CD40L deficiency attenuates diet-induced adipose tissue inflammation by impairing immune cell accumulation and production of pathogenic IgG-antibodies

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CD40L deficiency attenuates diet-induced adipose tissue inflammation by impairing immune cell accumulation and production of pathogenic IgG-antibodies is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...733026W
P356DOI10.1371/JOURNAL.PONE.0033026
P932PMC publication ID3297623
P698PubMed publication ID22412980
P5875ResearchGate publication ID221698744

P50authorAndreas ZirlikQ42685004
Karlheinz PeterQ47504540
Christoph J BinderQ54148886
Dennis WolfQ56949433
Christoph BodeQ60457714
P2093author name stringIngo Hilgendorf
Alexandra Ortiz Rodriguez
Andrey Lozhkin
Christian Colberg
Florian Willecke
Natalie Hoppe
Constantin von zur Muhlen
Bianca Dufner
Peter Stachon
Ansgar Wiedemann
Benjamin Rupprecht
Felix Jehle
Mark Febbraio
Nicole Bassler
P2860cites workAdiposity and cardiovascular disorders: disturbance of the regulatory system consisting of humoral and neuronal signalsQ36872199
Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humansQ37170775
CD40 and autoimmunity: the dark side of a great activator.Q37365433
A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alphaQ38321742
Diabetes and cardiovascular disease. The "common soil" hypothesisQ40495289
TRAF-1, -2, -3, -5, and -6 are induced in atherosclerotic plaques and differentially mediate proinflammatory functions of CD40L in endothelial cells.Q42509065
The inflammatory receptor CD40 is expressed on human adipocytes: contribution to crosstalk between lymphocytes and adipocytes.Q42803704
Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesityQ42811622
A protective role for CD154 in hepatic steatosis in miceQ42824021
Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men.Q44055110
Association between enhanced soluble CD40L and prothrombotic state in hypercholesterolemia: effects of statin therapyQ44075631
Elevated plasma levels of the atherogenic mediator soluble CD40 ligand in diabetic patients: a novel target of thiazolidinedionesQ44438462
Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL.Q46095021
Unexpected trafficking of immune cells within the adipose tissue during the onset of obesityQ47861318
Reduction of atherosclerosis in mice by inhibition of CD40 signallingQ24316540
B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodiesQ24598772
Obesity and insulin resistanceQ24607078
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistanceQ24617743
A simple method for the isolation and purification of total lipides from animal tissuesQ25939009
Inflammation and metabolic disordersQ27860923
Obesity is associated with macrophage accumulation in adipose tissueQ27860976
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistanceQ28131660
The CD40/CD154 receptor/ligand dyadQ28202756
Obesity induces a phenotypic switch in adipose tissue macrophage polarizationQ29547686
MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesityQ29614283
Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination SurveyQ29614468
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesityQ29617380
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parametersQ29617381
Adipocytokines: mediators linking adipose tissue, inflammation and immunityQ29619393
Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesisQ29619888
Obesity and the regulation of energy balanceQ30080025
The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesityQ33550783
Tumor necrosis factor receptor associated factor 6 is not required for atherogenesis in mice and does not associate with atherosclerosis in humansQ33996260
The case of visceral fat: argument for the defenseQ34328606
Tumor necrosis factor receptor-associated factor 1 (TRAF1) deficiency attenuates atherosclerosis in mice by impairing monocyte recruitment to the vessel wallQ34369244
Mechanisms linking obesity with cardiovascular diseaseQ34590832
Chemokines in atherosclerosis: an updateQ34656531
A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responsesQ34778834
Normalization of obesity-associated insulin resistance through immunotherapyQ34994222
Inhibition of CD40 signaling limits evolution of established atherosclerosis in miceQ35160907
Hepatic steatosis: a mediator of the metabolic syndrome. Lessons from animal modelsQ35625539
Preprocedural level of soluble CD40L is predictive of enhanced inflammatory response and restenosis after coronary angioplasty.Q53850992
Increased Inflammatory Properties of Adipose Tissue Macrophages Recruited During Diet-Induced ObesityQ58197140
CD154 (CD40 ligand)Q73902274
Growth hormone in obesityQ77292368
T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistanceQ81108550
Atherogenesis in mice does not require CD40 ligand from bone marrow-derived cellsQ81475509
CD40L induces inflammation and adipogenesis in adipose cells--a potential link between metabolic and cardiovascular diseaseQ82991481
TRAF5 deficiency accelerates atherogenesis in mice by increasing inflammatory cell recruitment and foam cell formationQ84586722
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
P304page(s)e33026
P577publication date2012-03-08
P1433published inPLOS OneQ564954
P1476titleCD40L deficiency attenuates diet-induced adipose tissue inflammation by impairing immune cell accumulation and production of pathogenic IgG-antibodies
P478volume7

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cites work (P2860)
Q35753282Adaptive Immunity and Antigen-Specific Activation in Obesity-Associated Insulin Resistance
Q47670316Adaptive Immunity and Metabolic Health: Harmony Becomes Dissonant in Obesity and Aging
Q37031087Adipose tissue macrophages function as antigen-presenting cells and regulate adipose tissue CD4+ T cells in mice
Q38152732B Lymphocytes in obesity-related adipose tissue inflammation and insulin resistance
Q51035537Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice.
Q36836306CD40 deficiency in mice exacerbates obesity-induced adipose tissue inflammation, hepatic steatosis, and insulin resistance
Q35360534CD40-mediated maintenance of immune homeostasis in the adipose tissue microenvironment.
Q92463116Deficiency of T cell CD40L has minor beneficial effects on obesity-induced metabolic dysfunction
Q90663200Depletion of CD40 on CD11c+ cells worsens the metabolic syndrome and ameliorates hepatic inflammation during NASH
Q49519207Dichotomous roles of co-stimulatory molecules in diabetes mellitus.
Q50722340Generation of mice with conditional ablation of the Cd40lg gene: new insights on the role of CD40L.
Q50276949IgG is elevated in obese white adipose tissue but does not induce glucose intolerance via Fcγ-receptor or complement.
Q55043186Interrelation of Diet, Gut Microbiome, and Autoantibody Production.
Q27687298Lymphocyte roles in metabolic dysfunction: of men and mice
Q91719323Myeloid-derived suppressor cells are bound and inhibited by anti-thymocyte globulin
Q43182095New frontiers for platelet CD154.
Q41179559Regulatory role of CD40 in obesity-induced insulin resistance
Q41338463The Cell Surface Markers Expression in Postmenopausal Women and Relation to Obesity and Bone Status

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