scholarly article | Q13442814 |
review article | Q7318358 |
P50 | author | Robert Lefkowitz | Q80910 |
P2093 | author name string | Louis M Luttrell | |
P433 | issue | Pt 3 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | G protein-coupled receptor | Q38173 |
P304 | page(s) | 455-465 | |
P577 | publication date | 2002-02-01 | |
P1433 | published in | Journal of Cell Science | Q1524177 |
P1476 | title | The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals | |
P478 | volume | 115 |
Q34583782 | (11)C-CUMI-101, a PET radioligand, behaves as a serotonin 1A receptor antagonist and also binds to α(1) adrenoceptors in brain. |
Q41979400 | (R,R')-4'-methoxy-1-naphthylfenoterol targets GPR55-mediated ligand internalization and impairs cancer cell motility |
Q28547577 | 14-3-3 Proteins Buffer Intracellular Calcium Sensing Receptors to Constrain Signaling |
Q38653533 | A Bright Future for Serial Femtosecond Crystallography with XFELs. |
Q90210858 | A Genetically Encoded Fluorescent Sensor Enables Rapid and Specific Detection of Dopamine in Flies, Fish, and Mice |
Q33779634 | A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation. |
Q27936217 | A calcineurin-dependent switch controls the trafficking function of α-arrestin Aly1/Art6. |
Q33249099 | A critical role for endocytosis in Wnt signaling |
Q34218573 | A high-content, live-cell, and real-time approach to the quantitation of ligand-induced β-Arrestin2 and Class A/Class B GPCR mobilization. |
Q34298001 | A naturally occurring GIP receptor variant undergoes enhanced agonist-induced desensitization, which impairs GIP control of adipose insulin sensitivity |
Q33401598 | A nonsense mutation in S-antigen (p.Glu306*) causes Oguchi disease |
Q24299867 | A novel protease-activated receptor-1 interactor, Bicaudal D1, regulates G protein signaling and internalization |
Q38695082 | A roadmap to understanding toll pathway changes: an educational primer for use with "regulation of toll signaling and inflammation by β-arrestin and the SUMO protease Ulp1". |
Q24337712 | ARRDC3 suppresses breast cancer progression by negatively regulating integrin beta4 |
Q24647504 | ATP stimulates GRK-3 phosphorylation and beta-arrestin-2-dependent internalization of P2X7 receptor |
Q27301914 | Acoustofluidic chemical waveform generator and switch. |
Q36110572 | Activated human hydroxy-carboxylic acid receptor-3 signals to MAP kinase cascades via the PLC-dependent PKC and MMP-mediated EGFR pathways |
Q38234911 | Adrenal adrenoceptors in heart failure. |
Q38125685 | Adrenergic mechanism in the control of endothelial function |
Q34304875 | Adrenergic receptor activation involves ATP release and feedback through purinergic receptors |
Q35213193 | Agonist-directed interactions with specific beta-arrestins determine mu-opioid receptor trafficking, ubiquitination, and dephosphorylation. |
Q42549992 | Agonist-induced internalization and downregulation of gonadotropin-releasing hormone receptors |
Q37156680 | Altered CXCR2 signaling in beta-arrestin-2-deficient mouse models |
Q33632079 | Altered agonist sensitivity of a mutant v2 receptor suggests a novel therapeutic strategy for nephrogenic diabetes insipidus. |
Q38739512 | An overview of pharmacodynamic modelling, ligand-binding approach and its application in clinical practice |
Q34496676 | Angiotensin II receptors and drug discovery in cardiovascular disease |
Q41195003 | Angiotensin II receptors and peritoneal dialysis-induced peritoneal fibrosis |
Q35849415 | Arrestins 2 and 3 differentially regulate ETA and P2Y2 receptor-mediated cell signaling and migration in arterial smooth muscle. |
Q34672108 | Arrestins differentially regulate histamine- and oxytocin-evoked phospholipase C and mitogen-activated protein kinase signalling in myometrial cells. |
Q35999193 | Assessing Gonadotropin Receptor Function by Resonance Energy Transfer-Based Assays |
Q33700017 | Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling |
Q36512963 | Beta-Arrestin1 Levels in Mononuclear Leukocytes Support Depression Scores for Women with Premenstrual Dysphoric Disorder |
Q34324913 | Beta-arrestin2 functions as a phosphorylation-regulated suppressor of UV-induced NF-kappaB activation. |
Q42420177 | Beta-arrestins 1 and 2 differentially regulate LPS-induced signaling and pro-inflammatory gene expression. |
Q24653656 | Beta-arrestins and heterotrimeric G-proteins: collaborators and competitors in signal transduction |
Q36445260 | Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle |
Q40025332 | Beta2-adrenergic receptor regulates Toll-like receptor-4-induced nuclear factor-kappaB activation through beta-arrestin 2. |
Q64097803 | Biased Signaling and Allosteric Modulation at the FSHR |
Q47142451 | Biventricular differences in β-adrenergic receptor signaling following burn injury. |
