Differential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels.

scientific article published on 3 November 2009

Differential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1000880172
P356DOI10.1186/1744-8069-5-62
P8608Fatcat IDrelease_cmrpt5oc5vfeplj7lvkkzloyri
P932PMC publication ID2778643
P698PubMed publication ID19886999
P5875ResearchGate publication ID38065016

P50authorFélix VianaQ46535668
P2093author name stringAntonio Ferrer-Montiel
Gregorio Fernández-Ballester
María Pertusa
Annika Malkia
P2860cites workThe ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivityQ24312830
Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assayQ24672180
Pharmacological modulation of monovalent cation currents through the epithelial Ca2+ channel ECaC1Q28361016
The menthol receptor TRPM8 is the principal detector of environmental coldQ28508677
TRPM8 is required for cold sensation in miceQ28509502
A TRP channel that senses cold stimuli and mentholQ28511363
Identification of a cold receptor reveals a general role for TRP channels in thermosensationQ28580334
Voltage dependence of the Ca2+-activated cation channel TRPM4Q28587585
Attenuated cold sensitivity in TRPM8 null miceQ28593805
High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by mentholQ33235641
Chemical and cold sensitivity of two distinct populations of TRPM8-expressing somatosensory neuronsQ33342029
Diversity in the neural circuitry of cold sensing revealed by genetic axonal labeling of transient receptor potential melastatin 8 neuronsQ33903991
Specificity of cold thermotransduction is determined by differential ionic channel expressionQ34113463
Making optimal use of empirical energy functions: force-field parameterization in crystal spaceQ34351595
The Ca2+-activated cation channel TRPM4 is regulated by phosphatidylinositol 4,5-biphosphateQ34410954
A hot-sensing cold receptor: C-terminal domain determines thermosensation in transient receptor potential channels.Q34521627
Dissection of the components for PIP2 activation and thermosensation in TRP channelsQ34634374
Comparative modeling of the quaternary structure for the human TRPM8 channel and analysis of its binding featuresQ34949068
Neuropathic pain: a clinical perspectiveQ34995660
Gating of TRP channels: a voltage connection?Q36119232
Structure of TRPV1 channel revealed by electron cryomicroscopyQ36677137
TRP channels entering the structural era.Q37183885
Modulation of the cold-activated channel TRPM8 by lysophospholipids and polyunsaturated fatty acidsQ37304544
Converting cold into pain.Q37462345
Clues to understanding cold sensation: thermodynamics and electrophysiological analysis of the cold receptor TRPM8.Q37585521
Action potential initiation in the peripheral terminals of cold-sensitive neurones innervating the guinea-pig cornea.Q39308469
A role of the transient receptor potential domain of vanilloid receptor I in channel gating.Q40062691
Regulation of transient receptor potential channels of melastatin type 8 (TRPM8): effect of cAMP, cannabinoid CB(1) receptors and endovanilloidsQ40146865
Bidirectional shifts of TRPM8 channel gating by temperature and chemical agents modulate the cold sensitivity of mammalian thermoreceptors.Q40167692
TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuliQ40172246
Contribution of TRPM8 channels to cold transduction in primary sensory neurons and peripheral nerve terminals.Q40202804
Ca2+-independent phospholipase A2-dependent gating of TRPM8 by lysophospholipids.Q40212726
Ethanol inhibits cold-menthol receptor TRPM8 by modulating its interaction with membrane phosphatidylinositol 4,5-bisphosphateQ40214222
Conservation of functional and pharmacological properties in the distantly related temperature sensors TRVP1 and TRPM8.Q40418274
Functional control of cold- and menthol-sensitive TRPM8 ion channels by phosphatidylinositol 4,5-bisphosphate.Q40457196
Inhibition of TRPM2 channels by the antifungal agents clotrimazole and econazole.Q40467443
The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channelQ40516374
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channelsQ40526282
Oxidizing reagent copper-o-phenanthroline is an open channel blocker of the vanilloid receptor TRPV1.Q40540772
Molecular determinants of vanilloid sensitivity in TRPV1.Q40583076
SK&F 96365, a novel inhibitor of receptor-mediated calcium entryQ41771065
N-(4-Tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a Novel, Orally Effective Vanilloid Receptor 1 Antagonist with Analgesic Properties: I. In Vitro Characterization and Pharmacokinetic PropertiesQ44422969
Two populations of cold-sensitive neurons in rat dorsal root ganglia and their modulation by nerve growth factorQ45138239
Molecular basis for species-specific sensitivity to "hot" chili peppersQ45712451
Proton activation does not alter antagonist interaction with the capsaicin-binding pocket of TRPV1.Q46429380
PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domainQ46455727
Identification of molecular determinants of channel gating in the transient receptor potential box of vanilloid receptor I.Q46535486
Transient receptor potential channels in sensory neurons are targets of the antimycotic agent clotrimazoleQ46804915
TRPM8 mechanism of cold allodynia after chronic nerve injury.Q46852224
P304page(s)62
P577publication date2009-11-03
P1433published inMolecular PainQ15766244
P1476titleDifferential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels
P478volume5

Reverse relations

cites work (P2860)
Q428510875-Benzyloxytryptamine as an antagonist of TRPM8
Q35177671AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia
Q46283697Activation of Human Transient Receptor Potential Melastatin-8 (TRPM8) by Calcium-Rich Particulate Materials and Effects on Human Lung Cells
Q42821660Bidirectional modulation of thermal and chemical sensitivity of TRPM8 channels by the initial region of the N-terminal domain.
Q89030821Critical role of the pore domain in the cold response of TRPM8 channels identified by ortholog functional comparison
Q37960107Current perspectives on the modulation of thermo-TRP channels: new advances and therapeutic implications
Q90210495Drosophila menthol sensitivity and the Precambrian origins of transient receptor potential-dependent chemosensation
Q28608608Expression of temperature-sensitive ion channel TRPM8 in sperm cells correlates with vertebrate evolution
Q38838714Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'.
Q28834356Implications of Human Transient Receptor Potential Melastatin 8 (TRPM8) Channel Gating from Menthol Binding Studies of the Sensing Domain
Q38168995Ionic channels as targets for drug design: a review on computational methods
Q41478711Novel selective, potent naphthyl TRPM8 antagonists identified through a combined ligand- and structure-based virtual screening approach
Q39635520Pharmacological and functional properties of TRPM8 channels in prostate tumor cells.
Q92376791Recent Progress in TRPM8 Modulation: An Update
Q35728001Short isoforms of the cold receptor TRPM8 inhibit channel gating by mimicking heat action rather than chemical inhibitors
Q48156868Structure of the cold- and menthol-sensing ion channel TRPM8.
Q41545232Synthesis, high-throughput screening and pharmacological characterization of β-lactam derivatives as TRPM8 antagonists.
Q37935626TRPM channels: same ballpark, different players, and different rules in immunogenetics
Q35602377TRPM8 acute desensitization is mediated by calmodulin and requires PIP(2): distinction from tachyphylaxis
Q89171881TRPM8 and prostate: a cold case?
Q38709214TRPM8: a potential target for cancer treatment
Q90463032The Immunosuppressant Macrolide Tacrolimus Activates Cold-Sensing TRPM8 Channels

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