Concomitant depletion of PTEN and p27 and overexpression of cyclin D1 may predict a worse prognosis for patients with post-operative stage II and III colorectal cancer

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Concomitant depletion of PTEN and p27 and overexpression of cyclin D1 may predict a worse prognosis for patients with post-operative stage II and III colorectal cancer is …
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scholarly articleQ13442814

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P356DOI10.3892/OL.2014.2350
P932PMC publication ID4156215
P698PubMed publication ID25202365
P5875ResearchGate publication ID265474557

P2093author name stringJing Li
Jing Wang
Gang-Feng Zhang
Ke-Li Su
Lin-Lin Yin
P2860cites workCDK inhibitors: positive and negative regulators of G1-phase progressionQ27860983
PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer modelQ32069431
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Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trialQ34607843
p27Kip1 in stage III colon cancer: implications for outcome following adjuvant chemotherapy in cancer and leukemia group B protocol 89803.Q34688671
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Overview of systemic therapy for colorectal cancerQ37484326
Ras/ERK1 pathway regulation of p27KIP1-mediated G1-phase cell-cycle arrest in cordycepin-induced inhibition of the proliferation of vascular smooth muscle cellsQ38465081
Prognostic significance of cyclinD1 amplification and the co-alteration of cyclinD1/pRb/ppRb in patients with esophageal squamous cell carcinomaQ39677822
Evaluation of immunohistochemical expression of p53, p21, p27, cyclin D1, and Ki67 in oral and oropharyngeal squamous cell carcinoma.Q39711832
The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cellsQ40507359
Deregulated G1-S control and energy stress contribute to the synthetic-lethal interactions between inactivation of RB and TSC1 or TSC2.Q41135408
Relationship between expression and prognostic ability of PTEN, STAT3 and VEGF-C in colorectal cancerQ41492330
Enhanced tumor suppression by adenoviral PTEN gene therapy combined with cisplatin chemotherapy in small-cell lung cancerQ45885573
Evaluation of the prognostic value of pSMAD immunohistochemistry in colorectal cancer.Q46032894
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Activation of the PI3K/Akt/mTOR pathway correlates with tumour progression and reduced survival in patients with urothelial carcinoma of the urinary bladderQ48839946
Activation of cyclin D1-kinase in murine fibroblasts lacking both p21(Cip1) and p27(Kip1).Q50335520
Inactivation of PTEN is associated with a low p27Kip1 protein expression in breast carcinoma.Q50752792
Cell cycle proteins predict recurrence in stage II and III colon cancer.Q53187334
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Sox17 regulates proliferation and cell cycle during gastric cancer progression.Q53252327
Clinical significance of tumor suppressor PTEN in colorectal carcinoma.Q53291653
Expression patterns of cyclins D1, E and cyclin-dependent kinase inhibitors p21waf1/cip1, p27kip1 in colorectal carcinoma: correlation with other cell cycle regulators (pRb, p53 and Ki-67 and PCNA) and clinicopathological features.Q53313878
The role of cyclins and cyclins inhibitors in the multistep process of HPV-associated cervical carcinoma.Q53323747
Histologic-type specific role of cell cycle regulators in non-small cell lung carcinoma.Q53376865
PAkt, cyclin D1 and p27/Kip.1 in glioblastomas with and without EGFR amplification and PTEN mutation.Q55471774
The prognostic impact of the ubiquitin ligase subunits Skp2 and Cks1 in colorectal carcinomaQ61439445
Multimarker phenotype predicts adverse survival in patients with lymph node-negative colorectal cancerQ63444324
Prognostic value of combined analysis of cyclin D1 and estrogen receptor status in breast cancer patientsQ73005503
Combined loss of PTEN and p27 expression is associated with tumor cell proliferation by Ki-67 and increased risk of recurrent disease in localized prostate cancerQ73235041
PTEN and VEGF: possible predictors for sentinel lymph node micro-metastasis in breast cancerQ81404347
Expression of phosphorylated Stat5 predicts expression of cyclin D1 and correlates with poor prognosis of colonic adenocarcinomaQ82466468
Expression of PTEN, cyclin D1, P27/KIP1 in invasive ductal carcinomas of the breast and correlation with clinicopathological parametersQ82730965
The prognostic value of the immunohistochemical aspects of tumor suppressor genes p53, bcl-2, PTEN and nuclear proliferative antigen Ki-67 in resected colorectal carcinomaQ84992843
CD44v6 expression is related to mesenchymal phenotype and poor prognosis in patients with colorectal cancerQ86103273
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectcolorectal cancerQ188874
colorectal carcinomaQ25493920
overexpressionQ61643320
P304page(s)1543-1550
P577publication date2014-07-14
P1433published inOncology LettersQ20640514
P1476titleConcomitant depletion of PTEN and p27 and overexpression of cyclin D1 may predict a worse prognosis for patients with post-operative stage II and III colorectal cancer
P478volume8