| scholarly article | Q13442814 |
| P356 | DOI | 10.2174/187569209788654005 |
| P953 | full work available at URL | https://europepmc.org/articles/pmc2944248?pdf=render |
| https://europepmc.org/articles/PMC2944248 | ||
| https://europepmc.org/articles/PMC2944248?pdf=render | ||
| https://doi.org/10.2174/187569209788654005 | ||
| http://eurekaselect.com/article/download/95268 | ||
| P932 | PMC publication ID | 2944248 |
| P698 | PubMed publication ID | 20871735 |
| P5875 | ResearchGate publication ID | 46428104 |
| P50 | author | William S Baldwin | Q87688105 |
| P2093 | author name string | J. P. Hernandez | |
| L. C. Mota | |||
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| The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR | Q24554260 | ||
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| Putative role of the orphan nuclear receptor SXR (steroid and xenobiotic receptor) in the mechanism of CYP3A4 inhibition by xenobiotics | Q28205500 | ||
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| Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin | Q28211706 | ||
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| What's more dangerous, your aspirin or your car? Thinking rationally about drug risks (and benefits) | Q28222935 | ||
| A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome | Q28240926 | ||
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| A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer | Q45195405 | ||
| The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years | Q45787554 | ||
| Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship | Q46265569 | ||
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| Docosahexaenoic acid downregulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes via the c-Jun NH2-terminal kinase mitogen-activated protein kinase pathway | Q46358067 | ||
| C-Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia | Q46362458 | ||
| Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor | Q46373371 | ||
| Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor | Q46438688 | ||
| The ratio of constitutive androstane receptor to pregnane X receptor determines the activity of guggulsterone against the Cyp2b10 promoter | Q46440348 | ||
| Transcriptional regulation of cytochrome P450 3A4 by four kinds of traditional Chinese medicines | Q46464767 | ||
| CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice | Q46573657 | ||
| Gene profiling in the livers of wild-type and PPARalpha-null mice exposed to perfluorooctanoic acid | Q46604217 | ||
| Activation of constitutive androstane receptor under the effect of hepatocarcinogenic aminoazo dyes in mouse and rat liver | Q46611657 | ||
| Activation of the constitutive androstane receptor decreases HDL in wild-type and human apoA-I transgenic mice. | Q46623064 | ||
| Gadd45beta is induced through a CAR-dependent, TNF-independent pathway in murine liver hyperplasia | Q46758233 | ||
| Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression. | Q46769572 | ||
| Distinct role of bilobalide and ginkgolide A in the modulation of rat CYP2B1 and CYP3A23 gene expression by Ginkgo biloba extract in cultured hepatocytes | Q46781756 | ||
| Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats | Q46788578 | ||
| Effect of ergot alkaloids associated with fescue toxicosis on hepatic cytochrome P450 and antioxidant proteins | Q46803668 | ||
| Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression | Q46813713 | ||
| Pregnane X receptor is essential for normal progression of liver regeneration | Q46827001 | ||
| Cytochrome P450 expression and regulation in CYP3A4/CYP2D6 double transgenic humanized mice | Q46874554 | ||
| Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1alpha | Q46955937 | ||
| Sexually dimorphic P450 gene expression in liver-specific hepatocyte nuclear factor 4alpha-deficient mice | Q47447915 | ||
| Gender dictates the nuclear receptor-mediated regulation of CYP3A44. | Q48404563 | ||
| Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole | Q48684324 | ||
| CAR/PXR provide directives for Cyp3a41 gene regulation differently from Cyp3a11. | Q44760621 | ||
| The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction | Q44788639 | ||
| Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat. | Q44805394 | ||
| Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences | Q44934633 | ||
| The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity | Q45052873 | ||
| Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR). | Q36473477 | ||
| Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver | Q36482946 | ||
| The antiapoptotic role of pregnane X receptor in human colon cancer cells | Q36512415 | ||
| Liver-specific hepatocyte nuclear factor-4alpha deficiency: greater impact on gene expression in male than in female mouse liver. | Q36629289 | ||
| Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration | Q36732805 | ||
| Activation of steroid and xenobiotic receptor (SXR, NR1I2) and its orthologs in laboratory, toxicologic, and genome model species | Q36755546 | ||
| The role of nuclear receptors in pharmacokinetic drug-drug interactions in oncology | Q36798797 | ||
| Phenobarbital mechanistic data and risk assessment: enzyme induction, enhanced cell proliferation, and tumor promotion | Q36831567 | ||
| Human PXR forms a tryptophan zipper-mediated homodimer | Q36835763 | ||
| The traditional Chinese herbal remedy tian xian activates pregnane X receptor and induces CYP3A gene expression in hepatocytes | Q36953154 | ||
| Global liver proteomics of rats exposed for 5 days to phenobarbital identifies changes associated with cancer and with CYP metabolism | Q36968714 | ||
| Effects of naturally occurring coumarins on hepatic drug-metabolizing enzymes in mice | Q36980315 | ||
| Pharmacogenetics of the constitutive androstane receptor | Q37043505 | ||
| Identification of Ginkgo biloba as a novel activator of pregnane X receptor | Q37061726 | ||
| Unique transcription start sites and distinct promoter regions differentiate the pregnane X receptor (PXR) isoforms PXR 1 and PXR 2. | Q37085272 | ||
| The roles of nuclear receptors CAR and PXR in hepatic energy metabolism | Q37096480 | ||
| Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways | Q37113524 | ||
| Di(2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2. | Q37168382 | ||
| Nuclear xenobiotic receptor pregnane X receptor locks corepressor silencing mediator for retinoid and thyroid hormone receptors (SMRT) onto the CYP24A1 promoter to attenuate vitamin D3 activation | Q37199090 | ||
| A concentration addition model for the activation of the constitutive androstane receptor by xenobiotic mixtures | Q37327104 | ||
| Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes | Q37493137 | ||
| Sterol regulatory element binding protein 1 interacts with pregnane X receptor and constitutive androstane receptor and represses their target genes | Q38292762 | ||
| Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia | Q38320243 | ||
| Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice | Q38343998 | ||
| The nuclear receptor CAR (NR1I3) regulates serum triglyceride levels under conditions of metabolic stress | Q38359844 | ||
| Effects of dioxins and polychlorinated biphenyls on thyroid hormone status of pregnant women and their infants | Q39383899 | ||
| PXR-mediated transcriptional activation of CYP3A4 by cryptotanshinone and tanshinone IIA. | Q39937718 | ||
| Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway. | Q39942098 | ||
| Expression of CAR in SW480 and HepG2 cells during G1 is associated with cell proliferation | Q40003866 | ||
| Stigmasterol, a soy lipid-derived phytosterol, is an antagonist of the bile acid nuclear receptor FXR. | Q40108919 | ||
| Differential regulation of constitutive androstane receptor expression by hepatocyte nuclear factor4alpha isoforms | Q40140191 | ||
| Phenobarbital suppresses vitamin D3 25-hydroxylase expression: a potential new mechanism for drug-induced osteomalacia | Q40143725 | ||
| Estrogens and antiestrogens activate hPXR. | Q40155447 | ||
| The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators | Q40166301 | ||
| Pregnane X receptor-dependent induction of the CYP3A4 gene by o,p'-1,1,1,-trichloro-2,2-bis (p-chlorophenyl)ethane | Q40221071 | ||
| Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions | Q40275355 | ||
| Identification of new human pregnane X receptor ligands among pesticides using a stable reporter cell system. | Q40299714 | ||
| Serine 202 regulates the nuclear translocation of constitutive active/androstane receptor | Q40336237 | ||
| A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR. | Q40364666 | ||
| An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway | Q28263744 | ||
| PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators | Q28281902 | ||
| The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors | Q28299263 | ||
