Regulation of RUNX2 transcription factor-DNA interactions and cell proliferation by vitamin D3 (cholecalciferol) prohormone activity

scientific article

Regulation of RUNX2 transcription factor-DNA interactions and cell proliferation by vitamin D3 (cholecalciferol) prohormone activity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/JBMR.1504
P698PubMed publication ID22189971
P5875ResearchGate publication ID51905899

P2093author name stringAverell Gnatt
Antonino Passaniti
Alexander D MacKerell
Moran Choe
Jessica Bennett
David R D'Souza
Karen F Underwood
Bahru Habtemariam
Adam D Pierce
Maria Mochin-Peters
Sravya Kommineni
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Cbfbeta interacts with Runx2 and has a critical role in bone developmentQ28586662
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Nuclear microenvironments support assembly and organization of the transcriptional regulatory machinery for cell proliferation and differentiationQ35638442
Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expressionQ35779750
Interfacial inhibition of macromolecular interactions: nature's paradigm for drug discoveryQ36062585
Phosphorylation, acetylation and ubiquitination: the molecular basis of RUNX regulationQ36329898
Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin geneQ36550226
Regulatory roles of Runx2 in metastatic tumor and cancer cell interactions with bone.Q36682092
Vitamin D signalling pathways in cancer: potential for anticancer therapeuticsQ36919979
Cyclin D1-cdk4 induce runx2 ubiquitination and degradationQ37113937
Hyperglycemia regulates RUNX2 activation and cellular wound healing through the aldose reductase polyol pathwayQ37258582
HIV-1 integrase pharmacophore: discovery of inhibitors through three-dimensional database searchingQ38347789
Epidermal growth factor and bone morphogenetic proteins upregulate osteoblast proliferation and osteoblastic markers and inhibit bone nodule formationQ39680824
The RUNX2 transcription factor cooperates with the YES-associated protein, YAP65, to promote cell transformationQ40144929
Mitotic control of RUNX2 phosphorylation by both CDK1/cyclin B kinase and PP1/PP2A phosphatase in osteoblastic cellsQ40195895
Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferationQ40331133
Cholecalciferol (vitamin D3) inhibits growth and invasion by up-regulating nuclear receptors and 25-hydroxylase (CYP27A1) in human prostate cancer cellsQ40374373
Identification of novel extracellular signal-regulated kinase docking domain inhibitors.Q40401482
Insulin-like growth factor-1 regulates endogenous RUNX2 activity in endothelial cells through a phosphatidylinositol 3-kinase/ERK-dependent and Akt-independent signaling pathwayQ40526648
Fidelity of Runx2 activity in breast cancer cells is required for the generation of metastases-associated osteolytic disease.Q40539678
Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signalingQ40540364
Regulation of TGFbeta1-mediated growth inhibition and apoptosis by RUNX2 isoforms in endothelial cellsQ40563055
Indispensable role of the transcription factor PEBP2/CBF in angiogenic activity of a murine endothelial cell MSS31.Q40904563
Electrophoretic mobility shift assay (EMSA) for detecting protein-nucleic acid interactionsQ41902384
Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2.Q42826927
Receptor-DNA interactions: EMSA and footprintingQ44828841
CDK11p58 represses vitamin D receptor-mediated transcriptional activation through promoting its ubiquitin-proteasome degradation.Q45962907
Prediagnostic serum vitamin D and breast cancerQ46780572
Energetic and functional contribution of residues in the core binding factor beta (CBFbeta ) subunit to heterodimerization with CBFalpha.Q52165310
An evaluation of the biologic activity and vitamin D receptor binding affinity of the photoisomers of vitamin D3 and previtamin D3Q56087774
Vitamin D and Reduced Risk of Breast Cancer: A Population-Based Case-Control StudyQ58231837
P433issue4
P921main subjectcholecalciferolQ139347
P304page(s)913-925
P577publication date2012-04-01
P1433published inJournal of Bone and Mineral ResearchQ15750941
P1476titleRegulation of RUNX2 transcription factor-DNA interactions and cell proliferation by vitamin D3 (cholecalciferol) prohormone activity
P478volume27

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cites work (P2860)
Q38312698A quantitative assay to study protein:DNA interactions, discover transcriptional regulators of gene expression, and identify novel anti-tumor agents
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Q33697210RUNX2 is overexpressed in melanoma cells and mediates their migration and invasion
Q36947310The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells
Q45316819Transcriptional regulation by RUNX2
Q38712047Vitamin D Impacts the Expression of Runx2 Target Genes and Modulates Inflammation, Oxidative Stress and Membrane Vesicle Biogenesis Gene Networks in 143B Osteosarcoma Cells