Anti-angiogenic activity of a small molecule STAT3 inhibitor LLL12.

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Anti-angiogenic activity of a small molecule STAT3 inhibitor LLL12. is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...735513B
P356DOI10.1371/JOURNAL.PONE.0035513
P932PMC publication ID3328460
P698PubMed publication ID22530037
P5875ResearchGate publication ID224822180

P50authorPeter J. HoughtonQ112045947
P2093author name stringChenglong Li
Cheryl A London
Jiayuh Lin
Hemant K Bid
Duane Oswald
P2860cites workCardiac-specific activation of signal transducer and activator of transcription 3 promotes vascular formation in the heart.Q54435115
STAT3 is activated in a subset of the Ewing sarcoma family of tumours.Q54619002
Development and characterization of pediatric osteosarcoma xenograftsQ68759338
Inhibition of angiogenic differentiation of human umbilical vein endothelial cells by curcuminQ74490421
Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasisQ78836958
Stat3 promotes directional cell migration by regulating Rac1 activity via its activator betaPIXQ84793774
A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cellsQ30492764
Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cellsQ30493841
Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cellsQ33289241
Characterization of STAT3 activation and expression in canine and human osteosarcomaQ33417870
The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumorsQ33613105
The small molecule, LLL12, inhibits STAT3 phosphorylation and induces apoptosis in medulloblastoma and glioblastoma cellsQ33883721
A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cellsQ33935165
Molecular characterization of the pediatric preclinical testing panelQ34406965
Activated STAT signaling in human tumors provides novel molecular targets for therapeutic interventionQ34595904
STAT3: a critical transcription activator in angiogenesis.Q36801186
Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C.Q36986233
The role of Ephs, Ephrins, and growth factors in Kaposi sarcoma and implications of EphrinB2 blockadeQ37039134
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesisQ38290076
Inhibition of growth and metastasis of human hepatocellular carcinoma by antisense oligonucleotide targeting signal transducer and activator of transcription 3.Q38307015
STAT3-stathmin interactions control microtubule dynamics in migrating T-cellsQ39878474
Initial testing (stage 1) of sunitinib by the pediatric preclinical testing programQ40009993
Initial testing of the VEGFR inhibitor AZD2171 by the pediatric preclinical testing programQ40141410
VEGF differentially activates STAT3 in microvascular endothelial cellsQ44489900
Nuclear translocation of phosphorylated STAT3 is essential for vascular endothelial growth factor-induced human dermal microvascular endothelial cell migration and tube formationQ47745076
The pediatric preclinical testing program: description of models and early testing results.Q48387109
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectangiogenesis inhibitorQ574834
P304page(s)e35513
P577publication date2012-04-17
P1433published inPLOS OneQ564954
P1476titleAnti-angiogenic activity of a small molecule STAT3 inhibitor LLL12.
P478volume7

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cites work (P2860)
Q58800840A novel small inhibitor, LLL12, targets STAT3 in non-small cell lung cancer and
Q39225305Biologic activity of the novel small molecule STAT3 inhibitor LLL12 against canine osteosarcoma cell lines
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Q33861173Development, characterization, and reversal of acquired resistance to the MEK1 inhibitor selumetinib (AZD6244) in an in vivo model of childhood astrocytoma
Q36069142Gastric tumour-derived ANGPT2 regulation by DARPP-32 promotes angiogenesis
Q34361391Initial solid tumor testing (stage 1) of AZD1480, an inhibitor of Janus kinases 1 and 2 by the pediatric preclinical testing program
Q35977309Intravitreal dobesilate in the treatment of choroidal neovascularisation associated with age-related macular degeneration: report of two cases
Q36626455Melittin derived peptides for nanoparticle based siRNA transfection
Q38686229Monocytic microRNA profile associated with coronary collateral artery function in chronic total occlusion patients.
Q41660975Myeloperoxidase oxidized LDL interferes with endothelial cell motility through miR-22 and heme oxygenase 1 induction: possible involvement in reendothelialization of vascular injuries
Q35835942Novel Etoposide Analogue Modulates Expression of Angiogenesis Associated microRNAs and Regulates Cell Proliferation by Targeting STAT3 in Breast Cancer.
Q90480455Overexpression of miR-206 in osteosarcoma and its associated molecular mechanisms as assessed through TCGA and GEO databases
Q35540652Plasma-activated medium suppresses choroidal neovascularization in mice: a new therapeutic concept for age-related macular degeneration
Q40471161Protective effect of suppressing STAT3 activity in LPS-induced acute lung injury
Q35130808RECK controls breast cancer metastasis by modulating a convergent, STAT3-dependent neoangiogenic switch
Q38265472STAT3 as a possible therapeutic target in human malignancies: lessons from acute myeloid leukemia
Q28538093Synthesis and mechanistic studies of a novel homoisoflavanone inhibitor of endothelial cell growth
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Q27014674Targeting SH2 domains in breast cancer
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Q36918007The Bromodomain BET Inhibitor JQ1 Suppresses Tumor Angiogenesis in Models of Childhood Sarcoma
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Q26829949Understanding the Biology of Bone Sarcoma from Early Initiating Events through Late Events in Metastasis and Disease Progression
Q37631111ΔNp63 promotes pediatric neuroblastoma and osteosarcoma by regulating tumor angiogenesis

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