Capsaicin Activation of the Pain Receptor, VR1: Multiple Open States from Both Partial and Full Binding

scientific article published on May 1, 2003

Capsaicin Activation of the Pain Receptor, VR1: Multiple Open States from Both Partial and Full Binding is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0006-3495(03)70022-8
P953full work available at URLhttp://www.cell.com/article/S0006349503700228/pdf
https://europepmc.org/articles/PMC1302858
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P932PMC publication ID1302858
P698PubMed publication ID12719227

P2093author name stringKwokyin Hui
Feng Qin
Beiying Liu
P2860cites workThe capsaicin receptor: a heat-activated ion channel in the pain pathwayQ24322558
Subunit modification and association in VR1 ion channels.Q24806374
Induction of vanilloid receptor channel activity by protein kinase CQ28141740
Molecular mechanisms of nociceptionQ28216291
The cloned capsaicin receptor integrates multiple pain-producing stimuliQ29547511
Vanilloid (Capsaicin) receptors and mechanismsQ29617371
The vanilloid receptor: a molecular gateway to the pain pathwayQ33941065
Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed eventsQ34016948
On the stochastic properties of bursts of single ion channel openings and of clusters of burstsQ34247298
Glutamate receptor channel kinetics: the effect of glutamate concentrationQ34259822
The TRP ion channel family.Q34271602
Acid potentiation of the capsaicin receptor determined by a key extracellular siteQ35177598
The activation mechanism of rat vanilloid receptor 1 by capsaicin involves the pore domain and differs from the activation by either acid or heatQ35579932
Kinetic structure of large-conductance Ca2+-activated K+ channels suggests that the gating includes transitions through intermediate or secondary states. A mechanism for flickers.Q36412088
Kinetic time constants independent of previous single-channel activity suggest Markov gating for a large conductance Ca-activated K channelQ36434398
Allosteric gating of a large conductance Ca-activated K+ channelQ36435872
Cloning and functional expression of a human orthologue of rat vanilloid receptor-1.Q40846291
A general solution to the time interval omission problem applied to single channel analysisQ41139107
Accounting for the Ca(2+)-dependent kinetics of single large-conductance Ca(2+)-activated K+ channels in rat skeletal muscleQ42620252
Quantitative description of three modes of activity of fast chloride channels from rat skeletal muscleQ42638241
Analysis of the native quaternary structure of vanilloid receptor 1.Q43612398
Functional analysis of capsaicin receptor (vanilloid receptor subtype 1) multimerization and agonist responsiveness using a dominant negative mutation.Q43792398
Reducing agent dithiothreitol facilitates activity of the capsaicin receptor VR-1.Q44006406
Molecular basis for species-specific sensitivity to "hot" chili peppersQ45712451
Identification of an aspartic residue in the P-loop of the vanilloid receptor that modulates pore propertiesQ48886267
Capsaicin binds to the intracellular domain of the capsaicin-activated ion channelQ48925618
Maximum likelihood estimation of aggregated Markov processes.Q51648476
Single-channel study of the cGMP-dependent conductance of retinal rods from incorporation of native vesicles into planar lipid bilayersQ51708802
Burst kinetics of single NMDA receptor currents in cell-attached patches from rat brain cortical neurons in culture.Q54005389
Identifying kinetic gating mechanisms for ion channels by using two-dimensional distributions of simulated dwell times.Q54090842
The viterbi algorithmQ55893915
Allosteric receptors after 30 yearsQ77694440
A study of the voltage dependence of capsaicin-activated membrane currents in rat sensory neurones before and after acute desensitizationQ78040201
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectbiophysicsQ7100
modelling biological systemsQ4299308
P304page(s)2957-2968
P577publication date2003-05-01
P1433published inBiophysical JournalQ2032955
P1476titleCapsaicin activation of the pain receptor, VR1: multiple open states from both partial and full binding
Capsaicin Activation of the Pain Receptor, VR1: Multiple Open States from Both Partial and Full Binding
P478volume84

Reverse relations

cites work (P2860)
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Q42978554Ca2+/calmodulin modulates TRPV1 activation by capsaicin.
Q36353443Charge movement in gating-locked HCN channels reveals weak coupling of voltage sensors and gate.
Q37585521Clues to understanding cold sensation: thermodynamics and electrophysiological analysis of the cold receptor TRPM8.
Q47113117Conformational dynamics in TRPV1 channels reported by an encoded coumarin amino acid.
Q41437118Conjugated polymers mediate effective activation of the Mammalian Ion Channel Transient Receptor Potential Vanilloid 1.
Q40108099Contribution of the putative inner-pore region to the gating of the transient receptor potential vanilloid subtype 1 channel (TRPV1).
Q58583333Different agonists induce distinct single-channel conductance states in TRPV1 channels
Q44930745Effect of nicotine on chorda tympani responses to salty and sour stimuli
Q28830324Engineering vanilloid-sensitivity into the rat TRPV2 channel
Q41955641Functional characterisation of the S512Y mutant vanilloid human TRPV1 receptor
Q98506400Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms
Q37359002High-resolution views of TRPV1 and their implications for the TRP channel superfamily
Q45064242Inhibitory modulation of distal C-terminal on protein kinase C-dependent phospho-regulation of rat TRPV1 receptors
Q33412519Interaction with phosphoinositides confers adaptation onto the TRPV1 pain receptor
Q34134625Kinetic and Energetic Analysis of Thermally Activated TRPV1 Channels
Q36447172Low pH potentiates both capsaicin binding and channel gating of VR1 receptors
Q41942584Metabolomics meets functional assays: coupling LC-MS and microfluidic cell-based receptor-ligand analyses
Q34187020Model-based fitting of single-channel dwell-time distributions
Q42943379Modulation of single-channel properties of TRPV1 by phosphorylation
Q40157311On the mechanism of TBA block of the TRPV1 channel.
Q36295896Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane.
Q35574727Prenatal nicotinic exposure augments cardiorespiratory responses to activation of bronchopulmonary C-fibers
Q37368601Promiscuous activation of transient receptor potential vanilloid 1 (TRPV1) channels by negatively charged intracellular lipids: the key role of endogenous phosphoinositides in maintaining channel activity
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Q33438712Rapid temperature jump by infrared diode laser irradiation for patch-clamp studies
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Q91790432TRPV1 Tunes Optic Nerve Axon Excitability in Glaucoma
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Q42362118The pain receptor TRPV1 displays agonist-dependent activation stoichiometry
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