Matrix production and remodeling as therapeutic targets for uterine leiomyoma

scientific article

Matrix production and remodeling as therapeutic targets for uterine leiomyoma is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1003986939
P356DOI10.1007/S12079-014-0234-X
P932PMC publication ID4165822
P698PubMed publication ID25012731

P2093author name stringJohn J Castellot
Caitlin Fujisawa
P2860cites workHuman leiomyoma smooth muscle cells show increased expression of transforming growth factor-beta 3 (TGF beta 3) and altered responses to the antiproliferative effects of TGF betaQ24290740
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1,25-dihydroxyvitamin D3 treatment shrinks uterine leiomyoma tumors in the Eker rat modelQ24632275
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Estrogen metabolite 2-methoxyestradiol induces apoptosis and inhibits cell proliferation and collagen production in rat and human leiomyoma cells: a potential medicinal treatment for uterine fibroidsQ29347067
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High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidenceQ33963976
Human uterine leiomyoma-derived fibroblasts stimulate uterine leiomyoma cell proliferation and collagen type I production, and activate RTKs and TGF beta receptor signaling in cocultureQ33964731
Comparative ultrastructure of collagen fibrils in uterine leiomyomas and normal myometriumQ34064015
Integrin β1 regulates leiomyoma cytoskeletal integrity and growthQ34084035
Gene expression analysis reveals an angiogenic profile in uterine leiomyoma pseudocapsuleQ53102062
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Engineering the Growth Factor Microenvironment with Fibronectin Domains to Promote Wound and Bone Tissue HealingQ53528097
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Expression of insulin-like growth factors (IGFs) and IGF signaling: molecular complexity in uterine leiomyomas.Q54535265
A novel selective progesterone receptor modulator asoprisnil (J867) down-regulates the expression of EGF, IGF-I, TGFbeta3 and their receptors in cultured uterine leiomyoma cells.Q54608831
Variation in the Incidence of Uterine Leiomyoma Among Premenopausal Women by Age and RaceQ57751559
Vitamin D Status in Women With Uterine LeiomyomasQ58860606
Efficacy of a low-dose leuprolide acetate depot in the treatment of uterine leiomyomata in Japanese womenQ68194610
Growth factors and cancerQ70121988
Mitogenic effect of basic fibroblast growth factor and estradiol on cultured human myometrial and leiomyoma cellsQ71985176
Growth factors in the extracellular matrixQ73075408
A prospective randomized study comparing endocrinological and clinical effects of two types of GnRH agonists in cases of uterine leiomyomas or endometriosisQ73370347
Expression of the fibroblast growth factor receptor in women with leiomyomas and abnormal uterine bleedingQ73691408
Extracellular matrix components in uterine leiomyoma and their alteration during the tumour growthQ77763549
A randomized, controlled trial of asoprisnil, a novel selective progesterone receptor modulator, in women with uterine leiomyomataQ79791604
Gonadotropin releasing hormone and transforming growth factor beta activate mitogen-activated protein kinase/extracellularly regulated kinase and differentially regulate fibronectin, type I collagen, and plasminogen activator inhibitor-1 expressionQ80974809
Fibroblast growth factors (FGF) in human myometrium and uterine leiomyomas in various stages of tumour growthQ81155526
Activity of matrix metalloproteinase-2 and -9 and contents of their tissue inhibitors in uterine leiomyoma and corresponding myometriumQ81456048
Expression and functional analysis of platelet-derived growth factor in uterine leiomyomataQ81492992
Downregulation of the integrin α(v) signaling pathway in uterine leiomyomasQ82847592
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Vitamin d and the risk of uterine fibroidsQ37671721
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Decorin-binding Sites for Collagen Type I Are Mainly Located in Leucine-rich Repeats 4-5Q38291995
Extracellular matrix binding properties of recombinant fibronectin type II-like modules of human 72-kDa gelatinase/type IV collagenase. High affinity binding to native type I collagen but not native type IV collagenQ38295371
