| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/J.BBAPAP.2009.07.020 |
| P8608 | Fatcat ID | release_m5dwqydejjhkja6f7zmhwo4pgq |
| P932 | PMC publication ID | 2930377 |
| P698 | PubMed publication ID | 19665597 |
| P5875 | ResearchGate publication ID | 26727477 |
| P50 | author | Stefan G. Sarafianos | Q30505408 |
| P2093 | author name string | Jason W Rausch | |
| Stuart F J Le Grice | |||
| Matthias Götte | |||
| Bruno Marchand | |||
| P2860 | cites work | Attenuation of DNA replication by HIV-1 reverse transcriptase near the central termination sequence | Q81608769 |
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| Stable complexes formed by HIV-1 reverse transcriptase at distinct positions on the primer-template controlled by binding deoxynucleoside triphosphates or foscarnet | Q24682670 | ||
| Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA. | Q27640046 | ||
| HIV-1 Reverse Transcriptase Structure with RNase H Inhibitor Dihydroxy Benzoyl Naphthyl Hydrazone Bound at a Novel Site | Q27640888 | ||
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| Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms | Q27733392 | ||
| Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance | Q27766086 | ||
| Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution | Q27766103 | ||
| Long-term foscarnet therapy remodels thymidine analogue mutations and alters resistance to zidovudine and lamivudine in HIV-1 | Q28307524 | ||
| Mechanism and fidelity of HIV reverse transcriptase | Q28646717 | ||
| Reverse transcriptase.RNase H from the human immunodeficiency virus. Relationship of the DNA polymerase and RNA hydrolysis activities | Q28646746 | ||
| Analysis of plus-strand primer selection, removal, and reutilization by retroviral reverse transcriptases. | Q55034092 | ||
| Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors. | Q55063317 | ||
| Substituting a conserved residue of the ribonuclease H domain alters substrate hydrolysis by retroviral reverse transcriptase | Q73174664 | ||
| Nucleotide-induced stable complex formation by HIV-1 reverse transcriptase | Q73343560 | ||
| Temporal coordination between initiation of HIV (+)-strand DNA synthesis and primer removal | Q77298456 | ||
| HIV-1 reverse transcriptase plus-strand initiation exhibits preferential sensitivity to non-nucleoside reverse transcriptase inhibitors in vitro | Q79436291 | ||
| The sequence features important for plus strand priming by human immunodeficiency virus type 1 reverse transcriptase | Q28646831 | ||
| Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor | Q29547710 | ||
| DNA polymerases: structural diversity and common mechanisms | Q29619403 | ||
| Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA | Q29620616 | ||
| A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA. | Q30477242 | ||
| YADD mutants of human immunodeficiency virus type 1 and Moloney murine leukemia virus reverse transcriptase are resistant to lamivudine triphosphate (3TCTP) in vitro. | Q33842803 | ||
| The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase. | Q33907523 | ||
| Direct observation of one-dimensional diffusion and transcription by Escherichia coli RNA polymerase | Q34171591 | ||
| RNA-dependent DNA polymerase in virions of RNA tumour viruses | Q34206460 | ||
| Recognition of internal cleavage sites by retroviral RNases H. | Q34366158 | ||
| Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097. | Q34575882 | ||
| Probing transcription factor dynamics at the single-molecule level in a living cell | Q34631575 | ||
| Multiparameter single-molecule fluorescence spectroscopy reveals heterogeneity of HIV-1 reverse transcriptase:primer/template complexes. | Q34761256 | ||
| HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition | Q34849844 | ||
| Non-nucleoside HIV-1 reverse transcriptase inhibitors di-halo-indolyl aryl sulfones achieve tight binding to drug-resistant mutants by targeting the enzyme-substrate complex | Q34872382 | ||
| Specific Cleavages by RNase H Facilitate Initiation of Plus-Strand RNA Synthesis by Moloney Murine Leukemia Virus | Q34976431 | ||
| Indolopyridones inhibit human immunodeficiency virus reverse transcriptase with a novel mechanism of action | Q35185934 | ||
| Unique progressive cleavage mechanism of HIV reverse transcriptase RNase H | Q35360809 | ||
| Purine analog substitution of the HIV-1 polypurine tract primer defines regions controlling initiation of plus-strand DNA synthesis | Q35646719 | ||
| Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA- and DNA-dependent RNA and DNA polymerases | Q35721277 | ||
| 'Binding, bending and bonding': polypurine tract-primed initiation of plus-strand DNA synthesis in human immunodeficiency virus | Q35796073 | ||
| Sequence and structural determinants required for priming of plus-strand DNA synthesis by the human immunodeficiency virus type 1 polypurine tract. | Q35866117 | ||
