Relating structure and function of inner hair cell ribbon synapses

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Relating structure and function of inner hair cell ribbon synapses is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1011797689
P356DOI10.1007/S00441-014-2102-7
P932PMC publication ID4487357
P698PubMed publication ID25874597

P50authorTobias MoserQ19310084
P2093author name stringC Wichmann
P2860cites workTransmitter release at the hair cell ribbon synapseQ34110366
In vivo knockdown of Piccolino disrupts presynaptic ribbon morphology in mouse photoreceptor synapsesQ34127109
Exocytosis at the hair cell ribbon synapse apparently operates without neuronal SNARE proteinsQ34168869
The presynaptic cytomatrix of brain synapses.Q34169245
Synaptic ribbon. Conveyor belt or safety belt?Q34176044
Interactions between Piccolo and the actin/dynamin-binding protein Abp1 link vesicle endocytosis to presynaptic active zonesQ34185752
Otoferlin is a calcium sensor that directly regulates SNARE-mediated membrane fusionQ34191602
Regulation of synaptic vesicle docking by different classes of macromolecules in active zone materialQ34206193
Ionic basis of the receptor potential in a vertebrate hair cellQ34211370
Sharp Ca²⁺ nanodomains beneath the ribbon promote highly synchronous multivesicular release at hair cell synapsesQ34233304
CaV1.3 channels are essential for development and presynaptic activity of cochlear inner hair cells.Q34279866
The auditory hair cell ribbon synapse: from assembly to functionQ34282892
Calcium dependence of the rate of exocytosis in a synaptic terminalQ34324078
Time and intensity coding at the hair cell's ribbon synapseQ34413081
Phase locking to high frequencies in the auditory nerve and cochlear nucleus magnocellularis of the barn owl, Tyto alba.Q34421012
Uniquantal release through a dynamic fusion pore is a candidate mechanism of hair cell exocytosisQ34437395
Transfer characteristics of the hair cell's afferent synapseQ34481679
Synaptic vesicle populations in saccular hair cells reconstructed by electron tomographyQ34485356
Maturation of ribbon synapses in hair cells is driven by thyroid hormoneQ34611014
Three-dimensional architecture of presynaptic terminal cytomatrix.Q34642485
Multiple RIBEYE-RIBEYE interactions create a dynamic scaffold for the formation of synaptic ribbonsQ34805032
Development of the inner ear efferent system across vertebrate speciesQ34968753
Kinetics of exocytosis and endocytosis at the cochlear inner hair cell afferent synapse of the mouseQ34980908
A correlative electron microscopic study of basket cells and large GABAergic neurons in the monkey sensory-motor cortexQ35044749
FM dye photo-oxidation as a tool for monitoring membrane recycling in inner hair cellsQ35088703
Characterization of Ribeye subunits in zebrafish hair cells reveals that exogenous Ribeye B-domain and CtBP1 localize to the basal ends of synaptic ribbonsQ35246189
Piccolo regulates the dynamic assembly of presynaptic F-actinQ35533808
Neurogenesis in the central olfactory pathway of adult decapod crustaceans: development of the neurogenic niche in the brains of procambarid crayfishQ35695142
The architecture of the active zone in the presynaptic nerve terminalQ35894403
Piccolo modulation of Synapsin1a dynamics regulates synaptic vesicle exocytosisQ36677497
The entry and clearance of Ca2+ at individual presynaptic active zones of hair cells from the bullfrog's sacculusQ36817743
The AP-2 adaptor beta2 appendage scaffolds alternate cargo endocytosisQ36992906
In vivo synaptic recovery following optogenetic hyperstimulationQ37088738
Developmental segregation in the afferent projections to mammalian auditory hair cellsQ37104641
Release sites and calcium channels in hair cells of the chick's cochleaQ73863909
Transport, capture and exocytosis of single synaptic vesicles at active zonesQ74265534
Depolarization redistributes synaptic membrane and creates a gradient of vesicles on the synaptic body at a ribbon synapseQ78541546
Ultrastructure of retinal rod synapses of the guinea pig eye as revealed by three-dimensional reconstructions from serial sectionsQ78559736
Structure of the nerve endings on the external hair cells of the guinea pig cochlea as studied by serial sectionsQ79420839
Automated detection and segmentation of synaptic contacts in nearly isotropic serial electron microscopy imagesQ21090988
Serial block-face scanning electron microscopy to reconstruct three-dimensional tissue nanostructureQ21563638
A mutation in OTOF, encoding otoferlin, a FER-1-like protein, causes DFNB9, a nonsyndromic form of deafnessQ22009151
Aczonin, a 550-kD putative scaffolding protein of presynaptic active zones, shares homology regions with Rim and Bassoon and binds profilinQ22010610
TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner earQ24599460
Channelrhodopsin-2, a directly light-gated cation-selective membrane channelQ24631167
Some features of the submicroscopic morphology of synapses in frog and earthwormQ24641866
OTOF mutations revealed by genetic analysis of hearing loss families including a potential temperature sensitive auditory neuropathy alleleQ24651350
Molecular dissection of the photoreceptor ribbon synapse: physical interaction of Bassoon and RIBEYE is essential for the assembly of the ribbon complexQ24678467
The presynaptic active zoneQ26269863
Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosisQ26269909
Molecular machines governing exocytosis of synaptic vesiclesQ26849286
Sustaining rapid vesicular release at active zones: potential roles for vesicle tetheringQ26865975
Sensing sound: molecules that orchestrate mechanotransduction by hair cellsQ26866077
Roles of AP-2 in clathrin-mediated endocytosisQ27329510
RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon functionQ28143542
Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle primingQ28188061
The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein PiccoloQ28217022
Phase-locked response to low-frequency tones in single auditory nerve fibers of the squirrel monkeyQ28248734
Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapseQ28269823
A multicenter study on the prevalence and spectrum of mutations in the otoferlin gene (OTOF) in subjects with nonsyndromic hearing impairment and auditory neuropathyQ28274777
Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteinsQ28276992
A SNARE complex containing syntaxin 3 is present in ribbon synapses of the retinaQ28291107
A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell functionQ28510685
Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cellsQ28511702
The presynaptic particle web: ultrastructure, composition, dissolution, and reconstitutionQ34095414
Two types of afferent terminals innervate cochlear inner hair cells in C57BL/6J mice.Q50479098
Cholinergic synaptic inhibition of inner hair cells in the neonatal mammalian cochlea.Q50495695
The synaptic ribbon is a site of phosphatidic acid generation in ribbon synapses.Q50508564
The cochlear frequency map for the cat: labeling auditory-nerve fibers of known characteristic frequency.Q50595087
On understanding the organisation of the retinal receptor synapsesQ51115380
The cytology of the developing molecular layer of mouse motor cortex. An electron microscopical and a Golgi impregnation study.Q51200273
Fast vesicle replenishment allows indefatigable signalling at the first auditory synapse.Q51818002
Increase in efficiency and reduction in Ca2+ dependence of exocytosis during development of mouse inner hair cells.Q52061934
The expression pattern and assembly profile of synaptic membrane proteins in ribbon synapses of the developing mouse retina.Q52108896
Ribbon synapses in the developing intact and cultured organ of Corti in the mouse.Q52504845
Spontaneous synaptic potentials from afferent terminals in the guinea pig cochleaQ53846736
Phase-locking in the cochlear nerve of the guinea-pig and its relation to the receptor potential of inner hair-cells.Q53893220
Innervation Densities of the CochleaQ58082485
Innervation Patterns in the Organ of Corti of the CatQ58178732
Serial Section Scanning Electron Microscopy of Adult Brain Tissue Using Focused Ion Beam MillingQ64868700
Colocalization of ion channels involved in frequency selectivity and synaptic transmission at presynaptic active zones of hair cellsQ67674833
Neurotransmitter release from hair cells and its blockade by glutamate-receptor antagonistsQ68306026
Central projections of intracellularly labeled auditory nerve fibers in cats: Morphometric correlations with physiological propertiesQ68415309
Afferent and efferent innervation of the cat cochlea: quantitative analysis with light and electron microscopyQ68637686
Ultrastructure of the synaptic ribbons in photoreceptor cells of Rana catesbeiana revealed by freeze-etching and freeze-substitutionQ68818564
Immunoelectron microscopic and immunofluorescent localization of cytoskeletal and muscle-like contractile proteins in inner ear sensory hair cellsQ69925621
Single-neuron labeling in the cat auditory nerveQ70357936
Hair-cell innervation by spiral ganglion cells in adult catsQ70383959
Voltage- and ion-dependent conductances in solitary vertebrate hair cellsQ70990965
The presynaptic grid: a new approachQ71139897
Morphological differences among radial afferent fibers in the cat cochlea: an electron-microscopic study of serial sectionsQ71269057
Fine structure of cochlear innervation in the catQ71430372
