aconitine

chemical compound

DBpedia resource is: http://dbpedia.org/resource/Aconitine

Abstract is: Aconitine is an alkaloid toxin produced by various plant species belonging to the genus Aconitum (family Ranunculaceae), known also commonly by the names wolfsbane and monkshood. Monkshood is notorious for its toxic properties. Aconitine is also present in Yunnan Baiyao, a proprietary traditional Chinese medicine.

Wikimedia Commons category is Aconitine

C₃₄H₄₇NO₁₁

aconitine is …
instance of (P31):
group of stereoisomersQ59199015

sublass of (P279):
aconitane alkaloidQ109416739

External links are
P233canonical SMILESCCN1CC2(C(CC(C34C2C(C(C31)C5(C6C4CC(C6OC(=O)C7=CC=CC=C7)(C(C5O)OC)O)OC(=O)C)OC)OC)O)COC
P231CAS Registry Number302-27-2
P683ChEBI ID2430
P592ChEMBL IDCHEMBL1979562
P661ChemSpider ID214292
P8494DSSTOX compound identifierDTXCID2026319
P3117DSSTox substance IDDTXSID4046319
P232EC number206-121-7
P2566ECHA Substance Infocard ID100.005.566
P1417Encyclopædia Britannica Online IDscience/aconitine
P3219Encyclopædia Universalis IDaconitine
P646Freebase ID/m/0gb8t
P595Guide to Pharmacology Ligand ID2617
P7025HCIS ID88
P234InChIInChI=1S/C34H47NO11/c1-7-35-15-31(16-41-3)20(37)13-21(42-4)33-19-14-32(40)28(45-30(39)18-11-9-8-10-12-18)22(19)34(46-17(2)36,27(38)29(32)44-6)23(26(33)35)24(43-5)25(31)33/h8-12,19-29,37-38,40H,7,13-16H2,1-6H3/t19-,20-,21+,22-,23+,24+,25-,26?,27+,28-,29+,31+,32-,33+,34-/m1/s1
P235InChIKeyXFSBVAOIAHNAPC-XTHSEXKGSA-N
P2017isomeric SMILESCCN1C[C@@]2([C@@H](C[C@@H]([C@@]34[C@@H]2[C@H]([C@@H](C31)[C@@]5([C@@H]6[C@H]4C[C@@]([C@@H]6OC(=O)C7=CC=CC=C7)([C@H]([C@@H]5O)OC)O)OC(=O)C)OC)OC)O)COC
P8408KBpedia IDAconitine
P665KEGG IDC06091
P2064KNApSAcK IDC00001611
P6689MassBank accession IDMSBNK-NaToxAq-NA002479
MSBNK-NaToxAq-NA002480
MSBNK-NaToxAq-NA002481
MSBNK-NaToxAq-NA002482
MSBNK-NaToxAq-NA002483
MSBNK-NaToxAq-NA002874
MSBNK-NaToxAq-NA002875
MSBNK-NaToxAq-NA002876
MSBNK-NaToxAq-NA002877
MSBNK-NaToxAq-NA002878
MSBNK-NaToxAq-NA003254
MSBNK-NaToxAq-NA003255
MSBNK-NaToxAq-NA003256
MSBNK-NaToxAq-NA003257
MSBNK-NaToxAq-NA003258
MSBNK-NaToxAq-NA003619
MSBNK-NaToxAq-NA003620
MSBNK-NaToxAq-NA003621
MSBNK-NaToxAq-NA003622
MSBNK-NaToxAq-NA003623
MSBNK-RIKEN-PR300718
MSBNK-RIKEN-PR300722
MSBNK-RIKEN-PR300727
MSBNK-RIKEN-PR300732
MSBNK-RIKEN-PR300736
MSBNK-RIKEN-PR300741
MSBNK-RIKEN-PR300746
MSBNK-RIKEN-PR300751
MSBNK-RIKEN-PR300756
MSBNK-RIKEN-PR300760
MSBNK-RIKEN-PR300764
MSBNK-RIKEN-PR300768
P486MeSH descriptor IDD000157
P672MeSH tree codeD02.455.849.291.184.037
D03.132.301.030
P6366Microsoft Academic ID2777547430
P2004NALT ID207732
P2085Nikkaji IDJ9.871J
P2840NSC number759627
P10283OpenAlex IDC2777547430
P11199Probes And Drugs IDPD047426
P662PubChem CID245005
P1579Reaxys registry number74608
P657RTECS numberAR5960000
P5076Römpp online IDRD-01-00593
P2877SureChEMBL IDSCHEMBL73323
P2892UMLS CUIC0001159
P11089UniChem compound ID1074270
P652UNIIX8YN71D5WC
P679ZVG number510021

