Age-related impairment in insulin release: the essential role of β(2)-adrenergic receptor

scientific article

Age-related impairment in insulin release: the essential role of β(2)-adrenergic receptor is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2337/DB11-1027
P932PMC publication ID3282797
P698PubMed publication ID22315324
P5875ResearchGate publication ID221815494

P50authorGuido IaccarinoQ56670390
Bruno TrimarcoQ38321707
Pietro FormisanoQ40900662
P2093author name stringClaudia Miele
Daniela Sorriento
Gaetano Santulli
Angela Lombardi
Antonio Anastasio
Carmine Del Giudice
Francesco Béguinot
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A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes.Q51552154
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Effect of exercise intensity and AICAR on isoform-specific expressions of murine skeletal muscle PGC-1α mRNA: a role of β₂-adrenergic receptor activation.Q54631292
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Abscisic acid synergizes with rosiglitazone to improve glucose tolerance and down-modulate macrophage accumulation in adipose tissue: possible action of the cAMP/PKA/PPAR γ axisQ33925358
Pharmacological agents that directly modulate insulin secretionQ33964696
Human ageing and the sympathoadrenal systemQ34074347
Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin actionQ34181813
Metabolic effects of beta 2-agonistsQ35261267
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Beta cell-specific deficiency of the stimulatory G protein alpha-subunit Gsalpha leads to reduced beta cell mass and insulin-deficient diabetes.Q36288742
Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasisQ36549465
The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alphaQ36976809
Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitusQ37141727
The effect of age on insulin sensitivity and insulin secretion in first-degree relatives of type 1 diabetic patients: a population analysisQ37257559
Age-associated reductions in cardiac beta1- and beta2-adrenergic responses without changes in inhibitory G proteins or receptor kinasesQ37379383
Positive and negative control of Ucp1 gene transcription and the role of β-adrenergic signaling networksQ37799247
Increased hexosamine biosynthetic pathway flux dedifferentiates INS-1E cells and murine islets by an extracellular signal-regulated kinase (ERK)1/2-mediated signal transmission pathway.Q39456743
Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E.Q39485974
Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.Q39562288
Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-kappaB-dependent hypertrophic gene expression.Q39675542
Reduced β-adrenergic receptor concentrations in ageing manQ40093721
Rosiglitazone reverses salbutamol-induced β(2) -adrenoceptor tolerance in airway smooth muscleQ41828663
Mechanisms of the age-associated deterioration in glucose tolerance: contribution of alterations in insulin secretion, action, and clearanceQ42443829
Independent influence of age on basal insulin secretion in nondiabetic humans. European Group for the Study of Insulin ResistanceQ42469370
Impaired neoangiogenesis in β₂-adrenoceptor gene-deficient mice: restoration by intravascular human β₂-adrenoceptor gene transfer and role of NFκB and CREB transcription factorsQ42613659
Transcriptional activation of peroxisome proliferator-activated receptor-gamma requires activation of both protein kinase A and Akt during adipocyte differentiationQ42824519
Overproduction of phosphoprotein enriched in diabetes (PED) induces mesangial expansion and upregulates protein kinase C-beta activity and TGF-beta1 expression.Q43269412
beta2-Agonist modulates epithelial gene expression involved in the T- and B-cell chemotaxis and induces airway sensitization in human isolated bronchiQ43291474
Transgenic overexpression of beta(2)-adrenergic receptors in airway epithelial cells decreases bronchoconstriction.Q43505793
Beta 2-agonist administration reverses muscle wasting and improves muscle function in aged rats.Q44655921
Genotype Gly/Gly of the Arg16Gly polymorphism of the beta2-adrenergic receptor is associated with elevated fasting serum insulin concentrations, but not with acute insulin response to glucose, in type 2 diabetic patientsQ44704721
Interactive effects of common beta2-adrenoceptor haplotypes and age on susceptibility to hypertension and receptor functionQ46106970
Age-associated decrease in beta-adrenergic receptors and adenylate cyclase activity in rat brown adipose tissueQ46337051
Effects of aging on insulin secretionQ46340705
Ischemic neoangiogenesis enhanced by beta2-adrenergic receptor overexpression: a novel role for the endothelial adrenergic systemQ46766115
The lack of beta-adrenoceptors results in enhanced insulin sensitivity in mice exhibiting increased adiposity and glucose intoleranceQ46818638
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 3.0 UnportedQ19125045
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectpreproinsulinQ7240673
P304page(s)692-701
P577publication date2012-02-07
P1433published inDiabetesQ895262
P1476titleAge-related impairment in insulin release: the essential role of β(2)-adrenergic receptor
P478volume61

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