High-level expression of the malaria blood-stage vaccine candidate Plasmodium falciparum apical membrane antigen 1 and induction of antibodies that inhibit erythrocyte invasion

scientific article

High-level expression of the malaria blood-stage vaccine candidate Plasmodium falciparum apical membrane antigen 1 and induction of antibodies that inhibit erythrocyte invasion is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/IAI.70.8.4471-4476.2002
P953full work available at URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC128198
P932PMC publication ID128198
P698PubMed publication ID12117958

P50authorClemens KockenQ28913773
Annemarie Voorberg-van der WelQ45380667
Augusto ValderramaQ55174934
Michael J BlackmanQ56786712
Chrislaine Withers-MartinezQ87837775
Fiona HackettQ107404870
Alan W ThomasQ121769890
P2093author name stringMartin A Dubbeld
P2860cites workIntegral membrane protein located in the apical complex of Plasmodium falciparumQ24633619
Human malaria parasites in continuous cultureQ28131626
Immunization with parasite-derived apical membrane antigen 1 or passive immunization with a specific monoclonal antibody protects BALB/c mice against lethal Plasmodium yoelii yoelii YM blood-stage infectionQ34004431
Specificity of the protective antibody response to apical membrane antigen 1Q34007362
Protective immune responses to apical membrane antigen 1 of Plasmodium chabaudi involve recognition of strain-specific epitopesQ35513031
High-level expression of Plasmodium vivax apical membrane antigen 1 (AMA-1) in Pichia pastoris: strong immunogenicity in Macaca mulatta immunized with P. vivax AMA-1 and adjuvant SBAS2.Q39509106
High prevalence of natural antibodies against Plasmodium falciparum 83-kilodalton apical membrane antigen (PF83/AMA-1) as detected by capture-enzyme-linked immunosorbent assay using full-length baculovirus recombinant PF83/AMA-1.Q40693588
Refocusing neutralizing antibody response by targeted dampening of an immunodominant epitope.Q41103077
Structural studies on a putative protective Plasmodium knowlesi merozoite antigenQ41925718
Molecular characterisation of Plasmodium reichenowi apical membrane antigen-1 (AMA-1), comparison with P. falciparum AMA-1, and antibody-mediated inhibition of red cell invasion.Q42632486
Immunisation with recombinant AMA-1 protects mice against infection with Plasmodium chabaudiQ44994461
Precise timing of expression of a Plasmodium falciparum-derived transgene in Plasmodium berghei is a critical determinant of subsequent subcellular localizationQ47831682
PCR-based gene synthesis as an efficient approach for expression of the A+T-rich malaria genome.Q47857173
Proteolytic processing and primary structure of Plasmodium falciparum apical membrane antigen-1.Q47884690
Vaccination trials in rhesus monkeys with a minor, invariant, Plasmodium knowlesi 66 kD merozoite antigenQ47909837
The Fab fragments of monoclonal IgG to a merozoite surface antigen inhibit Plasmodium knowlesi invasion of erythrocytesQ47983326
Protective immunity induced in squirrel monkeys with recombinant apical membrane antigen-1 of Plasmodium fragile.Q48005602
Differential localization of full-length and processed forms of PF83/AMA-1 an apical membrane antigen of Plasmodium falciparum merozoites.Q48006353
The disulfide bond structure of Plasmodium apical membrane antigen-1.Q48033627
Diversity of the vaccine candidate AMA-1 of Plasmodium falciparumQ48065126
Analysis of variation in PF83, an erythrocytic merozoite vaccine candidate antigen of Plasmodium falciparumQ48255494
Rat monoclonal antibodies which inhibit the in vitro multiplication of Plasmodium knowlesiQ56381024
Genetic conservation of the Plasmodium falciparum apical membrane antigen-1 (AMA-1)Q64134650
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectmalariaQ12156
antibodyQ79460
vaccineQ134808
malaria vaccineQ6741353
Plasmodium falciparumQ311383
erythrocyte invasionQ122665572
P1104number of pages6
P304page(s)4471-4476
P577publication date2002-08-01
P1433published inInfection and ImmunityQ6029193
P1476titleHigh-level expression of the malaria blood-stage vaccine candidate Plasmodium falciparum apical membrane antigen 1 and induction of antibodies that inhibit erythrocyte invasion
P478volume70

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cites work (P2860)
Q35877857A Library of Plasmodium vivax Recombinant Merozoite Proteins Reveals New Vaccine Candidates and Protein-Protein Interactions
Q36710710A diversity-covering approach to immunization with Plasmodium falciparum apical membrane antigen 1 induces broader allelic recognition and growth inhibition responses in rabbits
Q46423309A human phase 1 vaccine clinical trial of the Plasmodium falciparum malaria vaccine candidate apical membrane antigen 1 in Montanide ISA720 adjuvant
Q36141540A novel approach to identifying patterns of human invasion-inhibitory antibodies guides the design of malaria vaccines incorporating polymorphic antigens
Q37529646A novel malaria vaccine candidate antigen expressed in Tetrahymena thermophila.
