Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst.

scientific article

Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1083/JCB.201005026
P932PMC publication ID2953431
P698PubMed publication ID20876279
P5875ResearchGate publication ID46578464

P50authorDaniel B. ConstamQ43193993
P2093author name stringDaniel Mesnard
P2860cites workSecretory proprotein convertases PACE4 and PC6A are heparin-binding proteins which are localized in the extracellular matrix. Potential role of PACE4 in the activation of proproteins in the extracellular matrixQ24292847
Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathwayQ24299162
VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5Q24318787
SPC4/PACE4 regulates a TGFbeta signaling network during axis formationQ24606300
Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterningQ83854023
Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturationQ24652581
Furin at the cutting edge: from protein traffic to embryogenesis and diseaseQ24670432
Cutting back on pro-protein convertases: the latest approaches to pharmacological inhibitionQ28253642
PixFRET, an ImageJ plug-in for FRET calculation that can accommodate variations in spectral bleed-throughsQ28364730
Nodal activity in the node governs left-right asymmetryQ28509741
Membrane-anchorage of Cripto protein by glycosylphosphatidylinositol and its distribution during early mouse developmentQ28586753
Extraembryonic proteases regulate Nodal signalling during gastrulationQ28587824
Nodal signalling in the epiblast patterns the early mouse embryoQ28587896
Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furinQ28610296
Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development.Q33223370
Identification of inhibitors using a cell-based assay for monitoring Golgi-resident protease activityQ33275047
Riding shotgun: a dual role for the epidermal growth factor-Cripto/FRL-1/Cryptic protein Cripto in Nodal traffickingQ33420068
Inhibition of furin/proprotein convertase-catalyzed surface and intracellular processing by small moleculesQ33424237
Running the gauntlet: an overview of the modalities of travel employed by the putative morphogen NodalQ33486865
In vivo bioluminescence imaging of furin activity in breast cancer cells using bioluminogenic substrates.Q33926247
FRET imagingQ34274048
The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4.Q34562974
Making a commitment: cell lineage allocation and axis patterning in the early mouse embryoQ34917544
Synthetic small molecule furin inhibitors derived from 2,5-dideoxystreptamineQ35544367
Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases.Q36288112
alpha1-Antitrypsin Portland, a bioengineered serpin highly selective for furin: application as an antipathogenic agentQ36485158
In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrateQ36545901
Fluorescent biosensors of protein functionQ37087544
The activation and physiological functions of the proprotein convertasesQ37110934
Relationship between asymmetric nodal expression and the direction of embryonic turningQ38357925
Membrane-bound FRET probe visualizes MMP12 activity in pulmonary inflammation.Q39817857
Detection of MMP activity in living cells by a genetically encoded surface-displayed FRET sensorQ40190650
Correcting confocal acquisition to optimize imaging of fluorescence resonance energy transfer by sensitized emissionQ40278792
The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinasesQ40379230
Multicolour imaging of post-Golgi sorting and trafficking in live cellsQ40827648
A second mutant allele of furin in the processing-incompetent cell line, LoVo. Evidence for involvement of the homo B domain in autocatalytic activation.Q41272529
Generating green fluorescent mice by germline transmission of green fluorescent ES cellsQ42819708
The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substratesQ46881400
Tissue-specific requirements for the proprotein convertase furin/SPC1 during embryonic turning and heart looping.Q52172311
Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin.Q52182366
Imaging specific cell-surface proteolytic activity in single living cells.Q53631043
nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulationQ73124215
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)129-139
P577publication date2010-09-27
P1433published inJournal of Cell BiologyQ1524550
P1476titleImaging proprotein convertase activities and their regulation in the implanting mouse blastocyst
P478volume191

Reverse relations

cites work (P2860)
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Q30506212Dynamics of anterior-posterior axis formation in the developing mouse embryo
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Q37981645On the cutting edge of proprotein convertase pharmacology: from molecular concepts to clinical applications
Q35791220PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation.
Q41910908Pcsk5 is required in the early cranio-cardiac mesoderm for heart development
Q51859515RNA sequencing reveals novel gene clusters in bovine conceptuses associated with maternal recognition of pregnancy and implantation.
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Q38017196The biology and therapeutic targeting of the proprotein convertases
Q35220224The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities.