Neuropharmacological Effects of Mesaconitine: Evidence from Molecular and Cellular Basis of Neural Circuit

scientific article published on 21 August 2020

Neuropharmacological Effects of Mesaconitine: Evidence from Molecular and Cellular Basis of Neural Circuit is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1155/2020/8814531
P932PMC publication ID7456483
P698PubMed publication ID32904549

P50authorRan Ji CuiQ88525779
Wei YangQ96272927
Limin YangQ99239859
P2093author name stringLihong Zhao
Zhihui Sun
P2860cites workTricyclic antidepressant pharmacology and therapeutic drug interactions updatedQ24564967
Herbal Medicine for Anxiety, Depression and InsomniaQ26786225
Aconite poisoningQ28248079
Neuroplasticity regulation by noradrenaline in mammalian brainQ28749163
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressantsQ29547516
mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonistsQ29618120
Chronic antidepressant treatment increases neurogenesis in adult rat hippocampusQ29619400
Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressantsQ33604879
Analysis of the metabolites of mesaconitine in rat blood using ultrafast liquid chromatography and electrospray ionization mass spectrometryQ33722824
Norepinephrine directly activates adult hippocampal precursors via beta3-adrenergic receptors.Q33725000
Inhibition of the cAMP pathway decreases early long-term potentiation at CA1 hippocampal synapses.Q33904872
Both protein kinase A and mitogen-activated protein kinase are required in the amygdala for the macromolecular synthesis-dependent late phase of long-term potentiation.Q33915849
Atomoxetine alone or combined with fluoxetine for treating ADHD with comorbid depressive or anxiety symptoms.Q34444579
Efficacy and tolerability of venlafaxine compared with selective serotonin reuptake inhibitors and other antidepressants: a meta-analysisQ34620226
Transient CREB-mediated transcription is key in direct neuronal reprogrammingQ36315718
Neuropeptide Trefoil Factor 3 Reverses Depressive-Like Behaviors by Activation of BDNF-ERK-CREB Signaling in Olfactory Bulbectomized RatsQ36403997
BDNF - a key transducer of antidepressant effects.Q36608239
Aconitum in traditional Chinese medicine: a valuable drug or an unpredictable risk?Q37570760
Current perspectives of the roles of the central norepinephrine system in anxiety and depressionQ37644362
Depression and antidepressants: insights from knockout of dopamine, serotonin or noradrenaline re-uptake transportersQ37819312
Synaptic plasticity in depression: molecular, cellular and functional correlatesQ38069869
Antinociceptive mechanism of the aconitine alkaloids mesaconitine and benzoylmesaconineQ72899629
Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medicationQ74424004
Characterization of metabolites and human P450 isoforms involved in the microsomal metabolism of mesaconitineQ82596112
Development and validation of a highly sensitive UPLC-MS/MS method for simultaneous determination of aconitine, mesaconitine, hypaconitine, and five of their metabolites in rat blood and its application to a pharmacokinetics study of aconitine, mesaQ83087445
Analgesic activity of diterpene alkaloids from Aconitum baikalensisQ87539986
Metabonomics study of the effects of pretreatment with glycyrrhetinic acid on mesaconitine-induced toxicity in ratsQ87917361
Mechanisms of Panax ginseng action as an antidepressantQ90623862
From membrane receptors to protein synthesis and actin cytoskeleton: Mechanisms underlying long lasting forms of synaptic plasticityQ91003898
Protective role of metformin against methamphetamine induced anxiety, depression, cognition impairment and neurodegeneration in rat: The role of CREB/BDNF and Akt/GSK3 signaling pathwaysQ91455062
Depression and adult neurogenesis: Positive effects of the antidepressant fluoxetine and of physical exerciseQ91590400
Neuropharmacological effects of Aconiti Lateralis Radix PraeparataQ91977002
Evaluation of the Wistar-Kyoto rat model of depression and the role of synaptic plasticity in depression and antidepressant responseQ92123317
Neurogenesis and antidepressant actionQ92528976
Antidepressant-Like Action of Single Facial Injection of Botulinum Neurotoxin A is Associated with Augmented 5-HT Levels and BDNF/ERK/CREB Pathways in Mouse BrainQ92545090
Activating newborn neurons suppresses depression and anxiety-like behaviorsQ92756994
Locus Coeruleus, Noradrenaline, and Behavior: Network Effect, Network Effects?Q92775212
Additive antidepressant-like effects of fasting with β-estradiol in miceQ92845033
Enhanced noradrenergic activity by yohimbine and differential fear conditioning in patients with major depression with and without adverse childhood experiencesQ92846550
Psychotropic Drugs for the Management of Chronic Pain and ItchQ93018038
Synaptic mechanisms underlying rapid antidepressant action of ketamineQ38093623
Resistance to antidepressant drugs: the case for a more predisposition-based and less hippocampocentric research paradigmQ38235974
Ketamine: promising path or false prophecy in the development of novel therapeutics for mood disorders?Q38254452
A review on phytochemistry and pharmacological activities of the processed lateral root of Aconitum carmichaelii DebeauxQ38283773
Rapid-onset antidepressant efficacy of glutamatergic system modulators: the neural plasticity hypothesis of depression.Q38285502
