Interstitial insulin concentrations determine glucose uptake rates but not insulin resistance in lean and obese men

scientific article

Interstitial insulin concentrations determine glucose uptake rates but not insulin resistance in lean and obese men is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI116932
P932PMC publication ID293712
P698PubMed publication ID8282776

P50authorClifton BogardusQ64495509
P2093author name stringBergman R
Lillioja S
Castillo C
Thuillez P
P2860cites workFlow and composition of leg lymph in normal men during venous stasis, muscular activity and local hyperthermiaQ67553966
Peripheral lymphatic cannulation for physiological analysis of interstitial fluid compartment in humansQ68025578
Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps. Comparison of unlabeled and labeled exogenous glucose infusatesQ68161753
Glucose storage is a major determinant of in vivo "insulin resistance" in subjects with normal glucose toleranceQ68866015
Insulin oscillations per se do not affect glucose turnover parameters in normal manQ68884374
Mechanism for underestimation of isotopically determined glucose disposalQ69502995
Receptor-mediated transport of insulin across endothelial cellsQ69884874
Heterogeneity of insulin action in individual muscles in vivo: euglycemic clamp studies in ratsQ69891432
Interaction of sympathomimetics and insulin with hepatic glucose production by isolated perfused rat livers: effects of continuous versus pulsatile infusionQ70210889
Insulin Dose-Response Characteristics Among Individual Muscle and Adipose Tissues Measured in the Rat In Vivo with 3(H)2-DeoxyglucoseQ70314147
Restricted passage of insulin across capillary endothelium in perfused rat adipose tissueQ70368805
Peripheral glucose uptake in relation to physiological levels of plasma and lymph insulinQ70405987
The interstitial matrix as a barrier in blood-to-lymph solute movementQ71169790
Intrinsic contractility of prenodal lymph vessels and lymph flow in human legQ71425315
The capillary barrier to circulating insulinQ71462062
Passage of insulin and inulin across vascular membranes in the dogQ72127786
Body fat in adult manQ73270495
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitusQ28190307
Reduced capacity and affinity of skeletal muscle for insulin-mediated glucose uptake in noninsulin-dependent diabetic subjects. Effects of insulin therapyQ34182003
Glucose clamp technique: a method for quantifying insulin secretion and resistanceQ34191986
Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistanceQ34253010
A model of the kinetics of insulin in man.Q34518150
In vivo kinetics of insulin action on peripheral glucose disposal and hepatic glucose output in normal and obese subjectsQ34534199
Insulin transport across capillaries is rate limiting for insulin action in dogsQ34579532
Relationship between insulin-mediated glucose disposal and lipid metabolism in man.Q34624238
Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipidQ35013075
Skeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man.Q35577083
Dual effect of insulin on plasma volume and transcapillary albumin transportQ35915598
New morphological evidence for a mechanism of lymph formation in skeletal muscleQ36627488
Assessment of insulin sensitivity in vivo: a critical reviewQ38672441
Islet amyloid, islet-amyloid polypeptide, and diabetes mellitusQ38674648
Obesity and insulin resistance: lessons learned from the Pima Indians.Q39551648
Capillary permeability and how it may changeQ39578095
Pulsatile secretion of fuel-regulatory hormonesQ39764582
Enzyme patterns in single human muscle fibersQ39866920
Effects of endurance training on muscle fibre ATP-ase activity, capillary supply and mitochondrial content in manQ39902639
Capillary supply of the quadriceps femoris muscle of man: adaptive response to exerciseQ40100323
The Diagnosis of Diabetes: New International Classification and Diagnostic CriteriaQ40150733
Kinetics of Native Insulin in Diabetic, Obese, and Aged MenQ41005413
Myosin isozyme distribution in rodent hindlimb skeletal muscleQ41353807
Where all the glucose doesn't go in non-insulin-dependent diabetes mellitusQ44047897
Muscle capillary supply and fiber type characteristics in weight and power liftersQ47244311
Efficacy of pulsatile versus continuous insulin administration on hepatic glucose production and glucose utilization in type I diabetic humans.Q51633153
The effect of chronic sulfonylurea therapy on hepatic glucose production in non-insulin-dependent diabetes.Q51651477
Metabolic profiles of three fiber types of skeletal muscle in guinea pigs and rabbits.Q54032679
Graded modulation of frog microvessel permeability to albumin using ionophore A23187.Q54331803
Pancreatic amylin and calcitonin gene-related peptide cause resistance to insulin in skeletal muscle in vitro.Q54374951
Use of a variable insulin infusion to assess insulin action in obesity: defects in both the kinetics and amplitude of response.Q54407449
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectobesityQ12174
insulin resistanceQ1053470
preproinsulinQ7240673
P304page(s)10-16
P577publication date1994-01-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleInterstitial insulin concentrations determine glucose uptake rates but not insulin resistance in lean and obese men
P478volume93