Q47948366A recombinant vaccine based on domain II of Plasmodium vivax Apical Membrane Antigen 1 induces high antibody titres in mice.
Q27973519A role for apical membrane antigen 1 during invasion of hepatocytes by Plasmodium falciparum sporozoites
Q44397889A single malaria merozoite serine protease mediates shedding of multiple surface proteins by juxtamembrane cleavage
Q43986541Adenovectors induce functional antibodies capable of potent inhibition of blood stage malaria parasite growth
Q34145333Advances and challenges in malaria vaccine development.
Q35739071Age-dependent IgG subclass responses to Plasmodium falciparum EBA-175 are differentially associated with incidence of malaria in Mozambican children
Q39362577Allele Frequency-Based Analyses Robustly Map Sequence Sites Under Balancing Selection in a Malaria Vaccine Candidate Antigen
Q33558449Allele specificity of naturally acquired antibody responses against Plasmodium falciparum apical membrane antigen 1.
Q34290806Allelic diversity and naturally acquired allele-specific antibody responses to Plasmodium falciparum apical membrane antigen 1 in Kenya
Q33402457An inhibitory antibody blocks interactions between components of the malarial invasion machinery
Q55475163Analysis of Plasmodium vivax Apical Membrane Antigen-1 (PvAMA-1) Haplotypes among Iranian Isolates.
Q56368212Analysis of factors affecting the variability of a quantitative suspension bead array assay measuring IgG to multiple Plasmodium antigens
Q36906995Analysis of the dose-dependent stage-specific in vitro efficacy of a multi-stage malaria vaccine candidate cocktail
Q33761687Antibodies against multiple merozoite surface antigens of the human malaria parasite Plasmodium falciparum inhibit parasite maturation and red blood cell invasion
Q33197101Antibodies to malaria peptide mimics inhibit Plasmodium falciparum invasion of erythrocytes
Q34827195Antibodies to polymorphic invasion-inhibitory and non-Inhibitory epitopes of Plasmodium falciparum apical membrane antigen 1 in human malaria
Q45325016Assessment of the Combined Effect of Epstein-Barr Virus and Plasmodium falciparum Infections on Endemic Burkitt Lymphoma Using a Multiplex Serological Approach
Q34719080Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns
Q37635335Avidity of anti-malarial antibodies inversely related to transmission intensity at three sites in Uganda
Q39015319Babesia bovis merozoites invade human, ovine, equine, porcine and caprine erythrocytes by a sialic acid-dependent mechanism followed by developmental arrest after a single round of cell fission
Q43087423Bioinformatic Identification of Peptidomimetic-Based Inhibitors against Plasmodium falciparum Antigen AMA1.