| Zidovudine resistance is suppressed by mutations conferring resistance of human immunodeficiency virus type 1 to foscarnet. | Q35870930 | ||
| Effects of the translocation status of human immunodeficiency virus type 1 reverse transcriptase on the efficiency of excision of tenofovir | Q35912746 | ||
| Mutations in human immunodeficiency virus type 1 RNase H primer grip enhance 3'-azido-3'-deoxythymidine resistance | Q35914346 | ||
| Binding and kinetic properties of HIV-1 reverse transcriptase markedly differ during initiation and elongation of reverse transcription. | Q35917913 | ||
| Crystallography and the design of anti-AIDS drugs: conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors | Q35967899 | ||
| Hydrolysis of RNA/DNA hybrids containing nonpolar pyrimidine isosteres defines regions essential for HIV type 1 polypurine tract selection | Q36160662 | ||
| Effects of nucleotides and nucleotide analogue inhibitors of HIV-1 reverse transcriptase in a ratchet model of polymerase translocation | Q36489299 | ||
| The history of N-methanocarbathymidine: the investigation of a conformational concept leads to the discovery of a potent and selective nucleoside antiviral agent | Q36490651 | ||
| Structural probing of the HIV-1 polypurine tract RNA:DNA hybrid using classic nucleic acid ligands | Q36649670 | ||
| Polypurine tract adjacent to the U3 region of the Rous sarcoma virus genome provides a cis-acting function | Q36923155 | ||
| Mutations M184V and Y115F in HIV-1 reverse transcriptase discriminate against "nucleotide-competing reverse transcriptase inhibitors". | Q36949351 | ||
| Dynamic binding orientations direct activity of HIV reverse transcriptase | Q37126933 | ||
| Slide into action: dynamic shuttling of HIV reverse transcriptase on nucleic acid substrates | Q37278712 | ||
| Human immunodeficiency virus type 1 reverse transcriptase: spatial and temporal relationship between the polymerase and RNase H activities | Q37296280 | ||
| High-resolution NMR analysis of the conformations of native and base analog substituted retroviral and LTR-retrotransposon PPT primers | Q37310911 | ||
| Effects of mutations in the connection and RNase H domains of HIV-1 reverse transcriptase on drug susceptibility. | Q37353883 | ||
| Using pyrrolo-deoxycytosine to probe RNA/DNA hybrids containing the human immunodeficiency virus type-1 3' polypurine tract. | Q37518702 | ||
| HIV-1 reverse transcriptase-associated RNase H cleaves RNA/RNA in arrested complexes: implications for the mechanism by which RNase H discriminates between RNA/RNA and RNA/DNA | Q37694538 | ||
| Use of an oligoribonucleotide containing the polypurine tract sequence as a primer by HIV reverse transcriptase | Q38288991 | ||
| An expanded model of replicating human immunodeficiency virus reverse transcriptase | Q38296396 | ||
| The pyrophosphate analogue foscarnet traps the pre-translocational state of HIV-1 reverse transcriptase in a Brownian ratchet model of polymerase translocation | Q38307044 | ||
| Polypurine tract primer generation and utilization by Moloney murine leukemia virus reverse transcriptase | Q38318070 | ||
| Refined model for primer/template binding by HIV-1 reverse transcriptase: pre-steady-state kinetic analyses of primer/template binding and nucleotide incorporation events distinguish between different binding modes depending on the nature of the nuc | Q38320371 | ||
| Investigating HIV-1 polypurine tract geometry via targeted insertion of abasic lesions in the (-)-DNA template and (+)-RNA primer | Q38329151 | ||
| Synthesis of DNA by human immunodeficiency virus reverse transcriptase is preferentially blocked at template oligo(deoxyadenosine) tracts | Q38338653 | ||
| Human immunodeficiency virus 1 reverse transcriptase. Template binding, processivity, strand displacement synthesis, and template switching | Q38345021 | ||
| A model for the mechanism of polymerase translocation | Q38349372 | ||
| Helix structure and ends of RNA/DNA hybrids direct the cleavage specificity of HIV-1 reverse transcriptase RNase H. | Q38362524 | ||
| Localization of the active site of HIV-1 reverse transcriptase-associated RNase H domain on a DNA template using site-specific generated hydroxyl radicals | Q38552378 | ||
| Facilitated target location in biological systems | Q38597415 | ||
| In vitro inhibition of hepadnavirus polymerases by the triphosphates of BMS-200475 and lobucavir. | Q39559675 | ||
| RNA-primed initiation of Moloney murine leukemia virus plus strands by reverse transcriptase in vitro | Q40133605 | ||
| Quantitative analysis of RNA cleavage during RNAdirected DNA synthesis by human immunodeficiency and avian myeloblastosis virus reverse transcriptases | Q40401252 | ||
| Determinants of the RNase H cleavage specificity of human immunodeficiency virus reverse transcriptase | Q40410001 | ||
| Fixed conformation nucleoside analogs effectively inhibit excision-proficient HIV-1 reverse transcriptases | Q40484294 | ||
| Experimental and structural evidence that herpes 1 kinase and cellular DNA polymerase(s) discriminate on the basis of sugar pucker | Q40599894 | ||
