Nonribosomal peptides: from genes to products

scientific article

Nonribosomal peptides: from genes to products is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1039/B111145K
P698PubMed publication ID12828367

P2093author name stringMohamed A Marahiel
Dirk Schwarzer
Robert Finking
P433issue3
P304page(s)275-287
P577publication date2003-06-01
P1433published inNatural Product ReportsQ2376904
P1476titleNonribosomal peptides: from genes to products
P478volume20

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cites work (P2860)
Q36212512A Protocol for the Design of Protein and Peptide Nanostructure Self-Assemblies Exploiting Synthetic Amino Acids
Q34552773A glutamic acid 3-methyltransferase encoded by an accessory gene locus important for daptomycin biosynthesis in Streptomyces roseosporus
Q28539246A non-canonical NRPS is involved in the synthesis of fungisporin and related hydrophobic cyclic tetrapeptides in Penicillium chrysogenum
Q42330231A non-canonical peptide synthetase adenylates 3-methyl-2-oxovaleric acid for auriculamide biosynthesis.
Q57199533A polyketide interferes with cellular differentiation in the symbiotic cyanobacterium Nostoc punctiforme
Q84596142A stand-alone adenylation domain forms amide bonds in streptothricin biosynthesis
Q41607166A strategy for the identification of patterns in the biosynthesis of nonribosomal peptides by Betaproteobacteria species
Q98906781A way to thioacetate esters compatible with non-oxidative prebiotic conditions
Q40948814Activity of α-Aminoadipate Reductase Depends on the N-Terminally Extending Domain
Q46453851Alanine scan of the peptide antibiotic feglymycin: assessment of amino acid side chains contributing to antimicrobial activity
Q42338655An Activator of an Adenylation Domain Revealed by Activity but Not Sequence Homology
Q28487486An extracellular siderophore is required to maintain the mutualistic interaction of Epichloë festucae with Lolium perenne
Q38031395Anaerobic bacteria as producers of antibiotics
Q37303978Antimicrobial peptides from marine proteobacteria
Q36335698Aspergillus hancockii sp. nov., a biosynthetically talented fungus endemic to southeastern Australian soils
Q90005473Assessment of Synthesis Machinery of Two Antimicrobial Peptides from Paenibacillus alvei NP75
Q48202788Bacterial Alkaloids Prevent Amoebal Predation
Q57563961Bacterial Alkaloids Prevent Amoebal Predation
Q33528140Biochemical evidence for conformational changes in the cross-talk between adenylation and peptidyl-carrier protein domains of nonribosomal peptide synthetases.
Q37418682Biocombinatorial Synthesis of Novel Lipopeptides by COM Domain-Mediated Reprogramming of the Plipastatin NRPS Complex
Q28649879Biodiversity of genes encoding anti-microbial traits within plant associated microbes
Q36797634Biogenetic diversity of cyanobacterial metabolites
Q54220404Bioprospection of actinobacteria derived from freshwater sediments for their potential to produce antimicrobial compounds.
Q59124355Biosynthesis and Biological Activity of Carbasugars
Q33285736Biosynthesis and structure of aeruginoside 126A and 126B, cyanobacterial peptide glycosides bearing a 2-carboxy-6-hydroxyoctahydroindole moiety
Q42622719Biosynthesis of (R)-beta-tyrosine and its incorporation into the highly cytotoxic chondramides produced by Chondromyces crocatus
Q42408769Biosynthetic pathway for mannopeptimycins, lipoglycopeptide antibiotics active against drug-resistant gram-positive pathogens
Q47990371Chapter 13. Nonribosomal peptide synthetases mechanistic and structural aspects of essential domains
Q47247904Characterization of sulfhydryl oxidase from Aspergillus tubingensis
Q43739479Characterization of the Suillus grevillei quinone synthetase GreA supports a nonribosomal code for aromatic α-keto acids
Q28486188Characterization of the biocontrol activity of pseudomonas fluorescens strain X reveals novel genes regulated by glucose
Q35546948Characterization of the colistin (polymyxin E1 and E2) biosynthetic gene cluster.
