Suppression of nerve growth factor-induced neuronal differentiation of PC12 cells. N-acetylcysteine uncouples the signal transduction from ras to the mitogen-activated protein kinase cascade.

scientific article published in December 1996

Suppression of nerve growth factor-induced neuronal differentiation of PC12 cells. N-acetylcysteine uncouples the signal transduction from ras to the mitogen-activated protein kinase cascade. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.271.51.33018
P698PubMed publication ID8955147
P5875ResearchGate publication ID14252674

P2093author name stringNishida E
Matsuda S
Hirata H
Yagisawa H
Tanaka C
Gotoh Y
Kamata H
P2860cites workNormal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1Q24309607
P433issue51
P407language of work or nameEnglishQ1860
P921main subjectacetylcysteineQ375613
P304page(s)33018-33025
P577publication date1996-12-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleSuppression of nerve growth factor-induced neuronal differentiation of PC12 cells. N-acetylcysteine uncouples the signal transduction from ras to the mitogen-activated protein kinase cascade.
P478volume271

Reverse relations

cites work (P2860)
Q36662707A direct redox regulation of protein kinase C isoenzymes mediates oxidant-induced neuritogenesis in PC12 cells
Q35689692Activation of the Ras/Raf/MEK pathway facilitates hepatitis C virus replication via attenuation of the interferon-JAK-STAT pathway
Q46555131Antioxidant N-acetylcysteine blocks nerve growth factor-induced H2O2/ERK signaling in PC12 cells
Q42511865Antioxidants N-acetylcysteine (NAC) and 2-mercaptoethanol (2-ME) affect the survival and differentiative potential of cholinergic precursors from the embryonic septal nuclei and basal forebrain: involvement of ras signaling
Q38368571Cerium oxide nanoparticles inhibit differentiation of neural stem cells
Q30471916Characterization of graf, the GTPase-activating protein for rho associated with focal adhesion kinase. Phosphorylation and possible regulation by mitogen-activated protein kinase.
Q37318152Cholinergic system during the progression of Alzheimer's disease: therapeutic implications
Q38314836Developmental neurotoxicity of chlorpyrifos in vivo and in vitro: effects on nuclear transcription factors involved in cell replication and differentiation
Q31873230Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells
Q38309763Downregulation of microsomal glutathione-S-transferase 1 modulates protective mechanisms in differentiated PC12 cells
Q33194313EGF mediates protection against Fas‐induced apoptosis by depleting and oxidizing intracellular GSH stocks
Q43288640Effect of N-acetylcysteine on sympathetic hyperinnervation in post-infarcted rat hearts
Q40811069Elevated superoxide production by active H-ras enhances human lung WI-38VA-13 cell proliferation, migration and resistance to TNF-alpha
Q73572489Epidermal growth factor receptor is modulated by redox through multiple mechanisms. Effects of reductants and H2O2
Q44061969Essential role of cAMP-response element-binding protein activation by A2A adenosine receptors in rescuing the nerve growth factor-induced neurite outgrowth impaired by blockage of the MAPK cascade
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Q44658021Expression of galectin‐3 in neuronally differentiating PC12 cells is regulated both via Ras/MAPK‐dependent and –independent signalling pathways
Q62601219Growth factor-mediated signal transduction and redox balance in isolated digestive gland cells from Mytilus galloprovincialis Lam
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Q28741832High throughput nano-liter RT-qPCR to classify soil contamination using a soil arthropod
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Q28204706Induction of neurite outgrowth in PC12 cells by alpha -phenyl-N-tert-butylnitron through activation of protein kinase C and the Ras-extracellular signal-regulated kinase pathway
Q33650641MAP kinase pathways
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Q34841250Mechanisms of manganese-induced rat pheochromocytoma (PC12) cell death and cell differentiation
Q28579492Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells
Q73731634N-acetylcysteine suppresses TNF-induced NF-kappaB activation through inhibition of IkappaB kinases
Q44013875Neuregulin induces sustained reactive oxygen species generation to mediate neuronal differentiation
Q33853144Oxidative stress and gene regulation
Q39659869Oxidative stress enhances granulocytic differentiation in HL 60 cells, an acute promyelocytic leukemia cell line
Q41750986Oxygen radicals and signaling
Q34335809Phosphatidylinositol 4-phosphate 5-kinase α negatively regulates nerve growth factor-induced neurite outgrowth in PC12 cells
Q74562743Prevention of PC12 cell death by N-acetylcysteine requires activation of the Ras pathway
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Q51997370Suppressing phosphatidylcholine-specific phospholipase C and elevating ROS level, NADPH oxidase activity and Rb level induced neuronal differentiation in mesenchymal stem cells.
Q33388432System theoretical investigation of human epidermal growth factor receptor-mediated signalling

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