Essential role of cAMP-response element-binding protein activation by A2A adenosine receptors in rescuing the nerve growth factor-induced neurite outgrowth impaired by blockage of the MAPK cascade

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Essential role of cAMP-response element-binding protein activation by A2A adenosine receptors in rescuing the nerve growth factor-induced neurite outgrowth impaired by blockage of the MAPK cascade is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M201206200
P698PubMed publication ID12114502

P50authorYijuang ChernQ38545210
P2093author name stringHsiu-Ming Shih
Hsiao-Chun Cheng
P2860cites work1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cellsQ24316333
Small GTPase RhoG is a key regulator for neurite outgrowth in PC12 cellsQ24551209
The myotonic dystrophy kinase-related Cdc42-binding kinase is involved in the regulation of neurite outgrowth in PC12 cellsQ47951201
Mechanisms of apoptosis in PC12 cells irreversibly differentiated with nerve growth factor and cyclic AMP.Q48271646
Protein kinase C inhibits adenylyl cyclase type VI activity during desensitization of the A2a-adenosine receptor-mediated cAMP responseQ48797347
Suppression of nerve growth factor-induced neuronal differentiation of PC12 cells. N-acetylcysteine uncouples the signal transduction from ras to the mitogen-activated protein kinase cascade.Q52198018
A2a adenosine receptor gene expression in developing rat brain.Q52221509
Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP.Q55240568
The selective and inducible activation of endogenous PI 3-kinase in PC12 cells results in efficient NGF-mediated survival but defective neurite outgrowthQ57903651
Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth FactorQ58197226
Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factorQ24561804
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by VavQ28646540
Nerve growth factor mediates signal transduction through trk homodimer receptorsQ28854581
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transductionQ29618388
CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signalsQ29620470
Borna disease virus persistent infection activates mitogen-activated protein kinase and blocks neuronal differentiation of PC12 cells.Q31552307
Signaling routes to CREM and CREB: plasticity in transcriptional activation.Q33677015
Adenosine A2A receptor interactions with receptors for other neurotransmitters and neuromodulators.Q33709251
A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fosQ33771493
Is CREB a key to neuronal survival?Q33826749
Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding.Q33896745
Activation of Trk neurotrophin receptors in the absence of neurotrophinsQ33937877
CREB is one component of the binding complex of the Ces-2/E2A-HLF binding element and is an integral part of the interleukin-3 survival signalQ33968736
Distinctive features of Trk neurotrophin receptor transactivation by G protein-coupled receptors.Q34467077
Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF.Q34576586
Protein kinase A directly regulates the activity and proteolysis of cubitus interruptusQ35915402
Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiationQ36552522
Identification of a cyclic-AMP-responsive element within the rat somatostatin geneQ37398428
Physiological and pharmacological properties of adenosine: therapeutic implicationsQ37478233
Differential responses to nerve growth factor and epidermal growth factor in neurite outgrowth of PC12 cells are determined by Rac1 activation systems.Q38302701
Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathwaysQ38354870
Characterization of a CREB gain-of-function mutant with constitutive transcriptional activity in vivoQ39453609
Adenosine receptor subtypes: characterization and therapeutic regulationQ40437012
The 5' untranslated regions of the rat A2A adenosine receptor gene function as negative translational regulators.Q40921056
Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activationQ41269491
NGFIA (EGR1) contains transcription activating domains in both the amino terminal and carboxyl terminal regions of the proteinQ41541701
Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiationQ41596156
Nerve growth factor induces Fos-like immunoreactivity within identified cholinergic neurons in the adult rat basal forebrainQ42437553
Regulation of dendritic growth and remodeling by Rho, Rac, and Cdc42.Q42445511
TrkA-immunoreactive profiles in the central nervous system: colocalization with neurons containing p75 nerve growth factor receptor, choline acetyltransferase, and serotoninQ42490267
Requirement of p38 mitogen-activated protein kinase for neuronal differentiation in PC12 cellsQ42539781
Characterization of the rat light neurofilament (NF-L) gene promoter and identification of NGF and cAMP responsive regionsQ42830438
Hepatitis C virus core protein enhances the activation of the transcription factor, Elk1, in response to mitogenic stimuliQ42833210
Activation of protein kinase A and atypical protein kinase C by A(2A) adenosine receptors antagonizes apoptosis due to serum deprivation in PC12 cellsQ43559421
Developmental regulation of nerve growth factor and its receptor in the rat caudate-putamen.Q46030268
P433issue37
P407language of work or nameEnglishQ1860
P921main subjectneuriteQ1534415
P304page(s)33930-33942
P577publication date2002-07-11
P1433published inJournal of Biological ChemistryQ867727
P1476titleEssential role of cAMP-response element-binding protein activation by A2A adenosine receptors in rescuing the nerve growth factor-induced neurite outgrowth impaired by blockage of the MAPK cascade
P478volume277

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