Q36594057Breadth and magnitude of antibody responses to multiple Plasmodium falciparum merozoite antigens are associated with protection from clinical malaria
Q37253541Cell-mediated immunity elicited by the blood stage malaria vaccine apical membrane antigen 1 in Malian adults: results of a Phase I randomized trial
Q36862490Cohort study of the association of antibody levels to AMA1, MSP119, MSP3 and GLURP with protection from clinical malaria in Ghanaian children
Q28278882Comparative genomic analysis and phylogenetic position of Theileria equi
Q36898029Comparative testing of six antigen-based malaria vaccine candidates directed toward merozoite-stage Plasmodium falciparum
Q80834997Correlation of structural development and differential expression of invasion-related molecules in schizonts of Plasmodium falciparum
Q35606847Crystal structure of Plasmodium knowlesi apical membrane antigen 1 and its complex with an invasion-inhibitory monoclonal antibody
Q34598177Cytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure
Q47883813Detailed functional characterization of glycosylated and nonglycosylated variants of malaria vaccine candidate PfAMA1 produced in Nicotiana benthamiana and analysis of growth inhibitory responses in rabbits
Q55342398Development of a high-throughput flexible quantitative suspension array assay for IgG against multiple Plasmodium falciparum antigens.
Q49353060Development of quantitative suspension array assays for six immunoglobulin isotypes and subclasses to multiple Plasmodium falciparum antigens
Q47859315Direct effect of Plasmodium vivax recombinant vaccine candidates AMA-1 and MSP-119 on the innate immune response
Q48013866Distinct mechanisms govern proteolytic shedding of a key invasion protein in apicomplexan pathogens
Q33859217Distinct patterns of diversity, population structure and evolution in the AMA1 genes of sympatric Plasmodium falciparum and Plasmodium vivax populations of Papua New Guinea from an area of similarly high transmission
Q47311278EDiP: the Epitope Dilution Phenomenon. Lessons learnt from a malaria vaccine antigen and its applicability to polymorphic antigens
Q35802357Effect of codon optimization on expression levels of a functionally folded malaria vaccine candidate in prokaryotic and eukaryotic expression systems
Q37427474Erythrocyte invasion by Babesia bovis merozoites is inhibited by polyclonal antisera directed against peptides derived from a homologue of Plasmodium falciparum apical membrane antigen 1.
Q47986453Evaluation of the genetic diversity of domain II of Plasmodium vivax Apical Membrane Antigen 1 (PvAMA-1) and the ensuing strain-specific immune responses in patients from Sri Lanka
Q37135480Expression and purification of an engineered, yeast-expressed Leishmania donovani nucleoside hydrolase with immunogenic properties
Q39518664Extensive antigenic polymorphism within the repeat sequence of the Plasmodium falciparum merozoite surface protein 1 block 2 is incorporated in a minimal polyvalent immunogen
Q34994491Finding the sweet spots of inhibition: understanding the targets of a functional antibody against Plasmodium vivax Duffy binding protein
Q48037113Fine mapping of an epitope recognized by an invasion-inhibitory monoclonal antibody on the malaria vaccine candidate apical membrane antigen 1.
Q42006881Functional analysis of Plasmodium falciparum apical membrane antigen 1 utilizing interspecies domains
Q37313879Genetic diversity and malaria vaccine design, testing and efficacy: preventing and overcoming 'vaccine resistant malaria'.
Q37348151Genetic diversity of the Plasmodium falciparum apical membrane antigen I gene in parasite population from the China-Myanmar border area
Q39730124Geographical structure of diversity and differences between symptomatic and asymptomatic infections for Plasmodium falciparum vaccine candidate AMA1.
Q35037036Global Population Structure of the Genes Encoding the Malaria Vaccine Candidate, Plasmodium vivax Apical Membrane Antigen 1 (PvAMA1).
Q41722962Heterologous expression of Plasmodium vivax apical membrane antigen 1 (PvAMA1) for binding peptide selection.
Q34965654High antibody responses against Plasmodium falciparum in immigrants after extended periods of interrupted exposure to malaria
Q33898336High yield expression of an AHL-lactonase from Bacillus sp. B546 in Pichia pastoris and its application to reduce Aeromonas hydrophila mortality in aquaculture
Q39362569Human antibodies to recombinant protein constructs of Plasmodium falciparum Apical Membrane Antigen 1 (AMA1) and their associations with protection from malaria
Q28727698Humoral immune responses to a single allele PfAMA1 vaccine in healthy malaria-naïve adults
Q36421572Humoral responses to plasmodium falciparum blood-stage antigens and association with incidence of clinical malaria in children living in an area of seasonal malaria transmission in Burkina Faso, West Africa.
