Inhibition of Notch1 signaling by Runx2 during osteoblast differentiation.

scientific article published on February 2011

Inhibition of Notch1 signaling by Runx2 during osteoblast differentiation. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/JBMR.227
P698PubMed publication ID20740684
P5875ResearchGate publication ID45952957

P50authorPaul ShoreQ56937291
P2093author name stringHwa-Young Kim
Eun-Jung Ann
Hee-Sae Park
Jung-Soon Mo
Mi-Sun Seo
Mi-Yeon Kim
Toshihisa Komori
Yun-Hee Choi
Jeong-Tae Koh
Won-Gu Jang
Ji-Hye Yoon
Jane Jung
Su-Man Kim
Ji-Ae Hong
Jeong-Sik Moon
P2860cites workSmad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradationQ24296392
AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localizationQ24311698
CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiationQ24656900
Notch signaling: cell fate control and signal integration in developmentQ27861061
Notch signaling: from the outside inQ28139768
Tip60 histone acetyltransferase acts as a negative regulator of Notch1 signaling by means of acetylationQ28236852
CCN3/NOV inhibits BMP-2-induced osteoblast differentiation by interacting with BMP and Notch signaling pathwaysQ28284875
Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H)Q28286560
Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation.Q28505355
PTH/PTHrP receptor delays chondrocyte hypertrophy via both Runx2-dependent and -independent pathwaysQ28508903
Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiationQ28513083
BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expressionQ28570736
The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2Q28573356
Transcriptional mechanisms regulating MyoD expression in the mouseQ33592140
Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo.Q33819359
Notch signal transduction: a real rip and moreQ33964063
Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondriumQ35106164
Oncogenic potential of the RUNX gene family: 'overview'.Q35779678
Integrin-linked kinase controls Notch1 signaling by down-regulation of protein stability through Fbw7 ubiquitin ligaseQ35950088
Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiationQ35967234
BMP signaling is required for RUNX2-dependent induction of the osteoblast phenotypeQ36731376
Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts.Q37109228
Cyclin D1-cdk4 induce runx2 ubiquitination and degradationQ37113937
Dimorphic effects of Notch signaling in bone homeostasis.Q37165102
Notch signaling contributes to the pathogenesis of human osteosarcomasQ37323322
Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiationQ37339719
Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitorsQ38289269
Expression and activity of Runx2 mediated by hyaluronan during chondrocyte differentiationQ38293954
BMP-2 promotes differentiation of osteoblasts and chondroblasts in Runx2-deficient cell linesQ38305733
Delta-induced Notch signaling mediated by RBP-J inhibits MyoD expression and myogenesisQ38327383
Coordinated activation of notch, Wnt, and transforming growth factor-beta signaling pathways in bone morphogenic protein 2-induced osteogenesis. Notch target gene Hey1 inhibits mineralization and Runx2 transcriptional activityQ38340399
The osteoblast transcription factor Runx2 is expressed in mammary epithelial cells and mediates osteopontin expression.Q38350119
Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis.Q40020072
Mitotic control of RUNX2 phosphorylation by both CDK1/cyclin B kinase and PP1/PP2A phosphatase in osteoblastic cellsQ40195895
HES1 cooperates with pRb to activate RUNX2-dependent transcriptionQ40271544
Bone morphogenetic protein-2 stimulates Runx2 acetylationQ40292757
Insulin-like growth factor-1 regulates endogenous RUNX2 activity in endothelial cells through a phosphatidylinositol 3-kinase/ERK-dependent and Akt-independent signaling pathwayQ40526648
Regulation of TGFbeta1-mediated growth inhibition and apoptosis by RUNX2 isoforms in endothelial cellsQ40563055
E3 Ubiquitin Ligase Smurf1 Mediates Core-binding Factor α1/Runx2 Degradation and Plays A Specific Role in Osteoblast DifferentiationQ40649010
The ins and outs of notch signalingQ41552048
Notch on the cutting edgeQ41684100
Notch 1 impairs osteoblastic cell differentiationQ42796277
Runx2 regulates FGF2-induced Bmp2 expression during cranial bone development.Q52055183
Genetic interactions among vestigial, hairy, and Notch suggest a role of vestigial in the differentiation of epidermal and neural cells of the wing and halter of Drosophila melanogaster.Q52551481
P433issue2
P921main subjectosteoblastQ917177
P304page(s)317-330
P577publication date2011-02-01
P1433published inJournal of Bone and Mineral ResearchQ15750941
P1476titleInhibition of Notch1 signaling by Runx2 during osteoblast differentiation
P478volume26

Reverse relations

cites work (P2860)
Q42559425Acute Lymphoblastic Leukemia Cells Inhibit the Differentiation of Bone Mesenchymal Stem Cells into Osteoblasts In Vitro by Activating Notch Signaling
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Q36407283E3 Ubiquitin Ligase Fbw7 Negatively Regulates Osteoblast Differentiation by Targeting Runx2 for Degradation.
Q33674433Gene expression profile in human induced pluripotent stem cells: Chondrogenic differentiation in vitro, part B.
Q38540501Impact of electromagnetic fields on stem cells: common mechanisms at the crossroad between adult neurogenesis and osteogenesis
Q27022156In vitro models of aortic valve calcification: solidifying a system
Q47220353Notch signaling negatively regulates BMP9-induced osteogenic differentiation of mesenchymal progenitor cells by inhibiting JunB expression
Q39390979Pathophysiology of Aortic Stenosis and Mitral Regurgitation
Q64902344RUNX family: Oncogenes or tumor suppressors (Review).
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Q39172384The role and clinical implications of the endosteal niche and osteoblasts in regulating leukemia.
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