Runx2 in human breast carcinoma: its potential roles in cancer progression

scientific article published on October 12, 2010

Runx2 in human breast carcinoma: its potential roles in cancer progression is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1349-7006.2010.01742.X
P953full work available at URLhttps://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1349-7006.2010.01742.x
https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1349-7006.2010.01742.x
P932PMC publication ID11158211
P698PubMed publication ID20946121
P5875ResearchGate publication ID47427763

P50authorTakashi SuzukiQ88151918
Kiyoshi TakagiQ92105856
Jun-Ichi AkahiraQ114292063
Yoshiaki OnoderaQ114411360
Takanori IshidaQ114411368
Noriaki OhuchiQ114411369
Mika WatanabeQ57528278
Yasuhiro MikiQ61119195
Hironobu SasanoQ61126397
P2093author name stringSatoshi Inoue
Jun-ichi Akahira
Takuya Sakyu
P2860cites workMutations involving the transcription factor CBFA1 cause cleidocranial dysplasiaQ24309601
RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesisQ24310469
Mechanisms of bone metastases of breast cancerQ24597798
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogeneQ27860693
Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone developmentQ28119185
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesisQ28140740
Osf2/Cbfa1: a transcriptional activator of osteoblast differentiationQ28240596
The RUNX genes: gain or loss of function in cancerQ28247901
Mechanisms of angiogenesisQ29547485
Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblastsQ29547605
Cancer treatment-related bone diseaseQ30438185
Basic mechanisms responsible for osteolytic and osteoblastic bone metastasesQ30441961
Molecular biology of bone metastasisQ30444749
Experimental metastasis is suppressed in MMP-9-deficient miceQ78015054
The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasionQ30447945
Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemiaQ33330210
Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo.Q33819359
The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblastsQ33953806
The mechanisms of estrogen regulation of bone resorptionQ34086515
Biology of osteoclast activation in cancerQ34324255
Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer.Q34382805
Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclastsQ34679499
A role for Runx2 in normal mammary gland and breast cancer bone metastasisQ36211777
Meeting highlights: international expert consensus on the primary therapy of early breast cancer 2005.Q36251476
The role of the immune system in the pathophysiology of osteoporosisQ36324969
Aromatase inhibitor and boneQ36955394
Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cellsQ37000350
Biology of breast cancer bone metastasisQ37024349
Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alphaQ37271202
Positive association between nuclear Runx2 and oestrogen-progesterone receptor gene expression characterises a biological subtype of breast cancer.Q37323255
Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysisQ37360238
Runx2, p53, and pRB status as diagnostic parameters for deregulation of osteoblast growth and differentiation in a new pre-chemotherapeutic osteosarcoma cell line (OS1).Q37401016
Maintaining bone density in patients undergoing treatment for breast cancer: is there an adjuvant benefit?Q37533796
The critical role of the bone microenvironment in cancer metastasesQ37555284
The osteoblast transcription factor Runx2 is expressed in mammary epithelial cells and mediates osteopontin expression.Q38350119
Impaired cell cycle regulation of the osteoblast-related heterodimeric transcription factor Runx2-Cbfbeta in osteosarcoma cellsQ39801788
Smad3 interacts with JunB and Cbfa1/Runx2 for transforming growth factor-beta1-stimulated collagenase-3 expression in human breast cancer cellsQ40566806
Oct-1 counteracts autoinhibition of Runx2 DNA binding to form a novel Runx2/Oct-1 complex on the promoter of the mammary gland-specific gene beta-caseinQ42709917
Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2.Q42826927
Bone mineral density in premenopausal women treated for node-positive early breast cancer with 2 years of goserelin or 6 months of cyclophosphamide, methotrexate and 5-fluorouracil (CMF)Q44609234
Immunochemical characterization of circulating parathyroid hormone-related protein in patients with humoral hypercalcemia of cancerQ46282102
Upregulation of MMP-13 via Runx2 in the stromal cell of Giant Cell Tumor of bone.Q47860378
Cell growth regulatory role of Runx2 during proliferative expansion of preosteoblastsQ51017945
Five Years of Letrozole Compared With Tamoxifen As Initial Adjuvant Therapy for Postmenopausal Women With Endocrine-Responsive Early Breast Cancer: Update of Study BIG 1-98Q58466062
Prostate cancer expression of runt‐domain transcription factor Runx2, a key regulator of osteoblast differentiation and functionQ73393498
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectbreast carcinomaQ18555947
P304page(s)2670-2675
P577publication date2010-10-12
P1433published inCancer ScienceQ326125
P1476titleRunx2 in human breast carcinoma: its potential roles in cancer progression
P478volume101

