| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/0168-9525(93)90026-E |
| P698 | PubMed publication ID | 8273148 |
| P2093 | author name string | Y Ito | |
| K Shigesada | |||
| M Ohki | |||
| M Satake | |||
| H Miyoshi | |||
| M Pepling | |||
| H Kagoshima | |||
| P Gergen | |||
| P433 | issue | 10 | |
| P304 | page(s) | 338-341 | |
| P577 | publication date | 1993-10-01 | |
| P1433 | published in | Trends in Genetics | Q2451468 |
| P1476 | title | The Runt domain identifies a new family of heteromeric transcriptional regulators. | |
| P478 | volume | 9 |
| Q52105870 | A DNA-binding-independent pathway of repression by the Drosophila Runt protein. |
| Q24652629 | A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia |
| Q41185124 | A conserved cysteine residue in the runt homology domain of AML1 is required for the DNA binding ability and the transforming activity on fibroblasts |
| Q24312874 | A novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cells |
| Q43539759 | A simple screening for mutant DNA binding proteins: application to murine transcription factor PEBP2alpha subunit, a founding member of the Runt domain protein family |
| Q74536317 | A unique AML1 (CBF2A) rearrangement, t(1;21)(p32;q22), observed in a patient with acute myelomonocytic leukemia |
| Q39968436 | A variant of Runx2 that differs from the bone isoform in its splicing is expressed in spermatogenic cells |
| Q28142631 | AML1 (CBFalpha2) cooperates with B cell-specific activating protein (BSAP/PAX5) in activation of the B cell-specific BLK gene promoter |
| Q40594028 | AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues. |
| Q40921582 | AML1, the target of chromosomal rearrangements in human leukemia, regulates the expression of human complement receptor type 1 (CR1) gene |
| Q28273478 | AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis |
| Q33943238 | AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations |
| Q52848045 | Aberrant expression of CD19 in AML with t(8;21) involves a poised chromatin structure and PAX5. |
| Q39576827 | Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO. |
| Q24626212 | Alternative splicing and genomic structure of theAML1gene involved in acute myeloid leukemia |
| Q37610593 | An AML-1 consensus sequence binds an osteoblast-specific complex and transcriptionally activates the osteocalcin gene |
| Q40489175 | Analysis of novel RUNX2 mutations in Chinese patients with cleidocranial dysplasia. |
| Q95811462 | Auto-inhibition and partner proteins, core-binding factor beta (CBFbeta) and Ets-1, modulate DNA binding by CBFalpha2 (AML1) |
| Q33961222 | Auto-inhibition of Ets-1 is counteracted by DNA binding cooperativity with core-binding factor alpha2. |
| Q51007406 | Biochemical and biophysical properties of the core-binding factor alpha2 (AML1) DNA-binding domain. |
| Q33961306 | Biological characteristics of the leukemia-associated transcriptional factor AML1 disclosed by hematopoietic rescue of AML1-deficient embryonic stem cells by using a knock-in strategy |
| Q52169722 | Biophysical characterization of interactions between the core binding factor alpha and beta subunits and DNA. |
| Q30434275 | CBFbeta allosterically regulates the Runx1 Runt domain via a dynamic conformational equilibrium |
| Q25255704 | CBFbeta is a facultative Runx partner in the sea urchin embryo |
| Q30439864 | CBFbeta is critical for AML1-ETO and TEL-AML1 activity |
| Q36557608 | CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter |
| Q38848457 | Characterisation of novel RUNX2 mutation with alanine tract expansion from Japanese cleidocranial dysplasia patient |
| Q40709828 | Characterization of an osteoblast-specific enhancer element in the CBFA1 gene |
| Q58008676 | Chloride binding by the AML1/Runx1 transcription factor studied by NMR |
| Q38858036 | Cleidocranial dysplasia and RUNX2-clinical phenotype-genotype correlation |
| Q52163862 | Cloning and embryonic expression patterns of the zebrafish Runt domain genes, runxa and runxb. |
| Q24319877 | Cloning, mapping and expression of PEBP2 alpha C, a third gene encoding the mammalian Runt domain |
| Q38324655 | Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation |
| Q34405458 | Common themes in the pathogenesis of acute myeloid leukemia |
| Q33884021 | Conservation and function of the transcriptional regulatory protein Runt |
| Q44142728 | Conserved cluster organization of insect Runx genes |
| Q34718183 | Core-binding factors in haematopoiesis and leukaemia |
| Q28348865 | Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation |
| Q24567977 | Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis |
| Q33948578 | Distinct contributions of conserved modules to Runt transcription factor activity |
| Q51973628 | Diversity of supernumerary tooth formation in siblings with cleidocranial dysplasia having identical mutation in RUNX2 : possible involvement of non-genetic or epigenetic regulation. |
