Mechanism of GnRH receptor signaling on gonadotropin release and gene expression in pituitary gonadotrophs

scientific article

Mechanism of GnRH receptor signaling on gonadotropin release and gene expression in pituitary gonadotrophs is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0083-6729(01)63003-6
P698PubMed publication ID11358118

P2093author name stringHarris D
Cohen I
Lewy H
Naor Z
Seger R
Ashkenazi IE
Shacham S
Ben-Shlomo H
Przedecki F
Bonfil D
P2860cites workArrangement of rhodopsin transmembrane α-helicesQ57668024
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A Locus of the Gonadotropin-releasing Hormone Receptor That Differentiates Agonist and Antagonist Binding SitesQ58853853
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Involvement of protein phosphatases in gonadotropin releasing hormone regulated gonadotropin secretionQ71994950
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Expression and function of the gonadotropin-releasing hormone receptor are dependent on a conserved apolar amino acid in the third intracellular loopQ73236819
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Heptahelical receptor signaling: beyond the G protein paradigm.Q33648620
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Evidence for the involvement of several intracellular domains in the coupling of oxytocin receptor to G alpha(q/11).Q34458084
Rhodopsin-family receptors associate with small G proteins to activate phospholipase D.Q34463533
Sequence alignment of the G-protein coupled receptor superfamilyQ35225323
In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptorsQ35227301
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A role for mitogen-activated protein kinase in mediating activation of the glycoprotein hormone alpha-subunit promoter by gonadotropin-releasing hormoneQ36552337
Is arachidonic acid a second messenger in signal transduction?Q37529298
Signal transduction mechanisms of Ca2+ mobilizing hormones: the case of gonadotropin-releasing hormoneQ37938857
Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomasQ38315242
Isolation and characterization of cDNAs encoding the rat pituitary gonadotropin-releasing hormone receptorQ38323360
Identification by polymerase chain reaction of the G protein-coupled receptor kinases expressed in the mouse gonadotropic alpha T3-1 cell lineQ38353627
Asn102 of the gonadotropin-releasing hormone receptor is a critical determinant of potency for agonists containing C-terminal glycinamideQ38356237
Comparative sequence analysis and functional characterization of the cloned sheep gonadotropin-releasing hormone receptor reveal differences in primary structure and ligand specificity among mammalian receptors.Q39093540
A single amino acid substitution in transmembrane helix VI results in overexpression of the human GnRH receptorQ39286132
Hypophysial Responses to Continuous and Intermittent Delivery of Hypothalamic Gonadotropin-Releasing HormoneQ39625743
Evolutionary aspects of gonadotropin-releasing hormone and its receptor.Q40467471
Structure and function of G protein-coupled receptorsQ40642980
Desensitization of cell signalling mediated by phosphoinositidase C.Q40767545
Constitutive activity of receptors coupled to guanine nucleotide regulatory proteinsQ40784172
The probable arrangement of the helices in G protein-coupled receptors.Q40872681
Epidermal growth factor receptor tyrosine kinase mediates Ras activation by gonadotropin-releasing hormoneQ40886648
Lack of a C-terminal tail in the mammalian gonadotropin-releasing hormone receptor confers resistance to agonist-dependent phosphorylation and rapid desensitizationQ40924312
Calcium influx through L-type channels is required for selective activation of extracellular signal-regulated kinase by gonadotropin-releasing hormoneQ40924382
Acute desensitization of phospholipase C-coupled muscarinic M3 receptors but not gonadotropin-releasing hormone receptors co-expressed in alphaT3-1 cells: implications for mechanisms of rapid desensitizationQ41027027
Stimulation of Jun N-terminal kinase (JNK) by gonadotropin-releasing hormone in pituitary alpha T3-1 cell line is mediated by protein kinase C, c-Src, and CDC42.Q41034209
Signal transduction of the gonadotropin releasing hormone (GnRH) receptor: cross-talk of calcium, protein kinase C (PKC), and arachidonic acidQ41041858
The third intracellular loop of the rat gonadotropin-releasing hormone receptor couples the receptor to Gs- and G(q/11)-mediated signal transduction pathways: evidence from loop fragment transfection in GGH3 cellsQ41043353
Differential activation of protein kinase C delta and epsilon gene expression by gonadotropin-releasing hormone in alphaT3-1 cells. Autoregulation by protein kinase C.Q41109568
Distinct efficacies for two endogenous ligands on a single cognate gonadoliberin receptor.Q41134208
Calcium and glycoprotein hormone alpha-subunit gene expression and secretion in alpha T3-1 gonadotropesQ41154191
Desensitization of gonadotropin-releasing hormone action in alphaT3-1 cells due to uncoupling of inositol 1,4,5-trisphosphate generation and Ca2+ mobilizationQ41166258
Residues in the seventh membrane-spanning segment of the dopamine D2 receptor accessible in the binding-site crevice.Q41169045