| Dehydroepiandrosterone induces human CYP2B6 through the constitutive androstane receptor | Q28307539 | ||
| Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element | Q28369384 | ||
| Endocrine disrupting chemicals, phthalic acid and nonylphenol, activate Pregnane X receptor-mediated transcription | Q28372771 | ||
| Insulin differentially affects xenobiotic-enhanced, cytochrome P-450 (CYP)2E1, CYP2B, CYP3A, and CYP4A expression in primary cultured rat hepatocytes | Q28373995 | ||
| Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands | Q28375193 | ||
| The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution | Q28378587 | ||
| Expression and inducibility of cytochrome P450 3A9 (CYP3A9) and other members of the CYP3A subfamily in rat liver | Q28578587 | ||
| Evolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile salts | Q28755660 | ||
| Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies | Q29616299 | ||
| A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis | Q29617241 | ||
| St John's wort, a herbal antidepressant, activates the steroid X receptor. | Q31438381 | ||
| The expression of pregnane X receptor and its target gene, cytochrome P450 3A1, in perinatal mouse | Q31875556 | ||
| Evaluation of cytotoxic, genotoxic and CYP450 enzymatic competition effects of Tanzanian plant extracts traditionally used for treatment of fungal infections. | Q33323218 | ||
| Evolution of pharmacologic specificity in the pregnane X receptor | Q33326759 | ||
| Induction of the hepatic cytochrome P450 2B subfamily by xenobiotics: research history, evolutionary aspect, relation to tumorigenesis, and mechanism | Q33342694 | ||
| Sexually dimorphic regulation and induction of P450s by the constitutive androstane receptor (CAR). | Q33559832 | ||
| Orphan nuclear receptors: shifting endocrinology into reverse | Q33604569 | ||
| The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor | Q33642959 | ||
| The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene | Q33779787 | ||
| Alterations in xenobiotic metabolism in the long-lived Little mice | Q33809704 | ||
| Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites | Q33837172 | ||
| Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury | Q33838275 | ||
| Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers | Q33881813 | ||
| CAR2 displays unique ligand binding and RXRalpha heterodimerization characteristics | Q33926322 | ||
| A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway | Q33945905 | ||
| Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR). | Q34161577 | ||
| Phenobarbital response elements of cytochrome P450 genes and nuclear receptors | Q34192683 | ||
| Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics | Q34241276 | ||
| Sex is a major determinant of CYP3A4 expression in human liver | Q34265530 | ||
| A structural model of the constitutive androstane receptor defines novel interactions that mediate ligand-independent activity | Q34283520 | ||
| Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation. | Q34283856 | ||
| Prenatal exposure to phenobarbital permanently decreases testosterone and causes reproductive dysfunction | Q48944729 | ||
| Importance of hepatic induction of constitutive androstane receptor and other transcription factors that regulate xenobiotic metabolism and transport | Q50086288 | ||
| Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor | Q50086805 | ||
| Orphan nuclear receptor constitutive active/androstane receptor-mediated alterations in DNA methylation during phenobarbital promotion of liver tumorigenesis. | Q50089976 | ||
| ADME transcriptome in Hispanic versus White donor livers: evidence of a globally enhanced NR1I3 (CAR, constitutive androstane receptor) gene signature in Hispanics | Q50090382 | ||
| Regulation and induction of CYP3A11, CYP3A13 and CYP3A25 in C57BL/6J mouse liver | Q50090478 | ||
| Changes in the expression of cytochromes P450 and nuclear receptors in the liver of genetically diabetic db/db mice | Q50092067 | ||
| Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins | Q50092710 | ||
| Activation of human CYP2C9 promoter and regulation by CAR and PXR in mouse liver | Q50093008 | ||
| Localization of the nuclear receptor CAR at the cell membrane of mouse liver | Q50095253 | ||
| Twenty-six novel single nucleotide polymorphisms and their frequencies of the NR1I3 (CAR) gene in a Japanese population | Q50098778 | ||
| Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes | Q50107216 | ||
