The nerve growth factor signaling and its potential as therapeutic target for glaucoma

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The nerve growth factor signaling and its potential as therapeutic target for glaucoma is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1155/2014/759473
P932PMC publication ID4164261
P698PubMed publication ID25250333
P5875ResearchGate publication ID266086659

P50authorHaitao WangQ83755254
Thilini ThrimawithanaQ85368007
Peter J LittleQ48286305
P2093author name stringZhong-Ping Feng
Rikang Wang
Wenhua Zheng
Jiangping Xu
P2860cites workEffects of nerve growth factor on neuronal plasticity of the kitten visual cortexQ48297598
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Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signalingQ24296451
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NGF stimulates extensive neurite outgrowth from implanted dorsal root ganglion neurons following transplantation into the adult rat inner ear.Q50475435
Transplantation of NGF-gene-modified bone marrow stromal cells into a rat model of Alzheimer' disease.Q50654338
Nerve growth factor collaborates with myocyte-derived factors to promote development of presynaptic sites in cultured sympathetic neurons.Q52170479
Connective tissue growth factor causes glaucoma by modifying the actin cytoskeleton of the trabecular meshwork.Q54514331
p75-deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGFQ71845313
Ranking of optic disc variables for detection of glaucomatous optic nerve damageQ73876330
Neurotrophic rationale in glaucoma: a TrkA agonist, but not NGF or a p75 antagonist, protects retinal ganglion cells in vivoQ80344531
Src and FAK are key early signalling intermediates required for neurite growth in NGF-responsive adult DRG neuronsQ81593501
Ocular application of nerve growth factor protects degenerating retinal ganglion cells in a rat model of glaucomaQ84144841
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Retinal p75 and bax overexpression is associated with retinal ganglion cells apoptosis in a rat model of glaucomaQ46408620
Interferon beta promotes nerve growth factor secretion early in the course of multiple sclerosisQ46433077
Brn3a-expressing retinal ganglion cells project specifically to thalamocortical and collicular visual pathways.Q46470843
Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's diseaseQ47695139
p75-mediated NF-kappaB activation enhances the survival response of developing sensory neurons to nerve growth factorQ48144985
Functionally antagonistic interactions between the TrkA and p75 neurotrophin receptors regulate sympathetic neuron growth and target innervationQ48181185
Molecular evolution of the neurotrophin family members and their Trk receptors.Q48231589
Nerve growth factor/p38 signaling increases intraepidermal nerve fiber densities in painful neuropathy of type 2 diabetesQ35577282
Neurotrophic regulation of retinal ganglion cell synaptic connectivity: from axons and dendrites to synapsesQ35959776
Role of JNK activation in apoptosis: a double-edged swordQ36027363
Associations between hepatocyte growth factor, c-Met, and basic fibroblast growth factor and survival in endometrial cancer patientsQ36072790
Cholinergic abnormalities, endosomal alterations and up-regulation of nerve growth factor signaling in Niemann-Pick type C diseaseQ36092402
Novel and known MYOC exon 3 mutations in an admixed Peruvian primary open-angle glaucoma populationQ36145931
A novel MYOC heterozygous mutation identified in a Chinese Uygur pedigree with primary open-angle glaucoma.Q36146045
Nerve growth factor-independent neuronal survival: a role for NO donorsQ36208432
PDGF-B-mediated downregulation of miR-21: new insights into PDGF signaling in glioblastomaQ36375834
N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescenceQ36512298
Elevated intraocular pressure causes inner retinal dysfunction before cell loss in a mouse model of experimental glaucoma.Q36581246
VEGF-A is necessary and sufficient for retinal neuroprotection in models of experimental glaucomaQ36715908
Tissue localization of nerve growth factor and nerve growth factor receptorsQ37179161
Individual molecular response to elevated intraocular pressure in perfused postmortem human eyesQ37265766
Experimental and clinical evidence of neuroprotection by nerve growth factor eye drops: Implications for glaucomaQ37304132
The cholinergic system, nerve growth factor and the cytoskeleton.Q37695362
Transforming growth factor-β in normal nociceptive processing and pathological pain modelsQ37962474
Recent preclinical evidence advancing cell therapy for Alzheimer's disease.Q38024220
The possible role of the Akt signaling pathway in schizophrenia.Q38024577
Nerve growth factor and Alzheimer's disease: new facts for an old hypothesisQ38039856
GDNF, NGF and BDNF as therapeutic options for neurodegeneration.Q38076581
Comparison of initial intraocular pressure response with topical beta-adrenergic antagonists and prostaglandin analogues in African American and white individuals in the Ocular Hypertension Treatment Study.Q38398163
Neuropeptides and neurotrophins in neonatal blood of children with autism or mental retardationQ38461332
Targeted delivery of nerve growth factor via encapsulated cell biodelivery in Alzheimer disease: a technology platform for restorative neurosurgeryQ39338594
Overexpression of p75(NTR) increases survival of breast cancer cells through p21(waf1).Q39674464
Comparison of expression profile of neurotrophins and their receptors in primary and transformed rat retinal ganglion cells.Q40097792
Neurotrophins live or let die: does p75NTR decide?Q41366415
High affinity nerve growth factor binding displays a faster rate of association than p140trk binding. Implications for multi-subunit polypeptide receptors.Q41481526