Q22001506 | CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B |
Q35106596 | CCR5 conformations are dynamic and modulated by localization, trafficking and G protein association |
Q38432470 | CCR9 antagonism: potential in the treatment of Inflammatory Bowel Disease. |
Q41382247 | CO2 pneumoperitoneum preserves β-arrestin 2 content and reduces high mobility group box-1 (HMGB-1) expression in an animal model of peritonitis. |
Q37105011 | Cannabinoid receptor subtype 2 (CB2R) agonist, GW405833 reduces agonist-induced Ca(2+) oscillations in mouse pancreatic acinar cells |
Q52806005 | Canonical TSH Regulation of Cathepsin-Mediated Thyroglobulin Processing in the Thyroid Gland of Male Mice Requires Taar1 Expression. |
Q35818355 | Cargo- and compartment-selective endocytic scaffold proteins |
Q33634673 | Caveolae-dependent internalization and homologous desensitization of VIP/PACAP receptor, VPAC₂, in gastrointestinal smooth muscle |
Q46007992 | Caveolin-1 restoration by cholesterol enhances the inhibitory effect of simvastatin on arginine vasopressin-induced cardiac fibroblasts proliferation. |
Q64285404 | Cell signaling dependence of rapid glucocorticoid-induced endocannabinoid synthesis in hypothalamic neuroendocrine cells |
Q90549248 | Cell-Free Protein Synthesis: A Promising Option for Future Drug Development |
Q26827583 | Cell-surface receptors transactivation mediated by g protein-coupled receptors |
Q36980604 | Cellular and molecular mechanisms of sexual differentiation in the mammalian nervous system |
Q34614905 | Characterisation of P2Y(12) receptor responsiveness to cysteinyl leukotrienes. |
Q36184275 | Chemokine receptor internalization and intracellular trafficking |
Q92960322 | Circularly Permuted Fluorescent Protein-Based Indicators: History, Principles, and Classification |
Q37529047 | Class B β-arrestin2-dependent CCR5 signalosome retention with natural antibodies to CCR5. |
Q24530597 | Clathrin-dependent endocytosis |
Q42136849 | Clathrin-independent internalization of the human histamine H1-receptor in CHO-K1 cells |
Q37983747 | Clozapine, atypical antipsychotics, and the benefits of fast-off D2 dopamine receptor antagonism |
Q30505951 | Cofilin under control of β-arrestin-2 in NMDA-dependent dendritic spine plasticity, long-term depression (LTD), and learning |
Q33869206 | Comparative muscle transcriptome associated with carcass traits of Nellore cattle. |
Q36191614 | Composition and function of g protein-coupled receptor signalsomes controlling mitogen-activated protein kinase activity. |
Q30557505 | Conformational biosensors reveal GPCR signalling from endosomes. |
Q36634318 | Contributions of protein kinases and β-arrestin to termination of protease-activated receptor 2 signaling |
Q53682448 | Controversial Role of Kisspeptins/KiSS-1R Signaling System in Tumor Development. |
Q34551853 | Core engagement with β-arrestin is dispensable for agonist-induced vasopressin receptor endocytosis and ERK activation. |
Q37162371 | Counterregulation of clathrin-mediated endocytosis by the actin and microtubular cytoskeleton in human neutrophils |
Q35973795 | Critical role of Src and SHP-2 in sst2 somatostatin receptor-mediated activation of SHP-1 and inhibition of cell proliferation |
Q24800189 | Cytochalasin B triggers a novel pertussis toxin sensitive pathway in TNF-alpha primed neutrophils |
Q89009026 | Decoding the chemotactic signal |
Q35645970 | Defective Resensitization in Human Airway Smooth Muscle Cells Evokes β-Adrenergic Receptor Dysfunction in Severe Asthma |
Q34064133 | Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice. |
Q37147052 | Deletion of the COOH-terminal domain of CXC chemokine receptor 4 leads to the down-regulation of cell-to-cell contact, enhanced motility and proliferation in breast carcinoma cells |
Q41991082 | Desensitization and internalization of endothelin receptor A: impact of G protein-coupled receptor kinase 2 (GRK2)-mediated phosphorylation |
Q24294614 | Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference |
Q58698789 | Designer Approaches for G Protein-Coupled Receptor Modulation for Cardiovascular Disease |
Q43075987 | Designing Safer Analgesics via μ-Opioid Receptor Pathways |
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Q33819496 | Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor |
Q35076051 | Differential activation and trafficking of micro-opioid receptors in brain slices |
Q37282807 | Differential desensitization of homozygous haplotypes of the beta2-adrenergic receptor in lymphocytes |
Q42126128 | Differential regulation of endosomal GPCR/β-arrestin complexes and trafficking by MAPK |
Q36270932 | Differential somatostatin receptor (SSTR) 1-5 expression and downstream effectors in histologic subtypes of growth hormone pituitary tumors |
