Short isoforms of the cold receptor TRPM8 inhibit channel gating by mimicking heat action rather than chemical inhibitors

scientific article published on 28 November 2011

Short isoforms of the cold receptor TRPM8 inhibit channel gating by mimicking heat action rather than chemical inhibitors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M111.272823
P8608Fatcat IDrelease_y2t5yuxzwveqrflxa73r2ri3xy
P932PMC publication ID3270953
P698PubMed publication ID22128172

P2093author name stringAlexander V Zholos
José A Fernández
Natalia Prevarskaya
Roman Skryma
C Norman Scholfield
J Graham McGeown
Karl L Magleby
Gabriel Bidaux
P2860cites workCharacterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assayQ24672180
A TRP channel that senses cold stimuli and mentholQ28511363
Identification of a cold receptor reveals a general role for TRP channels in thermosensationQ28580334
An introduction to TRP channelsQ29615753
Correcting single channel data for missed eventsQ30695058
Data transformations for improved display and fitting of single-channel dwell time histogramsQ30746057
Two-dimensional components and hidden dependencies provide insight into ion channel gating mechanismsQ33915564
Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed eventsQ34016948
Capsaicin Activation of the Pain Receptor, VR1: Multiple Open States from Both Partial and Full BindingQ34181057
Estimating kinetic constants from single channel dataQ34256696
A hot-sensing cold receptor: C-terminal domain determines thermosensation in transient receptor potential channels.Q34521627
Voltage- and cold-dependent gating of single TRPM8 ion channels.Q34545661
Dissection of the components for PIP2 activation and thermosensation in TRP channelsQ34634374
Kinetic structure of large-conductance Ca2+-activated K+ channels suggests that the gating includes transitions through intermediate or secondary states. A mechanism for flickers.Q36412088
Voltage and Ca2+ activation of single large-conductance Ca2+-activated K+ channels described by a two-tiered allosteric gating mechanism.Q36436726
G-protein-gated TRP-like cationic channel activated by muscarinic receptors: effect of potential on single-channel gatingQ36447244
Menthol: a refreshing look at this ancient compoundQ36820432
ThermoTRP channels as modular proteins with allosteric gating.Q36821074
Molecular mechanisms of TRP regulation in tumor growth and metastasisQ37356596
Regulation of activity of transient receptor potential melastatin 8 (TRPM8) channel by its short isoformsQ39435501
Identification of an N-terminal TRPC2 splice variant which inhibits calcium influxQ39702591
Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domainQ39711589
Pore region of TRPV3 ion channel is specifically required for heat activationQ39892274
Differential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels.Q39932650
Isoform-specific inhibition of TRPC4 channel by phosphatidylinositol 4,5-bisphosphateQ40019222
Bidirectional shifts of TRPM8 channel gating by temperature and chemical agents modulate the cold sensitivity of mammalian thermoreceptors.Q40167692
TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuliQ40172246
Contribution of TRPM8 channels to cold transduction in primary sensory neurons and peripheral nerve terminals.Q40202804
Ca2+-independent phospholipase A2-dependent gating of TRPM8 by lysophospholipids.Q40212726
Conservation of functional and pharmacological properties in the distantly related temperature sensors TRVP1 and TRPM8.Q40418274
Modulation of single-channel properties of TRPV1 by phosphorylationQ42943379
Transient receptor potential channels in sensory neurons are targets of the antimycotic agent clotrimazoleQ46804915
Maximum likelihood estimation of aggregated Markov processes.Q51648476
Dependency plots suggest the kinetic structure of ion channelsQ52415922
Asymptotic distributions of apparent open times and shut times in a single channel record allowing for the omission of brief eventsQ56555524
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)2963-2970
P577publication date2011-11-28
P1433published inJournal of Biological ChemistryQ867727
P1476titleShort isoforms of the cold receptor TRPM8 inhibit channel gating by mimicking heat action rather than chemical inhibitors
P478volume287

Reverse relations

cites work (P2860)
Q93071568Evolution of the human cold/menthol receptor, TRPM8
Q36275490Functional and Modeling Studies of the Transmembrane Region of the TRPM8 Channel
Q35944501Overexpression of short TRPM8 variant α promotes cell migration and invasion, and decreases starvation-induced apoptosis in prostate cancer LNCaP cells
Q36063830Rare Variants Association Analysis in Large-Scale Sequencing Studies at the Single Locus Level
Q39435501Regulation of activity of transient receptor potential melastatin 8 (TRPM8) channel by its short isoforms
Q26777996Roles of TRPM8 Ion Channels in Cancer: Proliferation, Survival, and Invasion
Q35988679Targeting of short TRPM8 isoforms induces 4TM-TRPM8-dependent apoptosis in prostate cancer cells.