Rac1-Dependent Intracellular Superoxide Formation Mediates Vascular Endothelial Growth Factor–Induced Placental Angiogenesis in Vitro

scientific article published on September 15, 2010

Rac1-Dependent Intracellular Superoxide Formation Mediates Vascular Endothelial Growth Factor–Induced Placental Angiogenesis in Vitro is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1210/EN.2010-0178
P953full work available at URLhttps://academic.oup.com/endo/article-pdf/151/11/5315/9007797/endo5315.pdf
http://intl-endo.endojournals.org/cgi/content/abstract/151/11/5315
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20844008/?tool=EBI
https://europepmc.org/articles/PMC2954717
https://doi.org/10.1210/en.2010-0178
http://academic.oup.com/endo/article-pdf/151/11/5315/9007797/endo5315.pdf
P932PMC publication ID2954717
P698PubMed publication ID20844008
P5875ResearchGate publication ID46281387

P2093author name stringLin Feng
Dong-bao Chen
Su-min Li
Ling-wen Zeng
P2860cites workVascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activationQ22004269
Characterization of RAC3, a novel member of the Rho familyQ24321818
rac, a novel ras-related family of proteins that are botulinum toxin substratesQ24339158
The biology of VEGF and its receptorsQ27860704
EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathwayQ28579324
Novel role of gp91(phox)-containing NAD(P)H oxidase in vascular endothelial growth factor-induced signaling and angiogenesisQ28609623
Mechanisms of angiogenesisQ29547485
Activation of Rac and Cdc42 by integrins mediates cell spreadingQ29616113
v-Crk activates the phosphoinositide 3-kinase/AKT pathway by utilizing focal adhesion kinase and H-RasQ30165212
Human placental NAD(P)H oxidase: solubilization and propertiesQ31854325
Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression.Q31858912
Vitamins C and E to prevent complications of pregnancy-associated hypertensionQ33389072
Oxidative stress in the pathogenesis of preeclampsiaQ33796834
Activation of AP-1 transcription factors differentiates FGF2 and vascular endothelial growth factor regulation of endothelial nitric-oxide synthase expression in placental artery endothelial cellsQ33885073
Vascular endothelial growth factor induces manganese-superoxide dismutase expression in endothelial cells by a Rac1-regulated NADPH oxidase-dependent mechanismQ43771298
Inhibition of angiogenesis-driven Kaposi's sarcoma tumor growth in nude mice by oral N-acetylcysteineQ43806552
Reactive oxygen species as downstream mediators of angiogenic signaling by vascular endothelial growth factor receptor-2/KDR.Q43806613
Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: regulation by angiotensin II.Q44028496
Nox4 as the major catalytic component of an endothelial NAD(P)H oxidase.Q44725224
Expression and localization of NOX2 and NOX4 in primary human endothelial cellsQ45261476
Xanthine oxidase, nitric oxide synthase and phospholipase A(2) produce reactive oxygen species via mitochondriaQ46390259
Cyclic stretch increases VEGF expression in pulmonary arterial smooth muscle cells via TGF-beta1 and reactive oxygen species: a requirement for NAD(P)H oxidaseQ46430381
Circulating angiogenic factors and the risk of preeclampsiaQ47217679
Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trialQ57624866
Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1Q59053220
Expression of phagocyte NADPH oxidase components in human endothelial cellsQ63676969
Translocation of Rac correlates with NADPH oxidase activation. Evidence for equimolar translocation of oxidase componentsQ70500542
NADPH oxidase activity is required for endothelial cell proliferation and migrationQ73303463
The respiratory burst oxidaseQ73884600
Cellular oxygen sensing by mitochondria: old questions, new insightQ33910357
Expression of NADPH oxidase isoform 1 (Nox1) in human placenta: involvement in preeclampsiaQ33938025
Deciphering mechanisms controlling placental artery endothelial cell migration stimulated by vascular endothelial growth factorQ33993849
Heme oxygenase: colors of defense against cellular stressQ34081677
Angiogenesis in the placentaQ34190112
The NADPH oxidase of endothelial cellsQ34235453
Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cellsQ34283019
Cytochrome p450 and vascular homeostasisQ34419338
Latest advances in understanding preeclampsiaQ34425288
Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial.Q34514153
Vitamins C and E and the risks of preeclampsia and perinatal complicationsQ34518082
Vascular NAD(P)H oxidases: specific features, expression, and regulationQ35175526
Nitric oxide, oxidative excess, and vascular complications of diabetes mellitus.Q35686185
Rho GTPases: potential candidates for anticancer therapyQ35687931
Invasive cytotrophoblasts manifest evidence of oxidative stress in preeclampsiaQ35793389
Oxidative stress in the placentaQ35833479
Oxidative stress and preeclampsia: rationale for antioxidant clinical trialsQ35869763
Reactive oxygen species as mediators of angiogenesis signaling: role of NAD(P)H oxidaseQ35949648
Oxidative enzymopathies and vascular diseaseQ36080154
Reactive oxygen species as mediators of cellular senescenceQ36203688
Rho, Rac, Pak and angiogenesis: old roles and newly identified responsibilities in endothelial cellsQ36255483
Molecular composition and regulation of the Nox family NAD(P)H oxidasesQ36255498
Regulation of NADPH oxidases: the role of Rac proteinsQ36412266
Redox signaling in hypertensionQ36502131
Protein phosphatase 3 differentially modulates vascular endothelial growth factor- and fibroblast growth factor 2-stimulated cell proliferation and signaling in ovine fetoplacental artery endothelial cellsQ36952742
Differential activation of multiple signalling pathways dictates eNOS upregulation by FGF2 but not VEGF in placental artery endothelial cellsQ37001282
Establishment of a functional ovine fetoplacental artery endothelial cell line with a prolonged life spanQ37263771
Compartmentalizing VEGF-induced ERK2/1 signaling in placental artery endothelial cell caveolae: a paradoxical role of caveolin-1 in placental angiogenesis in vitroQ37332402
Tyrosine phosphorylation of caveolin 1 by oxidative stress is reversible and dependent on the c-src tyrosine kinase but not mitogen-activated protein kinase pathways in placental artery endothelial cellsQ38513938
Exogenous nitric oxide stimulates cell proliferation via activation of a mitogen-activated protein kinase pathway in ovine fetoplacental artery endothelial cellsQ40357672
The phagocyte NADPH oxidase depends on cholesterol-enriched membrane microdomains for assemblyQ40591985
Activation of the mitogen-activated protein kinase cascade is necessary but not sufficient for basic fibroblast growth factor- and epidermal growth factor-stimulated expression of endothelial nitric oxide synthase in ovine fetoplacental artery endotQ40968932
Intracellular hydrogen peroxide and superoxide anion detection in endothelial cellsQ41043509
Generation of reactive oxygen species in a human keratinocyte cell line: role of calciumQ41065033
Placental NAD(P)H oxidase mediated superoxide generation in early pregnancyQ42487640
Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis factor-alpha is mediated by ceramideQ43646549
Enzyme histochemically detectable NAD(P)H oxidase in human placental trophoblasts: normal, preeclamptic, and fetal growth restriction-complicated pregnancyQ43692233
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
angiogenesisQ539568
P304page(s)5315-5325
P577publication date2010-09-15
P1433published inEndocrinologyQ3054009
P1476titleRac1-dependent intracellular superoxide formation mediates vascular endothelial growth factor-induced placental angiogenesis in vitro
Rac1-Dependent Intracellular Superoxide Formation Mediates Vascular Endothelial Growth Factor–Induced Placental Angiogenesis in Vitro
P478volume151

