| scholarly article | Q13442814 |
| P50 | author | Edwin Chapman | Q59541853 |
| Colin P Johnson | Q60023860 | ||
| P2860 | cites work | Mechanisms of tryptophan fluorescence shifts in proteins | Q24537447 |
| OTOF encodes multiple long and short isoforms: genetic evidence that the long ones underlie recessive deafness DFNB9. | Q24538784 | ||
| Q829X, a novel mutation in the gene encoding otoferlin (OTOF), is frequently found in Spanish patients with prelingual non-syndromic hearing loss. | Q24679154 | ||
| Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine | Q27637071 | ||
| Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold | Q27729921 | ||
| Solution structures of the Ca2+-free and Ca2+-bound C2A domain of synaptotagmin I: does Ca2+ induce a conformational change? | Q27766047 | ||
| How synaptotagmin promotes membrane fusion. | Q27863355 | ||
| Synaptotagmin activates membrane fusion through a Ca2+-dependent trans interaction with phospholipids | Q27863371 | ||
| SNAREpins: minimal machinery for membrane fusion | Q28131697 | ||
| Substitutions in the conserved C2C domain of otoferlin cause DFNB9, a form of nonsyndromic autosomal recessive deafness | Q28215256 | ||
| Characterization of lipid binding specificities of dysferlin C2 domains reveals novel interactions with phosphoinositides | Q28236858 | ||
| Phase-locked response to low-frequency tones in single auditory nerve fibers of the squirrel monkey | Q28248734 | ||
| Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse | Q28269823 | ||
| C2 domains from different Ca2+ signaling pathways display functional and mechanistic diversity | Q28360864 | ||
| Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form | Q28572163 | ||
| Differential expression of otoferlin in brain, vestibular system, immature and mature cochlea of the rat | Q28572458 | ||
| Synaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusion | Q28584744 | ||
| A missense mutation in the conserved C2B domain of otoferlin causes deafness in a new mouse model of DFNB9 | Q30492341 | ||
| How does synaptotagmin trigger neurotransmitter release? | Q33345212 | ||
| SNARE complex at the ribbon synapses of cochlear hair cells: analysis of synaptic vesicle- and synaptic membrane-associated proteins | Q33856876 | ||
| Transmitter release at the hair cell ribbon synapse | Q34110366 | ||
| The tandem C2 domains of synaptotagmin contain redundant Ca2+ binding sites that cooperate to engage t-SNAREs and trigger exocytosis. | Q36294041 | ||
| Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells | Q36325534 | ||
| Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+. | Q36943507 | ||
| The Janus-faced nature of the C(2)B domain is fundamental for synaptotagmin-1 function. | Q36983031 | ||
| Evidence that vesicles undergo compound fusion on the synaptic ribbon | Q38790578 | ||
| Ca(2+)-synaptotagmin directly regulates t-SNARE function during reconstituted membrane fusion. | Q41791620 | ||
| Synaptotagmin C2B domain regulates Ca2+-triggered fusion in vitro: critical residues revealed by scanning alanine mutagenesis | Q41894155 | ||
| Direct interaction of otoferlin with syntaxin 1A, SNAP-25, and the L-type voltage-gated calcium channel Cav1.3. | Q42138536 | ||
| Otoferlin interacts with myosin VI: implications for maintenance of the basolateral synaptic structure of the inner hair cell. | Q43779285 | ||
| Reconstitution of Ca2+-regulated membrane fusion by synaptotagmin and SNAREs. | Q44814891 | ||
| Fusion pore dynamics are regulated by synaptotagmin*t-SNARE interactions. | Q47874870 | ||
| Synaptotagmin: a calcium sensor on the synaptic vesicle surface | Q48480063 | ||
| The transmembrane domain of syntaxin 1A is critical for cytoplasmic domain protein-protein interactions | Q48933075 | ||
| Ca2+ regulates the interaction between synaptotagmin and syntaxin 1. | Q52508040 | ||