Ultrastructural differences among afferent synapses on cochlear hair cells: correlations with spontaneous discharge rateQ71603463
Confocal imaging of calcium microdomains and calcium extrusion in turtle hair cellsQ71623678
Three-dimensional aspects and synaptic relationships of a Golgi-impregnated spiny stellate cell reconstructed from serial thin sectionsQ72622700
Expression of alpha-actinin in the stereocilia of hair cells of the inner ear: immunohistochemical localizationQ72655943
Calcium-triggered exocytosis and endocytosis in an isolated presynaptic cell: capacitance measurements in saccular hair cellsQ72769744
The plasma membrane protein SNAP-25, but not syntaxin, is present at photoreceptor and bipolar cell synapses in the rat retinaQ73178456
Spatiotemporal definition of neurite outgrowth, refinement and retraction in the developing mouse cochlea.Q50456712
Hair cell synaptic ribbons are essential for synchronous auditory signalling.Q50473698
Bruchpilot, a protein with homology to ELKS/CAST, is required for structural integrity and function of synaptic active zones in DrosophilaQ47072025
Spike encoding of neurotransmitter release timing by spiral ganglion neurons of the cochleaQ47778790
Expression of a potassium current in inner hair cells during development of hearing in miceQ47908346
Evidence that vesicles on the synaptic ribbon of retinal bipolar neurons can be rapidly releasedQ47916923
Disruption of the presynaptic cytomatrix protein bassoon degrades ribbon anchorage, multiquantal release, and sound encoding at the hair cell afferent synapse.Q48136713
The unmyelinated nerve fibres of the cochleaQ48366148
Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoonQ48368670
The presynaptic active zone protein bassoon is essential for photoreceptor ribbon synapse formation in the retinaQ48368679
Molecular anatomy and physiology of exocytosis in sensory hair cells.Q48478986
Complexin-I is required for high-fidelity transmission at the endbulb of Held auditory synapse.Q48555363
Active zone protein CAST is a component of conventional and ribbon synapses in mouse retinaQ48646131
Synaptic patterns in the visual cortex of the cat and monkey. Electron microscopy of Golgi preparationsQ48650137
Enzymatic digestion of synaptic ribbons in amphibian retinal photoreceptorsQ48846989
Auditory hair cell-afferent fiber synapses are specialized to operate at their best frequenciesQ48947970
Probing the mechanism of exocytosis at the hair cell ribbon synapse.Q50454380
A common molecular basis for membrane docking and functional priming of synaptic vesiclesQ28512083
Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cellsQ28512601
Identification and immunocytochemical characterization of Piccolino, a novel Piccolo splice variant selectively expressed at sensory ribbon synapses of the eye and earQ28535170
The kinesin motor KIF3A is a component of the presynaptic ribbon in vertebrate photoreceptorsQ28568688
Localization of the presynaptic cytomatrix protein Piccolo at ribbon and conventional synapses in the rat retina: comparison with BassoonQ28570505
Bassoon and Piccolo maintain synapse integrity by regulating protein ubiquitination and degradationQ28572409
Otoferlin couples to clathrin-mediated endocytosis in mature cochlear inner hair cellsQ28572855
Rim is a putative Rab3 effector in regulating synaptic-vesicle fusionQ28575529
Molecular in situ topology of Aczonin/Piccolo and associated proteins at the mammalian neurotransmitter release siteQ28576284
Piccolo, a presynaptic zinc finger protein structurally related to bassoonQ28579838
Munc13-independent vesicle priming at mouse photoreceptor ribbon synapsesQ28586499
Calcium- and otoferlin-dependent exocytosis by immature outer hair cellsQ28592125
Fluorescence microscopy with diffraction resolution barrier broken by stimulated emissionQ29013438
RIBEYE, a Component of Synaptic RibbonsQ29540824
Far-field optical nanoscopyQ29615090
Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevinQ29619130
Definition of the readily releasable pool of vesicles at hippocampal synapsesQ29620402
Structure suggests function: the case for synaptic ribbons as exocytotic nanomachinesQ30307841
Developmental acquisition of sensory transduction in hair cells of the mouse inner earQ30311224
Phase-locking precision is enhanced by multiquantal release at an auditory hair cell ribbon synapseQ30402776
The precise temporal pattern of prehearing spontaneous activity is necessary for tonotopic map refinementQ30411197
Developmental refinement of hair cell synapses tightens the coupling of Ca2+ influx to exocytosisQ30419502
Quantitative analysis of ribbons, vesicles, and cisterns at the cat inner hair cell synapse: correlations with spontaneous rateQ30420214
Hair cell ribbon synapsesQ30432571
