Redox control systems in the nucleus: mechanisms and functions

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Redox control systems in the nucleus: mechanisms and functions is …
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scholarly articleQ13442814

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P356DOI10.1089/ARS.2009.3021
P932PMC publication ID2935340
P698PubMed publication ID20210649
P5875ResearchGate publication ID41824041

P50authorDean P. JonesQ43402223
P2093author name stringYoung-Mi Go
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Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiationQ24290624
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Overexpressed human mitochondrial thioredoxin confers resistance to oxidant-induced apoptosis in human osteosarcoma cellsQ24298232
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Nuclear and cytoplasmic peroxiredoxin-1 differentially regulate NF-kappaB activitiesQ24316248
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Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelopeQ24320769
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Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.Q24533236
Immunohistochemical detection of the placental form of glutathione S-transferase in dysplastic and neoplastic human uterine cervix lesionsQ68832490
Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxidesQ70305491
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Localization of the thioredoxin system in normal rat kidneyQ73448152
Glutathione-Related Antioxidant Defenses in Human Atherosclerotic PlaquesQ74604652
The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin.Q24535620
The redox state of SECIS binding protein 2 controls its localization and selenocysteine incorporation functionQ24548981
Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzymeQ24555669
Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart functionQ24563493
Crystal structure of a novel human peroxidase enzyme at 2.0 Å resolutionQ27757619
CRM1 is an export receptor for leucine-rich nuclear export signalsQ27860453
Characterization of mammalian selenoproteomes.Q27863319
Nuclear monothiol glutaredoxins of Saccharomyces cerevisiae can function as mitochondrial glutaredoxinsQ27930254
Glutaredoxins Grx3 and Grx4 regulate nuclear localisation of Aft1 and the oxidative stress response in Saccharomyces cerevisiae.Q27932221
Role of glutaredoxin-3 and glutaredoxin-4 in the iron regulation of the Aft1 transcriptional activator in Saccharomyces cerevisiaeQ27934787
ATP-dependent reduction of cysteine–sulphinic acid by S. cerevisiae sulphiredoxinQ27939560
Two enzymes in one; two yeast peroxiredoxins display oxidative stress-dependent switching from a peroxidase to a molecular chaperone functionQ27939677
Exportin 1 (Crm1p) is an essential nuclear export factorQ27939696
Structural organization of the human glutathione reductase gene: determination of correct cDNA sequence and identification of a mitochondrial leader sequenceQ28138037
A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damageQ28138556
Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expressionQ28140461
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Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cellsQ28214146
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidantsQ28218883
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Importin alpha1 (Rch1) mediates nuclear translocation of thioredoxin-binding protein-2/vitamin D(3)-up-regulated protein 1Q28270308
Thiol redox control via thioredoxin and glutaredoxin systemsQ28278752
Direct association with thioredoxin allows redox regulation of glucocorticoid receptor functionQ28294971
Correlation of nuclear color and opalescence with protein S-thiolation in human lensesQ28376061
Vitamin D3 up-regulated protein 1 mediates oxidative stress via suppressing the thioredoxin functionQ28506375
Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac developmentQ28510029
Regulation of reactive oxygen species, DNA damage, and c-Myc function by peroxiredoxin 1Q28511826
Identification of a specific sperm nuclei selenoenzyme necessary for protamine thiol cross-linking during sperm maturationQ28511848
Deletion of selenoprotein P alters distribution of selenium in the mouseQ28512024
Motexafin gadolinium, a tumor-selective drug targeting thioredoxin reductase and ribonucleotide reductaseQ28567883
Immunolocalization of microsomal glutathione S-transferase in rat tissuesQ28568879
Glutathione S-transferase pi (GSTP1) hypermethylation in prostate cancer: review 2007.Q36845013
Nucleoredoxin, a novel thioredoxin family member involved in cell growth and differentiationQ36848952
Thioredoxin Reductase 1 Expression and Castration-recurrent Growth of Prostate CancerQ36869643
Thioredoxin signaling as a target for cancer therapyQ36870409
Radical-free biology of oxidative stressQ36955833
Nonequilibrium thermodynamics of thiol/disulfide redox systems: a perspective on redox systems biologyQ36983473