| Connection domain mutations N348I and A360V in HIV-1 reverse transcriptase enhance resistance to 3'-azido-3'-deoxythymidine through both RNase H-dependent and -independent mechanisms | Q41262484 | ||
| HIV-1 Reverse Transcription A Termination Step at the Center of the Genome | Q41443092 | ||
| Delayed chain termination protects the anti-hepatitis B virus drug entecavir from excision by HIV-1 reverse transcriptase | Q41503130 | ||
| Nucleic acid polymerases use a general acid for nucleotidyl transfer | Q42239117 | ||
| Novel nonnucleoside inhibitors that select nucleoside inhibitor resistance mutations in human immunodeficiency virus type 1 reverse transcriptase | Q42549637 | ||
| Footprint analysis of replicating murine leukemia virus reverse transcriptase | Q43465096 | ||
| Human immunodeficiency virus reverse transcriptase ribonuclease H: specificity of tRNALys3-primer excision | Q43662972 | ||
| Polymerization and RNase H activities of the reverse transcriptases from avian myeloblastosis, human immunodeficiency, and Moloney murine leukemia viruses are functionally uncoupled | Q43749171 | ||
| Pre-existing distortions in nucleic acid structure aid polypurine tract selection by HIV-1 reverse transcriptase | Q43903247 | ||
| Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir | Q44859710 | ||
| Kinetic mechanism of the DNA-dependent DNA polymerase activity of human immunodeficiency virus reverse transcriptase | Q45786646 | ||
| Nuclease footprinting of human immunodeficiency virus reverse transcriptase/tRNA(Lys-3) complexes | Q45786901 | ||
| Characterization of reverse transcriptase and RNase H from friend-murine leukemia virus | Q45826426 | ||
| Plus-strand priming by Moloney murine leukemia virus. The sequence features important for cleavage by RNase H. | Q45847036 | ||
| Site-specific footprinting reveals differences in the translocation status of HIV-1 reverse transcriptase. Implications for polymerase translocation and drug resistance | Q47814140 | ||
| The structural mechanism of translocation and helicase activity in T7 RNA polymerase | Q47964330 | ||
| Visualization of single molecules of RNA polymerase sliding along DNA. | Q54647002 | ||
| P433 | issue | 5 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 1202-1212 | |
| P577 | publication date | 2009-08-07 | |
| P1433 | published in | Biochimica et Biophysica Acta | Q864239 |
| P1476 | title | Reverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions | |
| P478 | volume | 1804 |
| Q36553297 | A protein ballet around the viral genome orchestrated by HIV-1 reverse transcriptase leads to an architectural switch: from nucleocapsid-condensed RNA to Vpr-bridged DNA. |
| Q54472398 | A toolkit and benchmark study for FRET-restrained high-precision structural modeling. |
| Q33649797 | Biophysical Insights into the Inhibitory Mechanism of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors |
| Q36553113 | Effect of translocation defective reverse transcriptase inhibitors on the activity of N348I, a connection subdomain drug resistant HIV-1 reverse transcriptase mutant |
| Q42681111 | Effects of Mutations F61A and A62V in the Fingers Subdomain of HIV-1 Reverse Transcriptase on the Translocational Equilibrium |
| Q47152216 | Enzyme cycling contributes to efficient induction of genome mutagenesis by the cytidine deaminase APOBEC3B. |
| Q26826945 | Fragment screening and HIV therapeutics |
| Q56786269 | HIV Reverse Transcriptase Inhibitors |
| Q35943486 | HIV-1 and HIV-2 reverse transcriptases: different mechanisms of resistance to nucleoside reverse transcriptase inhibitors |
| Q34643481 | Identification and characterization of a novel HIV-1 nucleotide-competing reverse transcriptase inhibitor series |
| Q35120765 | Identification of a methylated oligoribonucleotide as a potent inhibitor of HIV-1 reverse transcription complex. |
| Q42021881 | Influence of insulators on transgene expression from integrating and non-integrating lentiviral vectors. |
| Q43038451 | Influence of the linkage between leaving group and nucleoside on substrate efficiency for incorporation in DNA catalyzed by reverse transcriptase |
| Q41925416 | Pausing kinetics dominates strand-displacement polymerization by reverse transcriptase. |
| Q37722585 | Retroviral reverse transcriptases |
| Q37828056 | Targeting viral reservoirs: ability of antiretroviral therapy to stop viral replication |
| Q51849196 | Template-independent DNA synthesis activity associated with the reverse transcriptase of the long terminal repeat retrotransposon Tf1. |
| Q36826857 | The (5Z)-5-Pentacosenoic and 5-Pentacosynoic Acids Inhibit the HIV-1 Reverse Transcriptase. |
| Q34352431 | The N348I mutation at the connection subdomain of HIV-1 reverse transcriptase decreases binding to nevirapine. |
| Q47145836 | The mechano-chemistry of a monomeric reverse transcriptase |
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