Phospholipase Cδ1 induces E-cadherin expression and suppresses malignancy in colorectal cancer cells

scientific article

Phospholipase Cδ1 induces E-cadherin expression and suppresses malignancy in colorectal cancer cells is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2014PNAS..11113505S
P356DOI10.1073/PNAS.1405374111
P932PMC publication ID4169964
P698PubMed publication ID25197077
P5875ResearchGate publication ID265418273

P2093author name stringTomomi Nakamura
Kiyoko Fukami
Yumi Murayama
Reiko Satow
Tamaki Hirano
Ryosuke Batori
P2860cites workβ-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cellsQ24299284
Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPKQ24672084
E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components.Q28972461
Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathwaysQ29615855
Phospholipase C isozymes are deregulated in colorectal cancer--insights gained from gene set enrichment analysis of the transcriptomeQ34016649
Quality of life analysis in patients with KRAS wild-type metastatic colorectal cancer treated first-line with cetuximab plus irinotecan, fluorouracil and leucovorinQ34644867
Activated KrasG¹²D is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherin.Q34727214
Identification of novel small compounds that restore E-cadherin expression and inhibit tumor cell motility and invasiveness.Q34987214
BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative studyQ35299011
Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitroQ37459913
Implications for KRAS status and EGFR-targeted therapies in metastatic CRC.Q37563971
Targeted therapy in metastatic colorectal cancer -- an example of personalised medicine in action.Q38078599
RAS signaling pathways, mutations and their role in colorectal cancerQ38116869
The physiological roles of primary phospholipase C.Q38138205
Phosphatidylinositol 5-phosphate 4-kinase type II beta is required for vitamin D receptor-dependent E-cadherin expression in SW480 cellsQ39554360
E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via β-catenin-Egr1-mediated PTEN expression.Q39597035
Gain of oncogenic function of p53 mutants regulates E-cadherin expression uncoupled from cell invasion in colon cancer cellsQ39724059
Phospholipase Cdelta1 is required for skin stem cell lineage commitmentQ39777505
Loss of homotypic cell adhesion by epithelial-mesenchymal transition or mutation limits sensitivity to epidermal growth factor receptor inhibitionQ40169788
Dual activation of phospholipase C-epsilon by Rho and Ras GTPasesQ42111341
Epidermal phospholipase Cδ1 regulates granulocyte counts and systemic interleukin-17 levels in miceQ42832660
Down-regulation of MEK/ERK signaling by E-cadherin-dependent PI3K/Akt pathway in differentiating intestinal epithelial cellsQ44773184
Oncogenic K-ras drives cell cycle progression and phenotypic conversion of primary pancreatic duct epithelial cellsQ45020384
Phospholipase Cepsilon promotes intestinal tumorigenesis of Apc(Min/+) mice through augmentation of inflammation and angiogenesis.Q46003371
Regulation of Wnt signaling by the nuclear pore complexQ46624298
Phospholipase C epsilon plays a suppressive role in incidence of colorectal cancer.Q54365151
Prognostic significance of the wnt signalling pathway molecules APC, beta-catenin and E-cadherin in colorectal cancer: a tissue microarray-based analysis.Q54442810
Extracellular calcium and calcium sensing receptor function in human colon carcinomas: promotion of E-cadherin expression and suppression of beta-catenin/TCF activation.Q54796398
Genetic pathways in colorectal and other cancersQ57337198
Prognostic significance of E-cadherin expression in human colorectal cancer tissueQ73719746
Loss of E-cadherin promotes the growth, invasion and drug resistance of colorectal cancer cells and is associated with liver metastasisQ83396650
P433issue37
P407language of work or nameEnglishQ1860
P921main subjectcolorectal cancerQ188874
colorectal carcinomaQ25493920
P304page(s)13505-13510
P577publication date2014-09-02
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titlePhospholipase Cδ1 induces E-cadherin expression and suppresses malignancy in colorectal cancer cells
P478volume111

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cites work (P2860)
Q37718354Blocking hepatic metastases of colon cancer cells using an shRNA against Rac1 delivered by activatable cell-penetrating peptide
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