Demonstration of nuclear compartmentalization of glutathione in hepatocytesQ37008104
Molecular mechanisms and potential clinical significance of S-glutathionylation.Q37037645
Redox compartmentalization in eukaryotic cellsQ37081874
Glutaredoxin systems.Q37214035
Reactive oxygen species-independent oxidation of thioredoxin in hypoxia: inactivation of ribonucleotide reductase and redox-mediated checkpoint controlQ37285111
Role of nuclear glutathione as a key regulator of cell proliferation.Q37397864
Transgenic mouse models for the vital selenoenzymes cytosolic thioredoxin reductase, mitochondrial thioredoxin reductase and glutathione peroxidase 4.Q37477495
Characterization of the promoter region of the human apurinic endonuclease gene (APE).Q38297816
Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo.Q38319417
Redox regulation of c-Jun DNA binding by reversible S-glutathiolation.Q38321185
Up-regulation of the human gamma-glutamylcysteine synthetase regulatory subunit gene involves binding of Nrf-2 to an electrophile responsive elementQ38321807
Glutathione depletion inhibits oxidant-induced activation of nuclear factor-kappa B, AP-1, and c-Jun/ATF-2 in cultured guinea-pig gastric epithelial cells.Q38332476
Overlapping antioxidant response element and PMA responseelement sequences mediate basal and β-naphthoflavone-induced expression of the human γ-glutamylcysteine synthetase catalytic subunit geneQ38336221
Formation of Disulfide Bond in p53 Correlates with Inhibition of DNA Binding and TetramerizationQ38348665
Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survivalQ38359163
Inhibitory effect of peroxiredoxin II (Prx II) on Ras-ERK-NFkappaB pathway in mouse embryonic fibroblast (MEF) senescenceQ38508323
Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localisation signal and a strong classical mitochondrial localisation signal, respectivelyQ39725305
The presence of two distinct 8-oxoguanine repair enzymes in human cells: their potential complementary roles in preventing mutationQ39725671
Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs.Q40026363
Nuclear thioredoxin-1 is required to suppress cisplatin-mediated apoptosis of MCF-7 cellsQ40102998
Selective protection of nuclear thioredoxin-1 and glutathione redox systems against oxidation during glucose and glutamine deficiency in human colonic epithelial cellsQ40185539
Endogenous thioredoxin is required for redox cycling of anthracyclines and p53-dependent apoptosis in cancer cellsQ40373992
Control of p53 nuclear accumulation in stressed cellsQ40382508
Overexpression of enzymatically active human cytosolic and mitochondrial thioredoxin reductase in HEK-293 cells. Effect on cell growth and differentiation.Q40506655
Mitochondrial thioredoxin system: effects of TrxR2 overexpression on redox balance, cell growth, and apoptosisQ40567213
Decreased GSSG reductase activity enhances cellular zinc toxicity in three human lung cell linesQ40664519
Selenium deficiency increases susceptibility to glutamate-induced excitotoxicityQ40691222
Thioredoxin facilitates the induction of heme oxygenase-1 in response to inflammatory mediatorsQ40878106
Glutathione S-transferases, structure, regulation, and therapeutic implicationsQ40913566
Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanism of redox regulation of transcription factor NF-kappaB.Q40928766
Compartmentation of glutathione: implications for the study of toxicity and disease.Q41112058
The heme-responsive element of the mouse heme oxygenase-1 gene is an extended AP-1 binding site that resembles the recognition sequences for MAF and NF-E2 transcription factorsQ41204736
Biological consequences of oxidative stress-induced DNA damage in Saccharomyces cerevisiaeQ41337790
Involvement of Jun and Fos proteins in regulating transcriptional activation of the human pi class glutathione S-transferase gene in multidrug-resistant MCF7 breast cancer cellsQ41461498
Distinct effects of glutathione disulphide on the nuclear transcription factor kappa B and the activator protein-1.Q41473567
S-Phase-specific expression of mammalian ribonucleotide reductase R1 and R2 subunit mRNAsQ41731157
Compartmental oxidation of thiol-disulphide redox couples during epidermal growth factor signallingQ42156579
Cellular Glutathione Peroxidase Knockout Mice Express Normal Levels of Selenium-Dependent Plasma and Phospholipid Hydroperoxide Glutathione Peroxidases in Various Tissues , ,Q42441950
Pag, a putative tumor suppressor, interacts with the Myc Box II domain of c-Myc and selectively alters its biological function and target gene expressionQ42811126
Distribution of the monochlorobimane-glutathione conjugate between nucleus and cytosol in isolated hepatocytesQ42811864
Glutathione is recruited into the nucleus in early phases of cell proliferation.Q42828949
The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stability.Q42941687
Mitochondrial thioredoxin in regulation of oxidant-induced cell deathQ43034833
Regular exercise improves cognitive function and decreases oxidative damage in rat brain.Q43505534