| Q84425399 | Domain analyses of the Runx1 transcription factor responsible for modulating T-cell receptor-beta/CD4 and interleukin-4/interferon-gamma expression in CD4(+) peripheral T lymphocytes |
| Q91983046 | Dopamine-dependent, swimming-induced paralysis arises as a consequence of loss of function mutations in the RUNX transcription factor RNT-1 |
| Q33966798 | Dosage-sensitive maternal modifiers of the drosophila segmentation gene runt |
| Q42703663 | Down-regulation of Runx1 expression by TCR signal involves an autoregulatory mechanism and contributes to IL-2 production. |
| Q36557398 | Drosophila homologs of the proto-oncogene product PEBP2/CBF beta regulate the DNA-binding properties of Runt |
| Q24653699 | ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex |
| Q47987634 | ETO-2, a new member of the ETO-family of nuclear proteins |
| Q52165310 | Energetic and functional contribution of residues in the core binding factor beta (CBFbeta ) subunit to heterodimerization with CBFalpha. |
| Q44478788 | Energetic contribution of residues in the Runx1 Runt domain to DNA binding. |
| Q40513638 | Expression of RUNX3 protein in human gastric mucosa, intestinal metaplasia and carcinoma |
| Q40903207 | Expression of the AML-1 oncogene shortens the G(1) phase of the cell cycle |
| Q28507097 | Expression of the Runt domain-encoding PEBP2 alpha genes in T cells during thymic development |
| Q37705859 | Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions |
| Q34440372 | Expression pattern, regulation, and biological role of runt domain transcription factor, run, in Caenorhabditis elegans |
| Q41676689 | Factors involved in leukaemogenesis and haemopoiesis |
| Q37202869 | Functional analysis of RUNX2 mutations in Japanese patients with cleidocranial dysplasia demonstrates novel genotype-phenotype correlations |
| Q53862836 | Functional analysis of RUNX2 mutations in cleidocranial dysplasia: novel insights into genotype–phenotype correlations |
| Q71860090 | Functional dissection of the alpha and beta subunits of transcription factor PEBP2 and the redox susceptibility of its DNA binding activity |
| Q39460739 | Gene targeting reveals a crucial role for MTG8 in the gut. |
| Q33966305 | Genetic and molecular analysis of the autosomal component of the primary sex determination signal of Drosophila melanogaster |
| Q77565717 | Genetic control of cell differentiation in the skeleton |
| Q28744443 | Genome-wide phylogenetic comparative analysis of plant transcriptional regulation: a timeline of loss, gain, expansion, and correlation with complexity |
| Q55263355 | Glucocorticoids Inhibit Oncogenic RUNX1-ETO in Acute Myeloid Leukemia with Chromosome Translocation t(8;21). |
| Q73064601 | Glucocorticoids induce apoptosis in acute myeloid leukemia cell lines with A t(8;21) chromosome translocation |
| Q36572515 | Groucho-dependent and -independent repression activities of Runt domain proteins |
| Q28609075 | Groucho/TLE family proteins and transcriptional repression |
| Q35932777 | Growth inhibition and induction of differentiation of t(8;21) acute myeloid leukemia cells by the DNA-binding domain of PEBP2 and the AML1/MTG8(ETO)-specific antisense oligonucleotide |
| Q34803072 | Hairless is a cofactor for Runt-dependent transcriptional regulation |
| Q28594445 | Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor |
| Q44472746 | Hemocyte production and maturation in an invertebrate animal; proliferation and gene expression in hematopoietic stem cells of Pacifastacus leniusculus |
| Q35779772 | Homologs of RUNX and CBF beta/PEBP2 beta in C. elegans |
| Q48350312 | Identification and comparative analysis of a second runx3 promoter |
| Q90244304 | Identification of RUNX2 variants associated with cleidocranial dysplasia |
| Q33341337 | Identification of a new pebp2alphaA2 isoform from zebrafish runx2 capable of inducing osteocalcin gene expression in vitro. |
| Q58789077 | Identification of a novel mutation of RUNX2 in a family with supernumerary teeth and craniofacial dysplasia by whole-exome sequencing: A case report and literature review |
| Q24533170 | Identification of homeotic target genes in Drosophila melanogaster including nervy, a proto-oncogene homologue |
| Q28288151 | Identification of two transcripts of AML1/ETO-fused gene in t(8;21) leukemic cells and expression of wild-type ETO gene in hematopoietic cells |
| Q35917558 | In vivo interactions of the Drosophila Hairy and Runt transcriptional repressors with target promoters |
| Q33888879 | Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation |
| Q37388143 | Is Runx a linchpin for developmental signaling in metazoans? |
| Q24309536 | Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene |
| Q38129376 | Making no bones about it: Transcription factors in vertebrate skeletogenesis and disease |