| Energy change in the formation of conjugated bilirubin: a possible responsive mechanism for liver cell pathology. | Q50699518 | ||
| Gender does not affect the degree of induction of tirilazad clearance by phenobarbital. | Q51018598 | ||
| Biotransformation of tirilazad in human: 1. Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes. | Q51033536 | ||
| Enzyme inducers improve insulin sensitivity in non-insulin-dependent diabetic subjects. | Q51637195 | ||
| Sex-dependent regulation of hepatic cytochrome P-450 by DDT. | Q52538614 | ||
| Activation of pregnane X receptor disrupts glucocorticoid and mineralocorticoid homeostasis. | Q52573580 | ||
| Mode of action in relevance of rodent liver tumors to human cancer risk. | Q53265627 | ||
| Up-regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver. | Q54000196 | ||
| Molecular pathogenesis of cholestasis. | Q54344101 | ||
| Sex is a major determinant of CYP3A4 expression in human liver | Q56453603 | ||
| More than just proliferation: Myc function in stem cells | Q58379812 | ||
| Cytochrome P450 in livers of diabetic rats: regulation by growth hormone and insulin | Q69293166 | ||
| Hexachlorobenzene episode in Turkey | Q69392322 | ||
| Reproductive dysfunction in male rats following prenatal exposure to phenobarbital | Q71121644 | ||
| Pharmacology. A worrisome side effect of an antianxiety remedy | Q73471762 | ||
| Hydroxylated polychlorinated biphenyls (PCBs) as estrogens and antiestrogens: structure-activity relationships | Q73507988 | ||
| Ginkgolide A contributes to the potentiation of acetaminophen toxicity by Ginkgo biloba extract in primary cultures of rat hepatocytes | Q79255916 | ||
| Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition | Q79843123 | ||
| Altered methylation in gene-specific and GC-rich regions of DNA is progressive and nonrandom during promotion of skin tumorigenesis | Q82995388 | ||
| Orphan nuclear receptors: the exotics of xenobiotics. | Q34311554 | ||
| Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor | Q34312377 | ||
| The mycoestrogen zearalenone induces CYP3A through activation of the pregnane X receptor | Q34312427 | ||
| Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23. | Q34337005 | ||
| Regulation of constitutive androstane receptor and its target genes by fasting, cAMP, hepatocyte nuclear factor alpha, and the coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha | Q34346480 | ||
| Pharmacogenetics: an opportunity for a safer and more efficient pharmacotherapy | Q34368342 | ||
| Regulation of CYP3A4 expression in human hepatocytes by pharmaceuticals and natural products | Q34532906 | ||
| Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations. | Q34533943 | ||
| The nuclear receptor constitutively active/androstane receptor regulates type 1 deiodinase and thyroid hormone activity in the regenerating mouse liver | Q34575060 | ||
| Expression of constitutive androstane receptor, hepatic nuclear factor 4 alpha, and P450 oxidoreductase genes determines interindividual variability in basal expression and activity of a broad scope of xenobiotic metabolism genes in the human liver | Q34580438 | ||
| How important are gender differences in pharmacokinetics? | Q34660699 | ||
| DHA down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes by attenuating CAR translocation | Q34695305 | ||
| CYP3A4 and pregnane X receptor humanized mice | Q34701039 | ||
| An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. | Q34732527 | ||
| Alteration in sexually dimorphic testosterone biotransformation profiles as a biomarker of chemically induced androgen disruption in mice | Q35029880 | ||
| Tumor promotion in rat liver | Q35037433 | ||
| Functional and structural comparison of PXR and CAR. | Q35062476 | ||
| The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors. | Q35062482 | ||
| Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines | Q35076110 | ||
| Induction of drug metabolism: the role of nuclear receptors. | Q35600898 | ||
| In silico approaches, and in vitro and in vivo experiments to predict induction of drug metabolism. | Q35605506 | ||
| In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMP-activated protein kinase | Q35612115 | ||
| The role of the nuclear receptor constitutive androstane receptor in the pathogenesis of non-alcoholic steatohepatitis | Q35761434 | ||
| Steroid hormone biotransformation and xenobiotic induction of hepatic steroid metabolizing enzymes | Q35769196 | ||
