KAI1 suppresses HIF-1α and VEGF expression by blocking CDCP1-enhanced Src activation in prostate cancer

scientific article published on March 6, 2012

KAI1 suppresses HIF-1α and VEGF expression by blocking CDCP1-enhanced Src activation in prostate cancer is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1032883037
P356DOI10.1186/1471-2407-12-81
P953full work available at URLhttp://link.springer.com/article/10.1186/1471-2407-12-81/fulltext.html
http://link.springer.com/content/pdf/10.1186/1471-2407-12-81
http://link.springer.com/content/pdf/10.1186/1471-2407-12-81.pdf
https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-12-81
https://europepmc.org/articles/PMC3313899
https://europepmc.org/articles/PMC3313899?pdf=render
https://link.springer.com/content/pdf/10.1186/1471-2407-12-81.pdf
P932PMC publication ID3313899
P698PubMed publication ID22390300
P5875ResearchGate publication ID221887984

P2093author name stringYoung-Gyu Ko
Yun-Sil Lee
Minyoung Lee
Yoon-Jin Lee
Jae-Seon Lee
Yeung Bae Jin
Jung-Jin Park
P2860cites workBiochimica et Biophysica ActaQ864239
KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2Q24318405
Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1Q28138628
The metastasis suppressor gene C33/CD82/KAI1 induces apoptosis through reactive oxygen intermediatesQ44641967
Expression of CUB domain containing protein (CDCP1) is correlated with prognosis and survival of patients with adenocarcinoma of lungQ46201034
Targeting CUB domain-containing protein 1 with a monoclonal antibody inhibits metastasis in a prostate cancer modelQ46316570
VHL down-regulation and differential localization as mechanisms in tumorigenesisQ53375202
Down-regulation of the KAI1 metastasis suppressor gene during the progression of human prostatic cancer infrequently involves gene mutation or allelic lossQ56927898
Metastasis-suppressor KAI1/CD82 induces homotypic aggregation of human prostate cancer cells through Src-dependent pathwayQ73140746
Prostate cancer and the met hepatocyte growth factor receptorQ28278555
Learning therapeutic lessons from metastasis suppressor proteinsQ30435922
β1A integrin is a master regulator of invadosome organization and function.Q30497504
The C2 domain of PKCdelta is a phosphotyrosine binding domainQ30851015
Proteomic analysis of the tetraspanin web using LC-ESI-MS/MS and MALDI-FTICR-MS.Q33231320
Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKCdelta.Q34074338
CUB-domain-containing protein 1 (CDCP1) activates Src to promote melanoma metastasisQ34534040
VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migrationQ34549885
Functional role of cell surface CUB domain-containing protein 1 in tumor cell dissemination.Q34748645
The cell surface glycoprotein CDCP1 in cancer--insights, opportunities, and challengesQ34985908
Role of VHL gene mutation in human cancerQ35990141
CUB-domain-containing protein 1 regulates peritoneal dissemination of gastric scirrhous carcinomaQ36691145
The role of membrane microdomains in transmembrane signaling through the epithelial glycoprotein Gp140/CDCP1.Q37083037
Hypoxia-inducible factor 1 and cancer pathogenesisQ37174625
Controlling cell surface dynamics and signaling: how CD82/KAI1 suppresses metastasisQ37281251
Molecular mechanisms of metastasis in prostate cancerQ37339692
VHL gene mutations in renal cell carcinoma: role as a biomarker of disease outcome and drug efficacyQ37393004
KAI-1/CD82, the molecule and clinical implication in cancer and cancer metastasisQ37395457
Metastasis mechanismsQ37580464
Tetraspanin-enriched microdomains: a functional unit in cell plasma membranesQ37587580
Src signaling in cancer invasionQ37668457
Src kinase inhibitors: an emerging therapeutic treatment option for prostate cancerQ37724378
Alterations in VHL as potential biomarkers in renal-cell carcinomaQ37724576
VEGF and prostatic cancer: a systematic reviewQ37760770
Hypoxia-mediated biological controlQ37843943
Tetraspanin protein contributions to cancer.Q37856398
Tetraspanin-induced death of myeloma cell lines is autophagic and involves increased UPR signallingQ39799320
Expression of the CUB domain containing protein 1 (CDCP1) gene in colorectal tumour cellsQ40163759
Ganglioside GM2-tetraspanin CD82 complex inhibits met and its cross-talk with integrins, providing a basis for control of cell motility through glycosynapseQ40184546
Epigenetic regulation of the expression of the novel stem cell marker CDCP1 in cancer cellsQ40258355
Tetraspanin KAI1/CD82 suppresses invasion by inhibiting integrin-dependent crosstalk with c-Met receptor and Src kinasesQ40343230
Requirement of the p130CAS-Crk Coupling for Metastasis Suppressor KAI1/CD82-mediated Inhibition of Cell MigrationQ40648952
Motility inhibition and apoptosis are induced by metastasis-suppressing gene product CD82 and its analogue CD9, with concurrent glycosylationQ40951942
The von Hippel-Lindau Tumor Suppressor Protein Is Destabilized by Src: Implications for Tumor Angiogenesis and ProgressionQ41612038
Immunohistochemical expression of hepatocyte growth factor and c-Met/HGF receptor in benign and malignant human prostate tissue.Q42445195
Hypoxic induction of human vascular endothelial growth factor expression through c-Src activationQ42826789
CUB domain-containing protein 1, a prognostic factor for human pancreatic cancers, promotes cell migration and extracellular matrix degradationQ43054551
Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-srcQ44049774
von Hippel-Lindau protein complex is regulated by cell densityQ44548991
P407language of work or nameEnglishQ1860
P921main subjectprostate cancerQ181257
P304page(s)81
P577publication date2012-03-06
P1433published inBMC CancerQ326300
P1476titleKAI1 suppresses HIF-1α and VEGF expression by blocking CDCP1-enhanced Src activation in prostate cancer
P478volume12