Fibromodulin is expressed in leiomyoma and myometrium and regulated by gonadotropin-releasing hormone analogue therapy and TGF-beta through Smad and MAPK-mediated signallingQ38321757
Down-regulation of collagen synthesis and matrix metalloproteinase expression in myofibroblasts from Dupuytren nodule using adenovirus-mediated relaxin gene therapy.Q38443986
Laparoscopic myomectomy focusing on the myoma pseudocapsule: technical and outcome reportsQ39255950
Uterine artery embolization for severe symptomatic fibroids: effects on fertility and symptomsQ39271323
2-Methoxyestradiol causes functional repression of transforming growth factor β3 signaling by ameliorating Smad and non-Smad signaling pathways in immortalized uterine fibroid cellsQ39349826
Myometrial cells undergo fibrotic transformation under the influence of transforming growth factor beta-3.Q39867260
AKAP13, a RhoA GTPase-specific guanine exchange factor, is a novel regulator of TLR2 signalingQ40079062
Src and focal adhesion kinase mediate mechanical strain-induced proliferation and ERK1/2 phosphorylation in human H441 pulmonary epithelial cellsQ40184472
Distinct modes of collagen type I proteolysis by matrix metalloproteinase (MMP) 2 and membrane type I MMP during the migration of a tip endothelial cell: insights from a computational model.Q40407111
Regulation of IGF-I production and proliferation of human leiomyomal smooth muscle cells by Scutellaria barbata D. Don in vitro: isolation of flavonoids of apigenin and luteolin as acting compoundsQ40416112
Wounding induces motility in sheets of corneal epithelial cells through loss of spatial constraints: role of heparin-binding epidermal growth factor-like growth factor signalingQ40574655
Tumor-stromal cell contact promotes invasion of human uterine cervical carcinoma cells by augmenting the expression and activation of stromal matrix metalloproteinasesQ40594336
The expression of integrins and cadherins in normal human uterus and uterine leiomyomasQ41180472
Insulin-like growth factor (IGF), IGF binding protein (IGFBP), and IGF receptor gene expression and IGFBP synthesis in human uterine leiomyomataQ41660451
Transforming growth factor beta (TGF beta) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblastsQ41955517
Human uterine leiomyoma cells: binding and growth responses to epidermal growth factor, platelet-derived growth factor, and insulin.Q42492565
Fibronectin Growth Factor-Binding Domains Are Required for Fibroblast SurvivalQ42825954
Levonorgestrel inhibits proliferation and induces apoptosis in uterine leiomyoma cellsQ42939335
Clinical long-term outcome after uterine artery embolization: sustained symptom control and improvement of quality of lifeQ43469535
Identification, quantification and fine structural characterization of glycosaminoglycans from uterine leiomyoma and normal myometriumQ43708391
Up-regulation by IGF-I of proliferating cell nuclear antigen and Bcl-2 protein expression in human uterine leiomyoma cellsQ43794640
Dysregulation of IGF-I signaling in uterine leiomyomaQ43851259
Proliferative activity of human uterine leiomyoma cells as measured by automatic image analysisQ44104200
A-kinase anchoring protein-Lbc promotes pro-fibrotic signaling in cardiac fibroblastsQ44243144
Expression of procollagen C‐proteinase enhancer in cultured rat heart fibroblasts: Evidence for co‐regulation with type I collagenQ44593470
Insulin-like growth factor II messenger RNA-binding protein 3 expression in gastrointestinal mesenchymal tumorsQ44771161
The kinetics of FGF-2 binding to heparan sulfate proteoglycans and MAP kinase signalingQ44908928
Comparative effects of heparin-binding epidermal growth factor-like growth factor on the growth of cultured human uterine leiomyoma cells and myometrial cellsQ46370773
Curcumin, a nutritional supplement with antineoplastic activity, enhances leiomyoma cell apoptosis and decreases fibronectin expression.Q46539035
Selective progesterone receptor modulator asoprisnil down-regulates collagen synthesis in cultured human uterine leiomyoma cells through up-regulating extracellular matrix metalloproteinase inducerQ46748582
Effects of human epidermal growth factor gene-transfected mesenchymal stem cells on fibroblast migration and proliferationQ47976863