Reverse relations

cites work (P2860)
Q37973600Antiangiogenic-induced hypertension: the molecular basis of signaling network
Q42323537Aspalatone Prevents VEGF-Induced Lipid Peroxidation, Migration, Tube Formation, and Dysfunction of Human Aortic Endothelial Cells
Q35643192Caveolin-1 orchestrates fibroblast growth factor 2 signaling control of angiogenesis in placental artery endothelial cell caveolae
Q45052622Contribution of guanine nucleotide exchange factor Vav2 to NLRP3 inflammasome activation in mouse podocytes during hyperhomocysteinemia
Q64945919Coordination between Rac1 and Rab Proteins: Functional Implications in Health and Disease.
Q36532079Hypochlorite-Modified Albumin Upregulates ICAM-1 Expression via a MAPK-NF-κB Signaling Cascade: Protective Effects of Apocynin
Q38874052Involvement of renin-angiotensin-aldosterone system in calcium oxalate crystal induced activation of NADPH oxidase and renal cell injury
Q30410662Melatonin suppresses hypoxia-induced migration of HUVECs via inhibition of ERK/Rac1 activation
Q42177157Nox4- and Nox2-dependent oxidant production is required for VEGF-induced SERCA cysteine-674 S-glutathiolation and endothelial cell migration
Q30430373PI3K and ERK-induced Rac1 activation mediates hypoxia-induced HIF-1α expression in MCF-7 breast cancer cells
Q36958966Selective Rac1 inhibition protects renal tubular epithelial cells from oxalate-induced NADPH oxidase-mediated oxidative cell injury
Q38970458The role of CEA-related cell adhesion molecule-1 (CEACAM1) in vascular homeostasis

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