Arachidonic acid and lipoxygenase products stimulate protein kinase C beta mRNA levels in pituitary alpha T3-1 cell line: role in gonadotropin-releasing hormone actionQ41195254
Rapid desensitization of GnRH-stimulated intracellular signalling events in alpha T3-1 and HEK-293 cells expressing the GnRH receptorQ41277993
Desensitization of gonadotropin-releasing hormone action in the gonadotrope-derived alpha T3-1 cell lineQ41278113
Effects of second intracellular loop mutations on signal transduction and internalization of the gonadotropin-releasing hormone receptorQ41293194
Mechanism of action of gonadotropin-releasing hormone upon gonadotropin alpha-subunit mRNA levels in the alpha T3-1 cell line: role of Ca2+ and protein kinase C.Q41332716
Identification and functional characterization of two new somatic mutations causing constitutive activation of the thyrotropin receptor in hyperfunctioning autonomous adenomas of the thyroidQ41414666
Molecular mechanisms of ligand interaction with the gonadotropin-releasing hormone receptorQ41430675
Arachidonic acid and Lipoxygenase Products Stimulate Gonadotropin .alpha.-Subunit mRNA Levels in Pituitary .alpha.T3-1 Cell Line: Role in Gonadotropin Releasing Hormone ActionQ41434542
GnRH receptor signaling: cross-talk of Ca2+ and protein kinase C.Q41443124
Molecular cloning, sequencing, and characterizing the bovine receptor for gonadotropin releasing hormone (GnRH).Q41523017
Molecular and functional characterization of GnRH receptors cloned from rat pituitary and a mouse pituitary tumor cell lineQ41565077
An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptorsQ41633574
Delayed activation of phospholipase D by gonadotropin-releasing hormone in a clonal pituitary gonadotrope cell line (αT3-1)Q41652479
Phosphorylation of phospholipase C-coupled receptorsQ41680658
The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascadesQ41688659
Further characterization of protein kinase-C subspecies in the hypothalamo-pituitary axis: differential activation by phorbol estersQ41741651
Simultaneous measurement of luteinizing hormone (LH)-releasing hormone, LH, and follicle-stimulating hormone release in intact and short-term castrate ratsQ41835016
Alanine-261 in intracellular loop III of the human gonadotropin-releasing hormone receptor is crucial for G-protein coupling and receptor internalization.Q41894380
Maintenance of gonadotropin-releasing hormone (GnRH)-stimulated luteinizing hormone release despite desensitization of GnRH-stimulated cytosolic calcium responsesQ42459724
Gonadotropin releasing hormone activates the lipoxygenase pathway in cultured pituitary cells: role in gonadotropin secretion and evidence for a novel autocrine/paracrine loopQ42461313
Spontaneous and agonist-induced calcium oscillations in pituitary gonadotrophsQ42473963
The cAMP response elements of the alpha subunit gene bind similar proteins in trophoblasts and gonadotropes but have distinct functional sequence requirementsQ42645161
Desensitization and recovery of muscarinic and histaminergic Ca2+ mobilization in 1321N1 astrocytoma cells.Q42857471
Irreversible activation of the gonadotropin-releasing hormone receptor by photoaffinity cross-linking: localization of attachment site to Cys residue in N-terminal segmentQ46970244
Gonadotropin and gonadal steroid release in response to a gonadotropin-releasing hormone agonist in Gqalpha and G11alpha knockout miceQ48024374
Rapid communication: nucleotide sequence of luteinizing hormone-releasing hormone (LHRH) receptor cDNA in the pig pituitaryQ48081455
Cloning and sequencing of the sheep pituitary gonadotropin-releasing hormone receptor and changes in expression of its mRNA during the estrous cycleQ48108915
From ultradian to infradian rhythms: LH release patterns in vitroQ48139975
Regulation of gonadotropin mRNA levels in cultured rat pituitary cells by gonadotropin-releasing hormone (GnRH): role for Ca2+ and protein kinase C.Q48154212
Activation of MAP kinase associated with the priming effect of LHRH.Q48181344
Dual intracellular pathways in gonadotropin releasing hormone (GNRH) induced desensitization of luteinizing hormone (LH) secretionQ48182937
Rhythmic exocytosis stimulated by GnRH-induced calcium oscillations in rat gonadotropesQ48305038
GnRH-induced Ca2+ oscillations and rhythmic hyperpolarizations of pituitary gonadotropesQ48546237
Immunocytochemical localization of protein kinase-C subtypes in anterior pituitary cells: colocalization in hormone-containing cells reveals heterogeneityQ48627068
Local Ca2+ release from internal stores controls exocytosis in pituitary gonadotrophsQ48819860
Rhythmicity of luteinizing hormone secretion expressed in vitroQ48899814
The second intracellular loop of metabotropic glutamate receptor 1 cooperates with the other intracellular domains to control coupling to G-proteins.Q49021662
Gonadotropin-releasing hormone receptor initiates multiple signaling pathways by exclusively coupling to G(q/11) proteins.Q52973183
Coincidence of down-regulation and desensitization in pituitary gonadotrophs stimulated by gonadotropin releasing hormoneQ54501890
P304page(s)63-90
P577publication date2001-01-01
P1433published inVitamins and HormonesQ15753296
P1476titleMechanism of GnRH receptor signaling on gonadotropin release and gene expression in pituitary gonadotrophs
P478volume63

