A Library of Plasmodium vivax Recombinant Merozoite Proteins Reveals New Vaccine Candidates and Protein-Protein Interactions

scientific article published on 23 December 2015

A Library of Plasmodium vivax Recombinant Merozoite Proteins Reveals New Vaccine Candidates and Protein-Protein Interactions is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PNTD.0004264
P932PMC publication ID4689532
P698PubMed publication ID26701602

P50authorJulian RaynerQ22278468
Rick M. FairhurstQ28033929
Gavin J. WrightQ55838269
Sumana SharmaQ56384118
P2093author name stringJessica B Hostetler
S Josefin Bartholdson
P2860cites workRed blood cell invasion by Plasmodium vivax: structural basis for DBP engagement of DARCQ21131367
Merozoite surface proteins of the malaria parasite: The MSP1 complex and the MSP7 familyQ21147068
Duffy negative antigen is no longer a barrier to Plasmodium vivax--molecular evidences from the African West Coast (Angola and Equatorial Guinea)Q21562260
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Plasmodium vivax clinical malaria is commonly observed in Duffy-negative Malagasy peopleQ24600330
Plasmodium vivax infection in Anajás, State of Pará: no differential resistance profile among Duffy-negative and Duffy-positive individualsQ24633012
Identification and characterization of a novel Plasmodium falciparum merozoite apical protein involved in erythrocyte binding and invasionQ27230023
A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasitesQ27230081
Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARCQ27670749
Structural and Functional Basis for Inhibition of Erythrocyte Invasion by Antibodies that Target Plasmodium falciparum EBA-175Q27678372
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Plasmodium falciparum merozoite surface protein 3: oligomerization, self-assembly, and heme complex formationQ27974527
A systems-based analysis of Plasmodium vivax lifecycle transcription from human to mosquitoQ28473572
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Structural analysis of the synthetic Duffy Binding Protein (DBP) antigen DEKnull relevant for Plasmodium vivax malaria vaccine designQ28544738
The neglected burden of Plasmodium vivax malariaQ29618450
Vivax malaria: neglected and not benignQ29619167
Distinct protein classes including novel merozoite surface antigens in Raft-like membranes of Plasmodium falciparumQ30038991
An EGF-like protein forms a complex with PfRh5 and is required for invasion of human erythrocytes by Plasmodium falciparumQ30043132
P-selectin is a host receptor for Plasmodium MSP7 ligandsQ30043222
Plasmodium falciparum Pf34, a novel GPI-anchored rhoptry protein found in detergent-resistant microdomainsQ30043644
Systematic genetic analysis of the Plasmodium falciparum MSP7-like family reveals differences in protein expression, location, and importance in asexual growth of the blood-stage parasiteQ30044844
Passive immunoprotection of Plasmodium falciparum-infected mice designates the CyRPA as candidate malaria vaccine antigenQ30049113
Construction of a large extracellular protein interaction network and its resolution by spatiotemporal expression profilingQ30431970
A cell surface interaction network of neural leucine-rich repeat receptorsQ30485804
Genome Comparison of Human and Non-Human Malaria Parasites Reveals Species Subset-Specific Genes Potentially Linked to Human DiseaseQ31044442
Antibodies to Plasmodium falciparum and Plasmodium vivax merozoite surface protein 5 in Indonesia: species-specific and cross-reactive responsesQ33333604
Phase 1 trial of malaria transmission blocking vaccine candidates Pfs25 and Pvs25 formulated with montanide ISA 51.Q33350210
Three members of the 6-cys protein family of Plasmodium play a role in gamete fertilityQ33553363
Naturally acquired antibodies to Plasmodium vivax Duffy binding protein (DBP) in Brazilian AmazonQ33617528
Naturally acquired inhibitory antibodies to Plasmodium vivax Duffy binding protein are short-lived and allele-specific following a single malaria infectionQ47812027
Immunogenicity of Plasmodium vivax combination subunit vaccine formulated with human compatible adjuvants in miceQ47834206
Comparative recognition by human IgG antibodies of recombinant proteins representing three asexual erythrocytic stage vaccine candidates of Plasmodium vivax.Q47835642
Plasmodium vivax thrombospondin related adhesion protein: immunogenicity and protective efficacy in rodents and Aotus monkeysQ47835703