Reverse relations

cites work (P2860)
Q40633085Association of genetic polymorphisms with survival of pancreatic ductal adenocarcinoma patients
Q42378493Characterization of CADD522, a small molecule that inhibits RUNX2-DNA binding and exhibits antitumor activity
Q86573068Combined Runx2 and Snail overexpression is associated with a poor prognosis in breast cancer
Q33732391Differential effects of RUNX2 on the androgen receptor in prostate cancer: synergistic stimulation of a gene set exemplified by SNAI2 and subsequent invasiveness.
Q35906122Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion
Q42366546LncRNA ANCR down-regulation promotes TGF-β-induced EMT and metastasis in breast cancer
Q35423697Lung tumor-associated osteoblast-derived bone morphogenetic protein-2 increased epithelial-to-mesenchymal transition of cancer by Runx2/Snail signaling pathway
Q47161497MicroRNA-218 inhibits proliferation and invasion in ovarian cancer by targeting Runx2.
Q37744995MicroRNA-466 inhibits tumor growth and bone metastasis in prostate cancer by direct regulation of osteogenic transcription factor RUNX2.
Q35692401Myeloma cell-derived Runx2 promotes myeloma progression in bone.
Q36937029Oncogenic cooperation between PI3K/Akt signaling and transcription factor Runx2 promotes the invasive properties of metastatic breast cancer cells
Q35751787Opposing effects of Runx2 and estradiol on breast cancer cell proliferation: in vitro identification of reciprocally regulated gene signature related to clinical letrozole responsiveness
Q36329328Overexpression of runt-related transcription factor-2 is associated with advanced tumor progression and poor prognosis in epithelial ovarian cancer
Q64902344RUNX family: Oncogenes or tumor suppressors (Review).
Q36413997RUNX2 and TAZ-dependent signaling pathways regulate soluble E-Cadherin levels and tumorsphere formation in breast cancer cells
Q33555996RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland
Q38061373RUNX2 in mammary gland development and breast cancer.
Q37259128Regulation of breast cancer and bone metastasis by microRNAs
Q35889648Regulation of breast cancer metastasis by Runx2 and estrogen signaling: the role of SNAI2.
Q28084968Role of RUNX2 in Breast Carcinogenesis
Q53197894Role of Runx2 in IGF-1Rβ/Akt- and AMPK/Erk-dependent growth, survival and sensitivity towards metformin in breast cancer bone metastasis.
Q39160361Runt-related transcription factor 2 (RUNX2) inhibits p53-dependent apoptosis through the collaboration with HDAC6 in response to DNA damage
Q24306101Runt-related transcription factor 2 attenuates the transcriptional activity as well as DNA damage-mediated induction of pro-apoptotic TAp73 to regulate chemosensitivity
Q39384202Runt-related transcription factor 2 in human colon carcinoma: a potent prognostic factor associated with estrogen receptor
Q39181420Runx Genes in Breast Cancer and the Mammary Lineage.
Q46303094Runx2 Expression as a Potential Prognostic Marker in Invasive Ductal Breast Carcinoma
Q88204157Runx2 Suppression by miR-342 and miR-363 Inhibits Multiple Myeloma Progression
Q37691008Runx2 activates PI3K/Akt signaling via mTORC2 regulation in invasive breast cancer cells
Q28244711Runx2 controls a feed-forward loop between androgen and prolactin-induced protein (PIP) in stimulating T47D cell proliferation
Q42533014Runx2 isoform I controls a panel of proinvasive genes driving aggressiveness of papillary thyroid carcinomas
Q58798661Screening Method for Anti-Colon Cancer Drugs Using Two Sensor Cell Lines with Human β4-Galactosyltransferase 4 Gene Promoters
Q57816460Serum miR-4530 sensitizes breast cancer to neoadjuvant chemotherapy by suppressing RUNX2
Q37167523Silencing of RUNX2 enhances gemcitabine sensitivity of p53-deficient human pancreatic cancer AsPC-1 cells through the stimulation of TAp63-mediated cell death.
Q57493778Somatic mutations, clinicopathologic characteristics, and survival in patients with untreated breast cancer with bone-only and non-bone sites of first metastasis
Q46087491Targeting protein quality control pathways in breast cancer
Q38744455The Emerging Roles of RUNX Transcription Factors in Epithelial-Mesenchymal Transition
Q38050410The RUNX family in breast cancer: relationships with estrogen signaling
Q36947310The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells
Q38743681The enigmatic role of RUNX1 in female-related cancers - current knowledge & future perspectives.
Q34306282The prognostic significance of RUNX2 and miR-10a/10b and their inter-relationship in breast cancer
Q48359215The role of Runx2 in facilitating autophagy in metastatic breast cancer cells
Q39340986Transcription factor Runx2 is a regulator of epithelial-mesenchymal transition and invasion in thyroid carcinomas
Q35673760Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents

Search more.