RUNX family: Oncogenes or tumor suppressors (Review).

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RUNX family: Oncogenes or tumor suppressors (Review). is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3892/OR.2019.7149
P932PMC publication ID6549079
P698PubMed publication ID31059069

P2093author name stringLiliana López-Kleine
Adriana Rojas
Berta Henríquez
Beatriz Andrea Otálora-Otálora
P2860cites workHallmarks of Cancer: The Next GenerationQ22252312
Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbetaQ22254263
MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2Q24294814
Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasmQ24297348
Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formationQ24300183
Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk geneQ24309536
RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesisQ24310469
AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localizationQ24311698
Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemiaQ24319864
Cloning, mapping and expression of PEBP2 alpha C, a third gene encoding the mammalian Runt domainQ24319877
The Hallmarks of CancerQ221226
Proviral insertion indicates a dominant oncogenic role for Runx1/AML-1 in T-cell lymphoma.Q54798575
The Runt domain identifies a new family of heteromeric transcriptional regulators.Q55066074
Expression levels of the runt-related transcription factor 1 and 3 genes in the development of acute myeloid leukemia.Q55355645
Canonical WNT Signaling Promotes Osteogenesis by Directly StimulatingRunx2Gene ExpressionQ57129723
Architecture and anatomy of the genomic locus encoding the human leukemia-associated transcription factor RUNX1/AML1Q57338760
TLE, the Human Homolog of Groucho, Interacts with AML1 and Acts as a Repressor of AML1-Induced TransactivationQ57662520
Genetic compensation of RUNX family transcription factors in leukemiaQ58699333
RUNX1 amplification in AML with myelodysplasia-related changes and ring 21 chromosomesQ64048554
AML1 gene amplification: a novel finding in childhood acute lymphoblastic leukemiaQ73651964
Runx2: a novel oncogenic effector revealed by in vivo complementation and retroviral taggingQ73787472
Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemiasQ74587955
Enforced expression of Runx2 perturbs T cell development at a stage coincident with beta-selectionQ74754525
Runx3 is required for the specification of TrkC-expressing mechanoreceptive trigeminal ganglion neuronsQ82338501
Helicobacter pylori causes runx3 gene methylation and its loss of expression in gastric epithelial cells, which is mediated by nitric oxide produced by macrophagesQ84372860
Functional relationship between p53 and RUNX proteinsQ90392099
Glycemic Variability Promotes Both Local Invasion and Metastatic Colonization by Pancreatic Ductal AdenocarcinomaQ91792797
Runx3 inactivation is a crucial early event in the development of lung adenocarcinomaQ24339585
Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoterQ24537942
Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemiaQ24596770
Alternative splicing and genomic structure of theAML1gene involved in acute myeloid leukemiaQ24626212
Modulation of Runx2 activity by estrogen receptor-alpha: implications for osteoporosis and breast cancerQ24654971
The evolution of Runx genes I. A comparative study of sequences from phylogenetically diverse model organismsQ24792586
CBFbeta is a facultative Runx partner in the sea urchin embryoQ25255704
RUNX2 and the PI3K/AKT axis reciprocal activation as a driving force for tumor progressionQ26800112
Activated Notch1 target genes during embryonic cell differentiation depend on the cellular context and include lineage determinants and inhibitorsQ27324100
Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domainQ27619000
Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbetaQ27630690
Regulation of Estrogen Receptor α by the SET7 Lysine MethyltransferaseQ27650581
Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activationQ28201036
Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cellsQ28204395
Histone deacetylase activity is required for full transcriptional repression by mSin3AQ28238079
Control of RUNX2 isoform expression: the role of promoters and enhancersQ28245927
The RUNX genes: gain or loss of function in cancerQ28247901
TGFbeta and Wnt pathway cross-talkQ28248305
Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factorsQ28258100
Whole-genome analysis informs breast cancer response to aromatase inhibitionQ28269291
The immunoglobulin superfamily--domains for cell surface recognitionQ28294978
AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemiaQ28304079
Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradationQ28348865
RUNX3 has an oncogenic role in head and neck cancerQ28475605
Causal relationship between the loss of RUNX3 expression and gastric cancerQ28509530
Generation and reproductive phenotypes of mice lacking estrogen receptor betaQ28513765
Conservation and expression of an alternative 3' exon of Runx2 encoding a novel proline-rich C-terminal domainQ28588614
Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartmentsQ28590882
Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neuronsQ28591148
The evolutionary origin of the Runx/CBFbeta transcription factors--studies of the most basal metazoansQ28757287
Epigenetics in cancerQ29617139
Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven CancersQ30276341
Runx transcription factors and the developmental balance between cell proliferation and differentiation.Q30332928
Runx1/AML1 in normal and abnormal hematopoiesis.Q30351255
The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasionQ30447945
An ensemble of regulatory elements controls Runx3 spatiotemporal expression in subsets of dorsal root ganglia proprioceptive neuronsQ30833502
PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesisQ32884406
Pim-1 kinase phosphorylates RUNX family transcription factors and enhances their activityQ33242887
Lack of RUNX3 regulation in human gastric cancerQ33254397
Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemiaQ33330210
Expression analysis of genes associated with human osteosarcoma tumors shows correlation of RUNX2 overexpression with poor response to chemotherapyQ33577472
Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation.Q33697682
Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBF(alpha)/AML/PEBP2(alpha)) dependent activation of tissue-specific gene transcriptionQ33902979
The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblastsQ33953806
Transcription-coupled translation control of AML1/RUNX1 is mediated by cap- and internal ribosome entry site-dependent mechanisms.Q33962440
runt homology domain transcription factors (Runx, Cbfa, and AML) mediate repression of the bone sialoprotein promoter: evidence for promoter context-dependent activity of Cbfa proteinsQ33967954
Transcriptional regulation of early B-lymphocyte differentiationQ33996239
Notch signaling: the core pathway and its posttranslational regulationQ34017623
Osteomimicry: how tumor cells try to deceive the boneQ34022631
Sequence analysis of mutations and translocations across breast cancer subtypesQ34032470
RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD.Q34042783
The RUNX3 gene--sequence, structure and regulated expressionQ34104024
Absence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumour suppressor functionQ34203284
Defining a tissue stem cell-driven Runx1/Stat3 signalling axis in epithelial cancer.Q34303695
The Role of RUNX2 in Osteosarcoma OncogenesisQ34423871
Expression pattern, regulation, and biological role of runt domain transcription factor, run, in Caenorhabditis elegansQ34440372
Hematopoietic stem cell fate is established by the Notch-Runx pathwayQ34451310
Tackling the cancer stem cells - what challenges do they pose?Q34523263
Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expressionQ34570006
The human SWI/SNF complex associates with RUNX1 to control transcription of hematopoietic target genesQ34606841
A continuum model for tumour suppressionQ34631552
Notch signaling and EMT in non-small cell lung cancer: biological significance and therapeutic applicationQ34712645
The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosisQ34718167
Core-binding factors in haematopoiesis and leukaemiaQ34718183
Transcription factors as targets for cancer therapyQ34932264
Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motilityQ34989177
A role for RUNX3 in inflammation-induced expression of IL23A in gastric epithelial cells.Q35018677
Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expressionQ35779750
Regulation of breast cancer metastasis by Runx2 and estrogen signaling: the role of SNAI2.Q35889648
Tumor suppressor function of RUNX3 in breast cancerQ35914643
Runx2 mediates epigenetic silencing of the bone morphogenetic protein-3B (BMP-3B/GDF10) in lung cancer cellsQ36040069
Specificity of Genetic Biomarker Studies in Cancer Research: A Systematic Review.Q36068850
Molecular mechanisms of cooperative binding of transcription factors Runx1-CBFβ-Ets1 on the TCRα gene enhancerQ36288656
Runx2 deficiency and defective subnuclear targeting bypass senescence to promote immortalization and tumorigenic potential.Q36288903
The RUNX Genes as Conditional Oncogenes: Insights from Retroviral Targeting and Mouse ModelsQ36309953
Targeting Transcription Factors in CancerQ36347511
Runx1: no longer just for leukemiaQ36382122
Runx3 controls growth and differentiation of gastric epithelial cells in mammalsQ36390962
Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): evidence for a new myc collaborating oncogeneQ36552332
The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation abilityQ36561099
Groucho-dependent and -independent repression activities of Runt domain proteinsQ36572515
Regulatory roles of Runx2 in metastatic tumor and cancer cell interactions with bone.Q36682092
Enhancer of zeste homologue 2 (EZH2) down-regulates RUNX3 by increasing histone H3 methylationQ36719239
RUNX1 permits E4orf6-directed nuclear localization of the adenovirus E1B-55K protein and associates with centers of viral DNA and RNA synthesisQ36747955