P1343described by sourceBrockhaus and Efron Encyclopedic DictionaryQ602358
The Nuttall EncyclopædiaQ3181656
Ottův slovník naučnýQ2041543
Granat Encyclopedic DictionaryQ4532138
Meyers Konversations-Lexikon, 4th edition (1885–1890)Q19219752
Great Soviet Encyclopedia (1926–1947)Q20078554
P1889different fromAconitaseQ342083
P703found in taxonAconitumQ155904
Liriodendron tulipiferaQ158783
Aconitum anthoraQ927257
Aconitum fischeriQ2075615
Aconitum carmichaeliiQ2561734
Aconitum napellusQ159218
Aconitum feroxQ2647500
Aconitum kusnezoffiiQ3281700
Aconitum altaicumQ4093579
Aconitum baicalenseQ4093582
Aconitum volubileQ4093587
Aconitum karakolicumQ4093597
Aconitum soongaricumQ4093599
Aconitum flavumQ10885296
Aconitum henryiQ11055991
Delphinium sclerocladumQ110470047
Gymnaconitum gymnandrumQ42687245
Aconitum sungpanenseQ11104766
Aconitum japonicumQ15360147
Aconitum turczaninowiiQ15362936
P527has part(s)carbonQ623
nitrogenQ627
P2067mass645.314911
P2101melting point202.5
P2868subject has roletoxinQ184651
immunologic adjuvantQ967453
Voltage-Gated Sodium Channel AgonistsQ50430450