Neighborhood matters: divergent patterns of stress-induced plasticity across the brain.Q38592629
A review of traditional and current methods used to potentially reduce toxicity of Aconitum roots in Traditional Chinese MedicineQ39407854
Neurochemical and electrophysiological events underlying stress-induced depression in an animal modelQ39472396
Mechanism of mesoconitine-induced contractile response in guinea pig vas deferensQ41555164
Adenylyl cyclase activation modulates activity-dependent changes in synaptic strength and Ca2+/calmodulin-dependent kinase II autophosphorylation.Q41615359
Mechanism of the antinociceptive action of mesaconitine: participation of brain stem and lumbar enlargementQ42575643
Antidepressant activity of diterpene alkaloids of Aconitum baicalense TurczQ42641433
The role of efflux transporters on the transport of highly toxic aconitine, mesaconitine, hypaconitine, and their hydrolysates, as determined in cultured Caco-2 and transfected MDCKII cellsQ42713995
Mitogen-activated protein kinase regulates early phosphorylation and delayed expression of Ca2+/calmodulin-dependent protein kinase II in long-term potentiation.Q43732514
Mesaconitine-induced relaxation in rat aorta: involvement of Ca2+ influx and nitric-oxide synthase in the endotheliumQ43891484
Vasorelaxing effect of mesaconitine, an alkaloid from Aconitum japonicum, on rat small gastric artery: possible involvement of endothelium-derived hyperpolarizing factorQ44137314
Enhancement of associative long-term potentiation by activation of beta-adrenergic receptors at CA1 synapses in rat hippocampal slices.Q44451980
Duloxetine for the treatment of major depressive disorder.Q44511365
The efficacy of reboxetine as an antidepressant, a meta-analysis of both continuous (mean HAM-D score) and dichotomous (response rate) outcomes.Q44996882
Regarding "Combining norepinephrine and serotonin reuptake inhibition mechanisms for treatment of depression: a double-blind randomized study": Optimizing initial interventionsQ45080048
BDNF protects against stress-induced impairments in spatial learning and memory and LTP.Q45099981
Identification of Potential Biomarkers from Aconitum carmichaelii, a Traditional Chinese Medicine, Using a Metabolomic ApproachQ46273530
Comparison of the antinociceptive action of crude Fuzei, the root of Aconitum, and its processed productsQ46483952
The alpha 2-adrenoreceptor agonist clonidine suppresses seizures, whereas the alpha 2-adrenoreceptor antagonist idazoxan promotes seizures in amygdala-kindled kittens: a comparison of amygdala and pontine microinfusion effectsQ46600456
The alpha2-adrenoceptor antagonist dexefaroxan enhances hippocampal neurogenesis by increasing the survival and differentiation of new granule cellsQ46808067
Emotion enhances learning via norepinephrine regulation of AMPA-receptor traffickingQ46960872
Antidepressant-like effect of Fuzi total alkaloid on ovariectomized miceQ48273661
Enhanced long-term synaptic depression in an animal model of depressionQ48349720
The effects of Aconitum alkaloids on the central nervous systemQ48381745
Inhibition of stimulus-triggered and spontaneous epileptiform activity in rat hippocampal slices by the Aconitum alkaloid mesaconitineQ48487945
Aconitum sp. alkaloids: the modulation of voltage-dependent Na+ channels, toxicity and antinociceptive propertiesQ48563303
Noradrenaline increases neural precursor cells derived from adult rat dentate gyrus through β2 receptorQ48902192
Persistent changes in ability to express long-term potentiation/depression in the rat hippocampus after juvenile/adult stressQ48932602
Anticonvulsant effects of Fuzi total alkaloid on pentylenetetrazole-induced seizure in miceQ48956124
Five cases of aconite poisoning: toxicokinetics of aconitines.Q51749683
Nortriptyline and interpersonal psychotherapy as maintenance therapies for recurrent major depression: a randomized controlled trial in patients older than 59 years.Q51988085
A systematic review of pharmacokinetic studies on herbal drug Fuzi: Implications for Fuzi as personalized medicine.Q53703106
Noradrenergic modulation of epileptiform activity in the hippocampus.Q53830897
Molecular mechanism of noradrenaline during the stress-induced major depressive disorderQ56619553
Relationships between the Toxicities of Radix Aconiti Lateralis Preparata (Fuzi) and the Toxicokinetics of Its Main Diester-Diterpenoid AlkaloidsQ58694075
NMDA receptor antagonists block norepinephrine-induced long-lasting potentiation and long-term potentiation in rat dentate gyrusQ69368856
Effect of cyclic AMP on mesaconitine-induced analgesia in miceQ70080894
Mechanism of analgesic action of mesaconitine. I. Relationship between analgesic effect and central monoamines or opiate receptorsQ72385476
Anticonvulsant and Proconvulsant Actions of Alpha- and Beta-Noradrenergic Agonists onEpileptiform Activity in Rat Hippocampus In VitroQ72543530
nMDA receptor activation increases cyclic AMP in area CA1 of the hippocampus via calcium/calmodulin stimulation of adenylyl cyclaseQ72656528
Anti-nociceptive effects of aconiti tuber and its alkaloidsQ72888908
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P921main subjectbrainQ1073
neuronQ43054
aconitineQ342108
P304page(s)8814531
P577publication date2020-08-21
P1433published inNeural PlasticityQ15716605
P1476titleNeuropharmacological Effects of Mesaconitine: Evidence from Molecular and Cellular Basis of Neural Circuit
P478volume2020

Search more.