Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function

scientific article

Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.24.21.9414-9423.2004
P3181OpenCitations bibliographic resource ID1817395
P932PMC publication ID522221
P698PubMed publication ID15485910
P5875ResearchGate publication ID8230628

P50authorMarcus ConradQ56517307
W. WurstQ67390467
Stéphanie G. MorenoQ73757461
Georg W BornkammQ94069890
P2093author name stringKenneth R Chien
Antonis K Hatzopoulos
Fred Sinowatz
Wolfgang Schmahl
Manuela Schneider
Markus Brielmeier
Ursula Just
Heike Beck
Ana Banjac
Cemile Jakupoglu
Stefanie Lippl
P2860cites workThioredoxin reductaseQ24531944
Characterization of mammalian selenoproteomes.Q27863319
Cloning, sequencing and functional expression of a novel human thioredoxin reductaseQ28115611
Human thioredoxin reductase from HeLa cells: selective alkylation of selenocysteine in the protein inhibits enzyme activity and reduction with NADPH influences affinity to heparinQ28115980
Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stressQ28142513
Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppressionQ28191015
Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in miceQ28204189
DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1Q28204282
Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disordersQ28272795
Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron depositsQ28505173
TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndromeQ28512803
Essential role of selenium in the catalytic activities of mammalian thioredoxin reductase revealed by characterization of recombinant enzymes with selenocysteine mutationsQ28581387
Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesisQ28591886
Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systemsQ28593944
A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cellsQ29614542
Physiological functions of thioredoxin and thioredoxin reductaseQ29615600
Reactive oxygen species, antioxidants, and the mammalian thioredoxin systemQ29619367
Recombination signal sequence-binding protein Jkappa alters mesodermal cell fate decisions by suppressing cardiomyogenesisQ30477732
Atrial-like phenotype is associated with embryonic ventricular failure in retinoid X receptor alpha -/- mice.Q34051459
Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosisQ34086331
Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophyQ34274405
Mouse embryonic hematopoiesisQ34289044
Cloning and sequencing of a human thioredoxin reductaseQ34297828
The absence of mitochondrial thioredoxin 2 causes massive apoptosis, exencephaly, and early embryonic lethality in homozygous miceQ34463545
Mammalian thioredoxin reductase: oxidation of the C-terminal cysteine/selenocysteine active site forms a thioselenide, and replacement of selenium with sulfur markedly reduces catalytic activityQ35076291
Detection of apoptosis using in situ markers for DNA strand breaks in the failing human heart. Fact or epiphenomenon?Q35546856
Apoptosis in heart failure: release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathyQ36417773
Heterogeneity within animal thioredoxin reductases. Evidence for alternative first exon splicingQ40845256
Redox-dependent trafficking of 2,3,4,5, 6-pentafluorodihydrotetramethylrosamine, a novel fluorogenic indicator of cellular oxidative activityQ40869115
Dynamics and efficiency in vivo of UGA-directed selenocysteine insertion at the ribosomeQ42672346
E2F1 and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSOD-mediated ROS eliminationQ42814364
Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre proteinQ43664631
Involvements of mitochondrial thioredoxin reductase (TrxR2) in cell proliferationQ44410254
Optimized vector for conditional gene targeting in mouse embryonic stem cellsQ44482475
cDNA cloning, expression and chromosomal localization of the mouse mitochondrial thioredoxin reductase gene(1).Q47925664
Genomic organization and identification of a novel alternative splicing variant of mouse mitochondrial thioredoxin reductase (TrxR2) gene.Q48292369
Efficient FLP recombination in mouse ES cells and oocytesQ48875650
Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Gαq/Gα11 in cardiomyocytesQ60687218
Increased cardiomyocyte apoptosis during the transition to heart failure in the spontaneously hypertensive ratQ73399760
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
mitochondrionQ39572
hemopoiesisQ919283
Thioredoxin reductase 2Q21992229
P304page(s)9414-9423
P577publication date2004-11-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleEssential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function
P478volume24