Redox regulation of the DNA repair function of the human AP endonuclease Ape1/ref-1.Q43735652
Doxorubicin‐induced DNA intercalation and scavenging by nuclear glutathioneS‐transferase πQ43811107
Direct comparison of the nature of mouse and human GST T1-1 and the implications on dichloromethane carcinogenicityQ43909310
Site-directed mutagenesis of cysteine to serine in the DNA binding region of Nrf2 decreases its capacity to upregulate antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 geneQ43955949
Thioredoxin reductase regulates AP-1 activity as well as thioredoxin nuclear localization via active cysteines in response to ionizing radiationQ44127151
Nuclear and nucleolar glutathione reductase, peroxidase, and transferase activities in livers of male and female Fischer-344 ratsQ44128207
Significance of nuclear glutathione S-transferase pi in resistance to anti-cancer drugsQ44163689
Glutathione and thioredoxin redox during differentiation in human colon epithelial (Caco-2) cellsQ44217769
N-terminal domain of the dual-targeted pea glutathione reductase signal peptide controls organellar targeting efficiencyQ44235302
Thioredoxin-dependent redox regulation of p53-mediated p21 activationQ44275159
Thioredoxin-dependent redox regulation of the antioxidant responsive element (ARE) in electrophile responseQ44379311
Structural integrity of the nuclear matrix: differential effects of thiol agents and metal chelatorsQ44572683
Compartmentation of Nrf-2 redox control: regulation of cytoplasmic activation by glutathione and DNA binding by thioredoxin-1.Q44999323
Nuclear glutathione S-transferase pi prevents apoptosis by reducing the oxidative stress-induced formation of exocyclic DNA productsQ45140395
Peroxiredoxin-mediated redox regulation of the nuclear localization of Yap1, a transcription factor in budding yeastQ45261481
Selenite is a potent cytotoxic agent for human primary AML cellsQ46061772
Redox regulation of NF-kappa B activationQ46098446
Relation between animal-type melanoma and reduced nuclear expression of glutathione S-transferase pi.Q46157323
Quantification of redox conditions in the nucleusQ46297046
Oxidation and nuclear localization of thioredoxin-1 in sparse cell culturesQ46668133
Ribonucleotide reductase small subunit p53R2 suppresses MEK-ERK activity by binding to ERK kinase 2.Q47928930
Rat phospholipid-hydroperoxide glutathione peroxidase. cDNA cloning and identification of multiple transcription and translation start sitesQ48069265
Glutathione peroxidase, glutathione reductase and protein oxidation in patients with glioblastoma multiforme and transitional meningiomaQ48189306
Zinc stimulates the production of toxic reactive oxygen species (ROS) and inhibits glutathione reductase in astrocytes.Q48230345
Glutathione S-transferase isoenzymes in rat brain neurons and glia.Q48291202
Prognostic significance of glutathione S-transferase pi expression and subcellular localization in human gliomasQ48350372
Selective oxidative stress in cell nuclei by nuclear-targeted D-amino acid oxidaseQ48468841
Mitochondrial thioredoxin-2 has a key role in determining tumor necrosis factor-alpha-induced reactive oxygen species generation, NF-kappaB activation, and apoptosisQ48506716
Immunohistologic localization of alpha, mu, and pi class glutathione S-transferases in human tissuesQ48768693
Distribution of oxidized and reduced forms of glutathione and cysteine in rat plasmaQ49218490
Increased expression of glutathione reductase in macrophages decreases atherosclerotic lesion formation in low-density lipoprotein receptor-deficient miceQ50693355
Glutathione redox potential in response to differentiation and enzyme inducersQ52082817
Mammalian Peroxiredoxin Isoforms Can Reduce Hydrogen Peroxide Generated in Response to Growth Factors and Tumor Necrosis Factor-αQ54198428
Nonenzymatic cleavage of proteins by reactive oxygen species generated by dithiothreitol and iron.Q54789188
Vitamin D3 up-regulated protein 1 (VDUP1) expression in gastrointestinal cancer and its relation to stage of disease.Q54793016
Purification, Redox Sensitivity, and RNA Binding Properties of SECIS-binding Protein 2, a Protein Involved in Selenoprotein BiosynthesisQ56929381
A Novel Nuclear Export Signal Sensitive to Oxidative Stress in the Fission Yeast Transcription Factor Pap1Q57228780
Redox regulation of fos and jun DNA-binding activity in vitroQ57963256
Accumulation of DNA damage in the organs of mice deficient in γ-glutamyltranspeptidaseQ60584763
Nuclear Redox-Signaling Is Essential for Apoptosis Inhibition in Endothelial Cells—Important Role for Nuclear Thioredoxin-1Q63303253
The multifunctional DNA repair/redox enzyme Ape1/Ref-1 promotes survival of neurons after oxidative stressQ64379010
Gene dose effect: regional mapping of human glutathione reductase on chromosome 8Q68249502
Real-time imaging of the intracellular glutathione redox potential.Q34777807
Urinary 8-oxo-2'-deoxyguanosine: redox regulation of DNA repair in vivo?Q34934874
Origins of spontaneous mutations: specificity and directionality of base-substitution, frameshift, and sequence-substitution mutagenesesQ34995468
Hydrogen donor system for Escherichia coli ribonucleoside-diphosphate reductase dependent upon glutathioneQ35008888
Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cellsQ35042904
Regulation of tumor suppressors by nuclear-cytoplasmic shuttlingQ35047240
Analytical developments in the assay of intra- and extracellular GSH homeostasis: specific protein S-glutathionylation, cellular GSH and mixed disulphide compartmentalisation and interstitial GSH redox balanceQ35191223
Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neuronsQ35786982
Nitric oxide controls nuclear export of APE1/Ref-1 through S-nitrosation of cysteines 93 and 310Q35829268
Trafficking and signaling pathways of nuclear localizing protein ligands and their receptorsQ35880061
Bcl-2 expression causes redistribution of glutathione to the nucleusQ35975065
Thioredoxin and its related molecules: update 2005.Q36125042
Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damageQ36459878
Extracellular redox state: refining the definition of oxidative stress in agingQ36481010
Role of cysteine residues in regulation of p53 functionQ36552986
Regulation of glutathione transferase P: a tumor marker of hepatocarcinogenesisQ36791976
Human p53 is inhibited by glutathionylation of cysteines present in the proximal DNA-binding domain during oxidative stress.Q36841921
Cloning of the peroxiredoxin gene family in rats and characterization of the fourth memberQ28569349
Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporinsQ28573887
The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insultsQ28587364
Mice with combined disruption of Gpx1 and Gpx2 genes have colitisQ28593227
Molecular mechanisms of thioredoxin and glutaredoxin as hydrogen donors for Mammalian s phase ribonucleotide reductaseQ28594627
Tissue-specific functions of individual glutathione peroxidasesQ28645787
Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental geneQ29409898
Regulatory mechanisms controlling gene expression mediated by the antioxidant response elementQ29616504
The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistanceQ29616511
Ribonucleotide reductasesQ29620027
Structure, function, and mechanism of ribonucleotide reductasesQ30164061
Oxidative stress-dependent structural and functional switching of a human 2-Cys peroxiredoxin isotype II that enhances HeLa cell resistance to H2O2-induced cell death.Q30350844
MsrB1 (methionine-R-sulfoxide reductase 1) knock-out mice: roles of MsrB1 in redox regulation and identification of a novel selenoprotein formQ30850851
Transcriptional regulation of the antioxidant response element. Activation by Nrf2 and repression by MafK.Q30854285
The role of glutathione in the regulation of nucleotide excision repair during oxidative stress.Q33268442
Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigensQ33557888
Functional expression of hMYH, a human homolog of the Escherichia coli MutY proteinQ33636195
Identification of a novel nuclear export signal sensitive to oxidative stress in yeast AP-1-like transcription factor.Q33833428
Urinary 8-oxo-2'-deoxyguanosine--source, significance and supplements.Q33892404
Rat skeletal muscle selenoprotein W: cDNA clone and mRNA modulation by dietary seleniumQ33923871
Does oxidative damage to DNA increase with age?Q33943307
Gene expression profiling reveals a signaling role of glutathione in redox regulation.Q34048072
Elevated levels of oxidative DNA damage and DNA repair enzymes in human atherosclerotic plaquesQ34145177
Antioxidant function of thioredoxin and glutaredoxin systemsQ34159139
Zinc fingers: a novel protein fold for nucleic acid recognitionQ34167428
The selenoenzyme phospholipid hydroperoxide glutathione peroxidaseQ34197670
Antioxidant role of glutathione S-transferases: protection against oxidant toxicity and regulation of stress-mediated apoptosisQ34306446
Glutathione-S-transferase family of enzymes.Q34355370
Functions of GI-GPx: lessons from selenium-dependent expression and intracellular localizationQ34377775
Evaluation of glutathione metabolic genes on outcomes in advanced non-small cell lung cancer patients after initial treatment with platinum-based chemotherapy: an NCCTG-97-24-51 based studyQ34385453
AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1Q34422019
The involvement of thioredoxin and thioredoxin binding protein-2 on cellular proliferation and aging processQ34480934
Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biologyQ34603682
Molecular biology of glutathione peroxidase 4: from genomic structure to developmental expression and neural function.Q34655209
Expression pattern of human glutaredoxin 2 isoforms: identification and characterization of two testis/cancer cell-specific isoformsQ34727779
P433issue4
P304page(s)489-509
P577publication date2010-08-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inAntioxidants & Redox SignalingQ4775078
P1476titleRedox control systems in the nucleus: mechanisms and functions
P478volume13