Serologic responses to recombinant Plasmodium vivax Duffy binding protein in a Colombian villageQ47838376
Codon usage in Plasmodium vivax nuclear genesQ47847683
Age-acquired immunity to a Plasmodium vivax invasion ligand, the duffy binding proteinQ47911026
Immunoproteomics profiling of blood stage Plasmodium vivax infection by high-throughput screening assaysQ47957075
Antibody response of naturally infected individuals to recombinant Plasmodium vivax apical membrane antigen-1.Q48003700
Dissection of merozoite surface protein 3, a representative of a family of Plasmodium falciparum surface proteins, reveals an oligomeric and highly elongated moleculeQ48015109
Antigenicity, immunogenicity, and protective efficacy of Plasmodium vivax MSP1 PV200l: a potential malaria vaccine subunitQ48019429
Presence of Memory T Cells and Naturally Acquired Antibodies in Plasmodium vivax Malaria-Exposed Individuals Against a Group of Tryptophan-Rich Antigens With Conserved SequencesQ48023293
Heterologous expression of proteins from Plasmodium falciparum: results from 1000 genesQ48028328
Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organismsQ48036866
Further definition of PfEMP-1 DBL-1alpha domains mediating rosetting adhesion of Plasmodium falciparumQ48124076
Wheat germ cell-free system-based production of malaria proteins for discovery of novel vaccine candidatesQ36539678
Heterologous expression of plasmodial proteins for structural studies and functional annotationQ36938795
The transcriptome of Plasmodium vivax reveals divergence and diversity of transcriptional regulation in malaria parasitesQ36945174
The C-terminal domain of Plasmodium falciparum merozoite surface protein 3 self-assembles into alpha-helical coiled coil tetramerQ37188653
Plasmodium falciparum merozoite surface protein 2 is unstructured and forms amyloid-like fibrilsQ37270041
Primary structure of the merozoite surface antigen 1 of Plasmodium vivax reveals sequences conserved between different Plasmodium speciesQ37506803
Host-parasite interactions that guide red blood cell invasion by malaria parasitesQ38376500
Antigenicity studies in humans and immunogenicity studies in mice: an MSP1P subdomain as a candidate for malaria vaccine developmentQ38943174
Characterization of a novel merozoite surface protein of Plasmodium vivax, Pv41.Q38943184
Pv12, a 6-Cys antigen of Plasmodium vivax, is localized to the merozoite rhoptryQ39175603
Profiling the humoral immune responses to Plasmodium vivax infection and identification of candidate immunogenic rhoptry-associated membrane antigen (RAMA).Q39191809
The GPI-anchored 6-Cys protein Pv12 is present in detergent-resistant microdomains of Plasmodium vivax blood stage schizontsQ39268260
Eroding the resistance of Duffy negativity to invasion by Plasmodium vivax?Q39341327
Epitope-specific humoral immunity to Plasmodium vivax Duffy binding protein.Q39746136
Identifying and characterising the Plasmodium falciparum merozoite surface protein 10 Plasmodium vivax homologue.Q42656009
Vaccination with recombinant Plasmodium vivax MSP-10 formulated in different adjuvants induces strong immunogenicity but no protectionQ43271064
The Plasmodium vivax homologues of merozoite surface proteins 4 and 5 from Plasmodium falciparum are expressed at different locations in the merozoiteQ43919502
Phase 1 vaccine trial of Pvs25H: a transmission blocking vaccine for Plasmodium vivax malariaQ44164504
Immunological responses to a 39.8kDa Plasmodium vivax tryptophan-rich antigen (PvTRAg39.8) among humansQ44647207
Role of the helical structure of the N-terminal region of Plasmodium falciparum merozoite surface protein 2 in fibril formation and membrane interactionQ44664188
Antigenic drift in the ligand domain of Plasmodium vivax duffy binding protein confers resistance to inhibitory antibodiesQ45062896
Plasmodium vivax malaria in Duffy-negative individuals from EthiopiaQ45728740
Immunogenicity of Plasmodium vivax merozoite surface protein-9 recombinant proteins expressed in E. coli.Q47664368
Baculovirus Merozoite Surface Protein 1 C-Terminal Recombinant Antigens Are Highly Protective in a Natural Primate Model for Human Plasmodium vivax MalariaQ33752297
New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-SeqQ33808824
A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarrayQ33859633
Prediction of potential GPI-modification sites in proprotein sequencesQ33874951
The Duffy receptor family of Plasmodium knowlesi is located within the micronemes of invasive malaria merozoitesQ33941679
