Leptin reduces the expression and increases the phosphorylation of the negative regulators of GLUT4 traffic TBC1D1 and TBC1D4 in muscle of ob/ob mice

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Leptin reduces the expression and increases the phosphorylation of the negative regulators of GLUT4 traffic TBC1D1 and TBC1D4 in muscle of ob/ob mice is …
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scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...729389S
P356DOI10.1371/JOURNAL.PONE.0029389
P932PMC publication ID3253781
P698PubMed publication ID22253718
P5875ResearchGate publication ID221755615

P50authorGema FrühbeckQ62991304
Antonio Herbert Lancha JuniorQ82058827
Beatriz RamírezQ47503298
Sara BecerrilQ38319149
Javier Gómez-AmbrosiQ38319166
Amaia RodríguezQ38319186
P2093author name stringVictoria Catalán
Neira Sáinz
Andoni Lancha
Emma Burgos-Ramos
P2860cites workA method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domainQ24296738
Sortilin is essential and sufficient for the formation of Glut4 storage vesicles in 3T3-L1 adipocytesQ24306529
Functional role of sortilin in myogenesis and development of insulin-responsive glucose transport system in C2C12 myocytesQ24311903
Leptin administration favors muscle mass accretion by decreasing FoxO3a and increasing PGC-1alpha in ob/ob miceQ27342830
Mechanism and regulation of GLUT-4 vesicle fusion in muscle and fat cellsQ28139490
AS160 regulates insulin- and contraction-stimulated glucose uptake in mouse skeletal muscle.Q52573139
Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training.Q54644240
Acute stimulation of glucose metabolism in mice by leptin treatmentQ59079790
Recovered insulin response by 2 weeks of leptin administration in high-fat fed rats is associated with restored AS160 activation and decreased reactive lipid accumulationQ63805137
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GLUT-4 expression is not consistently higher in type-1 than in type-2 fibres of rat and human vastus lateralis muscles; an immunohistochemical studyQ73519438
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Comparing effects of leptin and insulin on glucose metabolism in skeletal muscle: evidence for an effect of leptin on glucose uptake and decarboxylationQ74644086
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Discovery of TBC1D1 as an insulin-, AICAR-, and contraction-stimulated signaling nexus in mouse skeletal muscle.Q39646969
Insulin and leptin induce Glut4 plasma membrane translocation and glucose uptake in a human neuronal cell line by a phosphatidylinositol 3-kinase- dependent mechanism.Q40312136
Leptin stimulates glucose uptake in C2C12 muscle cells by activation of ERK2.Q40908774
Lack of effect of leptin on glucose transport, lipoprotein lipase, and insulin action in adipose and muscle cellsQ41043337
Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes: evidence for a P13-kinase mediated effectQ41113283
Differential effects of leptin in regulation of tissue glucose utilization in vivoQ41648220
Kinetics of GLUT4 trafficking in rat and human skeletal muscleQ41995118
Abundance, localization, and insulin-induced translocation of glucose transporters in red and white muscleQ42458711
Restoring AS160 phosphorylation rescues skeletal muscle insulin resistance and fatty acid oxidation while not reducing intramuscular lipidsQ42459278
Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating proteinQ42485048
Altered GLUT1 and GLUT3 gene expression and subcellular redistribution of GLUT4: protein in muscle from patients with acanthosis nigricans and severe insulin resistanceQ42506709
High leptin levels acutely inhibit insulin-stimulated glucose uptake without affecting glucose transporter 4 translocation in l6 rat skeletal muscle cellsQ42511585
Adipocytes exhibit abnormal subcellular distribution and translocation of vesicles containing glucose transporter 4 and insulin-regulated aminopeptidase in type 2 diabetes mellitus: implications regarding defects in vesicle traffickingQ42512678
Chronic leptin treatment normalizes basal glucose transport in a fiber type-specific manner in high-fat-fed ratsQ42522723
Exercise-induced TBC1D1 Ser237 phosphorylation and 14-3-3 protein binding capacity in human skeletal muscleQ42908848
GLUT4 is reduced in slow muscle fibers of type 2 diabetic patients: is insulin resistance in type 2 diabetes a slow, type 1 fiber disease?Q43618919
Transgenic overexpression of leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic diabetes.Q43618955
Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and GLUT-4 content in rat musclesQ44258939
Acute and chronic leptin treatment mediate contrasting effects on signaling, glucose uptake, and GLUT4 translocation in L6-GLUT4myc myotubesQ44564575
Chronic leptin treatment enhances insulin-stimulated glucose disposal in skeletal muscle of high-fat fed rodentsQ44741069
Ca2+ and AMPK both mediate stimulation of glucose transport by muscle contractionsQ44745133
Increased phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle in response to insulin or contractile activityQ45199120
Contraction- and hypoxia-stimulated glucose transport is mediated by a Ca2+-dependent mechanism in slow-twitch rat soleus muscleQ45229024
Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesityQ46309278
Effect of postexercise carbohydrate supplementation on glucose uptake-associated gene expression in the human skeletal muscleQ46468096
Effect of food restriction on the insulin signalling pathway in rat skeletal muscle and adipose tissueQ46635441
Regulation of muscle GLUT4 enhancer factor and myocyte enhancer factor 2 by AMP-activated protein kinaseQ46654991
Failure of leptin to affect basal and insulin-stimulated glucose metabolism of rat skeletal muscle in vitroQ47970331
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinaseQ28215845
Hexose transporter mRNAs for GLUT4, GLUT5, and GLUT12 predominate in human muscleQ28248747
Negative regulation of syntaxin4/SNAP-23/VAMP2-mediated membrane fusion by Munc18c in vitroQ28474414
Disruption of AMPKalpha1 signaling prevents AICAR-induced inhibition of AS160/TBC1D4 phosphorylation and glucose uptake in primary rat adipocytesQ28574876
Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjectsQ28632230
Inhibition of GLUT4 translocation by Tbc1d1, a Rab GTPase-activating protein abundant in skeletal muscle, is partially relieved by AMP-activated protein kinase activationQ30439894
Positive regulatory control loop between gut leptin and intestinal GLUT2/GLUT5 transporters links to hepatic metabolic functions in rodentsQ30940391
Relation between leptin and the regulation of glucose metabolismQ33831538
5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscleQ33869428
Beneficial effects of resistance exercise on glycemic control are not further improved by protein ingestionQ33942058
Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocationQ34183649
Rationale for the existence of additional adipostatic hormones.Q34353837
Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 traffickingQ34449983
The GLUT4 glucose transporterQ34614833
Analysis of paradoxical observations on the association between leptin and insulin resistanceQ34770089
Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 trafficQ34778453
Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking.Q34837082
Mechanisms for increased insulin-stimulated Akt phosphorylation and glucose uptake in fast- and slow-twitch skeletal muscles of calorie-restricted ratsQ35055461
Control of body weight: a physiologic and transgenic perspective.Q35081751
Exercise increases TBC1D1 phosphorylation in human skeletal muscleQ35086804
Effects of dietary fatty acids on insulin sensitivity and secretionQ35915585
Intracellular signalling pathways activated by leptinQ36334963
Correction of obesity and diabetes in genetically obese mice by leptin gene therapyQ37053330
Leptin and its metabolic interactions: an updateQ37088463
Inhibition of contraction-stimulated AMP-activated protein kinase inhibits contraction-stimulated increases in PAS-TBC1D1 and glucose transport without altering PAS-AS160 in rat skeletal muscleQ37163482
Increased AS160 phosphorylation, but not TBC1D1 phosphorylation, with increased postexercise insulin sensitivity in rat skeletal muscleQ37264161
Insulin-stimulated translocation of glucose transporter (GLUT) 12 parallels that of GLUT4 in normal muscleQ37341858
Evidence against a direct effect of leptin on glucose transport in skeletal muscle and adipocytesQ38340985
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)e29389
P577publication date2012-01-09
P1433published inPLOS OneQ564954
P1476titleLeptin reduces the expression and increases the phosphorylation of the negative regulators of GLUT4 traffic TBC1D1 and TBC1D4 in muscle of ob/ob mice
P478volume7

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cites work (P2860)
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Q38215702Regulation of adipocyte lipolysis

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