| A novel missense mutation in a C2 domain of OTOF results in autosomal recessive auditory neuropathy. | Q54649007 | ||
| Isolated p65 protein reproduces membrane binding activity of synaptic vesicles | Q68193009 | ||
| Morphological differences among radial afferent fibers in the cat cochlea: an electron-microscopic study of serial sections | Q71269057 | ||
| Kinetics of synaptotagmin responses to Ca2+ and assembly with the core SNARE complex onto membranes | Q73203897 | ||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 187-197 | |
| P577 | publication date | 2010-10-01 | |
| 2010-10-04 | |||
| P1433 | published in | Journal of Cell Biology | Q1524550 |
| P1476 | title | Otoferlin is a calcium sensor that directly regulates SNARE-mediated membrane fusion | |
| P478 | volume | 191 |
| Q57048250 | A Member of the Ferlin Calcium Sensor Family Is Essential for Toxoplasma gondii Rhoptry Secretion |
| Q30393203 | A novel missense mutation in the C2C domain of otoferlin causes profound hearing impairment in an Omani family with auditory neuropathy |
| Q42372763 | Activity-Dependent Phosphorylation by CaMKIIδ Alters the Ca2+ Affinity of the Multi-C2-Domain Protein Otoferlin |
| Q38739507 | Auditory neuropathy--neural and synaptic mechanisms |
| Q37703486 | Ca2+-Calmodulin regulates SNARE assembly and spontaneous neurotransmitter release via v-ATPase subunit V0a1. |
| Q30575681 | Calcium regulates molecular interactions of otoferlin with soluble NSF attachment protein receptor (SNARE) proteins required for hair cell exocytosis |
| Q53115389 | Calpains, cleaved mini-dysferlinC72, and L-type channels underpin calcium-dependent muscle membrane repair. |
| Q34089077 | Characterization of the lipid binding properties of Otoferlin reveals specific interactions between PI(4,5)P2 and the C2C and C2F domains |
| Q30558105 | Cholinergic efferent synaptic transmission regulates the maturation of auditory hair cell ribbon synapses |
| Q36014550 | Comparative Transcriptome Analysis of Bombyx mori (Lepidoptera) Larval Midgut Response to BmNPV in Susceptible and Near-Isogenic Resistant Strains |
| Q83750661 | Deciphering the roles of C(2)-domain-containing proteins (synaptotagmins and otoferlin) in the inner ear |
| Q48695621 | Detection of Excitatory and Inhibitory Synapses in the Auditory System Using Fluorescence Immunohistochemistry and High-Resolution Fluorescence Microscopy |
| Q30430307 | Developmental acquisition of a rapid calcium-regulated vesicle supply allows sustained high rates of exocytosis in auditory hair cells |
| Q61449856 | Disruption of Otoferlin Alters the Mode of Exocytosis at the Mouse Inner Hair Cell Ribbon Synapse |
| Q26866150 | Distinct initial SNARE configurations underlying the diversity of exocytosis |
| Q35562324 | Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release. |
| Q64253691 | Dual AAV-mediated gene therapy restores hearing in a DFNB9 mouse model |
| Q42027752 | Dysferlin Binds SNAREs (Soluble N-Ethylmaleimide-sensitive Factor (NSF) Attachment Protein Receptors) and Stimulates Membrane Fusion in a Calcium-sensitive Manner |
| Q47096382 | Emerging Functional Differences between the Synaptotagmin and Ferlin Calcium Sensor Families |
| Q38201382 | Exocytosis and synaptic vesicle function |
| Q57339500 | Exocytotic Machineries of Vestibular Type I and Cochlear Ribbon Synapses Display Similar Intrinsic Otoferlin-Dependent Ca2+ Sensitivity But a Different Coupling to Ca2+ Channels |
| Q64940249 | Fer1l6 is essential for the development of vertebrate muscle tissue in zebrafish. |
| Q60016738 | FerA is a Membrane-Associating Four-Helix Bundle Domain in the Ferlin Family of Membrane-Fusion Proteins |
| Q92826260 | Ferlin Overview: From Membrane to Cancer Biology |
| Q27022787 | Ferlins: regulators of vesicle fusion for auditory neurotransmission, receptor trafficking and membrane repair |