Reverse relations

cites work (P2860)
Q48140957A computational model of the effect of capillary density variability on oxygen transport, glucose uptake, and insulin sensitivity in prediabetes.
Q30393746Angiotensin-(1-7) recruits muscle microvasculature and enhances insulin's metabolic action via mas receptor
Q52255379Assessment of insulin action on glucose uptake and production during a euglycemic-hyperinsulinemic clamp in dog: a new kinetic analysis.
Q40639994Bioavailability of insulin detemir and human insulin at the level of peripheral interstitial fluid in humans, assessed by open-flow microperfusion
Q45199147Delayed transcapillary delivery of insulin to muscle interstitial fluid after oral glucose load in obese subjects
Q42436723Desensitization of human adipose tissue to adrenaline stimulation studied by microdialysis
Q53744487Development of microdialysis methodology for interstitial insulin measurement in rodents.
Q33683551Diet-induced obesity prevents interstitial dispersion of insulin in skeletal muscle
Q45074259Direct Activation of the Angiotensin II Type-2 Receptors Enhances Muscle Microvascular Perfusion, Oxygenation and Insulin Delivery in Male Rats
Q38924286Endothelial Transcytosis of Insulin: Does It Contribute to Insulin Resistance?
Q37405747Getting the message across: mechanisms of physiological cross talk by adipose tissue
Q30413976Globular adiponectin enhances muscle insulin action via microvascular recruitment and increased insulin delivery
Q30371576Glucagon-like peptide 1 recruits muscle microvasculature and improves insulin's metabolic action in the presence of insulin resistance
Q40696222Hemodynamic actions of insulin
Q41250377Hyperinsulinaemia, insulin resistance, microalbuminuria and the risk of coronary heart disease
Q42529113Influence of moderate physical exercise on insulin-mediated and non-insulin-mediated glucose uptake in healthy subjects
Q46217097Insulin Access to Skeletal Muscle is Preserved in Obesity Induced by Polyunsaturated Diet
Q40975029Insulin access to skeletal muscle is impaired during the early stages of diet-induced obesity
Q30425679Insulin regulates its own delivery to skeletal muscle by feed-forward actions on the vasculature
Q90342813Insulin resistance disrupts cell integrity, mitochondrial function, and inflammatory signaling in lymphatic endothelium
Q39800118Insulin resistance of glucose uptake in skeletal muscle cannot be ameliorated by enhancing endothelium-dependent blood flow in obesity
Q36381003Insulin resistance: potential role of the endogenous nitric oxide synthase inhibitor ADMA.
Q44312400Insulin- and exercise-stimulated skeletal muscle blood flow and glucose uptake in obese men.
Q35752273Insulin-mediated skeletal muscle vasodilation contributes to both insulin sensitivity and responsiveness in lean humans
Q42521949Interstitial insulin during euglycemic-hyperinsulinemic clamp in obese and lean individuals
Q51561058Intracellular skeletal muscle glucose metabolism is differentially altered by dexamethasone treatment of normoglycemic relatives of type 2 diabetic patients.
Q33622116Is insulin the new intermittent hypoxia?
Q35671698Lipid-induced insulin resistance does not impair insulin access to skeletal muscle.
Q30414452Losartan increases muscle insulin delivery and rescues insulin's metabolic action during lipid infusion via microvascular recruitment
Q42650840Measurement of interstitial insulin in human adipose and muscle tissue under moderate hyperinsulinemia by means of direct interstitial access.
Q37377039Mechanisms of insulin resistance in experimental hyperinsulinemic dogs
Q51569832Minimal model of glucose metabolism: modified equations and its application in the study of insulin sensitivity in obese subjects.
Q58614459Modeling the acute effects of exercise on insulin kinetics in type 1 diabetes
Q34778851Modest hyperglycemia prevents interstitial dispersion of insulin in skeletal muscle
Q63976786Muscle Insulin Resistance and the Inflamed Microvasculature: Fire from Within
Q30422134Muscle microvascular recruitment predicts insulin sensitivity in middle-aged patients with type 1 diabetes mellitus
Q53518091Palmitate-induced inflammatory pathways in human adipose microvascular endothelial cells promote monocyte adhesion and impair insulin transcytosis.
Q71090513Rapid formation of capillary endothelial cells in rat skeletal muscle after exposure to insulin
Q41095098Role of insulin resistance in the pathogenesis of NIDDM.
Q58127046Skin Autofluorescence-Indicated Advanced Glycation End Products as Predictors of Cardiovascular and All-Cause Mortality in High-Risk Subjects: A Systematic Review and Meta-analysis
Q77826947Skin mini-erosion technique for monitoring metabolites in interstitial fluid: its feasibility demonstrated by OGTT results in diabetic and non-diabetic subjects
Q34201786The effects of non-insulin-dependent diabetes mellitus on the kinetics of onset of insulin action in hepatic and extrahepatic tissues
Q30414637The endothelial cell: an "early responder" in the development of insulin resistance
Q34985856The identification of insulin saturation effects during the dynamic insulin sensitivity test
Q30436236The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action
Q30416025The vascular contribution to insulin resistance: promise, proof, and pitfalls.
Q30439964The vascular endothelial cell mediates insulin transport into skeletal muscle
Q26995299The vascular endothelium in diabetes and its potential as a therapeutic target
Q30300466Vascular function, insulin action, and exercise: an intricate interplay