Matrix metalloproteinases of human leiomyoma in various stages of tumor growth.Q47990803
Leiomyoma fibrosis inhibited by liarozole, a retinoic acid metabolic blocking agent.Q50916738
Gonadotropin-releasing hormone (GnRH) agonist leuprolide acetate and GnRH antagonist cetrorelix acetate directly inhibit leiomyoma extracellular matrix production.Q50918854
Overexpression of integrin-β1 in leiomyoma promotes cell spreading and proliferation.Q52639069
Fibronectin at a glanceQ34150530
The role of the IGF system in cancer: from basic to clinical studies and clinical applicationsQ34157884
Molecular genetics and racial disparities of uterine leiomyomasQ34228266
Vitamin D inhibits proliferation of human uterine leiomyoma cells via catechol-O-methyltransferaseQ34354106
1,25-Dihydroxyvitamin D3 reduces TGF-beta3-induced fibrosis-related gene expression in human uterine leiomyoma cellsQ34758625
Extracellular matrix collagen alters cell proliferation and cell cycle progression of human uterine leiomyoma smooth muscle cellsQ34990653
Measurement of phenolic environmental estrogens in women with uterine leiomyomaQ35047452
Effects of all-trans retinoic acid on signal pathway of cyclooxygenase-2 and Smad3 in transforming growth factor-β-stimulated glomerular mesangial cellsQ35087174
Integrin signaling to the actin cytoskeleton.Q35547365
Epidermal homeostasis: the role of the growth hormone and insulin-like growth factor systemsQ35606164
Role of Fibroblast Growth Factor Type 1 and 2 in Carbon Tetrachloride-Induced Hepatic Injury and FibrogenesisQ35792203
The estimated annual cost of uterine leiomyomata in the United StatesQ35798693
Prevalence, symptoms and management of uterine fibroids: an international internet-based survey of 21,746 womenQ35927830
Leiomyoma: genetics, assisted reproduction, pregnancy and therapeutic advancesQ36198889
Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: role of extracellular matrixQ36220283
Immunohistochemical analysis of collagen expression in uterine leiomyomata during the menstrual cycleQ36230444
Extracellular matrix contains insulin-like growth factor binding protein-5: potentiation of the effects of IGF-IQ36232491
Fibronectin binding site in type I collagen regulates fibronectin fibril formationQ36232898
Estrogen Regulates MAPK-Related Genes through Genomic and Nongenomic Interactions between IGF-I Receptor Tyrosine Kinase and Estrogen Receptor-Alpha Signaling Pathways in Human Uterine Leiomyoma CellsQ36326856
The genetic heterogeneity of uterine leiomyomataQ36407931
Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomasQ36409237
Human prolyl hydroxylase expression in uterine leiomyoma during the menstrual cycleQ36594429
Characterization of tissue biomechanics and mechanical signaling in uterine leiomyomaQ36620511
Stimulatory and inhibitory effects of genistein on human uterine leiomyoma cell proliferation are influenced by the concentrationQ36631516
Insulin-like growth factor binding proteins: roles in regulating IGF physiologyQ36670514
Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrixQ36712745
A tense situation: forcing tumour progressionQ37112264
Progestins activate the AKT pathway in leiomyoma cells and promote survival.Q37198021
Mechanical homeostasis is altered in uterine leiomyomaQ37227767
Complex interactions between dietary and genetic factors impact lycopene metabolism and distributionQ37282026
Platelet-derived growth factor C is upregulated in human uterine fibroids and regulates uterine smooth muscle cell growthQ37369748
Protease-resistant form of insulin-like growth factor-binding protein 5 is an inhibitor of insulin-like growth factor-I actions on porcine smooth muscle cells in culture.Q37375061
Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?Q37378063
Rat skeletal myoblasts and arterial smooth muscle cells express the gene for the A chain but not the gene for the B chain (c-sis) of platelet-derived growth factor (PDGF) and produce a PDGF-like proteinQ37399155
P433issue3
P921main subjectleiomyomaQ4667534
P304page(s)179-194
P577publication date2014-07-11
P1433published inJournal of Cell Communication and SignalingQ26841964
P1476titleMatrix production and remodeling as therapeutic targets for uterine leiomyoma
P478volume8

Reverse relations

cites work (P2860)
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