Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid CB(1) receptor antagonist.

scientific article

Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid CB(1) receptor antagonist. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.EJPHAR.2010.10.085
P932PMC publication ID3034309
P698PubMed publication ID21114999
P5875ResearchGate publication ID49642732

P50authorRoger PertweeQ29643420
Jenny L. WileyQ42407062
Chris BreivogelQ73098633
Daniele BologniniQ93139102
P2093author name stringBilly R Martin
Robert E Vann
John W Huffman
Anu Mahadevan
Raj K Razdan
D Matthew Walentiny
Maria Grazia Cascio
P2860cites workA rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
An investigation into the structural determinants of cannabinoid receptor ligand efficacyQ33861944
The cannabinoid 1-receptor silent antagonist O-2050 attenuates preference for high-fat diet and activated astrocytes in miceQ34099625
SR141716A, a potent and selective antagonist of the brain cannabinoid receptorQ34332716
Inverse agonism and neutral antagonism at cannabinoid CB1 receptorsQ34388049
Agonist-antagonist characterization of 6'-cyanohex-2'-yne-delta 8-tetrahydrocannabinol in two isolated tissue preparations.Q34410764
Potent cyano and carboxamido side-chain analogues of 1', 1'-dimethyl-delta8-tetrahydrocannabinolQ34476479
Suppression of feeding, drinking, and locomotion by a putative cannabinoid receptor 'silent antagonist'.Q34479817
Endocannabinoids in cognition and dependenceQ34673164
Cannabinoid agonists differentially substitute for the discriminative stimulus effects of Delta(9)-tetrahydrocannabinol in C57BL/6J miceQ34846838
Comparison of novel cannabinoid partial agonists and SR141716A in the guinea-pig small intestineQ35041929
CB1 cannabinoid receptor-mediated modulation of food intake in miceQ35048878
Δ9-Tetrahydrocannabinol discrimination in rats as a model for cannabis intoxicationQ35226616
The endocannabinoid system in brain reward processesQ36741861
Discriminative stimulus properties of delta9-tetrahydrocannabinol (THC) in C57Bl/6J miceQ37339113
SR141716A is an inverse agonist at the human cannabinoid CB1 receptorQ42445979
Delta(9)-tetrahydrocannabinol enhances an increase of plasma corticosterone levels induced by forced swim-stress.Q43232672
Cannabinoid receptor antagonism and inverse agonism in response to SR141716A on cAMP production in human and rat brainQ44014642
Paradoxical pharmacological effects of deoxy-tetrahydrocannabinol analogs lacking high CB1 receptor affinityQ44122181
SR-141716A-induced stimulation of locomotor activity. A structure-activity relationship studyQ44176704
(-)-Cannabidiol antagonizes cannabinoid receptor agonists and noradrenaline in the mouse vas deferensQ44228316
Structure-activity relationships for 1',1'-dimethylalkyl-Delta8-tetrahydrocannabinolsQ44356912
6"-Azidohex-2"-yne-cannabidiol: a potential neutral, competitive cannabinoid CB1 receptor antagonistQ44806888
Manipulation of the tetrahydrocannabinol side chain delineates agonists, partial agonists, and antagonistsQ44863367
Antinociceptive effects of tetrahydrocannabinol side chain analogs: dependence upon route of administrationQ44872680
Synthesis and pharmacological evaluation of amino, azido, and nitrogen mustard analogues of 10-substituted cannabidiol and 11- or 12-substituted delta 8-tetrahydrocannabinolQ44965916
Antagonism of the discriminative stimulus effects of delta 9-tetrahydrocannabinol in rats and rhesus monkeys.Q45081374
In vivo characterization of a specific cannabinoid receptor antagonist (SR141716A): inhibition of delta 9-tetrahydrocannabinol-induced responses and apparent agonist activityQ45096581
Evaluation of agonist-antagonist properties of nitrogen mustard and cyano derivatives of delta 8-tetrahydrocannabinolQ45103517
Differential blockade of the antinociceptive effects of centrally administered cannabinoids by SR141716A.Q45113533
Evolution of a series of peptidoleukotriene antagonists: synthesis and structure/activity relationships of 1,3,5-substituted indoles and indazolesQ45217781
Substituted 3-(phenylmethyl)-1H-indole-5-carboxamides and 1-(phenylmethyl)indole-6-carboxamides as potent, selective, orally active antagonists of the peptidoleukotrienesQ46159103
Antagonism of discriminative stimulus effects of delta(9)-THC and (R)-methanandamide in ratsQ46819535
A neutral CB1 receptor antagonist reduces weight gain in rat.Q46932962
Cannabinoid receptor agonist efficacy for stimulating [35S]GTPgammaS binding to rat cerebellar membranes correlates with agonist-induced decreases in GDP affinity.Q47921662
Endogenous cannabinoid system as a modulator of food intakeQ61479731
Cannabinoid receptor stimulation of guanosine-5'-O-(3-[35S]thio)triphosphate binding in rat brain membranesQ71407604
Biochemical and pharmacological characterisation of SR141716A, the first potent and selective brain cannabinoid receptor antagonistQ72302099
P433issue1-3
P407language of work or nameEnglishQ1860
P921main subjectpharmacologyQ128406
cannabinoid receptorQ421237
cannabinoidsQ422936
CNR2Q17907844
P304page(s)96-105
P577publication date2010-11-27
P1433published inEuropean Journal of PharmacologyQ1376712
P1476titleStructural and pharmacological analysis of O-2050, a putative neutral cannabinoid CB(1) receptor antagonist
P478volume651

Reverse relations

cites work (P2860)
Q37578979A major glucuronidated metabolite of JWH-018 is a neutral antagonist at CB1 receptors
Q57299911Assessment of rimonabant-like adverse effects of purported CB1R neutral antagonist / CB2R agonist aminoalkylindole derivatives in mice
Q41668062Biased Agonism of Three Different Cannabinoid Receptor Agonists in Mouse Brain Cortex.
Q37899264CB₁-independent mechanisms of Δ⁹-THCV, AM251 and SR141716 (rimonabant).
Q38848638Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor
Q34053352Cannabinoid CB1 receptor activation mediates the opposing effects of amphetamine on impulsive action and impulsive choice
Q38856900Human Drug Discrimination: Elucidating the Neuropharmacology of Commonly Abused Illicit Drugs
Q39508113Identification of a Potent and Selective Cannabinoid CB1 Receptor Antagonist from Auxarthron reticulatum.
Q48176768Metabolic Profiling of CB1 Neutral Antagonists
Q36783972Novel 3-substituted rimonabant analogues lack Δ(9) -tetrahydrocannabinol-like abuse-related behavioural effects in mice
Q46814567O-2050 facilitates noradrenaline release and increases the CB1 receptor inverse agonistic effect of rimonabant in the guinea pig hippocampus
Q91717872Overcoming the Psychiatric Side Effects of the Cannabinoid CB1 Receptor Antagonists: Current Approaches for Therapeutics Development
Q38274796Prostamide F(2) α receptor antagonism combined with inhibition of FAAH may block the pro-inflammatory mediators formed following selective FAAH inhibition
Q38025166Second generation CB1 receptor blockers and other inhibitors of peripheral endocannabinoid overactivity and the rationale of their use against metabolic disorders
Q36650335Structural analogs of pyrazole and sulfonamide cannabinoids: effects on acute food intake in mice
Q35818708Synthesis and pharmacology of 1-alkyl-3-(1-naphthoyl)indoles: steric and electronic effects of 4- and 8-halogenated naphthoyl substituents
Q64122226The motivation for exercise over palatable food is dictated by cannabinoid type-1 receptors

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