Q33304966Characterization of the saframycin A gene cluster from Streptomyces lavendulae NRRL 11002 revealing a nonribosomal peptide synthetase system for assembling the unusual tetrapeptidyl skeleton in an iterative manner
Q36416681Chemoenzymatic and template-directed synthesis of bioactive macrocyclic peptides
Q34801546Cloning and characterization of the gene cluster required for beauvericin biosynthesis in Fusarium proliferatum.
Q42119173Cloning and heterologous expression of the thioviridamide biosynthesis gene cluster from Streptomyces olivoviridis
Q33224197Combinatorial biosynthesis of lipopeptide antibiotics in Streptomyces roseosporus
Q24676630Combinatorial biosynthesis of novel antibiotics related to daptomycin
Q40975277Comparative genomics of an endophytic Pseudomonas putida isolated from mango orchard
Q33405800Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics from Streptomyces triostinicus
Q27000500Complexity generation during natural product biosynthesis using redox enzymes
Q35260240Computational survey of peptides derived from disulphide-bonded protein loops that may serve as mediators of protein-protein interactions
Q27652079Crystal structure of DltA. Implications for the reaction mechanism of non-ribosomal peptide synthetase adenylation domains
Q27678575Crystal structures of the first condensation domain of CDA synthetase suggest conformational changes during the synthetic cycle of nonribosomal peptide synthetases
Q38190893Cu-mediated enamide formation in the total synthesis of complex peptide natural products
Q33863512Cyanobacteria: an emerging source for drug discovery
Q38093448Cyanobacteria: potential candidates for drug discovery
Q47415251Cyclodipeptides: An Overview of Their Biosynthesis and Biological Activity.
Q34468738Dereplicating nonribosomal peptides using an informatic search algorithm for natural products (iSNAP) discovery.
Q38615264Dereplication, sequencing and identification of peptidic natural products: from genome mining to peptidogenomics to spectral networks
Q98457972Discovery of a Cryptic Depsipeptide from Streptomyces ghanaensis via MALDI-MS-Guided High-Throughput Elicitor Screening
Q58774660Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining
Q34543062Discovery of indolotryptoline antiproliferative agents by homology-guided metagenomic screening.
Q50664864Discovery of the rhizopodin biosynthetic gene cluster in Stigmatella aurantiaca Sg a15 by genome mining.
Q61801050Diversified secondary metabolite biosynthesis gene repertoire revealed in symbiotic dinoflagellates
Q59276667Diversity and antagonistic properties of culturable halophilic actinobacteria in soils of two arid regions of septentrional Sahara: M’zab and Zibans
Q41974687Diversity of nonribosomal peptide synthetase genes in the microbial metagenomes of marine sponges
Q35197225Elucidation of sevadicin, a novel non-ribosomal peptide secondary metabolite produced by the honey bee pathogenic bacterium Paenibacillus larvae
Q50864648Enhancement of Echinocandin B Production by a UV- and Microwave-Induced Mutant of Aspergillus nidulans with Precursor- and Biotin-Supplying Strategy.
Q38713113Enhancing Nonribosomal Peptide Biosynthesis in Filamentous Fungi
Q37672969Enniatin and Beauvericin Biosynthesis in Fusarium Species: Production Profiles and Structural Determinant Prediction
Q34425191Enzymatic processing of fumiquinazoline F: a tandem oxidative-acylation strategy for the generation of multicyclic scaffolds in fungal indole alkaloid biosynthesis
Q42602789Epsilon-poly-L-lysine dispersity is controlled by a highly unusual nonribosomal peptide synthetase.
Q33888721Evolution of an endofungal lifestyle: Deductions from the Burkholderia rhizoxinica genome
Q51351857Expanding Substrate Promiscuity by Engineering a Novel Adenylating-Methylating NRPS Bifunctional Enzyme.
Q51564331Exploring marine cyanobacteria for lead compounds of pharmaceutical importance.
Q30625182Fine de novo sequencing of a fungal genome using only SOLiD short read data: verification on Aspergillus oryzae RIB40.
