Alternative RUNX1 Promoter Regulation by Wnt/β-Catenin Signaling in Leukemia Cells and Human Hematopoietic Progenitors.

scientific article published on 18 November 2015

Alternative RUNX1 Promoter Regulation by Wnt/β-Catenin Signaling in Leukemia Cells and Human Hematopoietic Progenitors. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/JCP.25258
P698PubMed publication ID26580584

P50authorGiancarlo V De FerrariQ58239084
P2093author name stringAlvaro A Elorza
Giorgia D Ugarte
Macarena F Vargas
Matías A Medina
Miguel E Avila
David Necuñir
Soraya E Gutiérrez
P2860cites workIdentification of c-MYC as a target of the APC pathwayQ24310637
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinomaQ24336272
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APCQ24336321
Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesisQ24567977
A molecular mechanism for the effect of lithium on developmentQ24629067
Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia developmentQ26997109
Beta-catenin regulates expression of cyclin D1 in colon carcinoma cellsQ27860717
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cellQ27861001
AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesisQ28273478
Tcf7 is an important regulator of the switch of self-renewal and differentiation in a multipotential hematopoietic cell lineQ28481434
Canonical Wnt3a modulates intracellular calcium and enhances excitatory neurotransmission in hippocampal neuronsQ28570087
A role for Wnt signalling in self-renewal of haematopoietic stem cellsQ28592213
The haemangioblast generates haematopoietic cells through a haemogenic endothelium stageQ28593943
Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathwayQ28640887
Wnt proteins are lipid-modified and can act as stem cell growth factorsQ29615009
Expression and function of a stem cell promoter for the murine CBFalpha2 gene: distinct roles and regulation in natural killer and T cell development.Q30659791
Wnt/β-catenin signaling enhances cyclooxygenase-2 (COX2) transcriptional activity in gastric cancer cellsQ33873644
Transcription-coupled translation control of AML1/RUNX1 is mediated by cap- and internal ribosome entry site-dependent mechanisms.Q33962440
Hematopoietic stem cell fate is established by the Notch-Runx pathwayQ34451310
Role of RUNX1 in adult hematopoiesis: analysis of RUNX1-IRES-GFP knock-in mice reveals differential lineage expressionQ34543370
CD34(+) or CD34(-): which is the more primitive?Q34802505
Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interactionQ34871118
Structure and regulated expression of mammalian RUNX genesQ35779684
Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphomaQ37153719
Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regionsQ37705859
Wnt signaling induces transcription, spatial proximity, and translocation of fusion gene partners in human hematopoietic cells.Q38422753
Assaying beta-catenin/TCF transcription with beta-catenin/TCF transcription-based reporter constructsQ38497336
TCF/LEF factor earn their wingsQ41684115
The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML.Q42723875
The differential activities of Runx1 promoters define milestones during embryonic hematopoiesisQ43254478
Nonredundant roles for Runx1 alternative promoters reflect their activity at discrete stages of developmental hematopoiesisQ45345500
Alternative Runx1 promoter usage in mouse developmental hematopoiesisQ47740290
Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia.Q50649768
The mouse Runx1 +23 hematopoietic stem cell enhancer confers hematopoietic specificity to both Runx1 promoters.Q51750816
Increased expression of AML1 during retinoic-acid-induced differentiation of U937 cells.Q52508473
Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion.Q54351186
Canonical WNT Signaling Promotes Osteogenesis by Directly StimulatingRunx2Gene ExpressionQ57129723
P433issue7
P921main subjectleukemiaQ29496
P304page(s)1460-1467
P577publication date2016-02-11
P1433published inJournal of Cellular PhysiologyQ1524270
P1476titleAlternative RUNX1 Promoter Regulation by Wnt/β-Catenin Signaling in Leukemia Cells and Human Hematopoietic Progenitors
P478volume231

Reverse relations

cites work (P2860)
Q89634514Complex Interplay between the RUNX Transcription Factors and Wnt/β-Catenin Pathway in Cancer: A Tango in the Night
Q91816459Core Binding Factor Leukemia: Chromatin Remodeling Moves Towards Oncogenic Transcription
Q37575507Early Transcriptional Changes Induced by Wnt/β-Catenin Signaling in Hippocampal Neurons
Q90581528Increased expression of RUNX1 in clear cell renal cell carcinoma predicts poor prognosis
Q64902344RUNX family: Oncogenes or tumor suppressors (Review).
Q92348349RUNX1 promotes tumour metastasis by activating the Wnt/β-catenin signalling pathway and EMT in colorectal cancer
Q45316804Regulation of RUNX1 Expression and Activity
Q33443278Transcription Factor RUNX1 Regulates Platelet PCTP (Phosphatidylcholine Transfer Protein): Implications for Cardiovascular Events
Q50418437Wnt/β-catenin signaling stimulates the expression and synaptic clustering of the autism-associated Neuroligin 3 gene.

Search more.