| Q36595115 | Metaphyseal dysplasia with maxillary hypoplasia and brachydactyly is caused by a duplication in RUNX2. |
| Q45345530 | Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia. |
| Q30789277 | Mouse glutaredoxin - cDNA cloning, high level expression in E. coli and its possible implication in redox regulation of the DNA binding activity in transcription factor PEBP2. |
| Q33774804 | Multiple functional domains of AML1: PU.1 and C/EBPalpha synergize with different regions of AML1 |
| Q28590672 | Mutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunit |
| Q47708056 | Novel Mutation of the RUNX2 Gene in Patients with Cleidocranial Dysplasia. |
| Q35145013 | Novel mutation of RUNX2 gene in a patient with cleidocranial dysplasia |
| Q35779678 | Oncogenic potential of the RUNX gene family: 'overview'. |
| Q28240596 | Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation |
| Q46158183 | Overexpression of an isoform of AML1 in acute leukemia and its potential role in leukemogenesis |
| Q36652625 | PEBP2 alpha B/mouse AML1 consists of multiple isoforms that possess differential transactivation potentials |
| Q73480363 | PEBP2alphaA/CBFA1 mutations in Japanese cleidocranial dysplasia patients |
| Q36858233 | PTH Signaling and Epigenetic Control of Bone Remodeling. |
| Q34508386 | Parathyroid hormone-dependent signaling pathways regulating genes in bone cells. |
| Q33874344 | Periovulatory expression of hyaluronan and proteoglycan link protein 1 (Hapln1) in the rat ovary: hormonal regulation and potential function |
| Q38289629 | Potential involvement of the AML1-MTG8 fusion protein in the granulocytic maturation characteristic of the t(8;21) acute myelogenous leukemia revealed by microarray analysis |
| Q50489558 | Precocious Phenotypic Transcription-Factor Expression During Early Development. |
| Q34608599 | Quantitative analysis of gene function in the Drosophila embryo |
| Q36554617 | RETRACTED: Overexpression of core-binding factor alpha (CBF alpha) reverses cellular transformation by the CBF beta-smooth muscle myosin heavy chain chimeric oncoprotein |
| Q47069273 | RNT-1, the C. elegans homologue of mammalian RUNX transcription factors, regulates body size and male tail development |
| Q64902344 | RUNX family: Oncogenes or tumor suppressors (Review). |
| Q37013889 | RUNX genes in development and cancer: regulation of viral gene expression and the discovery of RUNX family genes |
| Q38904259 | RUNX in Invertebrates |
| Q91559627 | RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation |
| Q36206674 | RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis |
| Q39914225 | RUNX1 and RUNX2 upregulate Galectin-3 expression in human pituitary tumors |
| Q35642451 | RUNX1 mutations in clonal myeloid disorders: from conventional cytogenetics to next generation sequencing, a story 40 years in the making |
| Q37822736 | RUNX1 translocations and fusion genes in malignant hemopathies |
| Q52577878 | RUNX1-PDCD6 fusion resulting from a novel t(5;21)(p15;q22) chromosome translocation in myelodysplastic syndrome secondary to chronic lymphocytic leukemia. |
| Q28207579 | RUNX1/AML1: a central player in hematopoiesis |
| Q47678907 | RUNX1: A Regulator of NF-kB Signaling in Pulmonary Diseases |
| Q78017212 | Regulated expression of the bone-specific osteocalcin gene by vitamins and hormones |
| Q52552639 | Runt domain partner proteins enhance DNA binding and transcriptional repression in cultured Drosophila cells. |
| Q38344674 | Runt homology domain proteins in osteoblast differentiation: AML3/CBFA1 is a major component of a bone-specific complex |
| Q28581464 | Runt-related transcription factor 1 regulates luteinized hormone-induced prostaglandin-endoperoxide synthase 2 expression in rat periovulatory granulosa cells |
| Q34852828 | Runx transcription factors repress human and murine c-Myc expression in a DNA-binding and C-terminally dependent manner |
| Q28282851 | Runx1 binds as a dimeric complex to overlapping Runx1 sites within a palindromic element in the human GM-CSF enhancer |
| Q36040957 | Runx1 dose-dependently regulates endochondral ossification during skeletal development and fracture healing |
| Q28592659 | Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis |
| Q40020072 | Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis. |
| Q42906074 | Runx3 Expression Inhibits Proliferation and Distinctly Alters mRNA Expression of Bax in AGS and A549 Cancer Cells |
| Q40675153 | Sex, segments, and the central nervous system: common genetic mechanisms of cell fate determination. |
| Q38326433 | Solution properties of the free and DNA-bound Runt domain of AML1. |
| Q36556397 | Specificity for the hairy/enhancer of split basic helix-loop-helix (bHLH) proteins maps outside the bHLH domain and suggests two separable modes of transcriptional repression |
