Phase II, randomized, double-blind, placebo-controlled, multicenter study to investigate the immunogenicity and safety of a West Nile virus vaccine in healthy adults

scientific article

Phase II, randomized, double-blind, placebo-controlled, multicenter study to investigate the immunogenicity and safety of a West Nile virus vaccine in healthy adults is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/INFDIS/JIQ003
P932PMC publication ID3086439
P698PubMed publication ID21148499
P5875ResearchGate publication ID49674368

P50authorGustavo H DayanQ88585456
Joan BevilacquaQ117812082
P2093author name stringMike Watson
Rex Biedenbender
Anne M Gregg
P2860cites workEpidemiology and transmission dynamics of West Nile virus diseaseQ24603195
Chimeric yellow fever virus 17D-Japanese encephalitis virus vaccine: dose-response effectiveness and extended safety testing in rhesus monkeysQ27469631
West Nile virus recombinant DNA vaccine protects mouse and horse from virus challenge and expresses in vitro a noninfectious recombinant antigen that can be used in enzyme-linked immunosorbent assaysQ27469785
A live, attenuated recombinant West Nile virus vaccineQ27473138
Pathogenesis of West Nile Virus Infection: a Balance between Virulence, Innate and Adaptive Immunity, and Viral EvasionQ27477543
Lymphocytic 2',5'-oligoadenylate synthetase activity increases prior to the appearance of neutralizing antibodies and immunoglobulin M and immunoglobulin G antibodies after primary and secondary immunization with yellow fever vaccineQ27477782
Preparation and immunogenic properties of a recombinant West Nile subunit vaccineQ27478202
Persistence of neutralizing antibody 30-35 years after immunization with 17D yellow fever vaccineQ27486149
A West Nile Virus DNA Vaccine Induces Neutralizing Antibody in Healthy Adults during a Phase 1 Clinical TrialQ27488963
Efficacy of killed virus vaccine, live attenuated chimeric virus vaccine, and passive immunization for prevention of West Nile virus encephalitis in hamster modelQ27489554
Origin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern United StatesQ27860919
The outbreak of West Nile virus infection in the New York City area in 1999Q29618175
ChimeriVax-West Nile virus live-attenuated vaccine: preclinical evaluation of safety, immunogenicity, and efficacyQ34362322
West Nile encephalitis: an emerging disease in the United StatesQ34398570
West Nile virus vaccineQ35010565
West Nile virus: epidemiology, clinical presentation, diagnosis, and preventionQ35214323
West Nile virus in the AmericasQ37369061
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A single immunization with a minute dose of a lentiviral vector-based vaccine is highly effective at eliciting protective humoral immunity against West Nile virusQ40492934
An attenuated West Nile prototype virus is highly immunogenic and protects against the deadly NY99 strain: a candidate for live WN vaccine developmentQ40495736
A recombinant envelope protein vaccine against West Nile virusQ40507551
Live measles vaccine expressing the secreted form of the West Nile virus envelope glycoprotein protects against West Nile virus encephalitisQ40518762
Induction of sterilizing immunity against West Nile Virus (WNV), by immunization with WNV-like particles produced in insect cellsQ40520793
Recombinant canarypoxvirus vaccine carrying the prM/E genes of West Nile virus protects horses against a West Nile virus-mosquito challengeQ40534658
The epidemic of West Nile virus in the United States, 2002.Q40538334
Equine vaccine for West Nile virusQ40543853
Chimeric live, attenuated vaccine against Japanese encephalitis (ChimeriVax-JE): phase 2 clinical trials for safety and immunogenicity, effect of vaccine dose and schedule, and memory response to challenge with inactivated Japanese encephalitis antiQ40548538
Molecularly engineered live-attenuated chimeric West Nile/dengue virus vaccines protect rhesus monkeys from West Nile virusQ40549292
Growth characteristics of the veterinary vaccine candidate ChimeriVax-West Nile (WN) virus in Aedes and Culex mosquitoesQ40551476
Influence of the IL-1Ra gene polymorphism on in vivo synthesis of IL-1Ra and IL-1beta after live yellow fever vaccinationQ40597122
In vivo synthesis of tumor necrosis factor-alpha in healthy humans after live yellow fever vaccination.Q40641221
CIRCULATING VIRUS, INTERFERON AND ANTIBODY AFTER VACCINATION WITH THE 17-D STRAIN OF YELLOW-FEVER VIRUS.Q40965650
Immunization of mice against West Nile virus with recombinant envelope proteinQ43035070
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectvaccineQ134808
West Nile virusQ158856
placeboQ269829
multicenter clinical trialQ6934595
P304page(s)75-84
P577publication date2011-01-01
P1433published inJournal of Infectious DiseasesQ4051141
P1476titlePhase II, randomized, double-blind, placebo-controlled, multicenter study to investigate the immunogenicity and safety of a West Nile virus vaccine in healthy adults
P478volume203

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Q27321020A Novel Synthetic TLR-4 Agonist Adjuvant Increases the Protective Response to a Clinical-Stage West Nile Virus Vaccine Antigen in Multiple Formulations
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Q38866173An Overview of Current Approaches Toward the Treatment and Prevention of West Nile Virus Infection
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