Reverse relations

cites work (P2860)
Q96576951An oncogenic viral interferon regulatory factor upregulates CUB domain-containing protein 1 to promote angiogenesis by hijacking transcription factor lymphoid enhancer-binding factor 1 and metastasis suppressor CD82
Q35908155Clinicopathological significance of KAI1 expression and epithelial-mesenchymal transition in non-small cell lung cancer
Q49787471Differential tumor biological role of the tumor suppressor KAI1 and its splice variant in human breast cancer cells
Q37106752Downregulation of coding transmembrane protein 35 gene inhibits cell proliferation, migration and cell cycle arrest in osteosarcoma cells
Q34182116Expression characteristics of KAI1 and vascular endothelial growth factor and their diagnostic value for hepatocellular carcinoma
Q35728113Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling
Q36948925Nm23-H1 was involved in regulation of KAI1 expression in high-metastatic lung cancer cells L9981.
Q37701094Overexpression of KAI1 inhibits retinoblastoma metastasis in vitro
Q37720265Overexpression of KAI1/CD82 suppresses in vitro cell growth, migration, invasion and xenograft growth in oral cancer
Q37370796RNAi-mediated knockdown of pituitary tumor- transforming gene-1 (PTTG1) suppresses the proliferation and invasive potential of PC3 human prostate cancer cells
Q41387582Relationship between the expression of CD133, HIF-1α, VEGF and the proliferation and apoptosis in hypoxic human prostate cancer cells
Q38750232Silencing of ST6Gal I enhances colorectal cancer metastasis by down-regulating KAI1 via exosome-mediated exportation and thereby rescues integrin signaling
Q38579796Tetraspanin CD82: a suppressor of solid tumors and a modulator of membrane heterogeneity.
Q26782593The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: new therapeutic targets
Q35832242The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1.
Q64917560c-Src is required for hypoxia-induced metastasis-associated functions in prostate cancer cells.

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