Q47682289 | Discovery of N-Substituted (2-Phenylcyclopropyl)methylamines as Functionally Selective Serotonin 2C Receptor Agonists for Potential Use as Antipsychotic Medications. |
Q35132371 | Distinct pathways of ERK1/2 activation by hydroxy-carboxylic acid receptor-1 |
Q36579520 | Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini |
Q37550019 | Diversity in arrestin function |
Q90075720 | Do Toxic Synthetic Cannabinoid Receptor Agonists Have Signature in Vitro Activity Profiles? A Case Study of AMB-FUBINACA |
Q60141581 | Dopamine: Functions, Signaling, and Association with Neurological Diseases |
Q34080461 | Dynamics of the G protein-coupled vasopressin V2 receptor signaling network revealed by quantitative phosphoproteomics. |
Q34803218 | EFR3s are palmitoylated plasma membrane proteins that control responsiveness to G-protein-coupled receptors |
Q39554030 | ET-1 induced Elevation of intracellular calcium in clonal neuronal and embryonic kidney cells involves endogenous endothelin-A receptors linked to phospholipase C through Gα(q/11) |
Q39188292 | Effect of CCR5 receptor antagonists on endocytosis of the human CCR5 receptor in CHO-K1 cells |
Q51872392 | Elevated β-arrestin1 expression correlated with risk stratification in acute lymphoblastic leukemia. |
Q41177526 | Endocytosis of the type III transforming growth factor-beta (TGF-beta) receptor through the clathrin-independent/lipid raft pathway regulates TGF-beta signaling and receptor down-regulation |
Q41906789 | Endothelin signalling in arterial smooth muscle is tightly regulated by G protein-coupled receptor kinase 2. |
Q42791086 | Essential role for beta-arrestin 2 in the regulation of Xenopus convergent extension movements |
Q34804942 | Expression Analysis of Visual Arrestin gene during Ocular Development of Olive Flounder (Paralichthys olivaceus). |
Q34089093 | FTY720 (s)-phosphonate preserves sphingosine 1-phosphate receptor 1 expression and exhibits superior barrier protection to FTY720 in acute lung injury |
Q90655306 | FVIIa (Factor VIIa) Induces Biased Cytoprotective Signal in Mice Through the Cleavage of PAR (Protease-Activated Receptor)-1 at Canonical Arg41 Site |
Q64997269 | Feedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system. |
Q38698390 | Feedback regulation of G protein-coupled receptor signaling by GRKs and arrestins. |
Q41952624 | Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis |
Q35999789 | Fulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism. |
Q42407015 | Functional Selectivity of CB2 Cannabinoid Receptor Ligands at a Canonical and Noncanonical Pathway |
Q34544364 | Functional competence of a partially engaged GPCR-β-arrestin complex |
Q37863171 | Functional relevance of biased signaling at the angiotensin II type 1 receptor |
Q39021630 | Functional selectivity at G-protein coupled receptors: Advancing cannabinoid receptors as drug targets |
Q35264421 | Functional selectivity at the μ-opioid receptor: implications for understanding opioid analgesia and tolerance. |
Q36692097 | G protein coupled receptor structure and activation |
Q28578948 | G protein-coupled receptor kinase 2 and arrestin2 regulate arterial smooth muscle P2Y-purinoceptor signalling |
Q35682949 | G protein-coupled receptor kinase/beta-arrestin systems and drugs of abuse: psychostimulant and opiate studies in knockout mice. |
Q36914223 | G protein-coupled receptor-promoted trafficking of Gbeta1gamma2 leads to AKT activation at endosomes via a mechanism mediated by Gbeta1gamma2-Rab11a interaction |
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Q34735704 | G-protein-coupled receptor phosphorylation: where, when and by whom |
Q35566599 | G-protein-coupled receptors: past, present and future. |
Q33828719 | GPCRs and cancer |
Q24630455 | GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects |
Q33707710 | GPR54 regulates ERK1/2 activity and hypothalamic gene expression in a Gα(q/11) and β-arrestin-dependent manner |
Q64252945 | GRKs and β-Arrestins: "Gatekeepers" of Mitochondrial Function in the Failing Heart |
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Q52642716 | Genomic and transcriptomic comparison of allergen and silver nanoparticle-induced mast cell degranulation reveals novel non-immunoglobulin E mediated mechanisms. |
Q35766985 | Gi-biased β2AR signaling links GRK2 upregulation to heart failure |
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Q39180630 | Growth factor receptor-Src-mediated suppression of GRK6 dysregulates CXCR4 signaling and promotes medulloblastoma migration |
Q42377918 | Gαs regulates Glucagon-Like Peptide 1 Receptor-mediated cyclic AMP generation at Rab5 endosomal compartment |
Q39414464 | Hallucinogens and Serotonin 5-HT2A Receptor-Mediated Signaling Pathways |