ACF7 is a hair-bundle antecedent, positioned to integrate cuticular plate actin and somatic tubulinQ30435772
Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochleaQ30435999
Modes and regulation of endocytic membrane retrieval in mouse auditory hair cellsQ30443429
Transmitter release from cochlear hair cells is phase locked to cyclic stimuli of different intensities and frequenciesQ30452490
Cytoskeletal changes in actin and microtubules underlie the developing surface mechanical properties of sensory and supporting cells in the mouse cochleaQ30453489
Synaptic profiles during neurite extension, refinement and retraction in the developing cochleaQ30459067
Striated organelle, a cytoskeletal structure positioned to modulate hair-cell transductionQ30469246
Opposing gradients of ribbon size and AMPA receptor expression underlie sensitivity differences among cochlear-nerve/hair-cell synapsesQ30470171
Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cellsQ30472648
Probing the functional equivalence of otoferlin and synaptotagmin 1 in exocytosisQ30474026
The diverse roles of ribbon synapses in sensory neurotransmissionQ30475345
Molecular Anatomy of the Hair Cell's Ribbon SynapseQ30476380
Frequency selectivity of synaptic exocytosis in frog saccular hair cellsQ30477026
Onset coding is degraded in auditory nerve fibers from mutant mice lacking synaptic ribbonsQ30478316
Otoferlin is critical for a highly sensitive and linear calcium-dependent exocytosis at vestibular hair cell ribbon synapsesQ30479008
Time course and calcium dependence of transmitter release at a single ribbon synapseQ30480290
Elementary properties of CaV1.3 Ca(2+) channels expressed in mouse cochlear inner hair cellsQ30483381
Mechanisms contributing to synaptic Ca2+ signals and their heterogeneity in hair cellsQ30486542
The unitary event underlying multiquantal EPSCs at a hair cell's ribbon synapseQ30489543
A missense mutation in the conserved C2B domain of otoferlin causes deafness in a new mouse model of DFNB9Q30492341
Null mutation of alpha1D Ca2+ channel gene results in deafness but no vestibular defect in miceQ30492652
Genetic deletion of SK2 channels in mouse inner hair cells prevents the developmental linearization in the Ca2+ dependence of exocytosisQ30493594
Two modes of release shape the postsynaptic response at the inner hair cell ribbon synapseQ30494256
Electron microscope observations on synaptic vesicles in synapses of the retinal rods and conesQ30494541
Calcium action potentials in hair cells pattern auditory neuron activity before hearing onsetQ30496297
Bassoon and the synaptic ribbon organize Ca²+ channels and vesicles to add release sites and promote refillingQ30497701
Control of exocytosis by synaptotagmins and otoferlin in auditory hair cellsQ30500089
Synapses involving auditory nerve fibers in primate cochleaQ30500963
Cryo-electron tomography reveals a critical role of RIM1α in synaptic vesicle tetheringQ30540085
Presynaptic maturation in auditory hair cells requires a critical period of sensory-independent spiking activityQ30540139
Burst activity and ultrafast activation kinetics of CaV1.3 Ca²⁺ channels support presynaptic activity in adult gerbil hair cell ribbon synapsesQ30544155
Cholinergic efferent synaptic transmission regulates the maturation of auditory hair cell ribbon synapsesQ30558105
Spatiotemporal pattern of action potential firing in developing inner hair cells of the mouse cochleaQ30571310
Calcium regulates molecular interactions of otoferlin with soluble NSF attachment protein receptor (SNARE) proteins required for hair cell exocytosisQ30575681
A study of cochlear innervation patterns in cats and rats with the Golgi method and Nomarski opticsQ30930143
The architecture of active zone material at the frog's neuromuscular junctionQ30981051
Passive diffusion as a mechanism underlying ribbon synapse vesicle release and resupplyQ31171218
Efficient quantification of afferent cochlear ultrastructure using design-based stereologyQ33222100
Quantitative analysis of the native presynaptic cytomatrix by cryoelectron tomographyQ33523242
A new probe for super-resolution imaging of membranes elucidates trafficking pathwaysQ33663162
SNARE complex at the ribbon synapses of cochlear hair cells: analysis of synaptic vesicle- and synaptic membrane-associated proteinsQ33856876
Neurotoxins affecting neuroexocytosisQ33881286
Presynaptic proteins of ribbon synapses in the retinaQ33966295
Characterization of transcriptomes of cochlear inner and outer hair cellsQ34037606
Ultrafast endocytosis at Caenorhabditis elegans neuromuscular junctionsQ37145198
The making of synaptic ribbons: how they are built and what they do.Q37584921
Action potential evoked transmitter release in central synapses: insights from the developing calyx of HeldQ37638786