Q37794952Frontiers and Opportunities in Chemoenzymatic Synthesis
Q59794850Full-length title: NRPPUR database search and in vitro analysis identify an NRPS-PKS biosynthetic gene cluster with a potential antibiotic effect
Q33770563Functional analysis of all nonribosomal peptide synthetases in Cochliobolus heterostrophus reveals a factor, NPS6, involved in virulence and resistance to oxidative stress
Q44956933Functional analysis of the Alternaria brassicicola non-ribosomal peptide synthetase gene AbNPS2 reveals a role in conidial cell wall construction
Q42920325Functional and phylogenetic divergence of fungal adenylate-forming reductases
Q37801553Fungal cyclooligomer depsipeptides: from classical biochemistry to combinatorial biosynthesis.
Q33206823Fusarin C biosynthesis in Fusarium moniliforme and Fusarium venenatum.
Q36038134Genome Assembly of the Fungus Cochliobolus miyabeanus, and Transcriptome Analysis during Early Stages of Infection on American Wildrice (Zizania palustris L.).
Q64055375Genomics-driven discovery of a biosynthetic gene cluster required for the synthesis of BII-Rafflesfungin from the fungus Phoma sp. F3723
Q36540647Gobichelin A and B: Mixed-Ligand Siderophores Discovered Using Proteomics
Q21999338Haloalkaliphilic Streptomyces spp. AJ8 isolated from solar salt works and its' pharmacological potential
Q37304016Harnessing the potential of halogenated natural product biosynthesis by mangrove-derived actinomycetes
Q33607074Hassallidins, antifungal glycolipopeptides, are widespread among cyanobacteria and are the end-product of a nonribosomal pathway
Q27682818Heterologous expression and structural characterisation of a pyrazinone natural product assembly line
Q58036319High-Resolution Tandem Mass Spectrometry for Nonribosomal Peptide and Polyketide Analysis
Q36233015Identification and Characterization of the Sulfazecin Monobactam Biosynthetic Gene Cluster
Q34408731Identification and functional analysis of gene cluster involvement in biosynthesis of the cyclic lipopeptide antibiotic pelgipeptin produced by Paenibacillus elgii
Q35949471Identification of a biosynthetic gene cluster and the six associated lipopeptides involved in swarming motility of Pseudomonas syringae pv. tomato DC3000.
Q36277224Identification of a gene involved in the synthesis of a dipeptidyl peptidase IV inhibitor in Aspergillus oryzae
Q35897780Identification of the Sfp-Type PPTase EppA from the Lichenized Fungus Evernia prunastri
Q33308511Identification, isolation, and analysis of a gene cluster involved in iron acquisition by Pseudomonas mendocina ymp.
Q34480679Imaging mass spectrometry and genome mining reveal highly antifungal virulence factor of mushroom soft rot pathogen
Q47138590In silico methods for linking genes and secondary metabolites: The way forward.
Q39869076In vivo modification of native carrier protein domains
Q34775615In vivo production of artificial nonribosomal peptide products in the heterologous host Escherichia coli
Q38333136Interrupted adenylation domains: unique bifunctional enzymes involved in nonribosomal peptide biosynthesis
Q104970550Isolation and Structure Determination of New Antibacterial Peptide Curacomycin Based on Genome Mining
Q34195155Kinetic and regiospecific interrogation of covalent intermediates in the nonribosomal peptide synthesis of yersiniabactin
Q35596404Learning from nature's drug factories: nonribosomal synthesis of macrocyclic peptides
Q35986033Lessons from natural molecules
Q82700549Marine natural products: totally tubular peptide synthesis
Q41855471Mechanism of epsilon-poly-L-lysine production and accumulation revealed by identification and analysis of an epsilon-poly-L-lysine-degrading enzyme.
Q38197830Metabolite induction via microorganism co-culture: a potential way to enhance chemical diversity for drug discovery
Q90282443Metabolomic-guided discovery of cyclic nonribosomal peptides from Xylaria ellisii sp. nov., a leaf and stem endophyte of Vaccinium angustifolium
Q35615376Mining the microbial metabolome: a new frontier for natural product lead discovery
Q38066160Molecular diversity sculpted by fungal PKS-NRPS hybrids
Q38060675N-methylation of peptides and proteins: an important element for modulating biological functions
Q33961066NCAD, a database integrating the intrinsic conformational preferences of non-coded amino acids
Q24649748NORINE: a database of nonribosomal peptides
Q42713872NRPSpredictor2--a web server for predicting NRPS adenylation domain specificity
Q38118601NRPSs and amide ligases producing homopoly(amino acid)s and homooligo(amino acid)s
Q36366473Natural insights for chemical biologists
Q36772397Natural products of filamentous fungi: enzymes, genes, and their regulation
Q36396672New insight into the ochratoxin A biosynthetic pathway through deletion of a nonribosomal peptide synthetase gene in Aspergillus carbonarius
Q52693047Nonribosomal biosynthesis of backbone-modified peptides.
Q44428224Novel nonribosomal peptide synthetase (NRPS) genes sequenced from intertidal mudflat bacteria
Q39383814Optimizing dimodular nonribosomal peptide synthetases and natural dipeptides in an Escherichia coli heterologous host
Q46534252Overexpression of a three-gene conidial pigment biosynthetic pathway in Aspergillus nidulans reveals the first NRPS known to acetylate tryptophan.
Q28817191Oxidative diversification of amino acids and peptides by small-molecule iron catalysis
Q37273353Paenimacrolidin, a novel macrolide antibiotic from Paenibacillus sp. F6-B70 active against methicillin-resistant Staphylococcus aureus
Q34401860Peptaibols from Trichoderma asperellum TR356 strain isolated from Brazilian soil
Q53440830Peptidomimetic bond formation by DNA-templated acyl transfer.
Q54965902Petroleum degradation by Pseudomonas sp. ZS1 is impeded in the presence of antagonist Alcaligenes sp. CT10.
Q38384804Plants and endophytes: equal partners in secondary metabolite production?
Q39208551Post-translational modifications involved in the biosynthesis of thiopeptide antibiotics
Q40831544Precursor Amino Acids Inhibit Polymyxin E Biosynthesis in Paenibacillus polymyxa, Probably by Affecting the Expression of Polymyxin E Biosynthesis-Associated Genes
Q37946763Protein engineering towards natural product synthesis and diversification
Q36016086Rationally engineered total biosynthesis of a synthetic analogue of a natural quinomycin depsipeptide in Escherichia coli
Q51636993Reactions catalyzed by mature and recombinant nonribosomal peptide synthetases.
Q36590659Reinvigorating natural product combinatorial biosynthesis with synthetic biology
Q93024745Reprogramming Escherichia coli for the production of prenylated indole diketopiperazine alkaloids
Q52730223Resistance to nonribosomal peptide antibiotics mediated by D-stereospecific peptidases.
Q41976680Rhizonin, the first mycotoxin isolated from the zygomycota, is not a fungal metabolite but is produced by bacterial endosymbionts
Q33327536Ribosomal synthesis of N-methyl peptides
Q37149912Ribosomal synthesis of nonstandard peptides
Q46286205Role of DptE and DptF in the lipidation reaction of daptomycin
Q35566572SecG is required for antibiotic activities of Pseudomonas sp. YL23 against Erwinia amylovora and Dickeya chrysanthemi
Q24561994Selective interaction between nonribosomal peptide synthetases is facilitated by short communication-mediating domains
Q42608852Sequencing and analysis of the biosynthetic gene cluster of the lipopeptide antibiotic Friulimicin in Actinoplanes friuliensis
Q51269628Solvent engineering substantially enhances the chemoenzymatic production of surfactin.
