Loss of osteoblast Runx3 produces severe congenital osteopenia

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Loss of osteoblast Runx3 produces severe congenital osteopenia is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.01106-14
P932PMC publication ID4355527
P698PubMed publication ID25605327

P2093author name stringShu Takeda
Omri Bauer
Yoram Groner
Ayako Kimura
Amnon Sharir
Shay Hantisteanu
P2860cites workTwenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studiesQ24289320
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Core-binding factors in hematopoiesis and immune functionQ28262826
Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehogQ28586013
Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasiaQ28591205
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Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblastsQ29547605
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Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels.Q30531794
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Accelerated chemokine receptor 7-mediated dendritic cell migration in Runx3 knockout mice and the spontaneous development of asthma-like diseaseQ33906792
Osteo-chondroprogenitor cells are derived from Sox9 expressing precursorsQ34055618
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Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fractureQ34268288
HES1 (Hairy and Enhancer of Split 1) Is a Determinant of Bone MassQ34509386
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Loss of Runx2 in committed osteoblasts impairs postnatal skeletogenesis.Q34790965
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A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic developmentQ35194624
Structure and regulated expression of mammalian RUNX genesQ35779684
Bone growth in length and width: the Yin and Yang of bone stability.Q36261554
Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fracturesQ36293998
DMP1 is essential for osteocyte formation and function.Q36337304
Role of Runx proteins in chondrogenesisQ36359365
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Role of Runx genes in chondrocyte differentiationQ38289933
The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neuronsQ39644959
Runx3/AML2/Cbfa3 regulates early and late chondrocyte differentiation.Q40135256
Genomic regions identified for BMD in a large sample including epistatic interactions and gender-specific effectsQ40285853
Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammationQ40734155
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The protein tyrosine phosphatase Rptpzeta is expressed in differentiated osteoblasts and affects bone formation in miceQ42818523
Mouse alpha1(I)-collagen promoter is the best known promoter to drive efficient Cre recombinase expression in osteoblastQ43434401
Association of a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene with bone phenotypes depends on plasma folate statusQ44812034
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Multiple osteoporosis susceptibility genes on chromosome 1p36 in Chinese.Q46012022
Phylogenesis and regulated expression of the RUNT domain transcription factors RUNX1 and RUNX3.Q47396753
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Confirmation and fine mapping of chromosomal regions influencing peak bone mass in miceQ48657499
An analysis of skeletal development in osteoblast-specific and chondrocyte-specific runt-related transcription factor-2 (Runx2) knockout miceQ50235797
Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors.Q50722204
Differential staining of cartilage and bone in whole mouse fetuses by alcian blue and alizarin red S.Q50941844
Regulation of skeletal development by the Runx family of transcription factors.Q50974881
Runx3-deficient mouse strains circa 2008: resemblance and dissimilarity.Q51808089
Quantitative trait loci for bone density in mice: the genes determining total skeletal density and femur density show little overlap in F2 mice.Q52115495
Spatial and temporal expression pattern of Runx3 (Aml2) and Runx1 (Aml1) indicates non-redundant functions during mouse embryogenesis.Q52126883
Col2a1-directed expression of Cre recombinase in differentiating chondrocytes in transgenic mice.Q52169988
Developmental expression of mouse stromelysin-3 mRNA.Q52209103
Core binding factor β of osteoblasts maintains cortical bone mass via stabilization of Runx2 in mice.Q53252888
Cbf beta regulates Runx2 function isoform-dependently in postnatal bone development.Q53615857
The distinct role of the Runx proteins in chondrocyte differentiation and intervertebral disc degeneration: findings in murine models and in human disease.Q54517855
AchondroplasiaQ57751572
First-stage autosomal genome screen in extended pedigrees suggests genes predisposing to low bone mineral density on chromosomes 1p, 2p and 4qQ57783993
Mice deficient in Abl are osteoporotic and have defects in osteoblast maturationQ58085524
Criteria to evaluate bone mineralization in cattle: I. Effect of dietary phosphorus on chemical, physical, and mechanical propertiesQ70214014
Association of a polymorphism in the TNFR2 gene with low bone mineral densityQ73995317
Regulation of matrix metalloproteinases (MMP-2, -3, -9, and -13) by interleukin-1 and interleukin-6 in mouse calvaria: association of MMP induction with bone resorptionQ74278303
Variance component linkage analysis indicates a QTL for femoral neck bone mineral density on chromosome 1p36Q77105209
Expression of Runx1, -2 and -3 during tooth, palate and craniofacial bone developmentQ79096024
High-throughput tool for discovery of bone regulating factorsQ79398611
Interleukin 10-deficient mice develop osteopenia, decreased bone formation, and mechanical fragility of long bonesQ80552322
Univariate and bivariate variance component linkage analysis of a whole-genome scan for loci contributing to bone mineral densityQ81644880
Meta-analysis of genome-wide linkage studies for bone mineral densityQ82811612
Cbfb regulates bone development by stabilizing Runx family proteinsQ85644607
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectcongenital disorderQ727096
osteoblastQ917177
P304page(s)1097-1109
P577publication date2015-01-20
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleLoss of osteoblast Runx3 produces severe congenital osteopenia
P478volume35

Reverse relations

cites work (P2860)
Q30833502An ensemble of regulatory elements controls Runx3 spatiotemporal expression in subsets of dorsal root ganglia proprioceptive neurons
Q50532624Cbfb2 Isoform Dominates More Potent Cbfb1 and Is Required for Skeletal Development.
Q35660938Global transcriptional profiling using RNA sequencing and DNA methylation patterns in highly enriched mesenchymal cells from young versus elderly women
Q64264178Identification of Genes Differentially Expressed in Simvastatin-Induced Alveolar Bone Formation
Q41636712Identification of a p53 target, CD137L, that mediates growth suppression and immune response of osteosarcoma cells.
Q52765383Identification of differentially expressed miRNAs associated with chronic kidney disease-mineral bone disorder.
Q61818043Identification of key transcription factors - gene regulatory network related with osteogenic differentiation of human mesenchymal stem cells based on transcription factor prognosis system
Q36530809In Vitro Expansion of Bone Marrow Derived Mesenchymal Stem Cells Alters DNA Double Strand Break Repair of Etoposide Induced DNA Damage
Q92377245Molecular Mechanism of Runx2-Dependent Bone Development
Q92999963Oncogenic RUNX3: A Link between p53 Deficiency and MYC Dysregulation
Q92291499Osteoporosis genome-wide association study variant c.3781 C>A is regulated by a novel anti-osteogenic factor miR-345-5p
Q96639920Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity
Q64902344RUNX family: Oncogenes or tumor suppressors (Review).
Q64076615Regulation of Proliferation, Differentiation and Functions of Osteoblasts by Runx2
Q51097637Roles of Runx2 in Skeletal Development.
Q48194394Runx2, an inducer of osteoblast and chondrocyte differentiation.
Q51097608Runx3 and Cell Fate Decisions in Pancreas Cancer.
Q38904246Runx3 in Immunity, Inflammation and Cancer
Q41550741The Proprioceptive System Regulates Morphologic Restoration of Fractured Bones
Q36309953The RUNX Genes as Conditional Oncogenes: Insights from Retroviral Targeting and Mouse Models

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