Ultrafast endocytosis at mouse hippocampal synapses.Q37642826
The active zone T-bar--a plasticity module?Q37765592
Structure and function of cochlear afferent innervationQ37783878
Otoferlin: a multi-C2 domain protein essential for hearingQ38041835
Revisiting planar cell polarity in the inner ear.Q38096733
Evolution and development of hair cell polarity and efferent function in the inner ear.Q38207860
Acute destruction of the synaptic ribbon reveals a role for the ribbon in vesicle primingQ38374281
FM1-43 dye behaves as a permeant blocker of the hair-cell mechanotransducer channel.Q39414905
A local, periactive zone endocytic machinery at photoreceptor synapses in close vicinity to synaptic ribbons.Q39755111
Myosin VI is required for the proper maturation and function of inner hair cell ribbon synapsesQ39801019
Sensory neural organization of the cochleaQ39830462
Quantal analysis of the size of excitatory post-synaptic potentials at synapses between hair cells and afferent nerve fibres in goldfishQ40146648
Acoustic trauma in cats. Cochlear pathology and auditory-nerve activityQ40565392
Protein composition of immunoprecipitated synaptic ribbonsQ40909612
Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter releaseQ41017986
Plasticity of retinal ribbon synapsesQ41336952
Two pathways of synaptic vesicle retrieval revealed by single-vesicle imagingQ41997492
Olivocochlear innervation maintains the normal modiolar-pillar and habenular-cuticular gradients in cochlear synaptic morphologyQ42128493
Direct interaction of otoferlin with syntaxin 1A, SNAP-25, and the L-type voltage-gated calcium channel Cav1.3.Q42138536
A procedure to label inner ear afferent nerve endings for calcium imagingQ42462424
Calcium currents in hair cells isolated from the cochlea of the chickQ42466252
Naked dense bodies provoke depression.Q42478978
Tubulin and microtubules in cochlear hair cells: comparative immunocytochemistry and ultrastructureQ42495531
Stepwise morphological and functional maturation of mechanotransduction in rat outer hair cells.Q42522454
Olivocochlear innervation of inner and outer hair cells during postnatal maturation: an immunocytochemical studyQ42525590
Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type Ca2+ channelsQ43505857
Organization of microtubules in cochlear hair cellsQ43535751
The presynaptic function of mouse cochlear inner hair cells during development of hearing.Q43653395
Otoferlin interacts with myosin VI: implications for maintenance of the basolateral synaptic structure of the inner hair cell.Q43779285
Fm1-43 reveals membrane recycling in adult inner hair cells of the mammalian cochlea.Q43999156
Evidence for synergistic and complementary roles of Bassoon and darkness in organizing the ribbon synapseQ44089492
Imaging calcium entry sites and ribbon structures in two presynaptic cells.Q44396199
A transiently expressed SK current sustains and modulates action potential activity in immature mouse inner hair cellsQ45032594
Developmental regulation of nicotinic synapses on cochlear inner hair cells.Q45050772
Neuroanatomical basis of cochlear coding mechanismsQ45201536
Two ribeye genes in teleosts: the role of Ribeye in ribbon formation and bipolar cell development.Q45240211
Tuning of synapse number, structure and function in the cochleaQ46095432
Concurrent maturation of inner hair cell synaptic Ca2+ influx and auditory nerve spontaneous activity around hearing onset in mice.Q46321677
Facilitating efferent inhibition of inner hair cells in the cochlea of the neonatal rat.Q46477236
Freeze-fracture organization of hair cell synapses in the sensory epithelium of guinea pig organ of CortiQ46512507
The ultrastructure of the innersegments of the retinal rods of the guinea pig eye as revealed by electron microscopyQ46862301
Evidence that fast exocytosis can be predominantly mediated by vesicles not docked at active zones in frog saccular hair cellsQ46880694
The origin of spontaneous activity in the developing auditory system.Q46922216
Synaptic and Golgi membrane recycling in cochlear hair cellsQ46948642
Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle releaseQ47070593
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P921main subjectribbon synapseQ7322268
cellQ7868
nervous systemQ9404
sensory nervous systemQ11101
P304page(s)95-114
P577publication date2015-01-22
2015-07-01
P1433published inCell and Tissue ResearchQ1524113
P1476titleRelating structure and function of inner hair cell ribbon synapses
P478volume361

Reverse relations

cites work (P2860)
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Q47867981The synaptic ribbon is critical for sound encoding at high rates and with temporal precision
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