Q41589017Specific disulfide cross-linking to constrict the mobile carrier domain of nonribosomal peptide synthetases
Q47154720Structural Diversity, Biological Properties and Applications of Natural Products from Cyanobacteria. A Review
Q86878619Structural characterization of actinomycin D using multiple ion isolation and electron induced dissociation
Q34249663Surveys of non-ribosomal peptide and polyketide assembly lines in fungi and prospects for their analysis in vitro and in vivo
Q37973514Synthetic biological approaches to natural product biosynthesis
Q42186560Synthetic fermentation of bioactive non-ribosomal peptides without organisms, enzymes or reagents
Q38088802Systems biology of cyanobacterial secondary metabolite production and its role in drug discovery.
Q46069690Tapping a bacterial enzymatic pathway for the preparation and manipulation of synthetic nanomaterials
Q96017074Targeted Discovery of Tetrapeptides and Cyclic Polyketide-Peptide Hybrids from a Fungal Antagonist of Farming Termites
Q38129759Tentative biosynthetic pathways of some microbial diketopiperazines
Q33786706The Draft Genome of the Non-Host-Associated Methanobrevibacter arboriphilus Strain DH1 Encodes a Large Repertoire of Adhesin-Like Proteins.
Q92290537The Genetic Basis of Toxin Biosynthesis in Dinoflagellates
Q41957039The Kolumbo submarine volcano of Santorini island is a large pool of bacterial strains with antimicrobial activity
Q36435230The biosynthesis, molecular genetics and enzymology of the polyketide-derived metabolites
Q33224671The lipopeptide antibiotic A54145 biosynthetic gene cluster from Streptomyces fradiae
Q33320836The minimized dead-end elimination criterion and its application to protein redesign in a hybrid scoring and search algorithm for computing partition functions over molecular ensembles
Q38023179The nonribosomal synthesis of diketopiperazines in tRNA-dependent cyclodipeptide synthase pathways.
Q45860951The screening of antimicrobial bacteria with diverse novel nonribosomal peptide synthetase (NRPS) genes from South China sea sponges
Q38038812The structural role of the carrier protein--active controller or passive carrier
Q43183408Three thioesterases are involved in the biosynthesis of phosphinothricin tripeptide in Streptomyces viridochromogenes Tü494.
Q46120567TioS T-TE--a prototypical thioesterase responsible for cyclodimerization of the quinoline- and quinoxaline-type class of chromodepsipeptides
Q33515265TmpL, a transmembrane protein required for intracellular redox homeostasis and virulence in a plant and an animal fungal pathogen
Q33997112Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli.
Q37929703Total synthesis and functional analysis of non-ribosomal peptides
Q39624965Total synthesis of the large non-ribosomal peptide polytheonamide B.
Q43179872Type II thioesterase ScoT, associated with Streptomyces coelicolor A3(2) modular polyketide synthase Cpk, hydrolyzes acyl residues and has a preference for propionate.
Q41068761Unique post-translational oxime formation in the biosynthesis of the azolemycin complex of novel ribosomal peptides from Streptomyces sp. FXJ1.264
Q35058923Unraveling terminal C-domain-mediated condensation in fungal biosynthesis of imidazoindolone metabolites.
Q36120027Utilizing the power of microbial genetics to bridge the gap between the promise and the application of marine natural products
Q40372125Whole Genome Sequencing of the Symbiont Pseudovibrio sp. from the Intertidal Marine Sponge Polymastia penicillus Revealed a Gene Repertoire for Host-Switching Permissive Lifestyle.
Q47243293Whole genome sequence of Auricularia heimuer (Basidiomycota, Fungi), the third most important cultivated mushroom worldwide
Q41992730Wide Distribution of Foxicin Biosynthetic Gene Clusters in Streptomyces Strains - An Unusual Secondary Metabolite with Various Properties
Q28585924Widespread Inter- and Intra-Domain Horizontal Gene Transfer of d-Amino Acid Metabolism Enzymes in Eukaryotes
Q54289419Yeast homologous recombination cloning leading to the novel peptides ambactin and xenolindicin.
Q28483744mMass as a software tool for the annotation of cyclic peptide tandem mass spectra
Q42118868ε-Poly-L-lysine peptide chain length regulated by the linkers connecting the transmembrane domains of ε-Poly-L-lysine synthetase

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