Neurotrophin activation of catecholamine storage vesicle protein gene expression: signaling to chromogranin a biosynthesisQ41644952
Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetiQ42449110
Effects of nerve growth factor (NGF), fluoxetine, and amitriptyline on gene expression profiles in rat brainQ42728159
The low affinity NGF receptor, p75, can collaborate with each of the Trks to potentiate functional responses to the neurotrophinsQ42795990
FKHRL1 and its homologs are new targets of nerve growth factor Trk receptor signalingQ42816513
PDGF beta-receptor kinase activity and ERK1/2 mediate glycosaminoglycan elongation on biglycan and increases binding to LDL.Q42976970
Peripheral neutralization of nerve growth factor induces immunosympathectomy and central neurodegeneration in transgenic mice.Q43150896
Alzheimer's Therapeutics: Neurotrophin Domain Small Molecule MimeticsQ43477496
Essential role of cAMP-response element-binding protein activation by A2A adenosine receptors in rescuing the nerve growth factor-induced neurite outgrowth impaired by blockage of the MAPK cascadeQ44061969
Insulin-like growth factor-1-induced phosphorylation of transcription factor FKHRL1 is mediated by phosphatidylinositol 3-kinase/Akt kinase and role of this pathway in insulin-like growth factor-1-induced survival of cultured hippocampal neuronsQ44072142
Changes in retinal expression of neurotrophins and neurotrophin receptors induced by ocular hypertensionQ44747101
Disruption of NGF binding to the low affinity neurotrophin receptor p75LNTR reduces NGF binding to TrkA on PC12 cellsQ44794856
A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer diseaseQ45883058
Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.Q27919621
Nerve growth factor levels and mast cell distribution in human coronary atherosclerosisQ28203216
Viktor Hamburger and Rita Levi-Montalcini: the path to the discovery of nerve growth factorQ28209950
Adult-onset primary open-angle glaucoma caused by mutations in optineurinQ28217964
Reduced plasma levels of NGF and BDNF in patients with acute coronary syndromesQ28254845
Tumor promoter arsenite activates extracellular signal-regulated kinase through a signaling pathway mediated by epidermal growth factor receptor and Shc.Q28368422
Inhibition of p75(NTR) in glia potentiates TrkA-mediated survival of injured retinal ganglion cellsQ28567866
Glutamate acting on N-methyl-D-aspartate receptors attenuates insulin-like growth factor-1 receptor tyrosine phosphorylation and its survival signaling properties in rat hippocampal neuronsQ28568388
The role of Akt/FoxO3a in the protective effect of venlafaxine against corticosterone-induced cell death in PC12 cellsQ28570801
The neurotrophin receptor p75NTR as a positive modulator of myelinationQ28572739
Interaction between two glaucoma genes, optineurin and myocilinQ28573610
Chronic and Acute Models of Retinal Neurodegeneration TrkA Activity Are Neuroprotective whereas p75NTR Activity Is Neurotoxic through a Paracrine MechanismQ28584166
Frs2α enhances fibroblast growth factor-mediated survival and differentiation in lens developmentQ28591710
Axon degeneration: Molecular mechanisms of a self-destruction pathwayQ29013985
NGF is essential for hippocampal plasticity and learningQ30491147
Role of pro-brain-derived neurotrophic factor (proBDNF) to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapsesQ30525529
Sustained ocular hypertension induces dendritic degeneration of mouse retinal ganglion cells that depends on cell type and locationQ30534999
Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic miceQ33180485
Nerve growth factor promotes breast cancer angiogenesis by activating multiple pathwaysQ33981022
Dissecting the involvement of tropomyosin-related kinase A and p75 neurotrophin receptor signaling in NGF deficit-induced neurodegenerationQ33982246
Topography of neuron loss in the retinal ganglion cell layer in human glaucomaQ34004263
Targeted Disruption of the Myocilin Gene (Myoc) Suggests that Human Glaucoma-Causing Mutations Are Gain of FunctionQ34012751
Glaucoma: genes, phenotypes, and new directions for therapyQ34090204
Myocilin and optineurin coding variants in Hispanics of Mexican descent with POAG.Q34259450
Neurotrophin presence in human coronary atherosclerosis and metabolic syndrome: a role for NGF and BDNF in cardiovascular disease?Q34286983
Nerve growth factor: from animal models of cholinergic neuronal degeneration to gene therapy in Alzheimer's diseaseQ34287016
The nerve growth factor and the neuroscience chess boardQ34287022
NGF and the treatment of Alzheimer's diseaseQ34347795
The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron deathQ34457074
Competitive signaling between TrkA and p75 nerve growth factor receptors determines cell survival.Q34464521
Ectopic vesicular glutamate release at the optic nerve head and axon loss in mouse experimental glaucomaQ34470829
Growth factor delivery-based tissue engineering: general approaches and a review of recent developmentsQ34548765
Comparative effectiveness of treatments for open-angle glaucoma: a systematic review for the U.S. Preventive Services Task ForceQ34591030
Protective effects of resveratrol in experimental retinal detachmentQ34990639
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectglaucomaQ159701
peptideQ172847
targeted therapyQ492646
signal transductionQ828130
nerve tissue proteinQ6996861
pharmaceutical preparationQ66089252
nerve growth factorsQ98072643
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)759473
P577publication date2014-08-31
P1433published inBioMed Research InternationalQ17509958
P1476titleThe nerve growth factor signaling and its potential as therapeutic target for glaucoma
P478volume2014