuronide in mice, rats, guinea pigs and rabbitsQ68600284
Interspecies comparison of in vivo caffeine pharmacokinetics in man, monkey, rabbit, rat, and mouseQ70803074
Role of CYP1A2 in caffeine pharmacokinetics and metabolism: studies using mice deficient in CYP1A2Q71690593
Identification of talinolol metabolites in urine of man, dog, rat and mouse after oral administration by high-performance liquid chromatography-thermospray tandem mass spectrometryQ71961450
Physiological parameters in laboratory animals and humansQ72935917
Spatio-temporal simulation of first pass drug perfusion in the liverQ27322901
A Microfabricated Platform for Generating Physiologically-Relevant Hepatocyte ZonationQ28829727
Using expression data for quantification of active processes in physiologically based pharmacokinetic modelingQ34147024
Clinical pharmacokinetics of pravastatin: mechanisms of pharmacokinetic eventsQ34147623
A concordance correlation coefficient to evaluate reproducibilityQ34527574
Hepatotoxicity and Mechanism of Action of Haloalkanes: Carbon Tetrachloride as a Toxicological ModelQ35112180
Metabolic zonation of the liver: regulation and implications for liver functionQ35417325
Modelling and PBPK simulation in drug discoveryQ37413064
Liver transporters in hepatic drug disposition: an updateQ37581643
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compoundsQ40100581
Expression, purification, and characterization of mouse CYP2d22.Q40295746
Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and diseaseQ40770241
Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseasesQ40881866
Zonation of cytochrome P450 expression, drug metabolism and toxicity in liverQ41333879
Applied Concepts in PBPK Modeling: How to Build a PBPK/PD ModelQ41582110
Clinical pharmacokinetics and pharmacodynamics of torasemideQ41706099
Pharmacokinetics of oral talinolol following a single dose and during steady state in patients with chronic renal failure and healthy volunteersQ43555022
Differences in caffeine and paraxanthine metabolism between human and murine CYP1A2.Q44058008
Expression of the Human CYP3A4 Gene in the Small Intestine of Transgenic Mice: In Vitro Metabolism and Pharmacokinetics of MidazolamQ44403612
Relationship between exposure and nonspecific binding of thirty-three central nervous system drugs in mice.Q45122051
Integrated metabolic spatial-temporal model for the prediction of ammonia detoxification during liver damage and regenerationQ46550945
A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolationQ46814759
Characterization of 1'-hydroxymidazolam glucuronidation in human liver microsomesQ46903207
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)6224
P577publication date2017-07-24
P1433published inScientific ReportsQ2261792
P1476titlePhysiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage
P478volume7

Reverse relations

cites work (P2860)
Q49218533Highlight report: Monitoring cytochrome P450 activities in living hepatocytes
Q64947056Highlight report: Necrosis-apoptosis conundrum of hepatocytes: mode of hepatocyte death after acetaminophen intoxication.
Q64932520Highlight report: Protection of cholestatic livers by shunting of bile from canaliculi to sinusoids.
Q49185998Highlight report: The pseudolobule in liver fibrosis
Q49607107Highlight report: physiologically-based modeling of diseased liver tissue
Q64062092Influence Factors of the Pharmacokinetics of Herbal Resourced Compounds in Clinical Practice
Q91762627Influence of Liver Fibrosis on Lobular Zonation
Q92644459Liver fibrosis causes periportalization of lobular zonation
Q64979594Modeling the Dynamics of Human Liver Failure Post Liver Resection.
Q92644463TGR5 regulates portal perfusion pressure of the liver
Q58802345The antioxidant activities of alkalic-extractable polysaccharides from Coprinus comatus on alcohol-induced liver injury in mice

Search more.