A Pleiotrophin C-terminus peptide induces anti-cancer effects through RPTPβ/ζ

scientific article published on August 25, 2010

A Pleiotrophin C-terminus peptide induces anti-cancer effects through RPTPβ/ζ is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1015501650
P356DOI10.1186/1476-4598-9-224
P953full work available at URLhttps://molecular-cancer.biomedcentral.com/track/pdf/10.1186/1476-4598-9-224
http://www.biomedcentral.com/1476-4598/9/224
http://www.biomedcentral.com/content/pdf/1476-4598-9-224.pdf
http://www.biomedcentral.com/1476-4598/9/224/abstract
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20738847/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20738847/pdf/?tool=EBI
https://europepmc.org/articles/PMC2936342
https://europepmc.org/articles/PMC2936342?pdf=render
https://link.springer.com/content/pdf/10.1186/1476-4598-9-224.pdf
P932PMC publication ID2936342
P698PubMed publication ID20738847
P5875ResearchGate publication ID45951121

P50authorApostolos PolykratisQ62838164
P2093author name stringJean Delbé
José Courty
Panagiotis Katsoris
Zoi Diamantopoulou
Yamina Hamma-Kourbali
Oya Bermek
P2860cites workPleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zetaQ22253290
Heparin affin regulatory peptide binds to vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesisQ24314425
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTENQ24322051
Domain structure of pleiotrophin required for transformationQ28142793
Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophinQ28208159
Pleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growthQ28216536
Characterization of heparin affin regulatory peptide signaling in human endothelial cellsQ28242363
Differential induction of glioblastoma migration and growth by two forms of pleiotrophinQ28252154
High affinity binding and overlapping localization of neurocan and phosphacan/protein-tyrosine phosphatase-zeta/beta with tenascin-R, amphoterin, and the heparin-binding growth-associated moleculeQ28265073
Multi-ligand interactions with receptor-like protein tyrosine phosphatase beta: implications for intercellular signalingQ28270605
6B4 proteoglycan/phosphacan, an extracellular variant of receptor-like protein-tyrosine phosphatase zeta/RPTPbeta, binds pleiotrophin/heparin-binding growth-associated molecule (HB-GAM)Q28565680
Src protein-tyrosine kinase structure and regulationQ30160814
Involvement of heparin affin regulatory peptide in human prostate cancerQ31909575
PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer modelQ32069431
Identification of candidate angiogenic inhibitors processed by matrix metalloproteinase 2 (MMP-2) in cell-based proteomic screens: disruption of vascular endothelial growth factor (VEGF)/heparin affin regulatory peptide (pleiotrophin) and VEGF/ConneQ33301092
Pleiotrophin transforms NIH 3T3 cells and induces tumors in nude miceQ36067348
Pleiotrophin stimulates fibroblasts and endothelial and epithelial cells and is expressed in human cancerQ38323421
Heterogeneity of the chondroitin sulfate portion of phosphacan/6B4 proteoglycan regulates its binding affinity for pleiotrophin/heparin binding growth-associated molecule.Q38352991
A basic peptide derived from the HARP C-terminus inhibits anchorage-independent growth of DU145 prostate cancer cellsQ40087892
RNA interference targeting protein tyrosine phosphatase zeta/receptor-type protein tyrosine phosphatase beta suppresses glioblastoma growth in vitro and in vivoQ40241308
Ribozyme-targeting reveals the rate-limiting role of pleiotrophin in glioblastomaQ40403714
Heparin affin regulatory peptide is a key player in prostate cancer cell growth and angiogenicityQ40415486
An 18-kd heparin-binding protein of developing brain that is distinct from fibroblast growth factorsQ40819536
Human breast cancer growth inhibited in vivo by a dominant negative pleiotrophin mutantQ42798861
Anti-apoptotic signaling of pleiotrophin through its receptor, anaplastic lymphoma kinase.Q42812907
Dominant negative effectors of heparin affin regulatory peptide (HARP) angiogenic and transforming activitiesQ42813705
The lysine-rich C-terminal tail of heparin affin regulatory peptide is required for mitogenic and tumor formation activitiesQ42832601
Identification of heparin affin regulatory peptide domains with potential role on angiogenesisQ47328872
Isolation from bovine brain and structural characterization of HBNF, a heparin-binding neurotrophic factorQ48239145
Mitogenic properties of a new endothelial cell growth factor related to pleiotrophinQ48639103
Isolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). Identification as N-syndecan (syndecan-3)Q53952099
Ribozyme-targeting elucidates a direct role of pleiotrophin in tumor growthQ72135965
Prostate cancer epidemiologyQ73138981
An angiogenic role for the neurokines midkine and pleiotrophin in tumorigenesisQ73306250
HARP induces angiogenesis in vivo and in vitro: implication of N or C terminal peptidesQ73661959
Heparin-binding growth-associated molecule contains two heparin-binding beta -sheet domains that are homologous to the thrombospondin type I repeatQ73731319
Endothelial cell proliferation induced by HARP: implication of N or C terminal peptidesQ74027801
Relationship between serum concentrations of the growth factor pleiotrophin and pleiotrophin-positive tumorsQ77425401
Correlation of elevated plasma levels of two structurally related growth factors, heparin affin regulatory peptide and midkine, in advanced solid tumor patientsQ80998521
P407language of work or nameEnglishQ1860
P304page(s)224
P577publication date2010-08-25
P1433published inMolecular CancerQ15724585
P1476titleA Pleiotrophin C-terminus peptide induces anti-cancer effects through RPTPβ/ζ
P478volume9

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cites work (P2860)
Q39316539Implications of pleiotrophin in human PC3 prostate cancer cell growth in vivo.
Q36418808Loss of receptor protein tyrosine phosphatase β/ζ (RPTPβ/ζ) promotes prostate cancer metastasis
Q35701268Midkine: a promising molecule for drug development to treat diseases of the central nervous system
Q38832365Pleiotrophin exerts its migration and invasion effect through the neuropilin-1 pathway
Q33915644The synthetic peptide P111-136 derived from the C-terminal domain of heparin affin regulatory peptide inhibits tumour growth of prostate cancer PC-3 cells

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