Estrogen receptor-alpha hinge-region lysines 302 and 303 regulate receptor degradation by the proteasomeQ36756461
Discriminating gene expression profiles of memory B cell subpopulations.Q36851928
RUNX3 acts as a tumor suppressor in breast cancer by targeting estrogen receptor αQ36971996
RUNX3 defines disease behavior in pancreatic ductal adenocarcinomaQ36998003
Oncogene-induced senescence: an essential role for RunxQ37234252
Parathyroid hormone/parathyroid hormone-related peptide regulate osteosarcoma cell functions: Focus on the extracellular matrix (Review).Q37255459
DNA methylation of Runx1 regulatory regions correlates with transition from primitive to definitive hematopoietic potential in vitro and in vivoQ37263155
Wnt signaling from development to disease: insights from model systemsQ37342306
RUNX1 translocations in malignant hemopathiesQ37469621
Post-translational Regulation of Runx2 in Bone and CartilageQ37592911
Transcription factor Runx3 regulates interleukin-15-dependent natural killer cell activationQ37643938
The role of chromosome 21 in hematology and oncologyQ37709977
RUNX3 is multifunctional in carcinogenesis of multiple solid tumorsQ37720402
Runx2 in normal tissues and cancer cells: A developing story.Q37767879
New insights into the inactivation of gastric tumor suppressor RUNX3: the role of H. pylori infectionQ37832453
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomesQ37849461
The RUNX family in breast cancer: relationships with estrogen signalingQ38050410
Context-dependent activation of Wnt signaling by tumor suppressor RUNX3 in gastric cancer cellsQ35051435
The Runx genes as dominant oncogenesQ35121742
Requisite roles of Runx2 and Cbfb in skeletal developmentQ35156615
Loss of osteoblast Runx3 produces severe congenital osteopeniaQ35165153
Multiple signaling pathways converge on the Cbfa1/Runx2 transcription factor to regulate osteoblast differentiationQ35210378
Temporal and spatial parameters of skeletal gene expression: targeting RUNX factors and their coregulatory proteins to subnuclear domainsQ35210386
Lineage-specific RUNX3 hypomethylation marks the preneoplastic immune component of gastric cancer.Q35463668
The corepressor mSin3A regulates phosphorylation-induced activation, intranuclear location, and stability of AML1.Q35544219
Runx2/Cbfa1: A Multifunctional Regulator of Bone FormationQ35552258
Retroviral insertional mutagenesis identifies RUNX genes involved in chronic myeloid leukemia disease persistence under imatinib treatmentQ35663526
RUNX3 Controls a Metastatic Switch in Pancreatic Ductal AdenocarcinomaQ35690596
Oncogenic potential of the RUNX gene family: 'overview'.Q35779678
Structure and regulated expression of mammalian RUNX genesQ35779684
Role of RUNX family members in transcriptional repression and gene silencingQ35779689
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemiaQ35779725
Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemiaQ35779731
The Runx genes: lineage-specific oncogenes and tumor suppressorsQ35779743
RUNX family: Regulation and diversification of roles through interacting proteinsQ38062515
Targeting transcription factors: promising new strategies for cancer therapyQ38139175
Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitorsQ38289269
Expression of transcription factor AML-2 (RUNX3, CBF(alpha)-3) is induced by Epstein-Barr virus EBNA-2 and correlates with the B-cell activation phenotypeQ38289967
Gene array analysis reveals a common Runx transcriptional programme controlling cell adhesion and survivalQ38289974
Requirement of Runx1/AML1/PEBP2alphaB for the generation of haematopoietic cells from endothelial cellsQ38304430
Runx3 regulates dendritic epidermal T cell developmentQ38305806
The RUNX family: developmental regulators in cancerQ38319972
Regulation of RUNX2 transcription factor-DNA interactions and cell proliferation by vitamin D3 (cholecalciferol) prohormone activityQ38329289
Runx3 at the interface of immunity, inflammation and cancerQ38340309
RUNX2 and OsteosarcomaQ38367587
Frequent amplification and rearrangement of chromosomal bands 6p12-p21 and 17p11.2 in osteosarcomaQ38481726
Inhibition of Notch1 signaling by Runx2 during osteoblast differentiation.Q38482269
Focus on the p38 MAPK signaling pathway in bone development and maintenanceQ38541335
The emerging role of RUNX3 in cancer metastasis (Review).Q38680772
RUNX super-enhancer control through the Notch pathway by Epstein-Barr virus transcription factors regulates B cell growth.Q38793717
Epigenetic Control of the Bone-master Runx2 Gene during Osteoblast-lineage Commitment by the Histone Demethylase JARID1B/KDM5B.Q38829110
Runx3 in Immunity, Inflammation and CancerQ38904246
Association of polyalanine and polyglutamine coiled coils mediates expansion disease-related protein aggregation and dysfunctionQ39027090
Runx transcription factors in the development and function of the definitive hematopoietic systemQ39127010
Role of RUNX1 in hematological malignanciesQ39127024
Runx3 protects gastric epithelial cells against epithelial-mesenchymal transition-induced cellular plasticity and tumorigenicityQ39296192
