A Locus of the Gonadotropin-releasing Hormone Receptor That Differentiates Agonist and Antagonist Binding Sites

scientific article published in Journal of Biological Chemistry

A Locus of the Gonadotropin-releasing Hormone Receptor That Differentiates Agonist and Antagonist Binding Sites is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.270.32.18853
P698PubMed publication ID7642539

P50authorColleen A FlanaganQ57191799
Harel WeinsteinQ62642462
Robert P. MillarQ38304462
P2093author name stringW Zhou
L Chi
S C Sealfon
S Kitanovic
S Maayani
V Rodic
P2860cites workIsolation and characterization of cDNAs encoding the rat pituitary gonadotropin-releasing hormone receptorQ38323360
Comparative sequence analysis and functional characterization of the cloned sheep gonadotropin-releasing hormone receptor reveal differences in primary structure and ligand specificity among mammalian receptors.Q39093540
Structure and function of G protein-coupled receptorsQ40642980
Molecular cloning, sequencing, and characterizing the bovine receptor for gonadotropin releasing hormone (GnRH).Q41523017
Molecular and functional characterization of GnRH receptors cloned from rat pituitary and a mouse pituitary tumor cell lineQ41565077
Inhibin increases and progesterone decreases receptors for gonadotropin-releasing hormone in ovine pituitary cultureQ44858648
Amino-aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345Q28263133
Cloning, sequencing, and expression of human gonadotropin releasing hormone (GnRH) receptorQ28645650
LIGAND: A versatile computerized approach for characterization of ligand-binding systemsQ29547346
Molecular cloning and characterisation of the rat pituitary gonadotropin-releasing hormone (GnRH) receptorQ30807953
Follistatins: more than follicle-stimulating hormone suppressing proteinsQ34363270
Sequence alignment of the G-protein coupled receptor superfamilyQ35225323
Adrenergic receptors as models for G protein-coupled receptorsQ36064980
Gonadotropin-releasing hormone analog design. Structure-function studies toward the development of agonists and antagonists: rationale and perspectiveQ38160875
P433issue32
P407language of work or nameEnglishQ1860
P304page(s)18853-18857
P577publication date1995-08-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleA locus of the gonadotropin-releasing hormone receptor that differentiates agonist and antagonist binding sites
P478volume270

Reverse relations

cites work (P2860)
Q435913222-(3,5-Dimethylphenyl)tryptamine derivatives that bind to the GnRH receptor
Q31668486A chicken gonadotropin-releasing hormone receptor that confers agonist activity to mammalian antagonists. Identification of D-Lys(6) in the ligand and extracellular loop two of the receptor as determinants
Q40909890A new photoreactive antagonist cross-links to the N-terminal domain of the gonadotropin-releasing hormone receptor
Q48610952A temporally intermediate mode of gonadotropin releasing hormone-induced desensitization of luteinizing hormone secretion
Q38356237Asn102 of the gonadotropin-releasing hormone receptor is a critical determinant of potency for agonists containing C-terminal glycinamide
Q40756038Chimaeric gonadotropin-releasing hormone (GnRH) peptides with improved affinity for the catfish (Clarias gariepinus) GnRH receptor
Q43659974Critical implication of transmembrane Phe310, possibly in conjunction with Trp279, in the rat gonadotropin-releasing hormone receptor activation
Q52102037Developmental expression and subcellular localization of wallaby gonadotropin-releasing hormone receptor and its splice variants.
Q35037027Differences in structure-function relations between nonmammalian and mammalian GnRH receptors: what we have learnt from the African catfish GnRH receptor
Q50758432Dimerizations of the wallaby gonadotropin-releasing hormone receptor and its splice variants.
Q41134208Distinct efficacies for two endogenous ligands on a single cognate gonadoliberin receptor.
Q41120038Epitope-tagged gonadotropin-releasing hormone receptors heterologously-expressed in mammalian (COS-1) and insect (Sf9) cells
Q40374579Evolution of constrained gonadotropin-releasing hormone ligand conformation and receptor selectivity
Q28711288Evolution of vertebrate GnRH receptors from the perspective of a Basal vertebrate
Q58853832Functional Microdomains in G-protein-coupled Receptors
Q40986336Functional analysis of GnRH receptor ligand binding using biotinylated GnRH derivatives
Q60921607GPCR Modulation in Breast Cancer
Q35597631GnRH antagonists in the treatment of infertility
Q35049420Gonadotrophin-releasing hormone (GnRH) and GnRH agonists: mechanisms of action.
Q47130308Gonadotropin-Releasing Hormone (GnRH) Receptor Structure and GnRH Binding.
Q35805026Gonadotropin-releasing hormone receptors: structure, expression, and signaling transduction
Q45000472Identification of CC chemokine receptor 7 residues important for receptor activation
Q58853848Incorporation of an additional glycosylation site enhances expression of functional human gonadotropin-releasing hormone receptor
Q24323205Inhibition of gonadotropin-releasing hormone receptor signaling by expression of a splice variant of the human receptor
Q34254219Mechanism of GnRH receptor signaling on gonadotropin release and gene expression in pituitary gonadotrophs
Q33365169Modeling and high-throughput experimental data uncover the mechanisms underlying Fshb gene sensitivity to gonadotropin-releasing hormone pulse frequency
Q34486365Molecular approaches to contraceptive development
Q36049867Molecular cloning and pharmacological characterization of two novel GnRH receptors in the lamprey (Petromyzon marinus).
Q37106881Molecular mechanism of action of pharmacoperone rescue of misrouted GPCR mutants: the GnRH receptor
Q34667501Noise propagation and scaling in regulation of gonadotrope biosynthesis.
Q73316706Photoaffinity cross-linking identifies differences in the interactions of an agonist and an antagonist with the parathyroid hormone/parathyroid hormone-related protein receptor
Q43685868Proper receptor signalling in a mutant catfish gonadotropin-releasing hormone receptor lacking the highly conserved Asp(90) residue
Q48294750Regulation of levels of 5-HT2A receptor mRNA.
Q36065485Rescue of misrouted GnRHR mutants reveals its constitutive activity
Q33732720Salt bridge integrates GPCR activation with protein trafficking
Q35122859Salt bridges overlapping the gonadotropin-releasing hormone receptor agonist binding site reveal a coincidence detector for G protein-coupled receptor activation
Q58853821The Functional Microdomain in Transmembrane Helices 2 and 7 Regulates Expression, Activation, and Coupling Pathways of the Gonadotropin-releasing Hormone Receptor
Q36310854The G protein-coupled receptors: pharmacogenetics and disease
Q37225618The chicken type III GnRH receptor homologue is predominantly expressed in the pituitary, and exhibits similar ligand selectivity to the type I receptor
Q28755163Trafficking and quality control of the gonadotropin releasing hormone receptor in health and disease
Q37191489Two gonadotropin-releasing hormone receptor subtypes with distinct ligand selectivity and differential distribution in brain and pituitary in the goldfish (Carassius auratus)
Q42836460Use of Pharmacoperones to Reveal GPCR Structural Changes Associated with Constitutive Activation and Trafficking

Search more.