Absence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumour suppressor function

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Absence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumour suppressor function is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/EMMM.201100168
P932PMC publication ID3258485
P698PubMed publication ID21786422
P5875ResearchGate publication ID51518692

P2093author name stringJoseph Lotem
Yoram Groner
Ori Brenner
Ditsa Levanon
Raya Eilam
Varda Negreanu
Yael Bernstein
Amir Pozner
Karen Rae Bone
P2860cites workSpatial and temporal expression pattern of Runx3 (Aml2) and Runx1 (Aml1) indicates non-redundant functions during mouse embryogenesis.Q52126883
Cbfa2 is required for the formation of intra-aortic hematopoietic clusters.Q52177455
Ink4a/Arf and oncogene-induced senescence prevent tumor progression during alternative colorectal tumorigenesis.Q53306400
Smad4 signalling in T cells is required for suppression of gastrointestinal cancer.Q54462818
Runx3 expression in gastrointestinal tract epithelium: resolving the controversy.Q54497274
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RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesisQ24310469
AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localizationQ24311698
LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposisQ24319729
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locusQ24797230
Generalized lacZ expression with the ROSA26 Cre reporter strainQ27860837
Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic painQ28294561
Causal relationship between the loss of RUNX3 expression and gastric cancerQ28509530
Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehogQ28586013
Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neuronsQ28591148
Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasiaQ28591205
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Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCRQ29400573
Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertionQ29618089
Stromal fibroblasts in cancer initiation and progressionQ29618873
Developmentally regulated promoter-switch transcriptionally controls Runx1 function during embryonic hematopoiesisQ33290634
The RUNX3 gene--sequence, structure and regulated expressionQ34104024
Evidence for an instructive mechanism of de novo methylation in cancer cells.Q34489258
Transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer.Q34694010
Runx3 knockouts and stomach cancerQ35140789
Runx3 and Runx1 are required for CD8 T cell development during thymopoiesisQ35146679
Structure and regulated expression of mammalian RUNX genesQ35779684
Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell lineQ36861718
RUNX genes in development and cancer: regulation of viral gene expression and the discovery of RUNX family genesQ37013889
RUNX proteins in transcription factor networks that regulate T-cell lineage choiceQ37376016
RUNX3 functions as an oncogene in ovarian cancerQ39536608
The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neuronsQ39644959
RUNX3 protein is overexpressed in human epithelial ovarian cancerQ39927217
Exclusion of RUNX3 as a tumour-suppressor gene in early-onset gastric carcinomasQ40386868
GFPcre fusion vectors with enhanced expressionQ40953182
RUNX3 protein is overexpressed in human basal cell carcinomasQ42496689
Autofluorescence characterisation of isolated whole crypts and primary cultured human epithelial cells from normal, hyperplastic, and adenomatous colonic mucosa.Q43010189
Runx1 is expressed in adult mouse hematopoietic stem cells and differentiating myeloid and lymphoid cells, but not in maturing erythroid cellsQ44780658
A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversificationQ45345498
Runx3-deficient mouse strains circa 2008: resemblance and dissimilarity.Q51808089
P433issue10
P304page(s)593-604
P577publication date2011-08-08
P1433published inEMBO Molecular MedicineQ15817279
P1476titleAbsence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumour suppressor function
P478volume3

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cites work (P2860)
Q49668158Aberrant DNA Methylation in Colorectal Cancer: What Should We Target?
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Q46150570Author reply to: RUNX3 is expressed in the epithelium of the gastrointestinal tract.
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