Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action

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Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.24.11.5005-5015.2004
P932PMC publication ID416420
P698PubMed publication ID15143191
P5875ResearchGate publication ID8563245

P2093author name stringFrancesco Beguinot
Alessandra Trencia
Angela Cassese
Anna Perfetti
Claudia Miele
Francesco Oriente
Giovanni Vigliotta
Pietro Formisano
Stefania Santopietro
Chiara Romano
Giancarlo Troncone
Cecilia Tiveron
Giuseppe Portella
Francesca Fiory
Laura Tatangelo
Maria Alessandra Maitan
P2860cites workPED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosisQ22003766
PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitusQ24316231
Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic actionQ24683017
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with themQ28142706
PEA-15 mediates cytoplasmic sequestration of ERK MAP kinaseQ28204643
Multiple members of the mitogen-activated protein kinase family are necessary for PED/PEA-15 anti-apoptotic functionQ28215522
Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cellsQ28215810
Failure of insulin-regulated recruitment of the glucose transporter GLUT4 in cardiac muscle of obese Zucker rats is associated with alterations of small-molecular-mass GTP-binding proteinsQ28577351
The phosphoprotein protein PEA-15 inhibits Fas- but increases TNF-R1-mediated caspase-8 activity and apoptosisQ28587650
Knockout of PKC alpha enhances insulin signaling through PI3KQ28590618
Banting lecture 1988. Role of insulin resistance in human diseaseQ29547283
Global and societal implications of the diabetes epidemicQ29614551
Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetesQ33853693
Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinaseQ33958737
Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetesQ34330770
Diabetes mellitus and genetically programmed defects in beta-cell functionQ34462316
Insulin resistance in type 2 diabetes: role of fatty acidsQ34580981
Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction.Q34655571
Function and dysfunction of aPKC isoforms for glucose transport in insulin-sensitive and insulin-resistant statesQ34688703
IRS proteins and the common path to diabetesQ34778267
Insulin action and the regulation of hexose transportQ40284376
Protein kinase C (PKC)-alpha activation inhibits PKC-zeta and mediates the action of PED/PEA-15 on glucose transport in the L6 skeletal muscle cellsQ40803281
Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoformsQ41729392
The IR1152 mutant insulin receptor selectively impairs insulin action in skeletal muscle but not in liver.Q42491060
Photoaffinity labelling of cardiac membrane GTP-binding proteins in response to insulinQ42505170
Rosiglitazone, insulin treatment, and fasting correct defective activation of protein kinase C-zeta/lambda by insulin in vastus lateralis muscles and adipocytes of diabetic ratsQ43543575
Quantitative measurement of sn-1,2-diacylglycerolsQ45205999
Tissue and isoform-selective activation of protein kinase C in insulin-resistant obese Zucker rats - effects of feeding.Q51562050
Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance.Q52540333
Induction and intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediated apotosis in human malignant glioma cells.Q54018179
1,2-Diacylglycerol and ceramide levels in rat skeletal muscle and liver in vivo. Studies with insulin, exercise, muscle denervation, and vasopressin.Q54324021
Thiazolidinedione treatment enhances insulin effects on protein kinase C-zeta /lambda activation and glucose transport in adipocytes of nondiabetic and Goto-Kakizaki type II diabetic ratsQ73631016
METABOLISM OF ISOLATED FAT CELLS. I. EFFECTS OF HORMONES ON GLUCOSE METABOLISM AND LIPOLYSISQ76853134
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectpreproinsulinQ7240673
overexpressionQ61643320
P304page(s)5005-5015
P577publication date2004-06-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleOverexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action
P478volume24

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cites work (P2860)
Q42700870A peptide antagonist of Prep1-p160 interaction improves ceramide-induced insulin resistance in skeletal muscle cells.
Q34667784Adenoviral gene transfer of PLD1-D4 enhances insulin sensitivity in mice by disrupting phospholipase D1 interaction with PED/PEA-15.
Q34252924Age-related impairment in insulin release: the essential role of β(2)-adrenergic receptor
Q43565613Biomechanical insult switches PEA-15 activity to uncouple its anti-apoptotic function and promote erk mediated tissue remodeling
Q35001275Characterization of a MAPK scaffolding protein logic gate in gonadotropes.
Q35837406Clozapine impairs insulin action by up-regulating Akt phosphorylation and Ped/Pea-15 protein abundance
Q39541782Comparison between fibroblast wound healing and cell random migration assays in vitro
Q48206002Expression of phosphoprotein enriched in astrocytes 15 kDa (PEA-15) in astrocytic tumors: a novel approach of correlating malignancy grade and prognosis
Q43097133Hepatocyte nuclear factor (HNF)-4alpha-driven epigenetic silencing of the human PED gene.
Q43154745Molecular cloning and characterization of the human PED/PEA-15 gene promoter reveal antagonistic regulation by hepatocyte nuclear factor 4alpha and chicken ovalbumin upstream promoter transcription factor II.
Q42913727NMR backbone dynamics studies of human PED/PEA-15 outline protein functional sites
Q28476047Negative regulators of insulin signaling revealed in a genome-wide functional screen
Q26799216On the Quest of Cellular Functions of PEA-15 and the Therapeutic Opportunities
Q43269412Overproduction of phosphoprotein enriched in diabetes (PED) induces mesangial expansion and upregulates protein kinase C-beta activity and TGF-beta1 expression.
Q42272320PED/PEA-15 controls fibroblast motility and wound closure by ERK1/2-dependent mechanisms
Q36028460PED/PEA-15 induces autophagy and mediates TGF-beta1 effect on muscle cell differentiation
Q34663501PED/PEA-15 inhibits hydrogen peroxide-induced apoptosis in Ins-1E pancreatic beta-cells via PLD-1
Q54408005PREP1 deficiency downregulates hepatic lipogenesis and attenuates steatohepatitis in mice.
Q42416060Parkinson-like phenotype in insulin-resistant PED/PEA-15 transgenic mice
Q36466778Peroxisome proliferator-activated receptor-γ activation enhances insulin-stimulated glucose disposal by reducing ped/pea-15 gene expression in skeletal muscle cells: evidence for involvement of activator protein-1
Q53337896Phorbol esters induce intracellular accumulation of the anti-apoptotic protein PED/PEA-15 by preventing ubiquitinylation and proteasomal degradation.
Q34024181Phosphoprotein enriched in astrocytes (PEA)-15: a potential therapeutic target in multiple disease states
Q35190978Phosphoprotein enriched in astrocytes-15 kDa expression inhibits astrocyte migration by a protein kinase C delta-dependent mechanism
Q39652158Prep1 Controls Insulin Glucoregulatory Function in Liver by Transcriptional Targeting of SHP1 Tyrosine Phosphatase
Q36898758Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism.
Q40393314Raised expression of the antiapoptotic protein ped/pea-15 increases susceptibility to chemically induced skin tumor development.
Q46549512Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells.
Q39232367Targetting PED/PEA-15 for diabetes treatment.
Q40093567The PEA-15/PED protein protects glioblastoma cells from glucose deprivation-induced apoptosis via the ERK/MAP kinase pathway.
Q51488380The PEA15 gene is overexpressed and related to insulin resistance in healthy first-degree relatives of patients with type 2 diabetes.
Q37112520The roles of MAPKs in disease
Q28564173Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling
Q38405367Understanding type 2 diabetes: from genetics to epigenetics

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