Transcription factor Runx2 is a regulator of epithelial-mesenchymal transition and invasion in thyroid carcinomasQ39340986
Runt-related transcription factor 3 reverses epithelial-mesenchymal transition in hepatocellular carcinomaQ39367341
Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.Q39576827
C/EBPβ binds the P1 promoter of the Runx2 gene and up-regulates Runx2 transcription in osteoblastic cellsQ39596135
RUNX3 maintains the mesenchymal phenotype after termination of the Notch signalQ39598984
Runx2 regulates survivin expression in prostate cancer cellsQ39769098
Pim-1 kinase phosphorylates and stabilizes RUNX3 and alters its subcellular localization.Q39944141
Expression and function of Cbfa-1/Runx2 in thyroid papillary carcinoma cellsQ39996177
Differential regulation of estrogen receptor alpha turnover and transactivation by Mdm2 and stress-inducing agentsQ40124566
AML1/Runx1 rescues Notch1-null mutation-induced deficiency of para-aortic splanchnopleural hematopoiesisQ40247755
RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancerQ40259898
The transcriptionally active form of AML1 is required for hematopoietic rescue of the AML1-deficient embryonic para-aortic splanchnopleural (P-Sp) regionQ40532293
Fidelity of Runx2 activity in breast cancer cells is required for the generation of metastases-associated osteolytic disease.Q40539678
Transcriptional regulation of T-cell genes during T-cell developmentQ40623651
IRES-dependent translational control of Cbfa1/Runx2 expression.Q40676811
Oncogenic transcription factors in the human acute leukemiasQ41628889
Genetic regulation of the RUNX transcription factor family has antitumor effectsQ41661754
Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes.Q41676561
Characterization of CADD522, a small molecule that inhibits RUNX2-DNA binding and exhibits antitumor activityQ42378493
CHIP (carboxyl terminus of Hsc70-interacting protein) promotes basal and geldanamycin-induced degradation of estrogen receptor-alphaQ42481557
The vitamin D receptor, Runx2, and the Notch signaling pathway cooperate in the transcriptional regulation of osteopontinQ42484713
A specific targeting signal directs Runx2/Cbfa1 to subnuclear domains and contributes to transactivation of the osteocalcin geneQ42511041
Developmental-stage-dependent transcriptional response to leukaemic oncogene expression.Q42602670
Runx2 mRNA expression in the tissue, serum, and circulating non-hematopoietic cells of patients with thyroid cancerQ42644602
Runx2 disruption promotes immortalization and confers resistance to oncogene-induced senescence in primary murine fibroblastsQ42819809
Alternative RUNX1 Promoter Regulation by Wnt/β-Catenin Signaling in Leukemia Cells and Human Hematopoietic Progenitors.Q45345502
Roles of VWRPY motif-mediated gene repression by Runx proteins during T-cell developmentQ46165523
TNF-alpha's effects on proliferation and apoptosis in human mesenchymal stem cells depend on RUNX2 expressionQ46214032
RUNX1: A Regulator of NF-kB Signaling in Pulmonary DiseasesQ47678907
TGFβ Promotes Genomic Instability after Loss of RUNX3.Q47709830
Polycomb group ring finger 1 cooperates with Runx1 in regulating differentiation and self-renewal of hematopoietic cells.Q48027800
Emerging role of RUNX3 in the regulation of tumor microenvironment.Q50077138
RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization.Q50335772
Cell growth regulatory role of Runx2 during proliferative expansion of preosteoblastsQ51017945
RUNX3 and p53: How Two Tumor Suppressors Cooperate Against Oncogenic Ras?Q51097612
Shared and distinct roles mediated through C-terminal subdomains of acute myeloid leukemia/Runt-related transcription factor molecules in murine development.Q51540139
Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.Q52111650
Transcription factors RUNX1/AML1 and RUNX2/Cbfa1 dynamically associate with stationary subnuclear domains.Q52114278
Increased expression of AML1 during retinoic-acid-induced differentiation of U937 cells.Q52508473
RUNX1 positively regulates the ErbB2/HER2 signaling pathway through modulating SOS1 expression in gastric cancer cells.Q52568539
Mastermind is a putative activator for Notch.Q52580782
Mechanical stress-mediated Runx2 activation is dependent on Ras/ERK1/2 MAPK signaling in osteoblasts.Q53574018
Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor.Q54611050
Runx2 in human breast carcinoma: its potential roles in cancer progressionQ54643065
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivativesQ6937225
P433issue1
P921main subjectneoplasmQ1216998
P304page(s)3-19
P577publication date2019-05-06
2019-07-01
P1433published inOncology ReportsQ7092098
P1476titleRUNX family: Oncogenes or tumor suppressors (Review).
P478volume42

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cites work (P2860)
Q98195540COL4A1 promotes the growth and metastasis of hepatocellular carcinoma cells by activating FAK-Src signaling
Q92259245Gene Copy Number and Post-Transductional Mechanisms Regulate TRAP1 Expression in Human Colorectal Carcinomas

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