Reverse relations

cites work (P2860)
Q33642126A preformed signaling complex mediates GnRH-activated ERK phosphorylation of paxillin and FAK at focal adhesions in L beta T2 gonadotrope cells.
Q38872337Activins and Inhibins: Roles in Development, Physiology, and Disease
Q48246926Castration-induced modifications of GnRH-elicited [Ca2+](i) signaling patterns in male mouse pituitary gonadotrophs in situ: studies in the acute pituitary slice preparation
Q90725689Cholesterol: A Gatekeeper of Male Fertility?
Q39199813Differential signaling of the GnRH receptor in pituitary gonadotrope cell lines and prostate cancer cell lines
Q35989183Fanconi anemia A is a nucleocytoplasmic shuttling molecule required for gonadotropin-releasing hormone (GnRH) transduction of the GnRH receptor
Q35603346GnRH Regulates Gonadotropin Gene Expression Through NADPH/Dual Oxidase-Derived Reactive Oxygen Species
Q37125453GnRH-regulated expression of Jun and JUN target genes in gonadotropes requires a functional interaction between TCF/LEF family members and beta-catenin.
Q35805026Gonadotropin-releasing hormone receptors: structure, expression, and signaling transduction
Q40558834Gonadotropin-releasing hormone regulates expression of the DNA damage repair gene, Fanconi anemia A, in pituitary gonadotroph cells
Q40671263Gonadotropin-releasing hormone-induced stimulation of the rat secretogranin II promoter involves activation of CREB.
Q34204531Inhibin at 90: from discovery to clinical application, a historical review
Q28579718Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells
Q37068413Luteinizing hormone-releasing hormone I (LHRH-I) and its metabolite in peripheral tissues
Q35107560Regulation of fish gonadotropins
Q40389809The serotonin type 3A receptor facilitates luteinizing hormone release and LHbeta promoter activity in immortalized pituitary gonadotropes
Q44209245Ubiquitination and proteasomal degradation of endogenous and exogenous inositol 1,4,5-trisphosphate receptors in alpha T3-1 anterior pituitary cells

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