Q36984161Identification and prioritization of merozoite antigens as targets of protective human immunity to Plasmodium falciparum malaria for vaccine and biomarker development
Q92292593Identification of adjuvants for clinical trials performed with Plasmodium falciparum AMA1 in rabbits
Q35683634Identification of an Immunogenic Mimic of a Conserved Epitope on the Plasmodium falciparum Blood Stage Antigen AMA1 Using Virus-Like Particle (VLP) Peptide Display
Q53819699IgM and IgG against Plasmodium falciparum lysate as surrogates of malaria exposure and protection during pregnancy.
Q48031825Immune responses in mice induced by prime-boost schemes of the Plasmodium falciparum apical membrane antigen 1 (PfAMA1)-based DNA, protein and recombinant modified vaccinia Ankara vaccines
Q44367636Immunogenicity of a recombinant malaria vaccine candidate, domain I+II of AMA-1 ectodomain, from Indian P. falciparum alleles
Q34601683Immunoglobulin G antibodies to merozoite surface antigens are associated with recovery from chloroquine-resistant Plasmodium falciparum in Gambian children
Q46140366Immunological profile of a Plasmodium vivax AMA-1 N-terminus peptide-carbon nanotube conjugate in an infected Plasmodium berghei mouse model
Q35439859Impact of malaria preexposure on antiparasite cellular and humoral immune responses after controlled human malaria infection
Q35330733Impact of the RTS,S malaria vaccine candidate on naturally acquired antibody responses to multiple asexual blood stage antigens
Q36314049In immunization with Plasmodium falciparum apical membrane antigen 1, the specificity of antibodies depends on the species immunized
Q30967137Induction of parasite growth-inhibitory antibodies by a virosomal formulation of a peptidomimetic of loop I from domain III of Plasmodium falciparum apical membrane antigen 1
Q33214292Induction of strain-transcending immunity against Plasmodium chabaudi adami malaria with a multiepitope DNA vaccine
Q36349656Invasion-inhibitory antibodies inhibit proteolytic processing of apical membrane antigen 1 of Plasmodium falciparum merozoites
Q34011922Lack of allele-specific efficacy of a bivalent AMA1 malaria vaccine
Q34416904Limited antigenic diversity of Plasmodium falciparum apical membrane antigen 1 supports the development of effective multi-allele vaccines
Q36297353Low antibodies against Plasmodium falciparum and imbalanced pro-inflammatory cytokines are associated with severe malaria in Mozambican children: a case-control study
Q37566118Malaria epidemiology in central Myanmar: identification of a multi-species asymptomatic reservoir of infection
Q36313955Malaria vaccine-related benefits of a single protein comprising Plasmodium falciparum apical membrane antigen 1 domains I and II fused to a modified form of the 19-kilodalton C-terminal fragment of merozoite surface protein 1
Q36219634Malaria vaccines in development
Q28730794Measurement of the plasma levels of antibodies against the polymorphic vaccine candidate apical membrane antigen 1 in a malaria-exposed population.
Q54253318Micro-epidemiology of malaria in an elimination setting in Central Vietnam.
Q37172956Mixed allele malaria vaccines: host protection and within-host selection
Q42727356Mode of action of invasion-inhibitory antibodies directed against apical membrane antigen 1 of Plasmodium falciparum
Q43075976Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum.
Q35628510Multiple clinical episodes of Plasmodium falciparum malaria in a low transmission intensity setting: exposure versus immunity
Q39278961Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparum
Q40120062Multiplexing detection of IgG against Plasmodium falciparum pregnancy-specific antigens
Q37647647Naturally Acquired Binding-Inhibitory Antibodies to Plasmodium vivax Duffy Binding Protein in Pregnant Women Are Associated with Higher Birth Weight in a Multicenter Study
Q36302325Opinion: antibody-based therapies for malaria
Q44941813Optimization of a multi-stage, multi-subunit malaria vaccine candidate for the production in Pichia pastoris by the identification and removal of protease cleavage sites
Q55292950Optimization of incubation conditions of Plasmodium falciparum antibody multiplex assays to measure IgG, IgG1-4, IgM and IgE using standard and customized reference pools for sero-epidemiological and vaccine studies.
