The soluble form of BMPRIB is a novel therapeutic candidate for treating bone related disorders

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The soluble form of BMPRIB is a novel therapeutic candidate for treating bone related disorders is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SREP18849
P932PMC publication ID4702141
P698PubMed publication ID26732094
P5875ResearchGate publication ID289571132

P2093author name stringKazuma Tomizuka
Takeshi Oshima
Tsutomu Okada
Makoto Kakitani
Yuichiro Kondo
Kengo Yamawaki
P2860cites workA comparison of mechanical properties derived from multiple skeletal sites in mice.Q51553347
Bone Morphogenetic Proteins: A critical reviewQ37801468
First evidence supporting a potential role for the BMP/SMAD pathway in the progression of oestrogen receptor-positive breast cancer.Q38326323
Inhibition of Notch1 signaling by Runx2 during osteoblast differentiation.Q38482269
Reduced expression of bone morphogenetic protein receptor IA in pancreatic cancer is associated with a poor prognosisQ39106423
The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limbQ39526477
A soluble activin receptor type IIb prevents the effects of androgen deprivation on body composition and bone healthQ39688975
Inhibiting activin-A signaling stimulates bone formation and prevents cancer-induced bone destruction in vivoQ39695455
Sagopilone inhibits breast cancer bone metastasis and bone destruction due to simultaneous inhibition of both tumor growth and bone resorptionQ39846980
Bone morphogenetic protein signaling enhances invasion and bone metastasis of breast cancer cells through Smad pathwayQ39956368
Safety, pharmacokinetics, pharmacodynamics, and antitumor activity of dalantercept, an activin receptor-like kinase-1 ligand trap, in patients with advanced cancerQ44319244
BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signalingQ45065876
Multiple-dose, safety, pharmacokinetic, and pharmacodynamic study of sotatercept (ActRIIA-IgG1), a novel erythropoietic agent, in healthy postmenopausal womenQ45412595
A covalently dimerized recombinant human bone morphogenetic protein-15 variant identifies bone morphogenetic protein receptor type 1B as a key cell surface receptor on ovarian granulosa cellsQ48656274
TGF-beta signal transductionQ22003891
Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analysesQ24310450
Regulation of muscle growth by multiple ligands signaling through activin type II receptorsQ24538732
Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivoQ24555732
A novel transgenic chimaeric mouse system for the rapid functional evaluation of genes encoding secreted proteinsQ24794416
Human artificial chromosome (HAC) vector provides long-term therapeutic transgene expression in normal human primary fibroblastsQ29036440
Identification of the haematopoietic stem cell niche and control of the niche sizeQ29615008
Specificity and versatility in tgf-beta signaling through SmadsQ29616324
Granulosa cell-expressed BMPR1A and BMPR1B have unique functions in regulating fertility but act redundantly to suppress ovarian tumor development.Q30432180
ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growthQ34096297
A phase 1 study of ACE-536, a regulator of erythroid differentiation, in healthy volunteersQ34235483
Mitogenic influence of human R-spondin1 on the intestinal epitheliumQ34444196
Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in miceQ34680057
Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effectsQ34792580
BMPR1a and BMPR1b signaling exert opposing effects on gliosis after spinal cord injuryQ34979181
BMP4 inhibits the proliferation of breast cancer cells and induces an MMP-dependent migratory phenotype in MDA-MB-231 cells in 3D environmentQ34992889
Genetic analysis of the mammalian transforming growth factor-beta superfamilyQ35017076
Consequences of knocking out BMP signaling in the mouseQ35025212
Sotatercept in patients with osteolytic lesions of multiple myeloma.Q35035011
Adult-specific systemic over-expression reveals novel in vivo effects of the soluble forms of ActRIIA, ActRIIB and BMPRII.Q35035999
The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutationsQ35446158
A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strengthQ36132931
Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formationQ36325743
Disruption of BMP signaling in osteoblasts through type IA receptor (BMPRIA) increases bone mass.Q37203466
Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiationQ37339719
Humoral bone morphogenetic protein 2 is sufficient for inducing breast cancer microcalcification.Q37400376
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)18849
P577publication date2016-01-06
P1433published inScientific ReportsQ2261792
P1476titleThe soluble form of BMPRIB is a novel therapeutic candidate for treating bone related disorders
P478volume6

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cites work (P2860)
Q55411806Anabolic Strategies to Augment Bone Fracture Healing.
Q39019244Immunoregulation by members of the TGFβ superfamily

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