Runx2 isoform I controls a panel of proinvasive genes driving aggressiveness of papillary thyroid carcinomas

scientific article published on 20 July 2012

Runx2 isoform I controls a panel of proinvasive genes driving aggressiveness of papillary thyroid carcinomas is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1210/JC.2012-1903
P932PMC publication ID3462932
P698PubMed publication ID22821892

P50authorValentina SancisiQ42533055
Alessia CiarrocchiQ42533058
Simonetta PianaQ88792714
Ione TamagniniQ114429038
Davide NicoliQ114429047
Moira RagazziQ114576775
P2093author name stringSally Maramotti
Gloria Borettini
P2860cites workRunx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoterQ24537942
Id proteins in development, cell cycle and cancerQ28190570
Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cellsQ28204395
Osf2/Cbfa1: a transcriptional activator of osteoblast differentiationQ28240596
Runx2 controls a feed-forward loop between androgen and prolactin-induced protein (PIP) in stimulating T47D cell proliferationQ28244711
Tollip is a mediator of protein sumoylationQ28569172
Matrix metalloproteinases: regulators of the tumor microenvironmentQ29619858
Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesionsQ30435146
The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasionQ30447945
Thyroid cancer survival in the United States: observational data from 1973 to 2005.Q33579885
The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblastsQ33953806
The cancer-related Runx2 protein enhances cell growth and responses to androgen and TGFbeta in prostate cancer cells.Q34078444
Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expressionQ34570006
Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motilityQ34989177
FOXO1 inhibits Runx2 transcriptional activity and prostate cancer cell migration and invasionQ35024427
Gene expression and functional evidence of epithelial-to-mesenchymal transition in papillary thyroid carcinoma invasionQ35669749
Genomic promoter occupancy of runt-related transcription factor RUNX2 in Osteosarcoma cells identifies genes involved in cell adhesion and motilityQ35762938
MT1-MMP: a potent modifier of pericellular microenvironment.Q36141763
Advances in Runx2 regulation and its isoformsQ36562392
Regulatory roles of Runx2 in metastatic tumor and cancer cell interactions with bone.Q36682092
The impact of distant metastases at presentation on prognosis in patients with differentiated carcinoma of the thyroid gland.Q37022492
Co-stimulation of the bone-related Runx2 P1 promoter in mesenchymal cells by SP1 and ETS transcription factors at polymorphic purine-rich DNA sequences (Y-repeats)Q37075344
Positive association between nuclear Runx2 and oestrogen-progesterone receptor gene expression characterises a biological subtype of breast cancer.Q37323255
Ectopic runx2 expression in mammary epithelial cells disrupts formation of normal acini structure: implications for breast cancer progressionQ37343805
Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation.Q37906474
Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitorsQ38289269
Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoterQ38321841
Runx2 transcriptome of prostate cancer cells: insights into invasiveness and bone metastasisQ38340672
The osteoblast transcription factor Runx2 is expressed in mammary epithelial cells and mediates osteopontin expression.Q38350119
Inhibitor of DNA binding-1 induces mesenchymal features and promotes invasiveness in thyroid tumour cells.Q39621813
Glucose-activated RUNX2 phosphorylation promotes endothelial cell proliferation and an angiogenic phenotypeQ39959730
Expression and function of Cbfa-1/Runx2 in thyroid papillary carcinoma cellsQ39996177
Constitutive expression and regulation of collagenase-3 in human breast cancer cells.Q40868944
Description of a human papillary thyroid carcinoma cell line. Morphologic study and expression of tumoral markersQ41474200
Runx2 deficiency in mice causes decreased thyroglobulin expression and hypothyroidismQ42058727
Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2alpha A) is inhibited by tumor necrosis factor-alphaQ42513418
Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2.Q42826927
Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix.Q53923828
Runx2 in human breast carcinoma: its potential roles in cancer progressionQ54643065
Osteopontin is overexpressed in human papillary thyroid carcinomas and enhances thyroid carcinoma cell invasiveness.Q54655522
Management guidelines for patients with thyroid nodules and differentiated thyroid cancerQ82293286
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)E2006-15
P577publication date2012-07-20
P1433published inThe Journal of Clinical Endocrinology and MetabolismQ3186902
P1476titleRunx2 isoform I controls a panel of proinvasive genes driving aggressiveness of papillary thyroid carcinomas
P478volume97

Reverse relations

cites work (P2860)
Q37375359Aberrant expression of posterior HOX genes in well differentiated histotypes of thyroid cancers
Q39032755Autophagy and epithelial-mesenchymal transition: an intricate interplay in cancer
Q37708464CXCL12 methylation-mediated epigenetic regulation of gene expression in papillary thyroid carcinoma
Q34999638Cadherin 6 is a new RUNX2 target in TGF-β signalling pathway
Q47248660Cadherin 6 is activated by Epstein-Barr virus LMP1 to mediate EMT and metastasis as an interplay node of multiple pathways in nasopharyngeal carcinoma
Q36067156Cadherin-6 promotes EMT and cancer metastasis by restraining autophagy
Q102213210Gene expression profile unveils diverse biological effect of serum VitaminD in Hodgkin's and Diffuse Large B-Cell Lymphoma
Q92504777HDACs control RUNX2 expression in cancer cells through redundant and cell context-dependent mechanisms
Q88636947Integrated bioinformatics analysis reveals that the expression of cathepsin S is associated with lymph node metastasis and poor prognosis in papillary thyroid cancer
Q113223927Novel lncRNA LINC01614 Facilitates Bladder Cancer Proliferation, Migration and Invasion Through the miR-217/RUNX2/Wnt/β-Catenin Axis
Q26800112RUNX2 and the PI3K/AKT axis reciprocal activation as a driving force for tumor progression
Q47692014RUNX2 expression in thyroid and breast cancer requires the cooperation of three non-redundant enhancers under the control of BRD4 and c-JUN.
Q45762060Redefining the activity of a bone-specific transcription factor: novel insights for understanding bone formation
Q48301345Runt-Related Transcription Factor 2 (Runx2) Is Responsible for Galectin-3 Overexpression in Human Thyroid Carcinoma.
Q48194394Runx2, an inducer of osteoblast and chondrocyte differentiation.
Q92578198The Hippo pathway modulates resistance to BET proteins inhibitors in lung cancer cells
Q58695682The bHLH transcription factor DEC1 promotes thyroid cancer aggressiveness by the interplay with NOTCH1
Q90536694The significance of Runx2 mediating alcohol-induced Brf1 expression and RNA Pol III gene transcription
Q88639338Thyroid Hormone Receptor β Suppression of RUNX2 Is Mediated by Brahma-Related Gene 1-Dependent Chromatin Remodeling
Q38766996Thyroid Hormone Receptor-β (TRβ) Mediates Runt-Related Transcription Factor 2 (Runx2) Expression in Thyroid Cancer Cells: A Novel Signaling Pathway in Thyroid Cancer
Q64077103Transcription Factor HOXA9 is Linked to the Calcification and Invasion of Papillary Thyroid Carcinoma
Q57490424overexpression suppresses tumorigenesis of papillary thyroid cancer via inactivation of PTEN/PI3K/AKT pathway by targeting Runx2

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