Reverse relations

main subject (P921)
Q112753959MKL1888:Aconitīn
Q76997981A CASE OF ACONITINE POISONING WITH CARDIAC SYMPTOMS
Q44570834A new enzyme immunoassay for aconitine and its application to quantitative determination of aconitine levels in plasma
Q68070293A study of the diterpene alkaloids of Aconitum napellus ssp. neomontanum during its onthogenetic cycle
Q99982345A study ofaconitum alkaloids from aconite roots in Aconitum carmichaeli Debx using matrix-assisted laser desorption/ionization mass spectrometry
Q79604656Aconitine in Nectaries and Other Organs from an Icelandic Population of Aconitum napellus ssp. vulgare
Q46711799Aconitine induces prolonged seizure-like events in rat neocortical brain slices
Q33159306Aconitine intoxication mimicking acute myocardial infarction
Q22669533Aconitum alkaloid poisoning related to the culinary uses of aconite roots
Q104393764Alkaloids of Aconitum ferox
Q104921566Alkaloids of Some Mongolian Ranunculaceae Species: Detailed 1H- and 13C-NMR Studies of Denudatine and Lepenine
Q104390811Alkaloids of the Mongolian flora II. Alkaloids of Aconitum turczaninowii
Q104390807Alkaloids of the Mongolian flora. III. Altaconitine ? A new alkaloid from Aconitum altaicum
Q104390809Alkaloids of the Monolian flora. IV. Turcosine ? A new alkaloid from Aconitum turczaninowi
Q104952586Alkaloids of the cultivated speciesAconitum paniculatum andA. ferox
Q104921568Alkaloids of three species of Aconitum growing in Mongolia
Q104862524Alkaloids ofAconitum karakolicum. Structure of acetylnapelline
Q104384699Alkaloids ofAconitum saposhnikovii andA. karacolicum
Q43228183Analytical aspects of diterpene alkaloid poisoning with monkshood.
Q34186995Biological Evaluation of Polyherbal Ayurvedic Cardiotonic Preparation "Mahamrutyunjaya rasa".
Q76575293CHROMATOGRAPHIC SEPARATION OF ACONITINE AND PSEUDO-ACONITINE
Q34570531Characterization of metabolites and cytochrome P450 isoforms involved in the microsomal metabolism of aconitine
Q70738243Chemical studies on crude drug processing. III. Aconiti tuber (2). On the constituents of "pao-fuzi", the processed tuber of Aconitum carmichaeli Debx, and biological activities of lipo-alkaloids
Q79694157Clonal Multiplication of Aconitum carmichaeli by Tip Tissue Culture and Alkaloid Contents of Clonally Propagated Plant
Q79658492Determination of Aconitum alkaloids in the tubers of Aconitum japonicum using gas chromatography/selected ion monitoring
Q50706511Disruption of the intracellular Ca2+ homeostasis in the cardiac excitation-contraction coupling is a crucial mechanism of arrhythmic toxicity in aconitine-induced cardiomyocytes.
Q104390790Diterpenic Alkaloids of Aconitum napellus Roots from Switzerland
Q79704174Diterpenoid Alkaloids of Aconitum sungpanase
Q104384709Diterpenoid alkaloids from Aconitum talassicum
Q76733929EMETIC EFFECT OF APOMORPHINE, MORPHINE AND ACONITINE IN VARIOUS MODES OF ADMINISTRATION
Q46808963Effects of chronic administrations of aconitine on body weight and rectal temperature in mice
Q39502131Evidence for aconitine-induced inhibition of delayed rectifier K(+) current in Jurkat T-lymphocytes.
Q104921572Extraction of the total alkaloids fromAconitum soongoricum tubers
Q104384703Five new napelline-type diterpene alkaloids from Aconitum liangshanium.
Q62569595Giftpflanzen -Pflanzengifte
Q115950166HPLC DETERMINATION OF ACONITINE, HYPACONITINE AND MESACONITINE IN ACONITE EXTRACT
Q68003441Hypaconitine, the dominant constituent responsible for the neuromuscular blocking action of the Japanese-sino medicine "bushi" (aconite root)
Q83931007Identification of diterpenoid alkaloids from the roots of Aconitum kusnezoffii Reihcb
Q64134403In vivo acute toxicity of detoxified Fuzi (lateral root of Aconitum carmichaeli) after a traditional detoxification process
Q79843215Induction of cyp1a1 is a nonspecific biomarker of aryl hydrocarbon receptor activation: results of large scale screening of pharmaceuticals and toxicants in vivo and in vitro
Q39964248Influence of lipid-soluble gating modifier toxins on sodium influx in neocortical neurons
Q34161366Involvement of CYP3A4/5 and CYP2D6 in the metabolism of aconitine using human liver microsomes and recombinant CYP450 enzymes
Q48486517Involvement of Central adrenergic mechanisms in the induction of cardiac arrhythmias by aconitine nitrate administered intraventricularly
Q104972327Isolation and Identification of Four Norditerpenoid Alkaloids from Processed and Unprocessed Root Tubers of Aconitum Ferox