| Q38907535 | Function coupling of otoferlin with GAD65 acts to modulate GABAergic activity |
| Q36685141 | Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1. |
| Q89921518 | Functions of Vertebrate Ferlins |
| Q42618413 | Hair Cell Transduction, Tuning, and Synaptic Transmission in the Mammalian Cochlea |
| Q45161041 | Hair cell synaptic dysfunction, auditory fatigue and thermal sensitivity in otoferlin Ile515Thr mutants |
| Q30374560 | Identification of a novel pathogenic OTOF variant causative of nonsyndromic hearing loss with high frequency in the Ashkenazi Jewish population. |
| Q42576112 | Impaired muscle growth and response to insulin-like growth factor 1 in dysferlin-mediated muscular dystrophy. |
| Q47806680 | Limited proteolysis as a tool to probe the tertiary conformation of dysferlin and structural consequences of patient missense variant L344P. |
| Q92339969 | Mapping developmental maturation of inner hair cell ribbon synapses in the apical mouse cochlea |
| Q36190308 | Metabolic context regulates distinct hypothalamic transcriptional responses to antiaging interventions |
| Q30443429 | Modes and regulation of endocytic membrane retrieval in mouse auditory hair cells |
| Q42209023 | Muscle membrane repair and inflammatory attack in dysferlinopathy. |
| Q34103354 | Myogenesis in dysferlin-deficient myoblasts is inhibited by an intrinsic inflammatory response |
| Q28068730 | New insights into cochlear sound encoding |
| Q90523387 | Otoferlin C2F Domain-Induced Changes in Membrane Structure Observed by Sum Frequency Generation |
| Q90468170 | Otoferlin Depletion Results in Abnormal Synaptic Ribbons and Altered Intracellular Calcium Levels in Zebrafish |
| Q47373170 | Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses |
| Q28572855 | Otoferlin couples to clathrin-mediated endocytosis in mature cochlear inner hair cells |
| Q30403961 | Otoferlin deficiency in zebrafish results in defects in balance and hearing: rescue of the balance and hearing phenotype with full-length and truncated forms of mouse otoferlin |
| Q49839459 | Otoferlin is a multivalent calcium-sensitive scaffold linking SNAREs and calcium channels |
| Q36240722 | Plasma Membrane Repair: A Central Process for Maintaining Cellular Homeostasis |
| Q41846565 | Presynaptic pH and vesicle fusion in Drosophila larvae neurones |
| Q30474026 | Probing the functional equivalence of otoferlin and synaptotagmin 1 in exocytosis |
| Q28306546 | Quantitation of the calcium and membrane binding properties of the C2 domains of dysferlin |
| Q55100657 | RPGR protein complex regulates proteasome activity and mediates store-operated calcium entry. |
| Q30407369 | Relating structure and function of inner hair cell ribbon synapses |
| Q30472617 | Short-term facilitation modulates size and timing of the synaptic response at the inner hair cell ribbon synapse |
| Q37900809 | Structure and development of cochlear afferent innervation in mammals |
| Q38432303 | Synaptic plasticity in the auditory system: a review |
| Q30396025 | Synaptic transmission between end bulbs of Held and bushy cells in the cochlear nucleus of mice with a mutation in Otoferlin. |
| Q42908556 | The C2 domains of otoferlin, dysferlin, and myoferlin alter the packing of lipid bilayers |
| Q38588353 | The Extracellular Vesicles of the Helminth Pathogen, Fasciola hepatica: Biogenesis Pathways and Cargo Molecules Involved in Parasite Pathogenesis. |
| Q34267880 | The SNARE complex in neuronal and sensory cells |
| Q57158364 | Transmission Disrupted: Modeling Auditory Synaptopathy in Zebrafish |
| Q30452490 | Transmitter release from cochlear hair cells is phase locked to cyclic stimuli of different intensities and frequencies |
| Q45160944 | What's hot about otoferlin |
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