| Early increase in cyclin-D1 expression and accelerated entry of mouse hepatocytes into S phase after administration of the mitogen 1, 4-Bis[2-(3,5-Dichloropyridyloxy)] benzene | Q35793445 | ||
| The environmental estrogen, nonylphenol, activates the constitutive androstane receptor | Q36017105 | ||
| The role of the stages of initiation and promotion in phenotypic diversity during hepatocarcinogenesis in the rat. | Q36115704 | ||
| Herbal interactions involving cytochrome p450 enzymes: a mini review | Q36130218 | ||
| Induction of PXR-mediated metabolism by beta-carotene | Q36159358 | ||
| Extracellular signal-regulated kinase is an endogenous signal retaining the nuclear constitutive active/androstane receptor (CAR) in the cytoplasm of mouse primary hepatocytes | Q36178598 | ||
| CAR and PXR: xenosensors of endocrine disrupters? | Q36212927 | ||
| Transcriptional regulation and transformation by Myc proteins | Q36215755 | ||
| CAR, the continuously advancing receptor, in drug metabolism and disease | Q36230600 | ||
| Genetic variants of PXR (NR1I2) and CAR (NR1I3) and their implications in drug metabolism and pharmacogenetics | Q36230613 | ||
| Di-n-butyl phthalate activates constitutive androstane receptor and pregnane X receptor and enhances the expression of steroid-metabolizing enzymes in the liver of rat fetuses | Q40420671 | ||
| Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR). | Q40424407 | ||
| Functional characterization of a novel polymorphism of pregnane X receptor, Q158K, in Chinese subjects | Q40428536 | ||
| Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor. | Q40447949 | ||
| Novel CAR-mediated mechanism for synergistic activation of two distinct elements within the human cytochrome P450 2B6 gene in HepG2 cells. | Q40488292 | ||
| A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides | Q40490869 | ||
| Environmental phthalate monoesters activate pregnane X receptor-mediated transcription | Q40516176 | ||
| Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR. | Q40532103 | ||
| Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers | Q40587140 | ||
| Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region | Q40601663 | ||
| Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor | Q40768989 | ||
| Bisphenol-A, an environmental estrogen, activates the human orphan nuclear receptor, steroid and xenobiotic receptor-mediated transcription | Q40777528 | ||
| The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism | Q40845372 | ||
| Genetic diseases of bilirubin metabolism: the inherited unconjugated hyperbilirubinemias | Q41191189 | ||
| Humanized xenobiotic response in mice expressing nuclear receptor SXR. | Q41753938 | ||
| A physiological role of AMP-activated protein kinase in phenobarbital-mediated constitutive androstane receptor activation and CYP2B induction | Q42156016 | ||
| Induction of drug-metabolizing enzymes by garlic and allyl sulfide compounds via activation of constitutive androstane receptor and nuclear factor E2-related factor 2. | Q42165468 | ||
| Metabolism of the proestrogenic pesticide methoxychlor by hepatic P450 monooxygenases in rats and humans. Dual pathways involving novel ortho ring-hydroxylation by CYP2B. | Q42281381 | ||
| Estrogen activation of the nuclear orphan receptor CAR (constitutive active receptor) in induction of the mouse Cyp2b10 gene | Q42495851 | ||
| Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver | Q42501625 | ||
| Comparative analysis of the effect of phenobarbital, dichlorodiphenyltrichloroethane, butylated hydroxytoluene and nafenopin on rat hepatocarcinogenesis | Q42503535 | ||
| Compendium of gene expression profiles comprising a baseline model of the human liver drug metabolism transcriptome | Q42504457 | ||
| Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4. | Q42511482 | ||
| Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response | Q42522063 | ||
| Structure-dependent induction of CYP2B by polychlorinated biphenyl congeners in female Sprague-Dawley rats | Q42556768 | ||
| Cyclic AMP-dependent protein kinase signaling modulates pregnane x receptor activity in a species-specific manner | Q43167106 | ||
| The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR. | Q43601213 | ||
| Mechanism of induction of cytochrome p450 enzymes by the proestrogenic endocrine disruptor pesticide-methoxychlor: interactions of methoxychlor metabolites with the constitutive androstane receptor system. | Q43608370 | ||
| Plasma concentrations of persistent organochlorines in relation to thyrotropin and thyroid hormone levels in women | Q43609415 | ||
| The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp | Q43662706 | ||
| Different expression of hepatic and renal cytochrome P450s between the streptozotocin-induced diabetic mouse and rat. | Q43682845 | ||
| Association of prenatal phenobarbital and phenytoin exposure with genital anomalies and menstrual disorders | Q43765137 | ||
| Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor | Q43767882 | ||
| A pharmacophore for human pregnane X receptor ligands | Q43823795 | ||
| Nonadditive hepatic tumor promoting effects by a mixture of two structurally different polychlorinated biphenyls in female rat livers | Q43893628 | ||
| Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors | Q43974257 | ||
| Effects of dexamethasone on aryl (SULT1A1)- and hydroxysteroid (SULT2A1)-sulfotransferase gene expression in primary cultured human hepatocytes | Q44094353 | ||
| Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification | Q44104285 | ||
| Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans | Q44139044 | ||
| Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital. | Q44183092 | ||
| PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides | Q44205476 | ||
| Vitamin E activates gene expression via the pregnane X receptor | Q44264352 | ||
| A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression | Q44305000 | ||
| Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor | Q44381593 | ||
| Cytochrome P450 Genes Are Differentially Expressed in Female and Male Hepatocyte Retinoid X Receptor α-Deficient Mice | Q44440495 | ||
| The small heterodimer partner interacts with the pregnane X receptor and represses its transcriptional activity. | Q44477374 | ||
| Sex difference in the proliferative response of mouse hepatocytes to treatment with the CAR ligand, TCPOBOP. | Q44478729 | ||
| The environmental pollutant 1,1-dichloro-2,2-bis (p-chlorophenyl)ethylene induces rat hepatic cytochrome P450 2B and 3A expression through the constitutive androstane receptor and pregnane X receptor | Q44517647 | ||
| A common set of immediate-early response genes in liver regeneration and hyperplasia | Q44527576 | ||
| Vitamin K2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor SXR. | Q44550541 | ||
| Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity | Q44552108 | ||
| Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression | Q44613137 | ||
| Cytoplasmic Accumulation of the Nuclear Receptor CAR by a Tetratricopeptide Repeat Protein in HepG2 Cells | Q44628543 | ||
| Endocrine disruptors induce cytochrome P450 by affecting transcriptional regulation via pregnane X receptor | Q44652921 | ||
| The interaction between St John's wort and an oral contraceptive | Q44685310 | ||
| Feed-forward regulation of bile acid detoxification by CYP3A4: studies in humanized transgenic mice | Q44697387 | ||
| A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification | Q44741483 | ||
| P433 | issue | 2 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 81-105 | |
| P577 | publication date | 2009-06-01 | |
| P1433 | published in | Current Pharmacogenomics and Personalized Medicine: the international journal for expert reviews in pharmacogenomics | Q15752572 |
| P1476 | title | Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation | |
| P478 | volume | 7 |
| Q36801931 | A concentration addition model to assess activation of the pregnane X receptor (PXR) by pesticide mixtures found in the French diet |
| Q36596051 | A physiome interoperability roadmap for personalized drug development. |
| Q47427485 | A short-term high fat diet increases exposure to midazolam and omeprazole in healthy subjects. |
| Q37062595 | Age-Specific Regulation of Drug-Processing Genes in Mouse Liver by Ligands of Xenobiotic-Sensing Transcription Factors |
| Q34294566 | Annotation of the Daphnia magna nuclear receptors: comparison to Daphnia pulex |
| Q41347283 | Annotation of the Nuclear Receptors in an Estuarine Fish species, Fundulus heteroclitus |
| Q37302210 | Characterizing drug-metabolizing enzymes and transporters that are bona fide CAR-target genes in mouse intestine |
| Q36325362 | Compensatory changes in CYP expression in three different toxicology mouse models: CAR-null, Cyp3a-null, and Cyp2b9/10/13-null mice |
| Q34127926 | Constitutive androstane receptor -null mice are sensitive to the toxic effects of parathion: association with reduced cytochrome p450-mediated parathion metabolism [corrected]. |