Molecular evidence of Plasmodium vivax mono and mixed malaria parasite infections in Duffy-negative native CamerooniansQ33988947
Identification of proteins from Plasmodium falciparum that are homologous to reticulocyte binding proteins in Plasmodium vivaxQ34006077
Serologic markers in relation to parasite exposure history help to estimate transmission dynamics of Plasmodium vivaxQ34091277
High-level expression of the malaria blood-stage vaccine candidate Plasmodium falciparum apical membrane antigen 1 and induction of antibodies that inhibit erythrocyte invasionQ34129066
Avidity-based extracellular interaction screening (AVEXIS) for the scalable detection of low-affinity extracellular receptor-ligand interactionsQ34194654
Immunological markers of Plasmodium vivax exposure and immunity: a systematic review and meta-analysisQ34234390
Immunogenicity of a synthetic vaccine based on Plasmodium vivax Duffy binding protein region II.Q34260750
Influence of HLA-DRB1 and HLA-DQB1 alleles on IgG antibody response to the P. vivax MSP-1, MSP-3α and MSP-9 in individuals from Brazilian endemic area.Q34287358
Baculovirus-vectored multistage Plasmodium vivax vaccine induces both protective and transmission-blocking immunities against transgenic rodent malaria parasitesQ34298647
Natural human antibody responses to Plasmodium vivax apical membrane antigen 1 under low transmission and unstable malaria conditions in Sri Lanka.Q34301073
The global public health significance of Plasmodium vivax.Q34314657
Plasmodium vivax: clinical spectrum, risk factors and pathogenesisQ34314662
Protective efficacy of a Plasmodium vivax circumsporozoite protein-based vaccine in Aotus nancymaae is associated with antibodies to the repeat regionQ34350954
Profiling humoral immune responses to P. falciparum infection with protein microarraysQ34495128
Phase I Safety and Immunogenicity Trial of Plasmodium vivax CS Derived Long Synthetic Peptides Adjuvanted with Montanide ISA 720 or Montanide ISA 51Q34546201
Evidence for transmission of Plasmodium vivax among a duffy antigen negative population in Western Kenya.Q34573683
Plasmodium vivax infection among Duffy antigen-negative individuals from the Brazilian Amazon region: an exception?Q34644273
B cell epitope mapping and characterization of naturally acquired antibodies to the Plasmodium vivax Merozoite Surface Protein-3α (PvMSP-3α) in malaria exposed individuals from Brazilian AmazonQ34726966
Plasmodium vivax Merozoite Surface Protein-3 (PvMSP3): Expression of an 11 Member Multigene Family in Blood-Stage ParasitesQ34744820
A library of functional recombinant cell-surface and secreted P. falciparum merozoite proteinsQ34991300
Whole genome sequencing of field isolates reveals a common duplication of the Duffy binding protein gene in Malagasy Plasmodium vivax strainsQ35054176
Evaluation of the acquired immune responses to Plasmodium vivax VIR variant antigens in individuals living in malaria-endemic areas of BrazilQ35113431
New antigens for a multicomponent blood-stage malaria vaccineQ35216634
Sterile protective immunity to malaria is associated with a panel of novel P. falciparum antigensQ35264640
The origin and diversification of the merozoite surface protein 3 (msp3) multi-gene family in Plasmodium vivax and related parasites.Q35524269
Expression and serologic activity of a soluble recombinant Plasmodium vivax Duffy binding protein.Q35551014
Discovery of GAMA, a Plasmodium falciparum merozoite micronemal protein, as a novel blood-stage vaccine candidate antigenQ35671610
New insights into acquisition, boosting, and longevity of immunity to malaria in pregnant womenQ36330969
Plasmodium vivax: cloning and expression of a major blood-stage surface antigen.Q36428483
P275copyright licenseCreative Commons CC0 LicenseQ6938433
P6216copyright statuscopyrighted, dedicated to the public domain by copyright holderQ88088423
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectPlasmodium vivaxQ311376
protein-protein interactionQ896177
merozoiteQ2296434
6-cysteine protein P41Q59729268
conserved Plasmodium protein, unknown functionQ59736912
merozoite surface protein 3Q59746966
6-cysteine protein P12Q59749776
MSP7-like proteinQ59752685
P304page(s)e0004264
P577publication date2015-12-23
P1433published inPLoS Neglected Tropical DiseasesQ3359737
P1476titleA Library of Plasmodium vivax Recombinant Merozoite Proteins Reveals New Vaccine Candidates and Protein-Protein Interactions
P478volume9

Reverse relations

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