The immunoglobulin heavy chain locus: genetic variation, missing data, and implications for human disease

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The immunoglobulin heavy chain locus: genetic variation, missing data, and implications for human disease is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1021553554
P356DOI10.1038/GENE.2012.12
P698PubMed publication ID22551722
P5875ResearchGate publication ID224887542

P2093author name stringC T Watson
F Breden
P2860cites workThe diploid genome sequence of an individual humanQ21090194
Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cellsQ21562507
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Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120Q27643185
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A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22Q28283861
Origins and functional impact of copy number variation in the human genomeQ28730507
Identification of novel susceptibility Loci for kawasaki disease in a Han chinese population by a genome-wide association studyQ28943550
Missing heritability and strategies for finding the underlying causes of complex diseaseQ29614586
Somatic generation of antibody diversityQ29616439
Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infectionQ30398435
B cells in autoimmune diseases: insights from analyses of immunoglobulin variable (Ig V) gene usageQ33286220
Combinatorial antibody libraries from survivors of the Turkish H5N1 avian influenza outbreak reveal virus neutralization strategiesQ33328393
Physical map of the 3' region of the human immunoglobulin heavy chain locus: clustering of autoantibody-related variable segments in one haplotypeQ33428825
The frequency of homozygous deletion of a developmentally regulated Vh gene (Humhv3005) is increased in patients with chronic idiopathic thrombocytopenic purpuraQ33499241
The human immunoglobulin heavy variable genesQ33543808
Determination of gene organization in individual haplotypes by analyzing single DNA fragments from single spermatozoaQ33554290
Population-genetic nature of copy number variations in the human genomeQ33630664
Evidence for a locus (IDDM16) in the immunoglobulin heavy chain region on chromosome 14q32.3 producing susceptibility to type 1 diabetesQ58201241
Ethnic differences in VH gene polymorphismQ71556276
Simultaneous absence of the human IgG1, IgG2, IgG4 and IgA1 subclasses: immunological and immunogenetical considerationsQ71684366
IGH V3-23*01 and its allele V3-23*03 differ in their capacity to form the canonical human antibody combining site specific for the capsular polysaccharide of Haemophilus influenzae type bQ73622166
Susceptibility to multiple sclerosis and the immunoglobulin heavy chain gene clusterQ77675657
Determination of gene organization in the human IGHV region on single chromosomesQ81471186
Structural analysis of substitution patterns in alleles of human immunoglobulin VH genesQ81647979
Segmental duplication as one of the driving forces underlying the diversity of the human immunoglobulin heavy chain variable gene regionQ33805553
Rare antibodies from combinatorial libraries suggests an S.O.S. component of the human immunological repertoireQ33813643
Comparison of antibody repertoires produced by HIV-1 infection, other chronic and acute infections, and systemic autoimmune diseaseQ33867353
Characterization of missing human genome sequences and copy-number polymorphic insertionsQ33875113
Susceptibility to multiple sclerosis is associated with the proximal immunoglobulin heavy chain variable regionQ34183158
Population and family studies of three disease-related polymorphic genes in systemic lupus erythematosusQ34210066
Molecular basis of an autoantibody-associated restriction fragment length polymorphism that confers susceptibility to autoimmune diseasesQ34225507
The human immunoglobulin VH repertoireQ34312904
Population-genetic properties of differentiated human copy-number polymorphismsQ34687598
Wide prevalence of heterosubtypic broadly neutralizing human anti-influenza A antibodiesQ34756837
Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individualsQ34962766
HAPPY mapping of a YAC reveals alternative haplotypes in the human immunoglobulin VH locusQ35036716
Limitations of next-generation genome sequence assemblyQ35047159
A fetally expressed immunoglobulin VH1 gene belongs to a complex set of allelesQ35609941
Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablationQ35647840
Direct detection of insertion/deletion polymorphisms in an autosomal region by analyzing high-density markers in individual spermatozoaQ37203928
Expression of the immunoglobulin VH gene 51p1 is proportional to its germline gene copy numberQ37354531
A defective Vkappa A2 allele in Navajos which may play a role in increased susceptibility to haemophilus influenzae type b diseaseQ37354966
Novel substitution polymorphisms of human immunoglobulin VH genes in MexicansQ38520087
Gross deletions involving IGHM, BTK, or Artemis: a model for genomic lesions mediated by transposable elements.Q39141906
Inherited deletion of immunoglobulin heavy chain constant region genes in normal human individualsQ39168085
Molecular analysis of the T17 immunoglobulin CH multigene deletion (del A1-GP-G2-G4-E).Q39591553
Polymorphism and utilization of human VH Genes.Q40374426
Preferential use of the VH5-51 gene segment by the human immune response to code for antibodies against the V3 domain of HIV-1Q41816066
The inference of phased haplotypes for the immunoglobulin H chain V region gene loci by analysis of VDJ gene rearrangements.Q41860468
Individual variation in the germline Ig gene repertoire inferred from variable region gene rearrangements.Q41911217
Immunoglobulin heavy chain variable region polymorphisms and multiple sclerosis susceptibility.Q42622566
A segment of human Vh gene locus is duplicatedQ42625986
Polymorphism in the immunoglobulin VH gene V1-69 affects susceptibility to rheumatoid arthritis in subjects lacking the HLA-DRB1 shared epitopeQ42674576
No evidence for the involvement of interleukin 2 or the immunoglobulin heavy chain gene cluster in determining genetic susceptibility to multiple sclerosisQ43071810
The HuRef Browser: a web resource for individual human genomicsQ43122555
Genomic screening by 454 pyrosequencing identifies a new human IGHV gene and sixteen other new IGHV allelic variants.Q44418690
Association of homozygous deletion of the Humhv3005 and the VH3-30.3 genes with renal involvement in systemic lupus erythematosus.Q44452632
Effect of 51p1-related gene copy number (V1-69 locus) on production of hepatitis C-associated cryoglobulinsQ44990800
A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q.Q48082296
IGHV4-39 deletion polymorphism does not associate with risk or outcome of multiple sclerosisQ48197651
A multigene deletion in the human IGH constant region locus involves highly homologous hot spots of recombinationQ48285688
Nomenclature of the human immunoglobulin heavy (IGH) genesQ48739605
An utter refutation of the "fundamental theorem of the HapMap".Q51950798
The human immunoglobulin heavy diversity (IGHD) and joining (IGHJ) segments.Q53344826
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectgenetic variationQ349856
missing dataQ6878417
P304page(s)363-373
P577publication date2012-05-03
P1433published inGenes and ImmunityQ15745246
P1476titleThe immunoglobulin heavy chain locus: genetic variation, missing data, and implications for human disease
P478volume13

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