| Q40975402 | Structural alterations in the transcription factor PEBP2/CBF linked to four different types of leukemia |
| Q35121727 | Structural and functional characterization of Runx1, CBF beta, and CBF beta-SMMHC. |
| Q38360015 | Structural and functional characterization of the human CD36 gene promoter: identification of a proximal PEBP2/CBF site |
| Q52569163 | Structure and evolution of a pair-rule interaction element: runt regulatory sequences in D. melanogaster and D. virilis. |
| Q34299691 | Structure of the leukemia-associated human CBFB gene |
| Q24314024 | Subcellular localization of the alpha and beta subunits of the acute myeloid leukemia-linked transcription factor PEBP2/CBF |
| Q39551832 | Suppressor mutations within the core binding factor (CBF/AML1) binding site of a T-cell lymphomagenic retrovirus. |
| Q33851820 | Syndromes associated with Homo sapiens pol II regulatory genes |
| Q24324229 | The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1 |
| Q52036832 | The C. elegans RUNX transcription factor RNT-1/MAB-2 is required for asymmetrical cell division of the T blast cell. |
| Q28251560 | The Groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3 |
| Q51909449 | The HMG-box protein Lilliputian is required for Runt-dependent activation of the pair-rule gene fushi-tarazu. |
| Q27620201 | The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains |
| Q33911526 | The PEBP2beta/CBF beta-SMMHC chimeric protein is localized both in the cell membrane and nuclear subfractions of leukemic cells carrying chromosomal inversion 16. |
| Q34423871 | The Role of RUNX2 in Osteosarcoma Oncogenesis |
| Q42113879 | The Runx1 transcription factor inhibits the differentiation of naive CD4+ T cells into the Th2 lineage by repressing GATA3 expression |
| Q28590965 | The Runx3 distal transcript encodes an additional transcriptional activation domain |
| Q38269459 | The assembly of Vif ubiquitin E3 ligase for APOBEC3 degradation |
| Q39575319 | The capacity of polyomavirus enhancer binding protein 2alphaB (AML1/Cbfa2) to stimulate polyomavirus DNA replication is related to its affinity for the nuclear matrix |
| Q35068916 | The cleidocranial dysplasia-related R131G mutation in the Runt-related transcription factor RUNX2 disrupts binding to DNA but not CBF-beta |
| Q24792586 | The evolution of Runx genes I. A comparative study of sequences from phylogenetically diverse model organisms |
| Q40772958 | The expression of ETV6/CBFA2 (TEL/AML1) is not sufficient for the transformation of hematopoietic cell lines in vitro or the induction of hematologic disease in vivo |
| Q36561099 | The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability |
| Q24634247 | The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein traffic |
| Q34448188 | The role of the AML1 transcription factor in leukemogenesis |
| Q36719874 | The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation |
| Q64071863 | Thermodynamic investigation of DNA-binding affinity of wild-type and mutant transcription factor RUNX1 |
| Q38293060 | Transactivation of the Moloney murine leukemia virus and T-cell receptor beta-chain enhancers by cbf and ets requires intact binding sites for both proteins |
| Q33962440 | Transcription-coupled translation control of AML1/RUNX1 is mediated by cap- and internal ribosome entry site-dependent mechanisms. |
| Q39875687 | Transcriptional activation of a retrovirus enhancer by CBF (AML1) requires a second factor: evidence for cooperativity with c-Myb. |
| Q38296037 | Transcriptional activity of core binding factor-alpha (AML1) and beta subunits on murine leukemia virus enhancer cores |
| Q41589633 | Transcriptional regulation during myelopoiesis |
| Q34769502 | Transcriptional regulation of the Sex-lethal gene by helix-loop-helix proteins |
| Q24316983 | Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors |
| Q45373142 | Truncated forms of RUNX3 Unlike Full Length Protein Alter Cell Proliferation in a TGF-β Context Dependent Manner |
| Q33774997 | Two domains unique to osteoblast-specific transcription factor Osf2/Cbfa1 contribute to its transactivation function and its inability to heterodimerize with Cbfbeta |
| Q38895931 | Upregulation of Runt-Related Transcription Factor-2 Through CCAAT Enhancer Binding Protein-β Signaling Pathway in Microglial BV-2 Cells Exposed to ATP. |
| Q38350194 | VWRPY motif–dependent and –independent roles of AML1/Runx1 transcription factor in murine hematopoietic development |
| Q40503129 | Williams-Beuren syndrome critical region-5/non-T-cell activation linker: a novel target gene of AML1/ETO. |
| Q54575578 | [Cleidocranial dysplasia. Description and analysis of a patient cohort]. |
| Q73449354 | cDNA cloning of run, a Caenorhabditis elegans Runt domain encoding gene |
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