| Q93024849 | Cyp2b-Knockdown Mice Poorly Metabolize Corn Oil and Are Age-Dependent Obese |
| Q35907128 | Daphnia HR96 is a promiscuous xenobiotic and endobiotic nuclear receptor |
| Q37184675 | Differential regulation of CYP3A4 promoter activity by a new class of natural product derivatives binding to pregnane X receptor |
| Q41658107 | Editor's Highlight: Neonatal Activation of the Xenobiotic-Sensors PXR and CAR Results in Acute and Persistent Down-regulation of PPARα-Signaling in Mouse Liver |
| Q41456158 | Effect of Short-Term Fasting on Systemic Cytochrome P450-Mediated Drug Metabolism in Healthy Subjects: A Randomized, Controlled, Crossover Study Using a Cocktail Approach |
| Q41542803 | Effect of a high-fat diet on the hepatic expression of nuclear receptors and their target genes: relevance to drug disposition |
| Q36380561 | Exchange of polar lipids from adults to neonates in Daphnia magna: Perturbations in sphingomyelin allocation by dietary lipids and environmental toxicants |
| Q58577529 | Exploring the PXR ligand binding mechanism with advanced Molecular Dynamics methods |
| Q36620461 | Expression of human CAR splicing variants in BAC-transgenic mice |
| Q38958397 | Fipronil insecticide toxicology: oxidative stress and metabolism |
| Q37537458 | Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes. |
| Q90186771 | Gender differences in diet-induced steatotic disease in Cyp2b-null mice |
| Q92372464 | Gene Expression Profiling Reveals that PXR Activation Inhibits Hepatic PPARα Activity and Decreases FGF21 Secretion in Male C57Bl6/J Mice |
| Q37122768 | Genome-wide analysis of chromatin states reveals distinct mechanisms of sex-dependent gene regulation in male and female mouse liver |
| Q88605029 | High fat diet induced obesity is mitigated in Cyp3a-null female mice |
| Q35685373 | Lentiviral-mediated RNAi knockdown yields a novel mouse model for studying Cyp2b function |
| Q27022545 | Marine invertebrate xenobiotic-activated nuclear receptors: their application as sensor elements in high-throughput bioassays for marine bioactive compounds |
| Q27009230 | Modulation of xenobiotic receptors by steroids |
| Q38820078 | Molecular Basis of Metabolism-Mediated Conversion of PK11195 from an Antagonist to an Agonist of the Constitutive Androstane Receptor |
| Q36991523 | Molecular mechanisms underlying chemical liver injury |
| Q34909409 | Nonylphenol-mediated CYP induction is PXR-dependent: The use of humanized mice and human hepatocytes suggests that hPXR is less sensitive than mouse PXR to nonylphenol treatment |
| Q38768048 | Nuclear receptors and nonalcoholic fatty liver disease |
| Q36640752 | PXR antagonists and implication in drug metabolism |
| Q36414691 | Perturbations in polar lipids, starvation survival and reproduction following exposure to unsaturated fatty acids or environmental toxicants in Daphnia magna |
| Q58590765 | Pharmacological Activation of PXR and CAR Down-regulates Distinct Bile Acid-metabolizing Intestinal Bacteria and Alters Bile Acid Homeostasis |
| Q91793212 | Phase 0 of the Xenobiotic Response: Nuclear Receptors and Other Transcription Factors as a First Step in Protection from Xenobiotics |
| Q36573579 | Polychlorinated Biphenyl-Xenobiotic Nuclear Receptor Interactions Regulate Energy Metabolism, Behavior, and Inflammation in Non-alcoholic-Steatohepatitis. |
| Q50057182 | Polymorphisms in regulators of xenobiotic transport and metabolism genes PXR and CAR do not affect multiple myeloma risk: a case-control study in the context of the IMMEnSE consortium |
| Q34566467 | Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice |
| Q35998854 | RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome |
| Q64973888 | Role of xenobiotics in the induction and progression of fatty liver disease. |
| Q38736787 | Stable Overexpression of the Constitutive Androstane Receptor Reduces the Requirement for Culture with Dimethyl Sulfoxide for High Drug Metabolism in HepaRG Cells |
| Q35235739 | The HR96 activator, atrazine, reduces sensitivity of D. magna to triclosan and DHA. |
| Q34276287 | The HR97 (NR1L) group of nuclear receptors: a new group of nuclear receptors discovered in Daphnia species |
| Q38750759 | The regulation of human hepatic drug transporter expression by activation of xenobiotic-sensing nuclear receptors |
| Q98475105 | Weight of evidence and human relevance evaluation of the benfluralin mode of action in rodents (part I): Liver carcinogenesis |
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