Q24802878Optimized expression of Plasmodium falciparum erythrocyte membrane protein 1 domains in Escherichia coli
Q33742070Plasmodium berghei circumvents immune responses induced by merozoite surface protein 1- and apical membrane antigen 1-based vaccines
Q27972559Plasmodium falciparum AMA1 binds a rhoptry neck protein homologous to TgRON4, a component of the moving junction in Toxoplasma gondii
Q37103927Plasmodium falciparum malaria vaccines in development
Q92664225Plasmodium falciparum merozoite surface antigen-specific cytophilic IgG and control of malaria infection in a Beninese birth cohort
Q37270041Plasmodium falciparum merozoite surface protein 2 is unstructured and forms amyloid-like fibrils
Q35931132Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood-Stage Proteins of Plasmodium vivax
Q36286806Population genetic structure and natural selection of apical membrane antigen-1 in Plasmodium vivax Korean isolates
Q36391717Potential impact of host immunity on malaria treatment outcome in Tanzanian children infected with Plasmodium falciparum
Q36446656Production of the subdomains of the Plasmodium falciparum apical membrane antigen 1 ectodomain and analysis of the immune response
Q28554439Production, Quality Control, Stability and Pharmacotoxicity of a Malaria Vaccine Comprising Three Highly Similar PfAMA1 Protein Molecules to Overcome Antigenic Variation
Q46135488Production, quality control, stability and pharmacotoxicity of cGMP-produced Plasmodium falciparum AMA1 FVO strain ectodomain expressed in Pichia pastoris
Q39518657Prospective identification of malaria parasite genes under balancing selection
Q36536645Prospects for recombinant vaccines against Babesia bovis and related parasites
Q35875731Proteases in host cell invasion by the malaria parasite
Q35094826Protection of Malian children from clinical malaria is associated with recognition of multiple antigens
Q33394245Safety and immunogenicity of a recombinant Plasmodium falciparum AMA1 malaria vaccine adjuvanted with Alhydrogel, Montanide ISA 720 or AS02.
Q33316023Safety and immunogenicity of an AMA-1 malaria vaccine in Malian adults: results of a phase 1 randomized controlled trial
Q33530106Safety and immunogenicity of an AMA1 malaria vaccine in Malian children: results of a phase 1 randomized controlled trial
Q36398138Sequence diversity and natural selection at domain I of the apical membrane antigen 1 among Indian Plasmodium falciparum populations
Q35853662Sero-epidemiological evaluation of Plasmodium falciparum malaria in Senegal
Q27681409Structural and Functional Insights into the Malaria Parasite Moving Junction Complex
Q36728063Targets and Mechanisms Associated with Protection from Severe Plasmodium falciparum Malaria in Kenyan Children
Q33294829The Princeton Protein Orthology Database (P-POD): a comparative genomics analysis tool for biologists
Q28742887The RON2-AMA1 interaction is a critical step in moving junction-dependent invasion by apicomplexan parasites
Q35241288The antibody response to Plasmodium falciparum Merozoite Surface Protein 4: comparative assessment of specificity and growth inhibitory antibody activity to infection-acquired and immunization-induced epitopes
Q27318798The evolutionary consequences of blood-stage vaccination on the rodent malaria Plasmodium chabaudi
Q37471465The future for blood-stage vaccines against malaria
Q33512926The quantity and quality of African children's IgG responses to merozoite surface antigens reflect protection against Plasmodium falciparum malaria
Q28743564Transgene optimization, immunogenicity and in vitro efficacy of viral vectored vaccines expressing two alleles of Plasmodium falciparum AMA1
Q27336448Vaccination with Plasmodium knowlesi AMA1 formulated in the novel adjuvant co-vaccine HT™ protects against blood-stage challenge in rhesus macaques

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