Q41384201MECHANISM OF ATRIAL FLUTTER AND FIBRILLATION INDUCED BY ACONITINE IN THE DOG, WITH OBSERVATIONS ON THE ROLE OF CHOLINEGIC FACTORS
Q58763314Mechanisms for therapeutic effect of bulleyaconitine A on chronic pain
Q104979170Merckonine, a New Aconitine-Type Norditerpenoid Alkaloid with a -N=C-19H Functionality
Q38353219Methods for ECG evaluation of indicators of cardiac risk, and susceptibility to aconitine-induced arrhythmias in rats following status epilepticus.
Q34455629Mode of antinociceptive and toxic action of alkaloids of Aconitum spec..
Q105024202N-Deethylaconitine from Aconitum napellus ssp. vulgare
Q99239860Neuropharmacological Effects of Mesaconitine: Evidence from Molecular and Cellular Basis of Neural Circuit
Q76883253ON THE ROLE OF NODULAR GANGLIA OF THE VAGUS NERVE IN THE EMETIC RESPONSE TO ACONITINE AND VERATRINE
Q104390786On the Alkaloids contained in Roots of Domestic Aconite Species collected at Sado-island (Niigata Pref.)
Q84757636Oxymatrine, the main alkaloid component of Sophora roots, protects heart against arrhythmias in rats
Q104952588Qualitative mass spectrometric analysis of the total diterpene bases from the roots ofAconitum kusnezoffi
Q46825835Quantification of Aconitum alkaloids in aconite roots by a modified RP-HPLC method
Q44773579Quantitative determination of Aconitum alkaloids in blood and urine samples by high-performance liquid chromatography
Q104978123Quaternary Isoquinoline Alkaloids and Some Diterpenoid Alkaloids in Plants of the Czech Republic
Q78405330ROLE OF NODOSE GANGLION IN VOMITING REFLEX TO ACONITINE AND VERATRINE
Q76848567STUDIES ON ACONITINE-INDUCED VENTRICULAR FIBRILLATION BY SIMULTANEOUS RECORDING OF ELECTROCARDIOGRAMS AND TRANSMEMBRANE POTENTIALS IN SITU
Q104938670Separation of Diterpenoid Alkaloid Mixtures Using Vacuum Liquid Chromatography
Q79681077Simultaneous determination of lipo-alkaloids extracted from Aconitum carmiechaeli using electrospray ionization mass spectrometry and multiple tandem mass spectrometry
Q82123007Some Pharmacological Properties of the Monoanilide of Aconitic Acid
Q42240254Stimulating actions on ribonucleic acid biosynthesis of aconitines, diterpenic alkaloids of Aconitum roots
Q104390782Structure of Senbusine A, B and C, Diterpenie Alkaloids of Aconitum carmichaeli Roots From China
Q104980249Studies on Aconitum Species. VIII. Components of "Kako-Bushi-Matsu"
Q104390797Studies on the Active Principles from Aconitum flavum Hand-Mazz. The Structures of Five New Deterpenoid Alkaloids
Q67883740Studies on the constituents of Aconitum species. IX. The pharmacological properties of pyro-type aconitine alkaloids, components of processed aconite powder ‘Kako-bushi-matsu’: analgesic, antiinflammatory and acute toxic activities
Q105005721THE ALKALOIDS OF ACONITUM NAPELLUS.
Q35569993TRPA1 and sympathetic activation contribute to increased risk of triggered cardiac arrhythmias in hypertensive rats exposed to diesel exhaust
Q104390796The Diterpenoid Alkaloids from Aconitum napellus
Q41150199The central nervous effect of prostaglandins I2, E2 and F2α on aconitine — Induced cardiac arrhythmia in rats
Q69726720The effects of manganese on aconitine-induced ventricular tachycardia
Q85118834The relationship between growth of the aerial part and alkaloid content variation in cultivated Aconitum carmichaeli Debeaux
Q104938672Willipelletierine, a New Diterpenoid Alkaloid from Consolida Scleroclada (Boiss.) Schrod.
Q70738240[Chemical studies on crude drug processing. II. Aconiti tuber (1). On the constituents of "chuan-wu", the dried tuber of Aconitum carmichaeli Debx]
Q70738247[Chemical studies on crude drug processing. IV. Aconiti tuber (3). Quantitative determination of aconitine alkaloids in aconiti tuber by means of high performance liquid chromatography]
Q23849382Aconitin
Q29650345БСЭ1 / Аконитин
Q87336926ЭСГ/Аконитин

Q3459294Sodium voltage-gated channel alpha subunit 5physically interacts withP129
Q155904Aconitumthis taxon is source ofP1672
Q342083Aconitasedifferent fromP1889
Q63395816[(1S,2R,3R,4R,5R,6S,7S,8R,9R,10S,13R,14R,16S,17S,18R)-8-acetyloxy-11-ethyl-5,7,14-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] benzoatesubclass ofP279
Q62817151Appaconitine Patch for Oral Mucositis Pain Caused by Chemoradiotherapy in Patients With Nasopharyngeal Cancerresearch interventionP4844
uri / http://www.wikidata.org/entity/L85031-S1L85031-S1item for this senseP5137
Q16517031aconitine poisoninghas causeP828