Q34028196 | Heterotrimeric G protein signaling outside the realm of seven transmembrane domain receptors |
Q40983016 | Homogeneous time-resolved fluorescence-based assay to monitor extracellular signal-regulated kinase signaling in a high-throughput format |
Q35227742 | Human neutrophil formyl peptide receptor phosphorylation and the mucosal inflammatory response |
Q26821954 | Human β-cell proliferation and intracellular signaling: part 3 |
Q35589613 | IL-13 desensitizes β2-adrenergic receptors in human airway epithelial cells through a 15-lipoxygenase/G protein receptor kinase 2 mechanism |
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Q38758506 | Identification of human somatostatin receptor 2 domains involved in internalization and signaling in QGP-1 pancreatic neuroendocrine tumor cell line |
Q34467542 | Identification of serine 348 on the apelin receptor as a novel regulatory phosphorylation site in apelin-13-induced G protein-independent biased signaling |
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Q37014120 | Increased agonist affinity at the μ-opioid receptor induced by prolonged agonist exposure. |
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Q64065904 | Interplay between the Endogenous Opioid System and Proteasome Complex: Beyond Signaling |
Q38287475 | Intracellular signaling mechanisms of the melanocortin receptors: current state of the art. |
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Q38053088 | Involvement of β-arrestins in cancer progression |
Q37249506 | Kisspeptin/KISS1R System in Breast Cancer |
Q30479618 | Leukocyte migration and graft-versus-host disease |
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Q35090466 | Lysophosphatidylcholines activate G2A inducing G(αi)₋₁-/G(αq/)₁₁- Ca²(+) flux, G(βγ)-Hck activation and clathrin/β-arrestin-1/GRK6 recruitment in PMNs. |
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Q39321350 | Role of the CXCL8-CXCR1/2 Axis in Cancer and Inflammatory Diseases |
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Q45081795 | Rolipram reduces the inotropic tachyphylaxis of glucagon in rat ventricular myocardium |
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Q36562076 | SET protein interacts with intracellular domains of the gonadotropin-releasing hormone receptor and differentially regulates receptor signaling to cAMP and calcium in gonadotrope cells. |
Q33642724 | Selective regulation of H1 histamine receptor signaling by G protein-coupled receptor kinase 2 in uterine smooth muscle cells. |
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Q34402623 | Serotonin, but not N-methyltryptamines, activates the serotonin 2A receptor via a ß-arrestin2/Src/Akt signaling complex in vivo |
Q28731687 | Serotonin-1A receptors in major depression quantified using PET: controversies, confounds, and recommendations |
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Q35951259 | Seven-transmembrane receptors and ubiquitination |
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Q36735740 | Smoothened determines β-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium |
Q36565309 | Sorting nexin 27 interacts with Fzd7 and mediates Wnt signalling |
Q89517789 | Spatiotemporal dynamic monitoring of fatty acid-receptor interaction on single living cells by multiplexed Raman imaging |
Q36051502 | Specificity of arrestin subtypes in regulating airway smooth muscle G protein-coupled receptor signaling and function |
Q38457000 | Synthetic melatoninergic ligands: achievements and prospects. |
Q39106190 | TSHR as a therapeutic target in Graves' disease |
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Q38866310 | Targeting orphan G protein-coupled receptors for the treatment of diabetes and its complications: C-peptide and GPR146. |
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Q47240000 | The Abrogation of Phosphorylation Plays a Relevant Role in the CCR5 Signalosome Formation with Natural Antibodies to CCR5. |
Q35249092 | The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor κ light-chain enhancer of activated B cells (NF-κB) in mice |
Q36976809 | The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha |
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Q50285621 | The Role of G Protein-coupled Receptor Kinases in Cancer |
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Q39806707 | The Viral G Protein-Coupled Receptor ORF74 Hijacks β-Arrestins for Endocytic Trafficking in Response to Human Chemokines |
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Q37200963 | The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex |
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Q24657333 | The genetic design of signaling cascades to record receptor activation |
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